Patents Assigned to Curators of the University of Missouri
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Patent number: 11857112Abstract: A heat exchanging liquid container system comprising a main body; a phase change material (PCM) module disposable within the main body; a PCM disposed within the PCM module; a liquid reservoir defined by the main body and/or the PCM module configured to have liquid disposed therein having a first temperature; and a temperature conditioning channel formed along a wall of the PCM module and/or through the PCM module such that the temperature conditioning channel is in thermal contact with the PCM. The temperature conditioning channel configured to provide a flow path through which the liquid can flow to dispense the liquid from the liquid reservoir such that the liquid will be in thermal contact with the PCM while being dispensed. The PCM configured to exchange thermal energy with the liquid and thereby condition the liquid to be dispensed at a second temperature that is within a desired temperature range.Type: GrantFiled: July 31, 2019Date of Patent: January 2, 2024Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventor: Hongbin Ma
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Patent number: 11845670Abstract: The present disclosure is directed to novel functionalized ionic liquids (ILs) that are used, for example, for enhanced recovery and separation of rare earth elements from aqueous solutions. The liquids and processes disclosed herein lead to greater separation efficiency, increased stability of separation materials, increased selectivity, and a reduced amount of waste materials.Type: GrantFiled: May 15, 2020Date of Patent: December 19, 2023Assignee: The Curators of the University of MissouriInventors: Mostafa Khodakarami, Lana Alagha
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Patent number: 11844881Abstract: The present invention is directed to a composite material with a high dielectric constant. In certain embodiments, the composite material of the invention is biocompatible and is used in an implantable medical device, such as an implantable antenna, probe, sensor or electrode. In certain embodiments, the present invention comprises a biocompatible conductive or semi-conductive filler comprising filler particles dispersed within a biocompatible electrically insulating material. The filler particles may comprise an electrically insulating coating.Type: GrantFiled: May 17, 2019Date of Patent: December 19, 2023Assignee: The Curators of the University of MissouriInventors: Kevin O'Connor, Randy D. Curry
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Publication number: 20230398126Abstract: A method of treating and/or preventing Rift Valley fever, comprising administering an effective amount of a compound of formula (I), formula (II), formula (III), formula (IV), formula (V), formula (VI), formula (VII) or formula (VIII), or a salt thereof, to a subject need thereof; a pharmaceutical composition comprising a compound of formula (I), formula (II), formula (III), formula (IV), formula (V), formula (VI), formula (VII) or formula (VIII), or a salt thereof, and a pharmaceutically acceptable carrier; and a pharmaceutical composition comprising a compound selected from the group consisting of compound WMA-RV1, compound WMA-RV2, compound MA-RV3, compound WMA-RV4, compound WMA-RV5, compound WMA-RV6, compound WMA-RV7, or compound WMA-RV8, or a salt thereof, and a pharmaceutically acceptable carrier.Type: ApplicationFiled: June 12, 2023Publication date: December 14, 2023Applicants: The Curators of the University of Missouri, University of KansasInventors: Wenjun MA, Heidi LIU, Anuradha ROY
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Patent number: 11840659Abstract: A heat exchanging thermal liquid container system that comprises a main body at least partially defining a liquid reservoir structured and operable to retain a liquid, and a phase change material (PCM) liner comprising a PCM liner PCM having a selected melting temperature, and/or at least one PCM pod. Each of the at least one PCM pod(s) comprising a respective PCM pod PCM having a respective selected melting temperature. Wherein the PCM liner and/or the at least one PCM pod are disposable within the liquid reservoir such that when a liquid is disposed within the liquid reservoir the liquid will contact at least one of the PCM liner and the at least one PCM pod such that thermal energy can be exchanged between the liquid and the respective at least one of the PCM liner PCM and the at least one PCM pod PCM.Type: GrantFiled: September 13, 2021Date of Patent: December 12, 2023Assignee: The Curators of the University of MissouriInventors: Hongbin Ma, Michael Merwin, Hao Bai, Xiaoqin Liu, Robert L Riegler, Christopher J. Vincent
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Patent number: 11817588Abstract: Provided here is a method of manufacturing a lattice electrode useful in an energy storage device such as a battery or capacitor. A lattice electrode useful in an energy storage device such as a battery or capacitor also is provided, along with energy storage devices such as batteries or capacitors.Type: GrantFiled: October 4, 2019Date of Patent: November 14, 2023Assignees: Carnegie Mellon University, The Curators of the University of MissouriInventors: Rahul Panat, Jie Li, Jonghyun Park, Mohammad Sadeq Saleh
