Abstract: In one aspect, the invention provides an intraocular lens (IOL) that includes an optic and a peripheral optical flange that surrounds the optic. The optic can form an image of a field of view on the IOL user's retina and the peripheral flange can inhibit dysphotopsia. By way of example, the peripheral flange can include at least one textured surface that is adapted to receive peripheral light rays entering the eye at large visual angles so as to cause their scattering in order to inhibit dysphotopsia, e.g., by preventing the formation of a secondary peripheral image or scattering some light to a shadow region between such a secondary image and an image formed by the IOL.

Abstract: In one aspect, an intraocular lens (IOL) is discloses that includes an optic having a central portion and a peripheral extension that partially surrounds the central portion. Once implanted in a patient's eye, the IOL's optic forms an image of a field of view with the peripheral extension inhibiting dysphotopsia. While in some embodiments, the peripheral extension provides focusing of light incident thereon, in other embodiments, it can include at least one textured surface for scattering the light or at least one opaque surface for preventing the light from reaching the retina. In other embodiments, the peripheral extension can include one or more translucent surface(s) for diffusing the light passing therethrough to inhibit dysphotopsia.

Abstract: A surgical cassette for use in a combined anterior segment and posterior segment ophthalmic surgical procedure is disclosed. The surgical cassette includes an irrigation inlet for receiving irrigation fluid from a source, a first irrigation outlet for providing irrigation fluid to a first ophthalmic microsurgical instrument, a first manifold fluidly coupling the irrigation inlet with the first irrigation outlet, a second irrigation outlet for providing irrigation fluid to a second ophthalmic microsurgical instrument, and a second manifold fluidly coupling the irrigation inlet with the second irrigation outlet. The surgical cassette greatly simplifies the combined procedure by eliminating the need for separate anterior segment and posterior segment cassettes for the combined procedure.

Abstract: An improved, asynchronous method of operating a microsurgical instrument, such as a vitrectomy probe. The instrument includes a port for receiving tissue and an inner cutting member. A flow of tissue is induced into the port with a vacuum source. The port is at least partially occluded with the tissue. The occlusion is detected, and the inner cutting member is actuated to close the port and cut the tissue.

Abstract: A microsurgical system, and a method of mapping the surgical functions of the microsurgical system to a foot controller operatively coupled with the system, are disclosed. The microsurgical system includes a computer, a foot controller operatively coupled to the computer, and a touch screen display operatively coupled to the computer. The foot controller has a plurality of switches. Each of the switches is for controlling a surgical function of the microsurgical system and for actuation by a user's foot. The touch screen display has the ability to display a graphic representation of the foot controller including the plurality of switches, and to display a list of surgical functions so that the list is associated with the graphical representation of one of the plurality of switches. By touching one of the surgical functions in the list, a user can exchange the surgical functions associated with any two of the plurality of switches on the foot controller.

Abstract: Disclosed are soft, high refractive index, acrylic materials having an elongation of at least 150%. These materials, especially useful as intraocular lens materials, contain an aryl acrylic hydrophobic monomer as the single principal device-forming monomer. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.

Abstract: Covalently-bound, hydrophilic copolymer coatings for implants are disclosed. The copolymer coatings comprise 2-phenylethyl (meth)acrylate, a hydrophilic monomer selected from the group consisting of hydroxyalkyl (meth)acrylates and acrylamides, and a reactive plasticizer.

Abstract: Hydrophilic coatings for implantable ophthalmic lenses are disclosed. The coatings, which are applied to the edge surface of the ophthalmic lens, comprise a hydrophobic (meth)acrylic polymer and a hydrophilic polymer. When hydrated, the coatings reduce or eliminate edge glare.

Abstract: An improved cart for a surgical console. The cart includes a base, an internal frame coupled to the base, and an external housing substantially encasing the internal frame. The external housing comprises a single piece of molded plastic. The external housing prevents operating room fluid ingress into the internal frame. Therefore, the internal frame, its various portions, and the various electronic apparatus and consumables that are stored therein are protected from corrosion and damage.

Abstract: A system for protecting a sector of tissue from exposure to surgically directed radiation includes a processor and an input device, a camera, and an output screen in electronic communication with the processor. A software resident on the processor receives camera data containing an image of a region of tissue, which includes at least a portion of a predetermined area desired to receive therapeutic radiation. The software also routes the image for display superimposes thereon first indicia indicative of the predetermined area. Data are received on a location of a sector of the tissue desired to be protected from the radiation and for superimposing on the displayed image second indicia indicative of the sector. In a specific embodiment the tissue is an eye and the predetermined area is at least a portion of the cornea.

