Abstract: Devices and methods for differential numerical aperture analysis of samples, utilizing angle-of-incidence measurements resulting from variable illumination or observation numerical apertures, or both. Metrology applications are provided, and more particularly including scatterometer, ellipsometer and similar analysis methods, including bi-directional reflectance or transmission distribution function measurement. The provided devices and methods enable analysis of critical dimensions of samples utilizing a minimum of moving parts, with the range of striking or scattering angles varied by a variable numerical aperture or apertures.

Abstract: The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus nidulans atrD are also provided. The invention further provides assays which utilize these transformed host cells.

Abstract: A method of pruning a reference library of signatures and corresponding known structure parameter vectors, each signature composed of a reference signal vector, including, for a given reference signal vector, interpolating a parameter vector and deleting the given reference signal vector and the corresponding parameter vector for a sufficiently small interpolation error. Also a method of accessing an indexed reference library of signatures and corresponding known structure parameter vectors, each signature comprising a reference signal vector, including acquiring an unknown signal, calculating an index vector for the unknown signal; determining error between the index vector for the unknown signal and a calculated reference signal index vector of the library; and thereby identifying as a match candidate for the unknown signal a reference signal vector.

Abstract: The present invention relates to ester derivatives of 1,4-dihydropyridine-5-carboxylic acid of formula (I) wherein R1, R2 and R3 may be a coumarin group. These compounds possess an anti-viral activity. Most of the anti-viral compounds known in the art are nucleoside-derivatives. Various viruses become resistent against these. Because the compounds according to the invention are not nucleoside-derivatives, they form a suitable alternative. The invention also relates to a method of preparing the anti-viral substances according to the invention.

Abstract: Method and apparatus for trace metal detection and analysis using bismuth-coated electrodes and electrochemical stripping analysis. Both anodic stripping voltammetry and adsorptive stripping analysis may be employed.

Abstract: Methods for the isolation and identification of a toxicant in a sample are disclosed. Luminescent biological agents (i.e., bacteria) having sensitivity to a toxicant or an isolatable component in a sample are used to provide visually discernable zones of luminescent inhibition in the presence of a toxicant (or) in the presence of an isolatable sample component as separated by paper or thin layer chromatography. Kits for use in conjunction with the identification of a toxicant in a sample are also described, which include a luminescent biological reagent as the visualizing agent. Particular examples of luminescent bacterial agents useful in the practice of the present invention include Photobacterium leoganthi, Photobacterium phosphoreum, Vibrio fischeri, Vibrio harveyi a luminescent fungi, a luminescent fish extract, a luminescent dinoflagellate and fluorescent microorganisms, such as Cypridina.

Abstract: The present invention provides an anti-thrombogenic and cellular-adhesion coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I: wherein R1 is an C1-18 alkyl or C6-32 aryl group, each R2 is independently selected from the group consisting of C1-18 alkyl and C6-32 aryl, R3 is N or O, n is a number from 1 to 10, directly bound to a heparin molecule via covalent bonding, with an adhesive molecule directly bound to the heparin molecule. In one embodiment, the coating comprises benzyl-(1,2 dimethyl)disilyl heparin, wherein an adhesive molecule, such as fibronectin, is bound to the heparin.

Abstract: The invention relates to transgenic mammals characterized by 5-HT3 receptor over-expression in the central nervous system (CNS). The mammals have particular utility as models for studying the role of 5-HT3 receptors in the CNS, especially for the study of reward pathways for alcohol and other substances of abuse.

Abstract: Coatings, devices and methods are provided, wherein the contacting surface of a medical device with at least one contacting surface for contacting a bodily fluid or tissue is modified by plasma treatment in a plasma comprising nitrogen-containing molecules and oxygen-containing molecules. The nitrogen-containing molecules include NH3, (NH4)+, N2O, NO, NO2 and N2O4, and the oxygen-containing molecules include O2 and O3. The plasma-modified contacting surface exhibits decreased adhesion of at least some mammalian cells, such as platelets and leukocytes, decreased restenosis when used with stents, and increased apoptosis. Additional layers may be applied, including plasma polymerized hydrocyclosiloxane monomers, amine-providing groups such as N-trimethylsilyl-allylamine, polyoxyalkylene tethers, and bioactive compounds.

