Abstract: It has been discovered that certain (+)-3-substituted-N-alkylmorphinans are ffective anticonvulsant and neuroprotective agents. Novel compounds having these biological properties are presented in a method of use for preventing, treating or controlling convulsions in mammals having a need for such treatment. The compounds do not lead to dependency, have low toxicity, and provide effective anticonvulsant or neuroprotective treatment with little or no behavioral detriment to the recipient. A number of pharmacological formulations and methods of administering compounds of the invention are suitable for anticonvulsive or neuroprotective treatments.

Abstract: An automated, computer-driven amino acid indexer for peptide synthesis uses programmed computer, a circuit board controller, and a combination of microtiter sample well trays, light emitting diodes to illuminate each sample well, and circuitry to control the illumination of the diodes. The apparatus simplifies technical difficulties present in large-scale laboratory syntheses of peptides by substantially reducing the time required for dispensing amino acids into sample trays and reducing the occurrence of error in the process to negligible levels in typical syntheses. A programmed, automated technique for synthesizing peptides is also provided.

Abstract: Encapsulated PI compositions such as liposomes containing plant PI and th use to prevent mitogenic transformation of normal splenic lymphoid cells (including lymphocytes transformed induced by treatment of cells with lipid A) by exposing the cells thereto.

Abstract: A cassette holder and positioning assembly device for a portable x-ray mane, comprising: a mounting plate; oppositely adjustable vertical arms disposed in parallel relationship on the mounting plate attached in proximity to an outer periphery along vertical axes of the plate and opposite horizontal arms mounted fixedly on the plate and disposed in perpendicular relationship to the vertical arms; a selection handle disposed pivotally between alignment guides on a handle gear that meshes with a circumferential gear pivotally attached to linkage arms in perpendicular relationship to portions of the mounting plate beneath the alignment guides and pivotally attached to a backstop linkage arm in perpendicular relationship to the alignment guides, the backstop linkage arm is pivotally attached to a platform fixed to the mounting plate; a semi-circular indexing plate containing a plurality of notches in its inner arc and fixed in raised relation on the mounting plate above the selection handle; the selection handle h

Abstract: The degree of hemoglobin oxygenation in the blood vessels of the retina is etermined under conditions of dark-adaptation and light-adaptation by directing a beam of near-infrared light having a range of wavelengths from 700 to 100 nanometers at a blood vessel in the retina, measuring the intensity of the backscattered light from the blood vessel in the range from 700 to 800 nanometers at regularly spaced intervals of wavelength, such as 2 nanometers, and determining the degree of hemoglobin oxygenation by reference to a correlation between hemoglobin oxygen and light absorbance in the near-infrared spectral range.

Abstract: A drill chuck and revolving spindle guard for protecting a person operating machine with a revolving spindle comprising: a mounting bracket for attachment about a machine part having a revolving spindle; a pawl adapted to fall into a slot in a block attached to the mounting bracket; a locking block through which a threaded shaft is disposed to permit pivoting for swinging the guard in and out of working position in relation to a work-piece; a threaded shaft around which a compression spring is spirally wound to permit height adjustment of the guard; a compression spring for holding the guard in a locked position; a locking nut disposed at a base of the threaded shaft around which the compression spring is wound to hold the guard fast after height or position adjustments; a guard bracket upon which a base portion of the nut rests; a guard having a semi-circular configuration; whereby the guard bracket is attached to an arc of the semi-circular guard so that when the guard is moved to a drill change position by

Abstract: A height measurement system uses an inexpensive ultrasonic height measuring evice to provide an apparent height of a descending airborne object. To compensate for movement of the object during the ultrasonic measurement, a Doppler radar velocity measuring device determines the vertical velocity in a short measurement period. The measured vertical velocity is used to determine the vertical distance travelled during the ultrasonic measurement and to compensate therefor by converting the apparent height to a true height of the descending object. Updates of the true height may be obtained by storing the vertical velocity and retrieving the vertical velocity for multiplication by a time value to obtain an updated value of the true height.

Abstract: Novel compounds are provided which exhibit high levels of anti-parasitic activity, specifically against parasites of the genus Trypanosoma. The compounds are comprised of aryl-substituted quaternary heteroaromatic salts which include a positively charged imidazolium or other heterocyclic ring, a linking group, a phenyl ring, and a polar functional group. The polar functional group is preferably a quanylhydrazone or a heterocyclic hydrazone. A method is also provided for treating the diseases associated with Trypanosoma parasites which comprises administering to infected animals or humans an effective amount of a compound of the present invention.

Abstract: The present invention relates to a synergistic antimicrobial compound (mafenide-phosphanilate) having especially high activity for topical prophylaxis and therapy of burn wound infections. The invention further relates to anti-microbial pharmaceutical compositions and a method for treating microbial infection. More particularly, the invention relates to the effective unexpectedly improved treatment of burn wounds involving Pseudomonas and Proteus bacteria.

Abstract: A mine clearing rake comprising a rake assembly with alternately disposed large and small teeth which are arranged to form a broad "V" and are rigidly supported laterally by horizontally disposed bars and rods to provide a maximum proportion of open space rearwardly and are supported rearwardly by a rigid reinforcing frame assembly which is attached to the bottom edge of the moldboard of a propelling vehicle, such as a tank, and have four additional points of support and/or attachment to the moldboard. An extension grid assembly is also mounted above the rake assembly to prevent unearthed mines from rolling over the mine clearing rake. A skid shoe assembly is attached to the reinforcing frame assembly and protrudes through the rake assembly so that the skid shoe rests upon the surface of the minefield during operation of the mine clearing rake.

