Abstract: An immunologically active substantially pure peptide capable of inducing in human an immune response which is cross reactive with and protective against infection by a malaria parasite, wherein the peptide contains at least 2 consecutive repeats of a sequence Asn-X-Y-Pro wherein X is Ala or Val and Y is Asn or Asp or a sequence of the formula Thr-Glu-Trp-Z-Pro-Cys-Ser-Val-Thr-Cys-Gly-Asn-Gly wherein Z is Ser or Thr or the formula Lys-Pro-S-T-S-Lys-Leu-Lys-Gln-Pro-U-V-Gly-W-Pro wherein S is Lys or Asn, T is His or Glu, U is Gly or Asn, V is As or Glu, and W is Asn or Gln is disclosed along with DNA sequences and various other genetic materials useful in producing these peptides through biological methods.

Abstract: Process for preparing a detoxified polysaccharide-outer membrane protein complex from bacterial envelopes; the so-obtained products which are useful as vaccines against infection by the same bacteria and method for protecting animals against the same infection by administration of a pharmaceutical composition containing the detoxified polysaccharide-outer membrane protein complexes.

Abstract: The glycidyl azide polymer produced by hydrolysis of glycidyl chloride fowed by reaction with sodium azide is employed in a crosslinked composite-modified double-base propellant composition both in the casting powder portion and casting solvent portion as a superior replacement for nitroglycerin in each portion specified. The crosslinked composite-modified double-base propellant composition is characterized by having a greater safety in handling, reduced sensitivity to detonation, higher burning rate, higher specific impulse, and improved mechanical properties as compared with a like composition containing nitroglycerin in the casting powder and the casting solvent portions.

Abstract: A dermal substance collection device (DSCD) is described which provides means for the non-invasive, instantaneous and continuous monitoring of chemical substances which are present in a detectable amount in either or both interstitial fluid or sweat or which are on or in the skin. The transdermal substance collection device of this invention is comprised of three essential components: (1) a substance binding reservoir, wettable by (2) a liquid transfer medium which allows for liquid bridge transfer of a soluble substance from the skin surface to the binding reservoir by virtue of its wettability by the liquid, and (3) an occlusive cover.

Abstract: Solid oxidizer particles of ultrahigh surface area are produced by an etching process which includes employing selective extractants in a process which causes the formation of indentations and/or cavities on the surfaces of the oxidizer particles, and crevasses and tunnels in the oxidizer particles. The method is particularly attractive for manufacturing ultrahigh surface area ammonium perchlorate which has limited solubility in the extractants ethanol, butanol, or a mixture of these extractants.

Abstract: This invention relates to novel 2-acetyl- and 2-propionylpyridine selenosemicarbazones. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures used to prepare the selenosemicarbazones.

Abstract: The subject 8-[6-(N-heterocyclic-substituted)hexylamino]-6-methoxy lepidine erivatives have the formula: ##STR1## wherein Z represents methyl or, together with the two contiguous carbon atoms, the benzo moiety of a benzopiperazinyl derivative when Y is --N(R')--, n is an integer from 0 to 2; Y represents --O--, --S--, --S(O)--, --S(O).sub.2 --, and --N(R')--; R' represents hydrogen, alkyl, lower alkyl, R" substituted lower alkyl, cycloalkyl, aryl, sulfonyl, saturated 1,4-diazepinyl, lower alkyl N-cyanocarboximidothioate, or --C(O)R'"; R" represents at least one of hydroxy, alkoxy, aralkoxy, amino, lower alkyl substituted amino, phenyl, halogenated phenyl, or sufonyl; and R'" represents lower alkyl, alkoxy, aralkoxy, amino, lower alkyl substituted amino or aryl substituted amino; and pharmaceutically acceptable salts thereof. These derivatives afford improvement in means for the chemotherapy of leishmaniasis when administered parenterally or orally to infected animals.

Abstract: An improved method is provided for the prevention of schistosomal infecti in animals. The topical application of a 2-hydroxy-benzoic anilide provides prophylactic protection against penetration by infective cercariae of the parasitic worms.

Abstract: This invention relates to novel transition metal complexes of 2-acetyl- and -propionylpyridine thiosemicarbazones, their selenium analogs. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones and their selenium analogs.

Abstract: A high energy, high performance, ultrahigh-burning rate composite propell results when 2-azidoethyl acrylate is copolymerized with acrylic acid and is employed as the binder system for the composite propellant. The energetic binder when used in an amount of about 4.25 weight percent of an azido-based propellant composition as compared to a ethyl acrylate binder system results in a specific impulse increase from about 264 (lb-s/lb) to about 275 (lb-s/lb), and a burning rate increase from about 13.7 ips to about 19.8 ips at 1000 psia, and a burning rate increase from about 21.6 ips to about 30.2 ips at 2000 psia. The other propellant ingredients comprise a high solids loading of ammonium perchlorate, aluminum flake and aluminum powder, a burning rate catalyst of carboranylmethyl propionate, graphite linters, the crosslinking and curing agent 4,5-epoxycyclohexylmethyl 4',5'-epoxycyclohexylcarboxylate (ERL-4221), tris-1,2,3[bis(1,2-difluoroamino)ethoxy]propane (TVOPA), and a processing aid of lecithin.

