Abstract: A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, and an implantable device coated with the composition are provided.
Abstract: It is provided an implantable device including a polymer blend that contains a polymer formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer.
Abstract: It is provided a method of treating a disorder, the method comprising implanting in a patient an implantable device including a polymer formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer.
Abstract: A drug-eluting stent having a first cell pattern at one end and a second cell pattern on an opposite end. The cells in the first cell pattern have a smaller MCUSA than those in the second cell pattern. An anti-restonic drug can be coated on the first cell pattern and an anti-thrombotic drug on the second, with the anti-thrombotic drug overlaying and covering both the first and second cell patterns. The stent is operatively positionable at a distal graft-vein anastomosis with the first cell pattern adjacent the stenosis, and with the second cell pattern positioned adjacent the vein or the graft.
Type:
Grant
Filed:
December 19, 2005
Date of Patent:
August 27, 2013
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Paul Consigny, Tracey Krausa, Matthew C. Merkert
Abstract: A method including positioning a catheter at a location in a blood vessel; imaging a thickness of a portion of a wall of the blood vessel at the location; identifying a treatment site; advancing a needle a distance into the wall of the blood vessel to the treatment site; and introducing a treatment agent through the needle to the treatment site. A composition including an inflammation-inducing agent and a carrier in the form of microspheres having a particle size suitable for transvascular delivery. A composition including a therapeutic angiogenesis promoter in a carrier and an opsonin-inhibitor coupled to the carrier. An apparatus for delivery of a therapeutic angiogenesis promoter.
Type:
Grant
Filed:
February 18, 2004
Date of Patent:
August 27, 2013
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Evgenia Mandrusov, Murthy V. Simhambhatla, Syed Hossainy, Eugene T. Michal, Charles Claude, Jessica G. Chiu
Abstract: A stent delivery catheter system having a catheter with stent releasably mounted on a stent retention portion of the catheter for delivery and deployment within a patient's body lumen, and a method of mounting the stent on the stent retention portion of the catheter. The method generally includes exposing the stent retention portion and/or the stent to a solvent, the solvent being in the vapor phase. The vapor phase solvent typically softens the stent retention portion of the catheter, and/or, in one embodiment in which the stent has a coating on the stent body, the vapor phase solvent softens the stent coating. In a presently preferred embodiment, the stent polymeric coating has a therapeutic agent, and the method of the invention prevents or inhibits disadvantageously affecting the therapeutic agent coating during mounting of the stent on the catheter.
Type:
Grant
Filed:
June 24, 2004
Date of Patent:
August 20, 2013
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Wouter Roorda, Tim A. Limon, Stephen D. Pacetti
Abstract: A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, an implantable device coated with the composition, and a method of treating a disorder are provided.
Abstract: A radially expandable stent can comprise a proximal section tapering inward to a proximal end of the stent and a distal section tapering inward to a distal end of the stent. The tapered sections can be adapted to improve the attachment of the stent to the delivery system and to facilitate the delivery of the mounted stent into and through a bodily lumen.
Abstract: A stent coating apparatus for coating a stent includes a brush assembly, a stent support, and a dispensing mechanism. The brush assembly includes a plurality of fibers, and the stent support carries a stent at a position in which the stent is in contact with the fibers. The dispensing mechanism dispenses a coating composition to the plurality of fibers.
Abstract: Embodiments of a method and apparatus to prevent reperfusion injury. In one embodiment, blood flow proximal to a lesion is occluded. An infusion catheter is advanced to a region distal to the lesion and an anti-reperfusion injury drug is delivered. The lesion may then be treated with a dilating device to reintroduce blood flow to the region distal to the lesion.
Type:
Grant
Filed:
August 9, 2012
Date of Patent:
July 16, 2013
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Daniel L. Cox, Hongzhi Bai, Paul Consigny, Jessica G. Chiu
Abstract: A stent for implantation in a body lumen for protecting from rupture a fibrous cap in order to treat vulnerable plaque. One embodiment of the stent achieves staged expansion through stronger and weaker circumferential regions, and includes optional anchors positioned at the circumferential transition between the stronger and weaker regions. During the first stage expansion, the weaker region expands moving the anchors laterally apart. The anchors straddle the fibrous cap and embed into the vessel wall. The second stage expansion of the stent exerts gentler stresses by the weaker region against the fibrous cap while the stronger region exerts greater stresses on the remainder of the vessel wall to open the vessel.
Abstract: Medical assemblies with a releasable connection and methods of constructing such medical assemblies are disclosed. The medical assemblies generally comprise a stent, a catheter assembly having catheter body a balloon, and a releasable connection between the stent and the catheter assembly that releases the stent from the catheter assembly in response to enlargement of the balloon or when the balloon has been enlarged to an expanded configuration.
Type:
Grant
Filed:
August 14, 2007
Date of Patent:
June 25, 2013
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
David C. Gale, Klaus Kleine, Anthony Abbate, Svava M. Atladottir, Bin Huang
Abstract: Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
Type:
Grant
Filed:
October 19, 2011
Date of Patent:
June 25, 2013
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Thierry Glauser, Stephen D. Pacetti, Paul Consigny
Abstract: Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.