Abstract: An implantable electrical connector arrangement electrically connects a first electrical component and a second electrical component. The connector arrangement includes a first connector having a first terminal and a first coupling electrode connected to the first terminal and a second connector having a second terminal and a second coupling electrode connected to the second terminal. The first connector and the second connector are connectable to each other such that the first terminal and the second terminal are capacitively connectable via the first coupling electrode and the second coupling electrode in a connected state. A defined separation gap is formed between the first coupling electrode and the second coupling electrode in the connected state.
Type:
Application
Filed:
May 18, 2021
Publication date:
September 2, 2021
Applicant:
Albert-Ludwigs-Universität Freiburg
Inventors:
Patrick Kiele, Cristian Pasluosta, Thomas Stieglitz
Abstract: An implantable electrical connecting device includes a first elastic multi-ply layer and a second elastic multi-ply layer. The first elastic multi-ply layer has a first electrically conductive layer and a plurality of first electrical contacts electrically conductively connected to the first electrically conductive layer of the first elastic multi-ply layer. The second elastic multi-ply layer has a first electrically conductive layer and a plurality of second electrical contacts electrically conductively connected to the first electrically conductive layer of the second elastic multi-ply layer. The second electrical contacts make contact with the first electrical contacts.
Type:
Application
Filed:
May 20, 2021
Publication date:
September 2, 2021
Applicant:
Albert-Ludwigs-Universität Freiburg
Inventors:
Patrick Kiele, Eva Singler, Thomas Stieglitz, Juan Sebastian Ordonez
Abstract: A nano platelet gibbsite treated with compound of formula (ORa)3Si—R or of formula Rc—COOH wherein Ra equal to or different from each other is a C1-C10 alkyl radical; Rb is a C5-C30 hydrocarbon radical and Rc is a C5-C30 hydrocarbon radical is used as a catalyst support.
Abstract: A method for the magnetic resonance examination of a measurement object is described, in which a measurement sequence is used in which the magnetic resonance response to the transmitted signal during transmission is measured. It is provided that a correction signal corresponding to the transmitted signal be generated and be used for correction of the response signal. To this end, the correction signal is modulated by a phase value and an amplitude value. The phase value and the amplitude value are automatically and iteratively customized for optimum correction of the response signal by an optimization method using a respective present state value of the measurement signal. Further, a radio-frequency unit (1) is described that can be used to carry out the method according to the invention.
Abstract: A device having a channel with a sequence of compartments having molecules having specific binding sites, this sequence of compartments being suitable for the specific binding of analytes, characterized in that the molecules having specific binding sites are bound to porous cryogels as carriers and the cryogels are chemically bonded to the wall of the channel, a method for producing the device and the use of the device in analytics.
Type:
Application
Filed:
December 20, 2017
Publication date:
June 24, 2021
Applicant:
Albert-Ludwigs-Universitat Freiburg
Inventors:
Marc Zinggeler, Jurgen Ruehe, Thomas Brandstetter
Abstract: The present invention relates to a method for identifying ?T-cell (or ?T-cell) receptors chains or parts thereof that mediate an anti-tumor or anti-infection response by identifying amino acid sequences comprising ?T-cells (or ?T-cell) receptors chains or parts thereof that are shared between different donors.
Abstract: In a method (100 to 208) in which hyperpolarizable tracer molecules (20, 88 to 98) are hydrogenated and then optionally also hyperpolarized for magnetic resonance imaging, it is provided that, in a first method step (104, 202), a hydrogen solution (10, 12, 4) having a saturation factor of at least 50% be prepared and that the hydrogenation reaction (186 to 190, 206) not be triggered until a subsequent, second method step (106, 204). An apparatus (1) with which the method of the invention (100 to 208) is executable is also provided.
Type:
Application
Filed:
August 14, 2019
Publication date:
June 3, 2021
Applicant:
Albert-Ludwigs-Universität Freiburg
Inventors:
Andreas SCHMIDT, Jan-Bernd Hovener, Jurgen HENNIG, Stephan BERNER
Abstract: An electrophoretic separation device includes an anode and a cathode, a porous scaffold material, and a liquid separation medium, wherein the separation medium is located inside the porous scaffold material, is in contact with the cathode and the anode, and has been applied to the porous scaffold material in form of a custom-made geometrical shape defining a migration path for a biomolecule-containing sample, wherein the sample is enclosed by the separation medium.
Abstract: An implantable electrode arrangement includes an electrically insulating carrier structure and an electrically conductive layer including an electrically conductive thin film layer. The electrically conductive thin film layer is structured to form at least one implantable electrode. The at least one implantable electrode has a local fractalization through a self-similar structuring chosen such that a mechanical resonance of the electrode in response to electric excitation with an excitation voltage is minimized.
Type:
Application
Filed:
October 9, 2020
Publication date:
April 15, 2021
Applicant:
Albert-Ludwigs-Universität Freiburg
Inventors:
Jennifer Schulte, Thomas Stieglitz, Max Eickenscheidt
Abstract: The present invention discloses a matrix comprising a modified polysaccharide consisting of repeating disaccharide units whereby in at least 11% of the disaccharide units one primary alcohol group is oxidized into a carboxylic acid group.
Abstract: A miniaturized microsystem device including at least one of electrical, optical and mechanical components in a hermetically or non-hermetically sealed housing with respect to air humidity or encapsulated, which contains a desiccant. The humidity-dependent lifetime of the arrangement is determined by measuring the absorptivity of the desiccant.