Abstract: Preformed metal/oxidant agglomerates for enhancement of propellant burning ate are prepared from a finely divided metal (aluminum, boron, titanium, etc.), ammonium perchlorate, and a small quantity of the same binder material that goes into the manufacture of the propellant, such as, hydroxyl-terminated polybutadiene crosslinked with a polyisocyanate. Additional ingredients can be incorporated into the agglomerates to bring about further enhancement of burning rate, such as, an ammonium perchlorate decomposition accelerator triphenylbismuthine, a carboranyl burning rate enhancer, iron oxide, etc. Agglomerates are prepared in a fluorinated and/or chlorinated hydrocarbon solvent in which the agglomerate formulation ingredients are insoluble. Any remaining solvent is then evaporated under reduced pressure and the agglomerates are subsequently cured. Optimum mesh size of the agglomerates is 300-500 micrometers.

Abstract: A chemical contamination monitoring system is provided for monitoring and decontaminating protective clothing that has been exposed to toxic chemicals. The system includes a decontamination chamber in which the clothing is supported and a spray assembly, including a plurality of suitably directed spray nozzles, for spraying the clothing with a wash-solvent. Hot air is directed over the clothing to volitalize the contaminates and, after passing over the clothing, the hot air is withdrawn for analysis using gas chromatography or other known techniques. The used solvent can also be analyzed.

Abstract: The effectiveness of the burning rate accelerator, iron oxide (Fe.sub.2 Ob.3), is enhanced, and a markedly improvement in the mechanical properties of a propellant composition are simultaneously achieved as a result of grinding a composite propellant paste in a roller mill instead of in a conventional sigma blade propellant mixer. The propellant paste is composed of a hydroxyl-terminated polybutadiene prepolymer, fluid-energy mill-ground ammonium perchlorate, dioctyl adipate, aluminum oxide, isophthaloyl bis-1-(2-methylaziridine), and iron oxide. The final product has a higher stress capability, higher strain capability, higher modulus, and higher gel fraction, and a burning rate that is about 80% higher as compared with sigma blade propellant ground and mixed propellant.

Abstract: The invention provides a light sensitive dummy cartridge for insertion into he chamber of a magazine-type weapon. A muzzle collimator is inserted into the barrel in alignment with the cartridge photosensor and the longitudinal axis of the bore. The power supply, audible scoring apparatus, and electrical circuit for the photosensor, moreover, are mounted in a dummy magazine. This combination provides an easy-to-install apparatus for temporarily converting a conventional firearm into a photoresponsive training device.

Abstract: A novel bone repair material consisting essential of decalcified freeze-dd bone and biodegradable, biocompatible copolymer has been developed for improving and accelerating the healing of osseous tissue. The bone repair material was prepared by combining decalcified bone with a copolymer consisting essentially of a 50:50 poly(L)(-)lactide co-glycolide.

Abstract: A living, attenuated, oral vaccine system is described for the immunization gainst enteric disease. This oral vaccine is a genetic hybrid derivative of an attenuated galactose epimeraseless strain of S. typhi which carries at least one protective antigen other than normal somatic S. typhi antigens. The oral vaccine can provide protection against both typhoid fever and at least one other enteric disease. A bivalent oral vaccine is described wherein the non-typhoid protective antigen is the plasmid-encoded form I antigen of Shigella sonnei. A protective antigen from Shigella sonnei was transferred to a streptomycin resistant mutant of S. typhi strain Ty21a. The transconjugant S. typhi strain expressed both S. typhi and S. sonnei antigens and protected experimental animals against lethal infections with either S. typhi or S. sonnei. This strain is considered to be useful as a vaccine against typhoid fever and bacillary dysentery caused by S. sonnei. The mutated galactose epimeraseless S. typhi strain such as S.

Abstract: A method of error processing is disclosed in which the first erroneous line etected in a facsimile transmission is decoded, and printed in the normal manner, up to the point in the line where an error is detected. An erroneous portion of the line is then defined to be the point in the line from which the error is detected as well as four color changes to the left. This erroneous portion is replaced by the corresponding picture elements in the immediately preceding line. The resulting "corrected" line is then used as a new "previous line" and the process is repeated with the erroneous portion of each subsequent line being replaced with white until a full line is properly decoded.

Abstract: This invention relates to the use of various 2-acetylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom in the treatment of viral infections. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

Abstract: The frequency shift of reflected laser beam from a target is transformed o an angular measurement which is proportional to the velocity of the target relative to the measurement platform. The system uses the refraction angle of the reflected beam from a movable optical grating to produce the angular measurement.

Abstract: A sensitive and specific radioimmunoassay is developed for L-hyoscyamine ulting from atropine administration with which a concentration as low as 25 pg/ml using 0.1 ml of sample can be measured without the need for extraction. Specificity studies indicate that an antibody according to this invention has high specific recognition of L-hyoscyamine with only about 37% cross reaction with the D-hyoscyamine enantiomer of atropine. The antibody is produced from an immunogen having conjugated at least 42 and preferably 45 L-hyoscyamine-p-aminobenzoic acid haptenic molecules per molecule of bovine serum albumin. An antibody according to this invention can be used with a dilution titer as high as 1:2000.