Abstract: A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber.

Abstract: The invention provides a neck-worn sensor for simultaneously measuring a blood pressure (BP), pulse oximetry (SpO2), and other vital signs and hemodynamic parameters from a patient. The neck-worn sensor features a sensing portion having a flexible housing that is worn entirely on the patient's chest and encloses a battery, wireless transmitter, and all the sensor's sensing and electronic components. It measures electrocardiogram (ECG), impedance plethysmogram (IPG), photoplethysmogram (PPG), and phonocardiogram (PCG) waveforms, and collectively processes these to determine the vital signs and hemodynamic parameters. The sensor that measures PPG waveforms also includes a heating element to increase perfusion of tissue on the chest.

Abstract: A dialysis system is configured to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments. The example dialysis system includes a base unit configurable to provide a first fluid for use in preforming at least one peritoneal dialysis treatment at a first time. The base unit is further configurable to provide a second, different fluid for use in at least one extracorporeal blood treatment at a second, different time. The example dialysis system also includes a blood treatment unit configured to be docked to the base unit. The blood treatment unit includes a blood pump configured to pump blood from the patient to a blood filter and from the blood filter back to the patient. The blood filter or a blood line in communication with the blood filter receives the second fluid from the base unit for use in the at least one extracorporeal blood treatment.

Abstract: Devices, systems, and methods for monitoring patient hemodynamic status, systemic vascular resistance, reversal of cardiac and respiratory rates, and patient respiratory volume or effort are disclosed. A peripheral venous pressure is measured and used to detect levels, changes, or problems relating to patient blood volume. The peripheral venous pressure measurement is transformed from the time domain to the frequency domain for analysis. A heart rate frequency is identified, and harmonics of the heart rate frequency are detected and evaluated to determine, among other things, hypovolemia or hypervolemia, systemic vascular resistance, and of cardiac and respiratory rates, and patient respiratory volume or effort.

Abstract: The invention provides a neck-worn sensor for simultaneously measuring a blood pressure (BP), pulse oximetry (SpO2), and other vital signs and hemodynamic parameters from a patient. The neck-worn sensor features a sensing portion having a flexible housing that is worn entirely on the patient's chest and encloses a battery, wireless transmitter, and all the sensor's sensing and electronic components. It measures electrocardiogram (ECG), impedance plethysmogram (IPG), photoplethysmogram (PPG), and phonocardiogram (PCG) waveforms, and collectively processes these to determine the vital signs and hemodynamic parameters. The sensor that measures PPG waveforms also includes a heating element to increase perfusion of tissue on the chest.

Abstract: Devices, systems, and methods for monitoring patient hemodynamic status, systemic vascular resistance, reversal of cardiac and respiratory rates, and patient respiratory volume or effort are disclosed. A peripheral venous pressure is measured and used to detect levels, changes, or problems relating to patient blood volume. The peripheral venous pressure measurement is transformed from the time domain to the frequency domain for analysis. A heart rate frequency is identified, and harmonics of the heart rate frequency are detected and evaluated to determine, among other things, hypovolemia or hypervolemia, systemic vascular resistance, and of cardiac and respiratory rates, and patient respiratory volume or effort.

Abstract: A method of cleaning used dialysis fluid having urea to produce a cleaned dialysis fluid, the method including passing the used dialysis fluid having urea through a combination electrodialysis and urea oxidation cell, the cell including (i) a first set of electrodes for separation of the used dialysis fluid having urea into an acid stream and a basic stream, wherein the first set of electrodes includes an anode and a cathode; (ii) one or more second set of electrodes positioned to contact the basic stream with an electrocatalytic surface for decomposition of urea via electrooxidation, wherein the one or more second set of electrodes includes an anode and a cathode; and (iii) at least one power source to provide the first and second sets of electrodes with an electrical charge to activate the electrocatalytic surface.

Abstract: A pharmaceutically acceptable insulin premix formulation contains about 0.1-10.0 Unit/mL of insulin for intravenous administration and preferably further contains a tonicity adjuster. The methods for making and using such formulation are also provided. The pharmaceutically acceptable insulin premix formulation may be aseptically filled into a flexible container assembly to form a pharmaceutical insulin premix product. The insulin premix product can be a sterile and ready-to-use aqueous solution for glycemic control in an individual with metabolic disorders through intravenous infusion. The insulin premix product is unexpectedly stable when freshly prepared and also during its shelf-life of storage at refrigeration temperatures of 2° C. to 5° C. for 24 months followed by additional 30 days at room temperatures of 23° C. to 27° C., even without any added preservative, any added zinc, any added surfactant or any other added stabilizing excipient.

Abstract: A method for pairing a dialysis machine with peripheral devices is disclosed. An example method includes receiving, in an intermediate data transfer unit, data related to a patient from at least one of a weight sensor, a blood pressure sensor, or a remote exchange device. The method also includes causing the intermediate data transfer unit to detect a connection of a memory device to a port of the intermediate data transfer unit, and causing the intermediate data transfer unit to store the data to the memory device so that the memory device can be transported to a dialysis machine for transfer of the data from the memory device to the dialysis machine.

Abstract: An optical imaging assembly configured to obtain an image of an object. The assembly includes a light-transmissive sleeve arranged on an optical axis and configured to enclose the object. Four refractive elements are arranged in series on the optical axis and each have an input surface and an output surface. An aperture stop is disposed on the optical axis between the third and fourth refractive elements. The input surface of the third refractive element, the output surface of the third refractive element, the input surface of the fourth refractive element, the output surface of the fourth refractive element, of a combination of the foregoing have radial symmetry.