Abstract: An illustrative embodiment of the invention substitutes solid, non-carcinogenic bis(methanesulfonoxymethyl) ether for bis-chloromethyl ether in a low temperature reaction of about 0.degree.-5.degree. C. for the production of bis-methylene ether pyridinium quaternary compounds. In this way, the production of important nerve agent antidotes (toxogonin, HI-6 and HGG-12) by a method of synthesis using the reactant bis-mesylmethyl ether, is carried out in appreciably greater safety.

Abstract: A method of potentiating immunotoxin action in an immunotoxin/target-cell stem in which Brefeldin A is utilized as an immunopotentiator. The Brefeldin A enhances the immunotoxin pathway while blocking or inhibiting the nonspecific pathway, thus being particularly useful in conjunction with immunotoxins made from holotoxins. The Brefeldin A is effective in small, nontoxic concentrations and therefore may be utilized with either in vivo or in vitro systems.

Abstract: A three-color camouflage system comprises layers of camouflage material hng low, intermediate and high thermal emissivities in the infrared spectral range, and appearing black, green and brown in the visible spectral range. The camouflage surface is structured in such manner that there is color adaptation to the natural background in the visible spectral range, as well as adaptation to the natural background in thermal emissivity in the infrared spectral range so that targets cannot be recognized with infrared sensing devices. Thermal emissivity in the infrared spectral range is controlled by superimposing layers of intermediate and high emissivity onto a basic low emissivity camouflage layer and providing perforations in these layers allowing the low-emissivity layer to be seen. High-emissivity areas are provided by perforations allowing the high-emissivity surface of the object being camouflaged to be seen.

Abstract: A photo processing work station which facilitates application and drying of coatings to instant photographic prints is disclosed herein. The work station is a small, portable unit which includes a first shelf having a coating area and a utility area thereon. Attached to the first shelf is a means for covering the first shelf and a vertical backing member which includes a second shelf attached thereto. Located on the second shelf is a print dryer unit for drying the prints. The print dryer employs a high velocity fan for directing air onto a print so that it may be rapidly dried without the use of a heating element. In use, the instant photographic prints are located on the covered coating area, a chemical coating is applied and the prints are then physically moved into the print dryer unit for drying. The work station is advantageous in that it is simple, ergonomically designed and allows for rapid drying of prints without the problems associated with prior art methods.

Abstract: An insect containing test apparatus which is applied to a skin region of a est subject includes a rectangular slide and test cage made of a clear, autoclavable polycarbonate plastic. The test cage is injection molded to a generally rectangular shape and includes a peripheral flange extending outwardly from sides at an open top. A screen member covering the open top is then heat pressed onto this flange. Test holes are also punched into the bottom the test cage. During injection molding, U-shaped channels along each respective longitudinal side adjacent the bottom are also provided to receive the slide so that the slide is selectively moved to cover and uncover the test holes in the bottom.

Abstract: A mine effects simulator system for simulating the operation and encounter f land mines and their potential effects on an armored vehicle. The system utilizes an authentic land mine activation mechanism, radio transmitter and logic circuitry and provides a radio frequency signal when activated by the proximity of an armored vehicle. The armored vehicle has a receiver device which receives the signal to determine a "hit" or "kill" based upon the time of the mine detonation with respect to mine to vehicle position.

Abstract: Monoclonal antibodies produced by a family of murine hybrid cell lines are cross-reactive with both toxin A and toxin B of Clostridium difficile. The monoclonal antibodies are useful in an immunoassay for toxin A and toxin B of C. difficile, a casual agent of antibiotic-associated pseudomembranous colitis in humans and animals.

Abstract: Gem-difluoroamino compounds are employed as a partial or complete replacement for TVOPA (trisvinoxypropyl adduct), tris-1,2,3-[bis(1,2-difluoroamino)-ethoxy]propane, in accordance with the nomenclature established by the International Union of Pure and Applied Chemistry. A partial or complete replacement of the vicinal-(1,2-)difluoroamino plasticizer of a difluoroamino-based propellant with its structural isomer or a related structural isomer, namely, a geminal-(1,1-)bis-difluoroamino compound has resulted in two beneficial effects, namely, a marked reduction in pressure exponent and an enhancement of the burning rate of the propellant. Representative of the geminal compounds are the compounds identified as SYEP and SYPO and further identified by the following structural formulas and chemical nomenclatures:SYEPF(NO.sub.2).sub.2 C.CH.sub.2.O.CH.sub.2.C(NF.sub.2).sub.2.CH.sub.2.O.CH.sub.2.C(NO.sub.2).su b.

Abstract: This invention relates to a nucleic acid probe and method for the rapid detection of typhoid fever bacteria by use of a nucleic acid hybridization probe, equivalent to the DNA region encoding the Vi antigen of enteric bacteria such as Salmonella typhi, S. paratyphi C, or Citrobacter freundii, in a nucleic acid hybridization reaction with a clinical specimen containing typhoid fever bacteria.