Type:
Grant
Filed:
September 8, 2017
Date of Patent:
March 30, 2021
Assignee:
ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG
Inventors:
Linda Rudmann, Michael Langenmair, Juan Sebastian Ordonez, Thomas Stieglitz
Abstract: A semiconductor layer and a method and an apparatus for its manufacturing are disclosed. The semiconductor layer includes at least one compound of the formula M1aM21-aN, where M1 is selected from group 13 of the periodic table and M2 is selected from the group comprising scandium, yttrium, erbium, and europium and where the parameter a is selected between 0.01 and 0.99. The method includes supplying a first precursor into a reaction chamber, the first precursor including at least M2 and being supplied to the reaction chamber at a molar flow rate of at least 1·10?6 mol/min by providing the first precursor by means of a first bubbler from which it is evaporated and supplied to the reaction chamber, the temperature of the first bubbler being more than 90° C.
Type:
Application
Filed:
August 27, 2020
Publication date:
March 4, 2021
Applicants:
Albert-Ludwigs-Universität Freiburg, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
Inventors:
Stefano LEONE, Christian MANZ, Hanspeter MENNER, Joachim WIEGERT, Jana LIGL
Abstract: The present invention relates to a method for predicting the response of a structure, or a group of structures and/or a network profile, to a perturbation, in particular a perturbation caused by an agent or a combination of agents through modeling, optimizing, parameterizing, testing and/or validating of a dynamic network or of network perturbations.
Type:
Grant
Filed:
March 21, 2012
Date of Patent:
February 2, 2021
Assignees:
Albert-Ludwigs-Universität Freiburg, Northern Institute for Cancer Research
Inventors:
Kathrin Thedieck, Annika Sonntag, Daryl Shanley, Piero Dalle Pezze
Abstract: The present invention provides a polymer having antimicrobial and/or antifouling (protein-repellent) properties, a monomer that can be used in a method of producing the polymer of the invention, and a use of the polymer of the invention, including a method for coating the surface of a material, substrate or product with the polymer of the invention, as well as to products comprising the polymer of the invention and/or a coating comprising the polymer of the invention.
Type:
Grant
Filed:
November 15, 2016
Date of Patent:
January 12, 2021
Assignee:
ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG
Inventors:
Karen Lienkamp, David Boschert, Alexandra Schneider - Chaabane, Ali Al-Ahmad
Abstract: An integrative pharmacokinetic/pharmacodynamics (PK/PD) ESA-EpoR mathematical model calculates the binding behavior of erythropoiesis stimulating agents (ESA). The invention provides methods for the determining of ESA binding sites in cells or patients suffering from anemia. Knowing the amount of ESA binding sites enables the clinical practitioner to optimize the dosage regimen during a treatment of anemia, in particular in patients suffering from a cancerous disease. Further provided are methods for screening ESAs which have a higher specificity for cells strongly expressing the EPO receptor such as colony forming units-erythroid (CFU-E) cells, and not to cells with a low level of EPO receptor cell surface expression, which is the case in cancer cells. Also provided is a computer implemented method, comprising the use of the mathematical model of the invention.
Type:
Grant
Filed:
June 18, 2015
Date of Patent:
October 6, 2020
Assignees:
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS, ALBERT-LUDWIGS-UNIVERSITAT FREIBURG
Inventors:
Agustin Rodriguez Gonzalez, Marcel Schilling, Ursula Klingmueller, Andreas Raue, Max Schelker, Jens Timmer, Michael Jarsch, Bernhard Steiert
Abstract: The present invention relates to a circuit arrangement and a method for reading a capacitive vibratory gyroscope with an at least primary mass and at least one secondary mass that is connected to the primary mass, wherein the primary mass is excited to a primary vibration during operation, and wherein the secondary mass is deflected out of a resting position in a direction that is transversal to the primary vibration when the vibratory gyro-scope rotates around a sensitive axis.
Abstract: Improvements in MR spiral imaging are provided in that spiral segments (2 to 8) are reordered, in particular alternately traversed and/or permuted. Moreover, repeatedly approaching the same post-trajectory points (16) between the acquisitions of the spiral segments (2 to 8) is provided, in which the post-trajectory points (16) are located outside of the center (18) of k-space (9), preferably outside of a region (20) of the k-space (9) covered by the spiral segments (2 to 8).
Abstract: The present invention is inter alia concerned with a method of diagnosing Alzheimer's disease in a patient, wherein said method is based on determining the amount of at least one premature mitochondrial protein. Further, the present invention relates to the use of such a protein as marker for Alzheimer's disease. Accordingly, antibodies binding to such a preprotein may be used for diagnosing Alzheimer's disease. The present invention is based on the finding that premature mitochondrial proteins accumulate in Alzheimer's disease.
Type:
Grant
Filed:
March 6, 2015
Date of Patent:
July 21, 2020
Assignee:
Albert-Ludwigs-Universität Freiburg
Inventors:
Chris Meisinger, Nora Vögtle, Dirk Mossmann, Elzbieta Glaser, Caroline Graff, René P. Zahedi
Abstract: The present invention relates to a circuit arrangement and a method for reading a capacitive vibratory gyroscope with an at least primary mass and at least one secondary mass that is connected to the primary mass, wherein the primary mass is excited to a primary vibration during operation, and wherein the secondary mass is deflected out of a resting position in a direction that is transversal to the primary vibration when the vibratory gyroscope rotates around a sensitive axis.