Patents Represented by Attorney, Agent or Law Firm Scott A. Brown
  • Human GDP-mannose 4,6-dehydratase
    Patent number: 5869307
    Abstract: The invention provides a novel GDP-mannose 4,6-dehydratase.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: February 9, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Francis Sullivan, Ronald Kriz, Ravindra Kumar
  • Method for purification of IL-12
    Patent number: 5853714
    Abstract: Methods for the purification of interleukin-12 (IL-12) is provided.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: December 29, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Jeffrey S. Deetz, Bonnie Germain, Brian Hubbard, Lei Shi, Thomas Spitznagel, Dwight Winters
  • TNF receptor death ligand proteins and inhibitors of ligand binding
    Patent number: 5852173
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: September 26, 1995
    Date of Patent: December 22, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella, James Graham
  • TNF receptor death domain ligand proteins and method to identify inhibitors of ligand binding
    Patent number: 5849501
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: June 19, 1995
    Date of Patent: December 15, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella
  • TNF receptor death domain ligand proteins
    Patent number: 5847099
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: December 8, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen
  • Nucleic acid encoding a novel P-selectin ligand protein
    Patent number: 5843707
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Grant
    Filed: April 25, 1995
    Date of Patent: December 1, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw
  • TNF receptor death domain ligand proteins and inhibitors of ligand binding
    Patent number: 5843675
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: December 1, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella, James Graham
  • Method of inhibiting P-selectin ligand activity
    Patent number: 5840679
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 24, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw, Ray Camphausen
  • Chemotactic agents for t-cells
    Patent number: 5837247
    Abstract: Chemotactic activity of defensins and CAP37 is disclosed. Methods of treatment associated with such activity and compositions for such treatment are also provided.
    Type: Grant
    Filed: June 16, 1995
    Date of Patent: November 17, 1998
    Assignee: United States of America as represented by the Public Health Service National Institutes of Health
    Inventors: Joost J. Oppenhelm, Dennis Michiel, Oleg Chertov, Dennis D. Taub, Luoling Xu, Ji Ming Wang, William J. Murphy
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5837490
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: November 17, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5831056
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: November 3, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Michael Bowman, Vikki Spaulding
  • P-selectin ligand protein
    Patent number: 5827817
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 27, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw, Ray Camphausen
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5827688
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: October 27, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding
  • Polynucleotides encoding interleukin-1 receptor intracellular ligand proteins
    Patent number: 5817476
    Abstract: Novel IL-1-R intracellular ligand proteins are disclosed. Polynucleotides encoding the IL-1-R intracellular ligand protein are also disclosed, along with vectors, host cells, and methods of making the IL-1-R intracellular ligand protein. Pharmaceutical compositions containing the IL-1-R intracellular ligand protein, methods of treating inflammatory conditions, and methods of inhibiting IL-1-R intracellular domain binding are also disclosed. Methods of identifying inhibitors of IL-1-R intracellular domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 6, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, James Graham
  • Antibodies to natural killer stimulatory factor
    Patent number: 5811523
    Abstract: A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: September 22, 1998
    Inventors: Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Gordon G. Wong, Rodney Hewick, Michiko Kobayashi, Stanley F. Wolf
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5807709
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: September 15, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5807703
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: June 17, 1996
    Date of Patent: September 15, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Cheryl Evans, Vikki Spaulding, Michael Bowman
  • Secreted protein, BA3.1, and polynucleotides encoding same
    Patent number: 5792628
    Abstract: A novel secreted protein, BA3.1, is disclosed. Polynucleotides encoding BA3.1 are also provided.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: August 11, 1998
    Inventor: Michael Bowman
  • Methods for identification of inhibitors of IL-1-R intracellular ligand binding
    Patent number: 5789181
    Abstract: Novel IL-1-R intracellular ligand proteins are disclosed. Polynucleotides encoding the IL-1-R intracellular ligand protein are also disclosed, along with vectors, host cells, and methods of making the IL-1-R intracellular ligand protein. Pharmaceutical compositions containing the IL-1-R intracellular ligand protein, methods of treating inflammatory conditions, and methods of inhibiting IL-1-R intracellular domain binding are also disclosed. Methods of identifying inhibitors of IL-1-R intracellular domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: October 7, 1996
    Date of Patent: August 4, 1998
    Inventors: Lih-Ling Lin, James Graham
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5786465
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: July 28, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding