Abstract: Systems, methods, and related computer program products for medical imaging and image-guided radiation treatment (IGRT) are described. In one embodiment, an IGRT system selectively integrates x-ray source arrays, dual-energy imaging, stereoscopic imaging, static and dynamic source collimation, and/or inverse geometry tomosynthesis imaging to acquire and/or track a target during radiation treatment. Advantages include reduced patient x-ray dose and/or reduced treatment delivery margins.

Abstract: The disclosure relates to systems and methods for fast-switching operating of a standing wave linear accelerator (LINAC) for use in generating x-rays of at least two different energy ranges with advantageously low heating of electronic switches. In certain embodiments, the heating of electronic switches during a fast-switching operation of the LINAC can be kept advantageously low through the controlled, timed activation of multiple electronic switches located in respective side cavities of the standing wave LINAC, or through the use of a modified a side cavity that includes an electronic switch.

Abstract: A robotic treatment delivery system including a linear accelerator (LINAC), and a robotic manipulator coupled to the LINAC. The robotic manipulator is configured to move the LINAC along seven or more degrees of freedom, at least one of the seven degrees of freedom being a redundant degree of freedom.

Abstract: A robotic patient positioning assembly including a patient treatment couch, and a robotic arm coupled to the patient treatment couch. The robotic arm is configured to move the patient treatment couch along five rotational degrees of freedom and one substantially vertical, linear degree of freedom.

Abstract: A method of compensating for breathing and other motions of a patient during treatment includes periodically generating internal positional data about an internal target region. The method further includes generating external positional data about external motion of the patient's body using an external sensor and generating a correlation between one or more positions of the internal target region and one or more positions of an external region using the external positional data of the external sensor and the internal positional data of the internal target region. The method further includes predicting the position of the internal target region at some later time based on the correlation model.

Abstract: Controlling the timing of acquiring x-ray images based on target movement.

Abstract: A robotic treatment delivery system including a linear accelerator (LINAC), and a robotic arm coupled to the LINAC. The robotic arm is configured to move the LINAC along at least four rotational degrees of freedom and one substantially linear degree of freedom.

Abstract: A method of compensating for breathing and other motions of a patient during treatment includes periodically generating internal positional data about an internal target region. The method further includes continuously generating external positional data about external motion of the patient's body using an external sensor and generating a correlation model between the position of the internal target region and the external sensor using the external positional data of the external sensor and the internal positional data of the internal target region. The method further includes predicting the position of the internal target region at some later time based on the correlation model.

Abstract: Systems, methods, and related computer program products for medical imaging and image-guided radiation treatment (IGRT) are described. In one preferred embodiment, an IGRT system provides intrafraction target tracking based on a comparison of intrafraction x-ray tomosynthesis image data with initial x-ray tomosynthesis image data acquired with the patient in an initial treatment position, the initial x-ray tomosynthesis image data having an inherent registration with co-acquired image data from a setup imaging system integral with, or having known geometry relative to, the tomosynthesis imaging system. Repeated registration of intrafraction x-ray tomosynthesis image data with pre-acquired reference image data from a different frame of reference is not required during intrafraction radiation delivery. Advantages include streamlined intrafraction computation and/or reduced treatment delivery margins.

Abstract: Systems and methods for generating X-rays and neutrons using a single linear accelerator are disclosed. Such system and methods may interrogate an object at times with X-rays and at other times with neutrons, e.g., after suspicious material is detected based on the X-rays. A system may include a single linear accelerator for generating first and second electron beams; first and second targets; a magnet configured to control irradiation of the first and second targets by the first and second electron beams; and a controller that (a) causes the linear accelerator to generate the first electron beam and causes the magnet to direct the beam to first target to generate X-rays; and (b) causes the linear accelerator to generate the second electron beam and causes the magnet to direct the beam to the second target to generate neutrons.

Abstract: Systems, methods, and related computer program products for image-guided radiation treatment (IGRT) are described. For one preferred embodiment, an IGRT apparatus is provided comprising a ring gantry having a central opening sufficiently large to accommodate a body of a patient positioned along a longitudinal axis and extending therethrough, and a gantry tilting mechanism configured to tilt the ring gantry to a plurality of different tilt angles relative to the longitudinal axis. A radiation treatment head is coupled to the ring gantry and is rotatable around said central opening in at least a 180 degree arc. The radiation treatment head is mechanically coupled to the ring gantry such that a distance by which the radiation treatment head extends inwardly toward the central opening relative to the ring gantry is dynamically controllable.

Abstract: A method, apparatus and system for measuring the signal-to-noise ratio of x-ray images and to adaptively control x-ray exposure in response to image quality and patient movement.

Abstract: A patient positioning assembly is described. The patient positioning assembly including a plate member rotatably mounted on a base member, and an arm extending between a first end and a second end, wherein the first end is rotatably attached to the plate member. The patient positioning assembly further including a support device rotatably attached to the second end of the arm to support a patient thereon, with the support device is configured to move the patient in at least five degrees of freedom.

Abstract: A system, method and apparatus for subtracting a synthetically-generated image, including a segmented anatomical feature, from an acquired image.

Abstract: A method for removing position-dependent bias from tracking systems computes invertible transformations between a tracking system and a reference system, and applies an inverse of the transformation to measurements in the tracking system to estimate the locations of reference points in the reference system and to determine relative bias at the measured points.

Abstract: Embodiments of the invention provide systems and methods for achromatically bending beam of charged particles by about 90° during radiation treatment. A system may include first, second, third, and fourth bending magnets serially arranged along the particle beam path. The first and fourth bending magnets are configured to generate a positive field gradient that defocuses the particle beam in the bend plane. The second and third bending magnets are configured to generate a negative field gradient that focuses the particle beam in the bend plane. The first, second, third, and fourth bending magnets collectively bend the particle beam by about 90°, e.g., by about 22.5° each.

Abstract: A method and apparatus of a positioning system are described to position an upper-half of a body relative to a head-end of a couch. The positioning system may be a patient positioning system and may include a treatment couch, a leg rest coupled to the treatment couch, and a drive mechanism coupled to the leg rest. The patient positioning system may also include a treatment couch, having a base portion of a treatment couch and plurality of detachable portions of the treatment couch. The plurality of detachable portions to adjust a height of the treatment couch to accommodate differing heights of patients.

Abstract: A method and apparatus for positioning a patient for radiation treatment are described. The method includes obtaining a plurality of projection images of a patient positioned on a treatment couch, displaying at least one of the plurality of projection images with a corresponding synthetic projection image on a display, adjusting the position of the at least one projection image on the display to approximately align with the corresponding synthetic projection image in response to a user dragging the at least one projection image on the display with a user interface device, and moving the treatment couch to position the patient based on position adjustments of the at least one projection image.

Abstract: A method for precision registration of X-ray images to cone-beam CT scan for image-guided radiosurgery includes acquiring 2-D pre-treatment X-ray images of a region of interest, acquiring a 2-D X-ray image of the region of interest at approximately a time of treatment, registering the 2-D X-ray image with a corresponding 2-D pre-treatment X-ray image to obtain a 2-D registration result at approximately the time of treatment, and converting the 2-D registration result into a 3-D tracking result to track the region of interest.

Abstract: Systems and methods for tracking cardiac targets are disclosed. The cardiac targets may be tracked dynamically. The process may include registering a cardiac target at different phases of a cardiac cycle. Movement of the cardiac target can be determined by correlating respiratory motion and cardiac pumping motion. Radiation treatment can then be delivered to the cardiac target taking into account the movement of the cardiac target.