Abstract: A method and apparatus for treatment planning using four dimensional imaging data.

Abstract: Methods of two-dimensional x-ray imaging of a target volume and tracking a target structure contained within a target volume are described.

Abstract: Images that are associated with an identification of a tracking target of a patient to receive radiation treatment may be received. The images may be sorted into a sequence based on a motion of the patient. The sorted images may be provided via a graphical user interface. The sequence of the sorted images that are based on the motion of the patient may be provided.

Abstract: A method and apparatus to automatically control the timing of an image acquisition by an imaging system in developing a correlation model of movement of a target within a patient.

Abstract: A method and apparatus for treatment planning are described.

Abstract: Imaging data including images associated with a patient may be received. A subset of the images that are used with a model that is associated with the position and motion of a targeted region of the patient to receive radiation treatment may be identified. The subset of images may be sorted. A graphical user interface (GUI) that identifies two or more of the images of the sorted subset may be provided. A selection associated with one of the images of the sorted subset may be received by the GUI. Furthermore, a new model to identify the targeted region based on the selection that is associated with one of the two or more images may be generated.

Abstract: A radiation delivery system includes a multi-leaf collimator (MLC) that includes a housing, a plurality of leaves disposed within the housing, and an image sensor disposed within the housing at a position that is offset from a beam axis. The plurality of leaves are movable to define an aperture for the MLC, and the image sensor is directed toward the plurality of leaves. The image sensor is to generate an oblique-view image of the aperture. The radiation delivery system additionally includes a processing device to receive the oblique-view image, transform the oblique-view image into a top-view image having a reference coordinate space, and determine whether the aperture for the MLC corresponds to a specified aperture based on the top-view image.

Abstract: Tracking a target structure contained within a target volume using an x-ray tomosynthesis imaging detector is described.

Abstract: A method includes determining a first estimate of leaf positions for a plurality of leaves of a multi-leaf collimator (MLC) in a reference coordinate space based on an image generated by an image-based aperture verification system, wherein the leaf positions for the plurality of leaves define an aperture for the MLC. The method further includes determining a second estimate of the leaf positions for the plurality of leaves in the reference coordinate space based on data from an additional source. The method further includes verifying the leaf positions for the plurality of leaves based on comparing the first estimate to the second estimate, wherein the leaf positions are verified if the first estimate deviates from the second estimate by less than a threshold value.

Abstract: An IGRT system and methods are described embodiments of which perform selectively integration of x-ray source arrays, dual-energy imaging, stereoscopic imaging, static and source collimation, or inverse geometry tomosynthesis imaging to acquire or track a target during radiation treatment.

Abstract: Fiducial localization methods and apparatus are described.

Abstract: A method of ambient light suppression in an imaging system, including illuminating leaves of a multi-leaf collimator (MLC) with a first light of a lighting system inside a housing of the MCL, receiving ambient light inside the housing of the MLC through an aperture of the MLC, and capturing, using an imaging system having optics situated inside the housing of the MLC, an image of the leaves of the MLC illuminated with the first light and the ambient light. The method may further include, suppressing the ambient light in the first image to generate a second image of the leaves of the MLC and detecting a feature of the leaves of the MLC in the second image.

Abstract: A radiation treatment apparatus is described. The radiation treatment apparatus may include a gantry frame and a rotatable gantry structure rotatably coupled to the gantry frame, the rotatable gantry structure being rotatable around a rotation axis passing through an isocenter, with the rotatable gantry structure including a first beam member extending between first and second ends of the rotatable gantry structure. The radiation treatment apparatus may also include a radiation treatment head movably mounted to the first beam member in a manner that allows (i) translation of the radiation treatment head along the first beam member between the first and second ends, and (ii) gimballing of the radiation treatment head relative to the first beam member, the gimballing being characterized by pivotable movement in at least two independent pivot directions defined with respect to the first beam member.

Abstract: Systems, methods, and related computer program products for image-guided radiation treatment (IGRT) are described. For one preferred embodiment, an IGRT apparatus is provided comprising a ring gantry having a central opening and a radiation treatment head coupled to the ring gantry that is rotatable around the central opening in at least a 180 degree arc. For one preferred embodiment, the apparatus further comprises a gantry translation mechanism configured to translate the ring gantry in a direction of a longitudinal axis extending through the central opening. Noncoplanar radiation treatment delivery can thereby be achieved without requiring movement of the patient. For another preferred embodiment, an independently translatable 3D imaging device distinct from the ring gantry is provided for further achieving at least one of pre-treatment imaging and setup imaging of the target tissue volume without requiring movement of the patient.

Abstract: A method of compensating for breathing and other motions of a patient during treatment includes periodically generating internal positional data about an internal target region. The method further includes generating external positional data about external motion of the patient's body using an external sensor and generating a correlation between one or more positions of the internal target region and one or more positions of an external region using the external positional data of the external sensor and the internal positional data of the internal target region. The method further includes predicting the position of the internal target region at some later time based on the correlation model.

Abstract: Treatment targets such as tumors or lesions, located within an anatomical region that undergoes motion (which may be periodic with cycle P) are tracked. A 4D mathematical model may be established for the non-rigid motion and deformation of the anatomical region, from a set of CT or other 3D images. The 4D mathematical model relates the 3D locations of part(s) of the anatomical region with the targets being tracked, as a function of the position in time within P. Using non-rigid image registration between pre-operative and intra-operative images, the position of the target and/or other part(s) of the anatomical region may be determined.

Abstract: A multi-leaf collimator with electromagnetically actuated leaves. The multi-leaf collimator includes a plurality of leaves, a leaf guide configured to support the plurality of leaves, and a plurality of magnets. Each leaf includes a blocking portion that is radio opaque, a drive portion connected to the blocking portion, and a coil embedded in the drive portion. The coil is operatively connected to an electrical current source to generate a first magnetic field. The first magnetic field interacts with the magnetic field generated by the magnet to thereby move the leave to a desired state. The leaves have the capability of moving at speeds of 50 cm/s up to and higher than 1 m/s.

Abstract: A non-invasive method and system for using 2D angiographic images for radiosurgical target definition uses non-invasive calibration devices and methods to calibrate an angiographic imaging system and a six-parameter registration algorithm to register angiographic images with 3D scan data for radiation treatment planning.

Abstract: The disclosure relates to systems and methods for interleaving operation of a linear accelerator that use a magnetron as the source of electromagnetic waves for use in accelerating electrons to at least two different ranges of energies. The accelerated electrons can be used to generate x-rays of at least two different energy ranges. In certain embodiments, the accelerated electrons can be used to generate x-rays of at least two different energy ranges. The systems and methods are applicable to traveling wave linear accelerators.

Abstract: Apparatus for generating multi-energy x-ray images and systems and methods for processing and using multi-energy x-ray images are provided for treating a target, e.g., a tumor, for image-guided radiation therapy. An image-guided radiation therapy system is provided including a treatment delivery system, a multi-energy imaging system, and a system processor. The treatment delivery system includes a radiation source configured to generate treatment radiation beams. The multi-energy imaging system is configured to generate a first set of image data of the patient using imaging radiation at a first energy level and a second set of image data of the patient using imaging radiation at a second energy level. The system processor is configured to process the first and second sets of image data to generate an enhanced image of the patient and to direct the treatment delivery system based on information obtained from the enhanced image.