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Patent number: 11802286Abstract: The present invention provides a method and means to change fatty acid and ultimately triacylglycerol production in plants and algae. Methods of the invention comprise the step of altering the activity levels of the committed step for de novo fatty acid biosynthesis, acetyl-CoA carboxylases (ACCase). More specifically, methods of the invention directly enhance the activity of ACCase by overexpression of ?-CT or a catalytic portion thereof.Type: GrantFiled: July 6, 2017Date of Patent: October 31, 2023Assignee: The Curators of the University of MissouriInventors: Jay J. Thelen, Matthew Salie
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Patent number: 11796473Abstract: The invention broadly relates techniques for imaging and medical diagnosis and, more particularly, to the fabrication of flexible plasmonic gratings and the use thereof in detection of biomarkers. A first aspect of the invention provides for techniques for the fabrication of novel, flexible plasmonic gratings that can be inexpensively fabricated onto fiber optic cables, flexible films and substrates with non-uniform surfaces to enhance the imaging resolution. A second aspect of the invention provides for an ultra¬high sensitivity (single molecule counting) biomarker detection platform useable for medical diagnosis based on a fluorescent sandwich ELISA assay performed on a plasmonic grating platform incorporated with a fluorescence detection unit.Type: GrantFiled: July 11, 2018Date of Patent: October 24, 2023Assignee: The Curators of the University of MissouriInventors: Shubhra Gangopadhyay, Sangho Bok, Cherian Joseph Mathai, Keshab Gangopadhyay, Sheila Grant, Aaron Wood, Syed Barizuddin
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Publication number: 20230306874Abstract: A system and method for simulating a human respiratory system to facilitate investigating the functioning of the respiratory system, such as the generation and effects of secondhand smoke. An aerosol generator, which may include an atomizer, is configured to generate an aerosol. A series of filter media includes, in order, an inhaling extrathoracic filter media, an inhaling tracheobronchial filter media, an alveolar filter media, an exhaling tracheobronchial filter media, and an exhaling extrathoracic filter media. Each filter media includes one or more layers of a material having a fiber diameter and a weight that simulate the corresponding region of the respiratory system. A conduit may be configured to define a path for the aerosol from the aerosol generator through the series of filter media. An instrument, such as a scanning mobility particle sizer, may be used to measure a property of a secondhand aerosol exiting the exhaling extrathoracic filter media.Type: ApplicationFiled: March 24, 2023Publication date: September 28, 2023Applicant: The Curators of the University of MissouriInventors: Yang Wang, Weixing Hao, Yue-Wern Huang
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Patent number: 11753622Abstract: The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided.Type: GrantFiled: June 3, 2020Date of Patent: September 12, 2023Assignee: The Curators of the University of MissouriInventors: Ye Yuan, Lee D. Spate, Randall S. Prather, R. Michael Roberts
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Publication number: 20230282826Abstract: Various graphite additives were incorporated into the positive battery paste composition to compare their effects on the positive active mass utilization of lead-acid batteries. The disclosure is related to battery paste composition for preparing a lead-acid battery plate comprising a graphite additive selected from the group consisting of globular natural graphite, natural flake graphite, expanded flake graphite, and combinations thereof. The disclosure is also related to a battery paste composition comprising a sodium polymethacrylate dispersant. The disclosure is further related to batteries prepared by these battery paste compositions.Type: ApplicationFiled: March 4, 2022Publication date: September 7, 2023Applicant: The Curators of the University of MissouriInventors: Fatih Dogan, Julian Kosacki
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Patent number: 11738324Abstract: Carbon dioxide (CO2) capture materials comprising one or more 3D-printed zeolite monoliths for the capture and or removal of CO2 from air or gases in enclosed compartments, including gases or mixtures of gases having less than about 5% CO2. Methods for preparing 3D-printed zeolite monoliths useful as CO2 capture materials and filters, as well as methods of removing CO2 from a gas or mixture of gases in an enclosed compartment using 3D-printed zeolite monoliths are provided.Type: GrantFiled: March 8, 2022Date of Patent: August 29, 2023Assignee: The Curators of the University of MissouriInventors: Fateme Rezaei, Harshul V. Thakkar
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Patent number: 11740171Abstract: An open-ended hollow coaxial cable resonator probe configured to receive an aerosol sample for analysis. A metal post shorts the resonator's inner and outer conductors. A metal plate is spaced apart from an open end of the resonator by a dielectric layer that contains the received aerosol sample. Interrogator circuitry coupled to the resonator transmits an electromagnetic wave within the resonator and generates an electric field at the open end of the resonator. The interrogator circuitry is responsive to the generated electric field for determining a resonance frequency and an impedance of the resonator when the aerosol sample is present in the dielectric layer and is configured to identify virus particles in the aerosol sample as a function of the determined resonance frequency and impedance. A portable aerosol analyzer comprises the open-ended hollow coaxial cable resonator and a mouthpiece through which a subject expels a breath sample into the open end of the resonator.Type: GrantFiled: March 23, 2021Date of Patent: August 29, 2023Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Jie Huang, Chen Zhu, Rex E. Gerald, II
