Patents Represented by Attorney, Agent or Law Firm Stephen A. Slusher
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Patent number: 7550602Abstract: Compounds of the general formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, and X are as defined. Further provided are methods for treatment of sexual dysfunction, including erectile dysfunction and female sexual dysfunction, and combination drugs and method of use thereof, including a compound of the invention and one or more second sexual dysfunction pharmaceutical agents.Type: GrantFiled: January 14, 2005Date of Patent: June 23, 2009Assignee: Palatin Technologies, Inc.Inventor: Shubh D. Sharma
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Patent number: 7473760Abstract: A cyclic peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, R6, m, n and p are as defined. Further provided are compositions for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction, by administration of a cyclic peptide including a C-terminus —OH group. Routes of administration include injection, oral, urethral, vaginal, nasal and mucosal administration.Type: GrantFiled: November 9, 2005Date of Patent: January 6, 2009Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Wei Yang
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Patent number: 7425608Abstract: Method of making metallopeptides is provided, for use in biological, pharmaceutical and related applications. The metallopeptides are made of peptides, peptidomimetics and peptide-like constructs, and include a metal ion-binding region thereof which includes at least one orthogonal sulfur-protecting group, in which the peptide, peptidomimetic or construct is conformationally fixed on deprotection of the sulfur and complexation of the metal ion-binding region with a metal ion while the peptide, peptidomimetic or construct is cleavably bound to solid phase.Type: GrantFiled: September 7, 2005Date of Patent: September 16, 2008Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Yi-Qun Shi
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Patent number: 7417027Abstract: Linear and cyclic peptides are provided specific to one or melanocortin receptors, and which exhibit agonist, antagonist, or mixed agonist-antagonist activity.Type: GrantFiled: January 12, 2004Date of Patent: August 26, 2008Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Annette M. Shadiack, Wei Yang, Ramesh Rajpurohit
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Patent number: 7396814Abstract: Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The metallopeptides include at least one, and preferably two, aromatic amino acid side chain moieties, and are further characterized in that the metallopeptides preferably do not bind or significantly bind to a melanocortin receptor.Type: GrantFiled: January 14, 2005Date of Patent: July 8, 2008Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Annette M. Shadiack, Wei Yang, Ramesh Rajpurohit
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Patent number: 7385025Abstract: Metallopeptides with a sequence of a biologically active alpha-melanocyte stimulating hormone (?-MSH), gamma-melanocyte stimulating hormone (?-MSH), or bombesin sequence of length n residues, wherein a residue including a nitrogen atom and sulfur atom each available for complexation to a metal ion is inserted at any position from between the two and three position to the C-terminus side of the n position, or alternatively is substituted for the residue at any position from the three position to the n position, with a metal ion complexed thereto, with any proline (Pro) residue which is either of the two residues on the immediately adjacent N-terminus side of the inserted or substituent residue comprising a nitrogen atom and sulfur atom available for complexation to a metal ion is substituted with a homolog.Type: GrantFiled: July 25, 2005Date of Patent: June 10, 2008Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Yi-Qun Shi, Ramesh Rajpurohit, Hui-Zhi Cai, Margarita Bastos
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Patent number: 7345144Abstract: A highly selective melanocortin-4 receptor antagonist cyclic hexapeptide of the formula where R1, R2, R3a, R3b, R4, R5, x, y and z are as defined in the specification, and a method of treating body weight disorders, including cachexia, sarcopenia and wasting syndrome or disease, and treating inflammation and immune disorders.Type: GrantFiled: July 5, 2005Date of Patent: March 18, 2008Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Ramesh Rajpurohit, Annette M. Shadiack, Yi-Qun Shi, Kevin D. Burris
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Patent number: 7342089Abstract: A highly selective melanocortin-4 receptor antagonist cyclic peptide of the formula where R1, R2, R3, R4a, R4b, R5, R6, R7, x, y and z are as defined in the specification, and a method of treating body weight disorders, including cachexia, sarcopenia and wasting syndrome or disease, and treating inflammation and immune disorders.Type: GrantFiled: July 5, 2005Date of Patent: March 11, 2008Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Ramesh Rajpurohit, Annette M. Shadiack, Yi-Qun Shi, Kevin D. Burris
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Patent number: 7307063Abstract: Metallopeptides are provided for use in treatment of sexual dysfunction in mammals. The metallopeptides are agonists for at least one of melanocortin-3 or melanocortin-4 receptors. The metallopeptides are conformationally fixed on complexation of a metal ion-binding portion thereof with a metal ion. Also provided are metallopeptides that are antagonists for at least one of melanocortin-3 or melanocortin-4 receptors.Type: GrantFiled: August 13, 2003Date of Patent: December 11, 2007Assignee: Palatin Technologies, Inc.Inventors: Shubh Sharma, Annette Shadiack, Yi-Qun Shi, Wei Yang, Hui-Zhi Cai
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Patent number: 7235625Abstract: Multiple agent therapy for treatment of sexual dysfunction, including male erectile dysfunction, with sequential administration a type V phosphodiesterase inhibitor (PDE-5), such as sildenafil, preferably wherein the PDE-5 inhibitor is administered by oral dose means, and a melanocortin 3 and/or 4 receptor agonist, such as Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH (PT-141) preferably wherein the PT-141 is formulated for and administered by intranasal means, and further preferably wherein the PDE-5 inhibitor is administered prior to PT-141.Type: GrantFiled: May 26, 2005Date of Patent: June 26, 2007Assignee: Palatin Technologies, Inc.Inventors: Lisa E. Diamond, Dennis C. Earle, Annette M. Shadiack, Shubh D. Sharma, Carl Spana