Abstract: The invention provides a neck-worn sensor for simultaneously measuring a blood pressure (BP), pulse oximetry (SpO2), and other vital signs and hemodynamic parameters from a patient. The neck-worn sensor features a sensing portion having a flexible housing that is worn entirely on the patient's chest and encloses a battery, wireless transmitter, and all the sensor's sensing and electronic components. It measures electrocardiogram (ECG), impedance plethysmogram (IPG), photoplethysmogram (PPG), and phonocardiogram (PCG) waveforms, and collectively processes these to determine the vital signs and hemodynamic parameters. The sensor that measures PPG waveforms also includes a heating element to increase perfusion of tissue on the chest.

Abstract: Systems and methods for providing multiple pass continuous flow dialysis are provided. In an embodiment, a system for providing peritoneal dialysis includes a catheter in communication with a peritoneal cavity, a fluid loop in fluid communication with the catheter and capable of circulating a therapy fluid into, through and out of the patient's peritoneal cavity, a multi-line fluid circuit, the multi-line fluid circuit in fluid communication with the fluid loop and including a bypass line coupled to a discharge fluid line, and a cycler including a plurality of valves, the cycler programmed to operate the plurality of valves to selectively (i) discharge therapy fluid from the multi-line fluid circuit via the discharge fluid line or (ii) bypass the discharge fluid line via the bypass line and circulate the therapy fluid a plurality of times through the fluid loop prior to exiting the multi-line fluid circuit via the discharge fluid line.

Abstract: A method of providing filled product bags of sterile and particulate-free fluid includes securing a product bag to one of a plurality of movable cradles, wherein the product bag has a bladder, a stem fluidly connected to an opening of the bladder, and a filter disposed in-line with the stem. After securing the bag, an inlet of the stem is connected to an outlet of a nozzle assembly and at least partially filling the product bag with a fluid through a nozzle of the nozzle assembly to create a filled product bag, wherein filling the product bag includes passing the fluid through the filter and into the bladder. After filling, the stem of the filled product bag is sealed at a location below the filter. The stem is cut at a location above the seal and below the filter.

Abstract: A graph database for outbreak tracking and management is disclosed. In an example embodiment, an outbreak management system includes a memory device storing instructions that define a graph database for disease outbreak tracking. The instructions specify for a given host that a host node is created and an episode node is connected to the host node via a ‘case’ link. The episode node is associated with episode parameters that are related to a disease classification of the host. In addition, the instructions specify that an outbreak node is connected to the episode node via a ‘part of’ link to indicate that the host has become part of an outbreak of the disease. The outbreak node is connected to a definition node via a ‘defined as’ link. The definition node specifies disease parameters of the disease that is related to the outbreak node.

Abstract: A drip chamber for an infusion tube, including: a first end including a drip tube; a second end including an exit port; and a wall connecting the first and second ends and including an interior surface with a hydrophobic portion. The drip chamber includes a space enclosed by the interior wall and the first and second ends. The hydrophobic portion of the interior surface repels liquid contacting the hydrophobic coating. The hydrophobic portion of the interior surface enables light to refract through the hydrophobic portion and the wall in the same manner as is the case when the hydrophobic portion is not present on the interior surface.

Abstract: Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a first component comprising a dry preparation of a coagulation inducing agent, b) providing a second component comprising a dry preparation of a biocompatible polymer suitable for use in hemostasis, c) providing said first component and said second component in a combined form in a final container, c1) either by filling said first component and said second component into said final container so as to obtain a dry mixture in said final container, c2) or by providing said first component or said second component in said final container and adding said second component or said first component so as to obtain a combination of said first component with said second component in said final container, d) finishing the final container to a storable pharmaceutical device containing said first component and said second component in a combined form as a dry and stable hemostatic composition.

Abstract: The invention provides a neck-worn sensor that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure. And from pulse pressure and pulse transit time, a second algorithm, also employing a linear algorithm, can estimate systolic blood pressure and diastolic blood pressure. Thus, the sensor can measure all five vital signs along with hemodynamic parameters. It also includes a motion-detecting accelerometer, from which it can determine motion-related parameters such as posture, degree of motion, activity level, respiratory-induced heaving of the chest, and falls.

Abstract: Methods and devices for providing dialysis treatment are provided. The device comprises a cartridge for providing regenerative dialysis, the cartridge comprising: a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein at least two of the layers are blended together to provide a gradient of the two materials.

Abstract: A home medical device system includes a home therapy machine for performing a home therapy on a patient; a user interface operably connected to the home therapy machine, the user interface receiving operator inputs; a water treatment device in fluid communication with the home therapy machine; and a data connection between the home therapy machine and the water treatment device, wherein the home therapy machine transmits data via the connection to the water treatment device for control of the water treatment device, the data provided based on at least one of the operator inputs received via the user interface.

Abstract: A patient platform for patient engagement and treatment compliance is disclosed. In an example, a processor is configured to obtain medical information from a patient for engagement and treatment compliance tracking. To obtain the medical information, the processor causes a user interface to be displayed with fields to be populated with medical information. After receiving a selection of a data field, the processor provides an option to enter medical information from an image. If the option is selected, the processor receives a recorded image of a medical device or a screen of a medical device, extracts text from the image, enables a selection of at least a portion of the text from the image, and writes the selected text from the image into the data field of the user interface as the medical information. The processor transmits the medical information to a patient medical record stored in a clinician database.