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Patent number: 11707077Abstract: Provided are engineered meat products formed as a plurality of at least partially fused layers, wherein each layer comprises at least partially fused multicellular bodies comprising non-human myocytes and wherein the engineered meat is comestible. Also provided are multicellular bodies comprising a plurality of non-human myocytes that are adhered and/or cohered to one another; wherein the multicellular bodies are arranged adjacently on a nutrient-permeable support substrate and maintained in culture to allow the multicellular bodies to at least partially fuse to form a substantially planar layer for use in formation of engineered meat. Further described herein are methods of forming engineered meat utilizing said layers.Type: GrantFiled: November 27, 2013Date of Patent: July 25, 2023Assignee: The Curators of the University of MissouriInventors: Gabor Forgacs, Francoise Marga, Karoly Robert Jakab
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Patent number: 11702564Abstract: Coating compositions and methods for using the same are disclosed. The coating compositions can include an aminosilica adsorbent. The coating compositions can adsorb CO2.Type: GrantFiled: July 17, 2020Date of Patent: July 18, 2023Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Fateme Rezaei, Thomas P. Schuman, Glenn C. Morrison
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Patent number: 11684603Abstract: Disclosed are methods for ameliorating glycocalyx damage by administering a neuraminidase inhibitor. Also disclosed are methods for treating endothelial dysfunction and for improving flow mediated dilation.Type: GrantFiled: October 10, 2018Date of Patent: June 27, 2023Assignee: CURATORS OF THE UNIVERSITY OF MISSOURI UNIVERSITYInventors: Luis A. Martinez-Lemus, Christopher A. Foote, Jaume Padilla
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Patent number: 11672381Abstract: A drinking container system with multiple temperature zones, wherein the container system includes a main body having a sidewall and a bottom that define a phase change material (PCM) module receptacle, and a phase change material (PCM) module having a sidewall that defines a beverage chamber. The PCM module is disposable within the PCM module receptacle such that a beverage egress flow path is defined between the main body sidewall and the PCM module sidewall. The flow path formed in the container can make the beverage achieve the desired drinking temperature. The PCM module sidewall is at least partially filled with a phase change material and is structured and operable to provide a plurality temperature zones within the beverage chamber. Each temperature zone is operable to maintain a temperature of a respective portion of a liquid disposed within the beverage chamber within a respective temperature range.Type: GrantFiled: September 20, 2018Date of Patent: June 13, 2023Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Hongbin Ma, Michael Merwin, Hao Bai, Robert Riegler, Christopher Vincent, Susan Liu
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Patent number: 11667995Abstract: A cast iron alloy is provided with a composition in weight percent (wt. %) of carbon between 2.6 to 3.4 wt. %, silicon between 2.4 to 3.2 wt. %, manganese between 0.3 to 0.6 wt. %, molybdenum between 0.4 to 1.2 wt. %, nickel between 0.6 to 1.75 wt. %, magnesium between 0.01 to 0.075 wt. %, aluminum between 1.8 to 3.5 wt. %, sulfur between 0.003 to 0.025 wt. %, zirconium between 0.001 to 0.02 wt. %, cerium between 0.001 to 0.03 wt. %, lanthanum between 0.0005 to 0.02 wt. %, and a balance of iron and unavoidable trace elements. A part formed from the cast iron alloy is also provided and the part has an Ac1 temperature equal to or greater than 895° C. and a thermo-mechanical fatigue lifetime of at least 10,000 cycles when cycled between 400° C. to 800° C. with a total cyclic strain equal to 0.001 m/m.Type: GrantFiled: September 21, 2021Date of Patent: June 6, 2023Assignees: Ford Global Technologies, LLC, The Curators of the University of MissouriInventors: Larry Alan Godlewski, Mei Li, Carlos Engler-Pinto, Simon Naymovich Lekakh
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Patent number: 11660354Abstract: Described herein are novel conjugates containing an inhibitor (e.g., a PSMA inhibitor, e.g., a gastrin-releasing peptide receptor inhibitor) and metal chelator that are covalently attached to a macromolecule (e.g., a nanoparticle, a polymer, a protein). Such conjugates exhibit distinct properties over the free, unbound inhibitor/chelator construct.Type: GrantFiled: November 29, 2017Date of Patent: May 30, 2023Assignees: Memorial Sloan Kettering Cancer Center, Cornell University, The Curators of the University of MissouriInventors: Michelle S. Bradbury, Thomas P. Quinn, Barney Yoo, Wolfgang Weber, Karim Touijer, Howard Scher, Kai Ma, Ulrich Wiesner
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Patent number: 11647864Abstract: A heat loss protection lid for a thermal liquid container system, wherein the heat loss protection lid comprises a central body, a liquid ingress opening formed within the central body, a liquid dispensing opening formed within one of a peripheral edge of the central body or a lip formed around the peripheral edge of the central body. and a concealed air intake hole.Type: GrantFiled: April 21, 2021Date of Patent: May 16, 2023Assignee: The Curators of the University of MissouriInventor: Hongbin Ma