Abstract: The invention relates to a detection circuit for reading out at least one position signal of a micromechanical capacitive sensor having at least one oscillating element that can be excited so as to move in an oscillating manner. In particular, the invention relates to a sensor that is operated in a closed control loop by using the detection circuit according to the invention. The invention further relates to a method for operating such a sensor. During operation, a first input connection of the detection circuit (100) is connected to an output connection of the capacitive sensor (106) and an output connection of the detection circuit (100) is connected to a loop filter of a control loop (102), wherein the control loop feeds back a feedback voltage for providing a restoring force in dependence on an output voltage of the control loop (102) to a second input connection of the detection circuit (100).

Abstract: The present invention discloses new medical uses of phosphodiesterase 4 (PDE 4) inhibitors for treating dyslipoproteinaemia and of diseases when respectively correlated or associated with dyslipoproteinaemia or lipoprotein imbalance, in particular abnormally high low density lipoprotein (LDL) in blood or serum, such as endothelial dysfunction, cardiovascular diseases, in particular arteriosclerosis, myocardial infarction, stroke, peripheral artery disease, and vascular stenosis or restenosis, independent and distinct from inflammatory diseases or conditions such as inflammatory-associated cardiovascular pathology and cardiac hypertrophy. Accordingly the present invention allows reducing cardiovascular risks in new clinical settings, especially in circumstances of abnormal high LDL levels and especially LDL-cholesterol and LDL-triglyceride levels.

Abstract: The present invention in the fields of immunology and infectious diseases relates to opsonic and protective antibodies that are specific for Gram-positive bacteria, particularly to carbohydrate structures exposed on the surface of the bacteria. The invention includes monoclonal and chimeric antibodies, as well as fragments, regions and derivatives thereof. This invention also relates to the epitope to which the antibodies of the invention bind as well as the sequences, fragments, and regions of the epitopes. Both the antibodies and peptides that encompass the epitope, and regions and fragments thereof, may be used for diagnostic, prophylactic and therapeutic applications.

Abstract: The present invention relates to modulators of the interaction of astrin and raptor, and their uses in the treatment of mTOR related diseases, such as cancer.

Abstract: A multi-channel switching system (100) for an MRI gradient coil system is characterized in that the number of channels controlled by the power amplifiers is smaller than the number of switches and the number of channels controlled by the power amplifiers is smaller than the number of coil elements in the coil system. Current in each of the coil elements can be switched to flow in either a positive or negative direction or to bypass the respective coil element and power to the switch elements is delivered via a smaller amount of power lines using a power distribution system providing floating power to each of the switches. This allows to electrically connect matrix coil elements dynamically within a pulse sequence to generate dynamically switched magnetic field profiles and therefore reduce the number of gradient power amplifiers, gradient cables and power supplies needed.

Abstract: A method for the magnetic resonance examination of a measurement object is described, in which a measurement sequence is used in which the magnetic resonance response to the transmitted signal during transmission is measured. It is provided that a correction signal corresponding to the transmitted signal be generated and be used for correction of the response signal. To this end, the correction signal is modulated by a phase value and an amplitude value. The phase value and the amplitude value are automatically and iteratively customized for optimum correction of the response signal by an optimization method using a respective present state value of the measurement signal. Further, a radio-frequency unit (1) is described that can be used to carry out the method according to the invention.

Abstract: A receiving device and a method for operating a receiving device are provided in which a signal is divided into two separate signal parts. The two signal parts are demodulated simultaneously and, from the demodulated signals, the difference is formed. After the formation of the difference, an information item is obtained from the difference signal and compared with a predetermined information item. In the case of correspondence of the obtained information and the compared information, a wake-up signal is generated.

Abstract: Disclosed in the present application are: (i) a compound inhibiting the interaction between LSD1me2 and CHD1 for use in therapy, (ii) a compound inhibiting the interaction between LSD1me2 and CHD1 for use in treating cancer, in particular pro state cancer, and (iii) a method of screening for such a compound.

Abstract: Phase segregated block-copolymer based on repeating structural elements represented by formula I wherein PHA represents at least one block based on one or more ?-hydroxy acids, PDAS represents a central block based on a dialkylsiloxane, the PDAS block has a weight average molecular weight in the range of from 4000 to 10000, the blocks PHA have a weight average molecular weight in the range of from 2000 to 10 000, the phase segregated block copolymer has a weight average molecular weight of from 40 000 to 120 000.

Abstract: In a method to associate k-space lines with echo trains of raw magnetic resonance data, parallel k-space lines orthogonally intersect a plane at respective intersection points. Each echo train has a trajectory length, and the k-space lines are associated with the echo trains such that a sum of trajectory lengths of all echo trains is minimal. The trajectory length TL of an echo train is defined by TL = ? i = 1 L - 1 ? ? P i ? P i + 1 _ wherein L is a sequence of k-space lines, Pi is an intersection point of the i-th k-space line of the echo train with the plane; and PiPi+1 is the length of the path from the i-th intersection point to the (i+1)-th intersection point.

Abstract: The present invention relates to a method for adjusting the resonance frequency of a loop filter in a delta-sigma modulator, e.g. in an angular rate sensor, to a predetermined frequency value, wherein the sigma-delta modulator comprises an input terminal, which is connected to the loop filter, a quantizer, which is connected to an output of the loop filter, and a feedback branch, which couples an output of the quantizer back to the input terminal.