Abstract: An instrument for positioning an intracorneal optical lens within an intracorneal pocket is disclosed. The instrument generally includes a handle and a cannula associated with and having a distal portion extending from the handle. The cannula is for fluidly coupling to a vacuum source in a first mode of operation and to a reservoir of surgical fluid in a second mode of operation. The distal portion of the cannula is for receiving the lens in a folded position around the distal portion. The distal portion has an aperture for providing vacuum to hold the lens in the folded position in the first mode of operation and for ejecting surgical fluid in an outward direction from the distal portion to help unfold the lens in the second mode of operation. Methods of using the instrument for positioning of an intracorneal optical lens are also disclosed.

Abstract: A wavefront sensor includes an afocal relay stage for magnifying an incoming wavefront reflected from a source plane. In an exemplary application, a retina of an eye reflects an impinging light beam thereon to form a series of wavefronts. A lenslet array is positioned at a reference plane of the afocal relay stage to receive the magnified wavefront. Further downstream is positioned a means for imaging and demagnifying a focal plane image of the lenslet array at a final image plane. This demagnified image then serves as input to an analyzer, such as a charge-coupled-device (CCD) camera.

Abstract: A system and method for controlling an eye movement tracker includes monitoring a plurality of eye positions by following a feature using the tracker. An optical beam is sent into the eye, and an intensity of a reflected beam from the eye is sensed at each position. If the intensity of the reflected beam fluctuates from a predetermined acceptable intensity range, the tracker is returned to a frozen position. The frozen position comprises a most recent position at which the intensity lay within the intensity range. The tracker is also frozen if the noise in the signal exceeds a predetermined acceptable maximum noise level and for counting a number of times the tracker is frozen. The procedure is aborted if the tracker is frozen repeatedly and for a time exceeding a predetermined maximum acceptable time.

Abstract: A range of a wavefront sensor is extended by focusing collimated light onto a lenslet array, an output creating a grid formed by edges of the lenslets and a reference spot in the members of the grid. Each reference spot has a known relationship to the grid member and a centroid. A relationship between the reference centroids is determined. Next a wavefront emanating from an eye is focused onto the lenslet array, with the output from the lenslet array forming the grid and aberrated eye spots thereon, each eye spot having a centroid. A relationship between the eye spot centroids is determined. One known relationship between one reference centroid and the centroid of one eye spot is identified. Finally, at least some of the remaining relationships between the reference centroids and the eye spot centroids are determined. The determined relationships provide a measure indicative of the eye aberration.

Abstract: A surgical cassette for use in a combined anterior segment and posterior segment ophthalmic surgical procedure is disclosed. The surgical cassette includes an irrigation inlet for receiving irrigation fluid from a source, a first irrigation outlet for providing irrigation fluid to a first ophthalmic microsurgical instrument, a first manifold fluidly coupling the irrigation inlet with the first irrigation outlet, a second irrigation outlet for providing irrigation fluid to a second ophthalmic microsurgical instrument, and a second manifold fluidly coupling the irrigation inlet with the second irrigation outlet. The surgical cassette greatly simplifies the combined procedure by eliminating the need for separate anterior segment and posterior segment cassettes for the combined procedure.

Abstract: Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders are disclosed.

Abstract: Disclosed are soft, high refractive index, acrylic materials having an elongation of at least 150%. These materials, especially useful as intraocular lens materials, contain an aryl acrylic hydrophobic monomer as the single principal device-forming monomer. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.

Abstract: A method of operating a microsurgical instrument, such as a vitrectomy probe, is disclosed. The probe includes a port for receiving tissue and an inner cutting member. A flow of tissue is induced into the port with a vacuum source, and the member is actuated in a cyclic manner to open and close the port over a plurality of cut rates. A duty cycle of the member is varied with the cut rate to vary the flow of the tissue into the port. The method yields the ability to adjust flow rate into the probe and aperture of the probe for a given cut rate so as to effectively perform a wide variety of vitreoretinal surgical objectives.

Abstract: Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivatives act as mast cell stabilizers.

Abstract: Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivatives act as mast cell stabilizers.