Patents Assigned to Curators of the University of Missouri
  • Patent number: 11857112
    Abstract: A heat exchanging liquid container system comprising a main body; a phase change material (PCM) module disposable within the main body; a PCM disposed within the PCM module; a liquid reservoir defined by the main body and/or the PCM module configured to have liquid disposed therein having a first temperature; and a temperature conditioning channel formed along a wall of the PCM module and/or through the PCM module such that the temperature conditioning channel is in thermal contact with the PCM. The temperature conditioning channel configured to provide a flow path through which the liquid can flow to dispense the liquid from the liquid reservoir such that the liquid will be in thermal contact with the PCM while being dispensed. The PCM configured to exchange thermal energy with the liquid and thereby condition the liquid to be dispensed at a second temperature that is within a desired temperature range.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: January 2, 2024
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventor: Hongbin Ma
  • Patent number: 11845670
    Abstract: The present disclosure is directed to novel functionalized ionic liquids (ILs) that are used, for example, for enhanced recovery and separation of rare earth elements from aqueous solutions. The liquids and processes disclosed herein lead to greater separation efficiency, increased stability of separation materials, increased selectivity, and a reduced amount of waste materials.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: December 19, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Mostafa Khodakarami, Lana Alagha
  • Patent number: 11844881
    Abstract: The present invention is directed to a composite material with a high dielectric constant. In certain embodiments, the composite material of the invention is biocompatible and is used in an implantable medical device, such as an implantable antenna, probe, sensor or electrode. In certain embodiments, the present invention comprises a biocompatible conductive or semi-conductive filler comprising filler particles dispersed within a biocompatible electrically insulating material. The filler particles may comprise an electrically insulating coating.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: December 19, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Kevin O'Connor, Randy D. Curry
  • Publication number: 20230398126
    Abstract: A method of treating and/or preventing Rift Valley fever, comprising administering an effective amount of a compound of formula (I), formula (II), formula (III), formula (IV), formula (V), formula (VI), formula (VII) or formula (VIII), or a salt thereof, to a subject need thereof; a pharmaceutical composition comprising a compound of formula (I), formula (II), formula (III), formula (IV), formula (V), formula (VI), formula (VII) or formula (VIII), or a salt thereof, and a pharmaceutically acceptable carrier; and a pharmaceutical composition comprising a compound selected from the group consisting of compound WMA-RV1, compound WMA-RV2, compound MA-RV3, compound WMA-RV4, compound WMA-RV5, compound WMA-RV6, compound WMA-RV7, or compound WMA-RV8, or a salt thereof, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: June 12, 2023
    Publication date: December 14, 2023
    Applicants: The Curators of the University of Missouri, University of Kansas
    Inventors: Wenjun MA, Heidi LIU, Anuradha ROY
  • Patent number: 11840659
    Abstract: A heat exchanging thermal liquid container system that comprises a main body at least partially defining a liquid reservoir structured and operable to retain a liquid, and a phase change material (PCM) liner comprising a PCM liner PCM having a selected melting temperature, and/or at least one PCM pod. Each of the at least one PCM pod(s) comprising a respective PCM pod PCM having a respective selected melting temperature. Wherein the PCM liner and/or the at least one PCM pod are disposable within the liquid reservoir such that when a liquid is disposed within the liquid reservoir the liquid will contact at least one of the PCM liner and the at least one PCM pod such that thermal energy can be exchanged between the liquid and the respective at least one of the PCM liner PCM and the at least one PCM pod PCM.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: December 12, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Hongbin Ma, Michael Merwin, Hao Bai, Xiaoqin Liu, Robert L Riegler, Christopher J. Vincent
  • Patent number: 11817588
    Abstract: Provided here is a method of manufacturing a lattice electrode useful in an energy storage device such as a battery or capacitor. A lattice electrode useful in an energy storage device such as a battery or capacitor also is provided, along with energy storage devices such as batteries or capacitors.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: November 14, 2023
    Assignees: Carnegie Mellon University, The Curators of the University of Missouri
    Inventors: Rahul Panat, Jie Li, Jonghyun Park, Mohammad Sadeq Saleh
  • Patent number: 11802286
