Abstract: The use of interleukin-12 to prevent, to ameliorate, and to treat graft-versus-host disease in a mammal in need of such treatment is disclosed. In other embodiments, graft-vs. leukemia effects are maintained or promoted.
Type:
Grant
Filed:
April 30, 1996
Date of Patent:
May 26, 1998
Assignees:
Genetics Institute, Inc., The General Hospital Corporation
Abstract: Provided by the present invention are novel compositions and methods for obtaining concentrated preparations of IL-12 and formulations of IL-12 suitable for storage and administration.
Type:
Grant
Filed:
January 14, 1997
Date of Patent:
April 28, 1998
Assignee:
Genetics Institute, Inc.
Inventors:
Nicholas W. Warne, Thomas J. Crowley, Tracy M. Smith
Abstract: Polynucleotides encoding retenoid receptor-1 (RR1) are disclosed. RR1 proteins and methods for their production, ligands for the RR1 and methods for their identification, and inhibitors of binding of RR1 and its ligands and methods for their identification are also disclosed.
Abstract: A novel method for isolating novel secreted mammalian proteins is described in which mammalian secretory leader sequences are detected using the yeast invertase gene as a reporter system.
Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
Type:
Grant
Filed:
August 15, 1996
Date of Patent:
January 27, 1998
Assignee:
Genetics Institute, Inc.
Inventors:
Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella, James Graham
Abstract: Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
Type:
Grant
Filed:
March 1, 1996
Date of Patent:
January 20, 1998
Assignee:
Genetics Institute, Inc.
Inventors:
Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew Whitters, Clive Wood
Abstract: The present invention discloses a method for protecting cycling or dividing stem cells from the cytotoxic effects of chemotherapeutic agents and radiation by administering prior to exposure to these agents, an effective amount of Stem Cell Inhibitory Factor as well as a composition useful therefore.
Type:
Grant
Filed:
April 21, 1994
Date of Patent:
October 7, 1997
Assignee:
Genetics Institute, Inc.
Inventors:
Ian B. Pragnell, Debra D. Donaldson, Gerald J. Graham, Gordon G. Wong
Abstract: Methods are disclosed for producing a sequence tag from a polynucleotide. In preferred embodiments, the method comprises (a) digesting the polynucleotide with a type II restriction enzyme to produce a first cohesive end; (b) providing a promoter-linker cassette comprising an RNA polymerase promoter, a restriction site for a type IIS restriction enzyme and a second cohesive end which is complementary to the first cohesive end produced by the type II restriction enzyme; (c) ligating the digested polynucleotide to the cassette by joining the first cohesive end and the second cohesive end; (d) digesting the ligated product of step (c) with the type Iis restriction enzyme; and (e) transcribing the resulting construct from the promoter thereby producing a sequence tagged polyribonucleotide.
Abstract: A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.
Type:
Grant
Filed:
March 13, 1995
Date of Patent:
July 15, 1997
Assignee:
Genetics Institute, Inc.
Inventors:
Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Gordon G. Wong, Rodney Hewick, Michiko Kobayashi, Stanley F. Wolf
Abstract: Methods of inducing gamma interferon production and stimulating lymphocyte populations using Natural Killer Stimulatory Factor (NKSF) are disclosed.
Type:
Grant
Filed:
March 13, 1995
Date of Patent:
July 15, 1997
Assignee:
Genetics Institute, Inc.
Inventors:
Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Michiko Kobayashi, Gordon G. Wong, Rodney Hewick, Stanley F. Wolf
Abstract: The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
Abstract: The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
Abstract: The invention provides a novel calcium-independent cytosolic phospholipase A.sub.2 /B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.