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Patent number: 7189755Abstract: Melanocortin receptor-specific pyrrolidine compounds having the structure: and stereoisomer and pharmaceutically acceptable salts thereof, where R1, R2, and R3 are as described in the specification, preferably where R3 is a D-amino acid with at least one substituted or unsubstituted phenyl or naphthyl aromatic ring, and where R3 optionally further includes an amine capping group or from one to three additional amino acid residues, optionally with an amine capping group, which compounds are agonists, antagonists or mixed agonists and antagonists at one or more melanocortin receptors, and having utility in the treatment of melanocortin receptor-related disorders and conditions. Methods of synthesis of compounds of structure (I), pharmaceutical compositions containing a compound of structure (I) and methods relating to the use thereof are also disclosed.Type: GrantFiled: February 10, 2004Date of Patent: March 13, 2007Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Yi-Qun Shi, Zhijun Wu, Ramesh Rajpurohit
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Patent number: 7176279Abstract: A cyclic peptide with a C-terminus —OH group. Further provided are compositions and methods for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction, by administration of a cyclic peptide including a C-terminus —OH group. Methods of administration include injection, oral, urethral, vaginal, nasal and mucosal administration.Type: GrantFiled: August 8, 2003Date of Patent: February 13, 2007Assignee: Palatin Technologies, Inc.Inventors: Shubh Sharma, Annette Shadiack, Ramesh Rajpurohit, Wei Yang
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Patent number: 7170001Abstract: Methods of manufacturing back-contacted silicon solar cells fabricated using a gradient-driven solute transport process, such as thermomigration or electromigration, to create n-type conductive vias connecting the n-type emitter layer on the front side to n-type ohmic contacts located on the back side.Type: GrantFiled: June 26, 2003Date of Patent: January 30, 2007Assignees: Advent Solar, Inc., Sandia CorporationInventors: James M Gee, Russell R. Schmit
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Patent number: 7097824Abstract: Tuftsin receptor-specific peptides, peptidomimetics and peptide-like constructs are provided, particularly for use in biological, pharmaceutical and radiopharmaceutical applications, in which the peptide, peptidomimetic or construct is conformationally fixed on complexation of the metal ion-binding portion thereof with a metal ion, resulting in a peptide, peptidomimetic or construct with increased affinity for the tuftsin receptor.Type: GrantFiled: February 11, 2003Date of Patent: August 29, 2006Assignee: Palatin Technologies, Inc.Inventor: Shubh D. Sharma
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Patent number: 7049398Abstract: Metallopeptides and metallopeptide combinatorial libraries specific for melanocortin receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, in which the peptide, peptidomimetic or construct is conformationally fixed on complexation of a metal ion-binding portion thereof with a metal ion.Type: GrantFiled: June 15, 2000Date of Patent: May 23, 2006Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Yiqun Shi, Wei Yang, Hui-Zhi Cai
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Patent number: 6979436Abstract: Metallopeptides and metallopeptide combinatorial libraries specific for opioids receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, in which the peptide, peptidomimetic or construct is conformationally fixed in a biologically active configuration specific for one or more opioid receptors on complexation of a metal ion-binding portion thereof with a metal ion.Type: GrantFiled: May 17, 2002Date of Patent: December 27, 2005Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Wei Yang, Hui-Zhi Cai
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Patent number: 6794489Abstract: Compositions and methods are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. In one embodiment, a peptide-based composition including the peptide sequence Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH is administered. Methods of administration include injection, oral, nasal and mucosal administration.Type: GrantFiled: January 4, 2002Date of Patent: September 21, 2004Assignee: Palatin Technologies, Inc.Inventors: Christine H. Blood, Annette M. Shadiack, Joanna K. Bernstein, Guy H. Herbert
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Patent number: 6776984Abstract: A method of treatment of and composition for human degenerative neurologic diseases discloses the administration of therapeutically amounts of an enhancement agent, such as thrombopoietin, to enhance the repair of neurons, including re-myelinization. A regulatory agent, such as thyroid hormone or thyrotropin, may also be included as part of the method and composition as a regulator of cell division and oligodendroglia production.Type: GrantFiled: August 17, 2000Date of Patent: August 17, 2004Inventor: George R. Schwartz
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Patent number: 6765069Abstract: A method for making a hydrophilic and lubricious coating, the coating so made and a medical device including such coating, wherein the coating includes a hydrophilic polymeric unit layer cross-linked with a plasma deposited double bond monomer. The hydrophilic polymeric unit can include ethylene oxide with one or more primary or secondary alcohol groups or glycosaminoglycans such as hyaluronic acid, and the double bond monomer includes monomers containing at least one double bond, preferably a C═C, C═N or C═O bond, including N-trimethylsilyl-allylamine, ethylene, propylene and allyl alcohol. The invention also provides products containing such coatings and their uses in medical, pharmaceutical and cosmetic applications.Type: GrantFiled: September 27, 2002Date of Patent: July 20, 2004Assignee: BioSurface Engineering Technologies, Inc.Inventors: Paul O. Zamora, Meng Chen, Shigemas Osaki, Ting-Ting Hsieh, Ray Tsang
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Patent number: D499334Type: GrantFiled: September 12, 2003Date of Patent: December 7, 2004Inventor: Albert H. Murray, Jr.