    Abstract: The present invention provides a method and means to change fatty acid and ultimately triacylglycerol production in plants and algae. Methods of the invention comprise the step of altering the activity levels of the committed step for de novo fatty acid biosynthesis, acetyl-CoA carboxylases (ACCase). More specifically, methods of the invention directly enhance the activity of ACCase by overexpression of ?-CT or a catalytic portion thereof.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: October 31, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Jay J. Thelen, Matthew Salie
  • Patent number: 11796473
    Abstract: The invention broadly relates techniques for imaging and medical diagnosis and, more particularly, to the fabrication of flexible plasmonic gratings and the use thereof in detection of biomarkers. A first aspect of the invention provides for techniques for the fabrication of novel, flexible plasmonic gratings that can be inexpensively fabricated onto fiber optic cables, flexible films and substrates with non-uniform surfaces to enhance the imaging resolution. A second aspect of the invention provides for an ultra¬high sensitivity (single molecule counting) biomarker detection platform useable for medical diagnosis based on a fluorescent sandwich ELISA assay performed on a plasmonic grating platform incorporated with a fluorescence detection unit.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: October 24, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Shubhra Gangopadhyay, Sangho Bok, Cherian Joseph Mathai, Keshab Gangopadhyay, Sheila Grant, Aaron Wood, Syed Barizuddin
  • Publication number: 20230306874
    Abstract: A system and method for simulating a human respiratory system to facilitate investigating the functioning of the respiratory system, such as the generation and effects of secondhand smoke. An aerosol generator, which may include an atomizer, is configured to generate an aerosol. A series of filter media includes, in order, an inhaling extrathoracic filter media, an inhaling tracheobronchial filter media, an alveolar filter media, an exhaling tracheobronchial filter media, and an exhaling extrathoracic filter media. Each filter media includes one or more layers of a material having a fiber diameter and a weight that simulate the corresponding region of the respiratory system. A conduit may be configured to define a path for the aerosol from the aerosol generator through the series of filter media. An instrument, such as a scanning mobility particle sizer, may be used to measure a property of a secondhand aerosol exiting the exhaling extrathoracic filter media.
    Type: Application
    Filed: March 24, 2023
    Publication date: September 28, 2023
    Applicant: The Curators of the University of Missouri
    Inventors: Yang Wang, Weixing Hao, Yue-Wern Huang
  • Patent number: 11753622
    Abstract: The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: September 12, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Ye Yuan, Lee D. Spate, Randall S. Prather, R. Michael Roberts
  • Publication number: 20230282826
    Abstract: Various graphite additives were incorporated into the positive battery paste composition to compare their effects on the positive active mass utilization of lead-acid batteries. The disclosure is related to battery paste composition for preparing a lead-acid battery plate comprising a graphite additive selected from the group consisting of globular natural graphite, natural flake graphite, expanded flake graphite, and combinations thereof. The disclosure is also related to a battery paste composition comprising a sodium polymethacrylate dispersant. The disclosure is further related to batteries prepared by these battery paste compositions.
    Type: Application
    Filed: March 4, 2022
    Publication date: September 7, 2023
    Applicant: The Curators of the University of Missouri
    Inventors: Fatih Dogan, Julian Kosacki
  • Patent number: 11738324
    Abstract: Carbon dioxide (CO2) capture materials comprising one or more 3D-printed zeolite monoliths for the capture and or removal of CO2 from air or gases in enclosed compartments, including gases or mixtures of gases having less than about 5% CO2. Methods for preparing 3D-printed zeolite monoliths useful as CO2 capture materials and filters, as well as methods of removing CO2 from a gas or mixture of gases in an enclosed compartment using 3D-printed zeolite monoliths are provided.
    Type: Grant
    Filed: March 8, 2022
    Date of Patent: August 29, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Fateme Rezaei, Harshul V. Thakkar
  • Patent number: 11740171
    Abstract: An open-ended hollow coaxial cable resonator probe configured to receive an aerosol sample for analysis. A metal post shorts the resonator's inner and outer conductors. A metal plate is spaced apart from an open end of the resonator by a dielectric layer that contains the received aerosol sample. Interrogator circuitry coupled to the resonator transmits an electromagnetic wave within the resonator and generates an electric field at the open end of the resonator. The interrogator circuitry is responsive to the generated electric field for determining a resonance frequency and an impedance of the resonator when the aerosol sample is present in the dielectric layer and is configured to identify virus particles in the aerosol sample as a function of the determined resonance frequency and impedance. A portable aerosol analyzer comprises the open-ended hollow coaxial cable resonator and a mouthpiece through which a subject expels a breath sample into the open end of the resonator.