Abstract: A herbal composition that aids in the relief of symptoms caused by edema, cyanosis, blood stasis, neuropathy and related conditions is provided, including one or more of cayenne extract, myrrh essential oil, frankincense essential oil, cinnamon essential oil, ginger essential oil, and powdered saffron in a carrier oil, preferably safflower oil. Further provided is a method of administration of the herbal composition, by application to the exterior surfaces of the human body using massage strokes in the direction of venous blood flow.

Abstract: Methods for determination of parameters in lithographic devices and applications by diffraction signature difference analysis, including determination of center of focus in lithography devices and applications. Latent image analysis may be employed with exposed but undeveloped lithographic substrates. Control methods are provided for process control of center of focus in lithography devices utilizing diffraction signature difference analysis.

Abstract: A nucleic acid coating composition including a polyanion bound, directly or through one or more intermediates, to a medical device surface, with a condensate comprising a polycation and nucleic acid bound to the polyanion, devices incorporating such coating compositions, and methods for making. In one embodiment, a silyl-heparin complex is provided, bound to a medical device surface by hydrophobic interaction with the silyl moiety, with a polycation and nucleic acid condensate bound to the heparin by electrostatic interaction.

Abstract: Compositions and methods are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. In one embodiment, a peptide-based composition including the peptide sequence Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH is administered. Methods of administration include injection, oral, nasal and mucosal administration.

Abstract: A bioabsorbable brachytherapy device includes a tubular housing with sealed ends and an enclosed radioactive material. The radioactive material includes a radioisotope, such as palladium-103 or iodine-125. The tubular housing is made from a biocompatible and bioabsorbable polymeric material, and is sealed by means such as heat welding or solvent fixing. The device may further include a radiopaque medium and one or more therapeutic drugs.

Abstract: A method of fusing or welding bone in vivo and in a fluid medium, comprising: harvesting a piece of autologous implant bone; treating the implant bone and/or a receiving bone to expose organic component; treating the implant bone and/or the receiving bone by de-fatting; combining the implant bone with other compounds to create an interfacing agent; adding the interfacing agent between receiving bone segments to be fused or welded; and fusing or welding in vivo, in a fluid medium, utilizing electromagnetic energy.

Abstract: A nucleic acid sequence encoding for oryzacystatin-I peptides and a signal peptide therefore is provided. The oryzacystatin-I peptide is approximately 12.6 kDa, and is approximately twelve amino acid residues longer than previously described oryzacystatin-I peptides. The nucleic acid sequences may be cloned into vectors, and used to transform plants conferring resistance to plant pests, including insects and nematodes, that utilize cysteine proteases, and to viruses with processing mechanisms involving cysteine proteases.

Abstract: A composition for use as a tobacco substitute and as an aid in the cessation of tobacco use, containing a Vebascum thapsus component, an algae component, a Medicago sativa component, and a Symphytum officinale component, together with other optional components. Use of the composition of the present invention as a tobacco substitute, in cigarettes or pipes, produces a diminished desire for tobacco.

Abstract: A spherical free rotator, supported on an air film within an air support. Different weight and density inserts may be positioned within cylindrical holes along diameters by the sphere, so that both symmetric and asymmetric rotation may be demonstrated.

Abstract: A tri-peptide drug for treatment of neurological and neurobehavioral disorders of a mammal, such drug being derived from the following formula: pGlu-X-Pro-NH2, wherein the internal amino acid (X) is a non-histadine amino acid. Methods of treatment of neurological disorders using the tri-peptide, including as an adjunct, synergist or stand-alone therapy, in oral, parenteral, intranasal, transcutaneous, or rectal forms.

Abstract: An apparatus for electrochemical detection of DNA hybridization utilizing oligonucleotide-containing polymer-coated electrodes, and an apparatus for electrochemical detection of nucleic acids in flowing streams using doped polymer-coated electrodes. Also provided are methods for detection of DNA hybridization and for detection of nucleic acids in flowing streams.