Abstract: The present invention relates to a neural implant comprising a biomaterial having an outer surface with a stochastic nanoroughness (Rq), and the application of said stochastic nanoroughness in the diagnosis and/or treatment of a neurological disorder, such as, for example, Parkinson's disease, Alzheimer's disease, glioblastoma and/or for disrupting and/or preventing glial scars in the context of mammalian mechanosensing ion channels selected from the family of PIEZO-1 and PIEZO-2 ion channels.

Abstract: A circuit for activating a capacitive MEMS structure is provided, with the capacitive MEMS structure having an oscillator element and an electrostatic excitation unit with a first input connection and a second input connection. The circuit includes a high voltage generator, a first pump capacitor, a second pump capacitor, a control unit, and a low voltage operation amplifier. The high voltage generator generates a high voltage and connects to the first input connection and the second input connection. The first pump capacitor is connected to the high voltage generator and includes a first connection connected to the first input connection. The second pump capacitor connects to the high voltage generator and includes a first connection connected to the second input connection. The control unit connects to a second connection of the first pump capacitor and a second connection of the second pump capacitor. The low voltage operation amplifier connects to the control unit.

Abstract: The present invention is inter alia concerned with a method of diagnosing Alzheimer's disease in a patient, wherein said method is based on determining the amount of at least one premature mitochondrial protein. Further, the present invention relates to the use of such a protein as marker for Alzheimer's disease. Accordingly, antibodies binding to such a preprotein may be used for diagnosing Alzheimer's disease. The present invention is based on the finding that premature mitochondrial proteins accumulate in Alzheimer's disease.

Abstract: The present invention relates to a circuit arrangement and a method for reading a capacitive vibratory gyroscope with an at least primary mass and at least one secondary mass that is connected to the primary mass, wherein the primary mass is excited to a primary vibration during operation, and wherein the secondary mass is deflected out of a resting position in a direction that is transversal to the primary vibration when the vibratory gyroscope rotates around a sensitive axis.

Abstract: A carrier structure (2) of an arrangement (1) for modifying a main magnetic field generated in a magnetic resonance tomograph from multiple carrier elements (3, 37). A conductor arrangement (4) is respectively arranged on each carrier element (3, 37). The conductor arrangements (4) respectively comprise a primary conductor arrangement (6) for generating a primary magnetic field that modifies the main magnetic field and a secondary conductor arrangement (7) for shielding the primary magnetic field. A method for producing a modularly constructible arrangement (1), which can be used for example for spatial encoding.

Abstract: The present invention relates to a voltage converter circuit for transforming a low voltage applied to its input into a higher output voltage at an output. The voltage converter circuit comprises at least one first to fourth controllable switch of a first type, which are connected to each other in the form of an H-bridge, which is arranged between the input voltage and a reference potential, and a transformer with at least one primary winding arranged in a transversal branch of the H-bridge, and with a secondary winding, at which a transformed voltage can be tapped for generating the output voltage. In parallel to at least one of the controllable switches at least one controllable switch of a second type is arranged, which is conductive without a control potential being applied. The secondary winding of the transformer is furthermore connected with the control inputs of the controllable switches for feeding back the transformed voltage.

Abstract: The invention is related to a method and an apparatus for the automated fabrication of a molecular layer made from amphiphilic molecules, in particular lipids for a lipid bilayer membrane, in the apparatus, which has a support substrate for supporting the molecular layer, a rotation element, which can be rotated on top of the support substrate, and an actuator device, by means of which the rotation element can be automatically rotated, wherein the rotation element has an outer surface, which is formed hydrophobic at least in sections, the method having the following steps: placing a first solvent, which contains amphiphilic molecules, in a region above the support substrate; causing the automatic rotation of the rotation element above the support substrate; moving the first solvent between the support substrate and the rotation element by the interaction of the rotating rotation element with the first solvent, thus forming the molecular layer.

Abstract: The invention relates to a detection circuit for reading out at least one position signal of a micromechanical capacitive sensor having at least one oscillating element that can be excited so as to move in an oscillating manner. In particular, the invention relates to a sensor that is operated in a closed control loop by using the detection circuit according to the invention. The invention further relates to a method for operating such a sensor. During operation, a first input connection of the detection circuit (100) is connected to an output connection of the capacitive sensor (106) and an output connection of the detection circuit (100) is connected to a loop filter of a control loop (102), wherein the control loop feeds back a feedback voltage for providing a restoring force in dependence on an output voltage of the control loop (102) to a second input connection of the detection circuit (100).

Abstract: A stent having a tubular framework structure consisting of interconnected stent struts, fabricated as a whole from a bioresorbable material and being convertible from a compressed first geometric shape into a radially dilated, dimensionally stable, tubular second geometric shape. Characterized by all of the stent struts of the tubular framework structure has made of a uniform bioresorbable material, the tubular framework structure comprises at least one surface region, which is congruent in one piece and is situated on a lateral cylindrical surface the surface, region comprising stent struts surrounded by stent struts of the framework structure that are adjacent to the surface region, such that the stent struts within the surface region have a smaller amount by weight of bioresorbable material per one predefinable discrete strut length, than the stent struts of the framework structure adjacent to the surface regions.