    Type: Grant
    Filed: March 23, 2021
    Date of Patent: August 29, 2023
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Jie Huang, Chen Zhu, Rex E. Gerald, II
  • Patent number: 11707077
    Abstract: Provided are engineered meat products formed as a plurality of at least partially fused layers, wherein each layer comprises at least partially fused multicellular bodies comprising non-human myocytes and wherein the engineered meat is comestible. Also provided are multicellular bodies comprising a plurality of non-human myocytes that are adhered and/or cohered to one another; wherein the multicellular bodies are arranged adjacently on a nutrient-permeable support substrate and maintained in culture to allow the multicellular bodies to at least partially fuse to form a substantially planar layer for use in formation of engineered meat. Further described herein are methods of forming engineered meat utilizing said layers.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: July 25, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Gabor Forgacs, Francoise Marga, Karoly Robert Jakab
  • Patent number: 11702564
    Abstract: Coating compositions and methods for using the same are disclosed. The coating compositions can include an aminosilica adsorbent. The coating compositions can adsorb CO2.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: July 18, 2023
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Fateme Rezaei, Thomas P. Schuman, Glenn C. Morrison
  • Patent number: 11684603
    Abstract: Disclosed are methods for ameliorating glycocalyx damage by administering a neuraminidase inhibitor. Also disclosed are methods for treating endothelial dysfunction and for improving flow mediated dilation.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: June 27, 2023
    Assignee: CURATORS OF THE UNIVERSITY OF MISSOURI UNIVERSITY
    Inventors: Luis A. Martinez-Lemus, Christopher A. Foote, Jaume Padilla
  • Patent number: 11672381
    Abstract: A drinking container system with multiple temperature zones, wherein the container system includes a main body having a sidewall and a bottom that define a phase change material (PCM) module receptacle, and a phase change material (PCM) module having a sidewall that defines a beverage chamber. The PCM module is disposable within the PCM module receptacle such that a beverage egress flow path is defined between the main body sidewall and the PCM module sidewall. The flow path formed in the container can make the beverage achieve the desired drinking temperature. The PCM module sidewall is at least partially filled with a phase change material and is structured and operable to provide a plurality temperature zones within the beverage chamber. Each temperature zone is operable to maintain a temperature of a respective portion of a liquid disposed within the beverage chamber within a respective temperature range.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: June 13, 2023
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Hongbin Ma, Michael Merwin, Hao Bai, Robert Riegler, Christopher Vincent, Susan Liu
  • Patent number: 11667995
    Abstract: A cast iron alloy is provided with a composition in weight percent (wt. %) of carbon between 2.6 to 3.4 wt. %, silicon between 2.4 to 3.2 wt. %, manganese between 0.3 to 0.6 wt. %, molybdenum between 0.4 to 1.2 wt. %, nickel between 0.6 to 1.75 wt. %, magnesium between 0.01 to 0.075 wt. %, aluminum between 1.8 to 3.5 wt. %, sulfur between 0.003 to 0.025 wt. %, zirconium between 0.001 to 0.02 wt. %, cerium between 0.001 to 0.03 wt. %, lanthanum between 0.0005 to 0.02 wt. %, and a balance of iron and unavoidable trace elements. A part formed from the cast iron alloy is also provided and the part has an Ac1 temperature equal to or greater than 895° C. and a thermo-mechanical fatigue lifetime of at least 10,000 cycles when cycled between 400° C. to 800° C. with a total cyclic strain equal to 0.001 m/m.
    Type: Grant
    Filed: September 21, 2021
    Date of Patent: June 6, 2023
    Assignees: Ford Global Technologies, LLC, The Curators of the University of Missouri
    Inventors: Larry Alan Godlewski, Mei Li, Carlos Engler-Pinto, Simon Naymovich Lekakh
  • Patent number: 11660354
    Abstract: Described herein are novel conjugates containing an inhibitor (e.g., a PSMA inhibitor, e.g., a gastrin-releasing peptide receptor inhibitor) and metal chelator that are covalently attached to a macromolecule (e.g., a nanoparticle, a polymer, a protein). Such conjugates exhibit distinct properties over the free, unbound inhibitor/chelator construct.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: May 30, 2023
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University, The Curators of the University of Missouri
    Inventors: Michelle S. Bradbury, Thomas P. Quinn, Barney Yoo, Wolfgang Weber, Karim Touijer, Howard Scher, Kai Ma, Ulrich Wiesner
  • Patent number: 11647864
    Abstract: A heat loss protection lid for a thermal liquid container system, wherein the heat loss protection lid comprises a central body, a liquid ingress opening formed within the central body, a liquid dispensing opening formed within one of a peripheral edge of the central body or a lip formed around the peripheral edge of the central body. and a concealed air intake hole.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: May 16, 2023
    Assignee: The Curators of the University of Missouri
    Inventor: Hongbin Ma