Patents Assigned to Curators of the University of Missouri
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Patent number: 11268009Abstract: Described herein are compositions useful for controlling fluid flow, for example in a target zone of a subterranean environment, and methods of forming and using the same. The composition generally comprises a quantity of fibers and a quantity of swellable particles, which may be dispersed in a carrier fluid. The composition may be synthesized in the form of a bulk gel or may be gelatinated during use. The fibers in the compositions provide improved performance as compared to prior PPG and RPPG particle-containing compositions. Specifically, the compositions reinforce the re-cross-linked/re-associated hydrogel plug in underground features and support proper rehydration of RPPG particles with water or brine to better to provide structural support for the particles within the gel and to more completely fill underground void space conduits.Type: GrantFiled: September 8, 2020Date of Patent: March 8, 2022Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Baojun Bai, Ze Wang, Zhe Sun, Jingyang Pu, Thomas Schuman
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Patent number: 11241353Abstract: The present invention is an apparatus and method for use in a treatment for prevention of arthrofibrosis that includes a first and a second substantially L-shaped frames, each L-shaped frame having a first member and a second member extending from the first member in a substantially perpendicular direction and terminating in a first end, a fixed plate extending between the first members of the L-shaped frames, the fixed plate being parallel with the first members of the L-shaped frames, a movable plate pivotally coupled to the first ends of the first members of the L-shaped frames with, a pneumatic piston coupled to the movable plate and the fixed plate, a hand operated valve operatively coupled to the pneumatic piston and a goniometer coupled to the movable plate and one of the L-shaped frames, the goniometer adapted and configured to indicate the angle between the movable plate and the fixed plate.Type: GrantFiled: November 5, 2018Date of Patent: February 8, 2022Assignee: The Curators of the University of MissouriInventors: James L. Cook, Cory Crecelius, Trent Guess, Kylee Rucinski, Jonathan Williams
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Publication number: 20220013118Abstract: Methods and system for testing a voice-enabled device. A signal generator generates a carrier signal having a variable resonant frequency, and a frequency mixer mixes an audible voice command signal with the carrier signal to generate an inaudible amplitude-modulated test signal. An antenna transmits the amplitude-modulated test signal at a variable attack angle to a voice-enabled device. The resonant frequency of the carrier signal and/or the attack angle of the transmitted amplitude-modulated signal are varied and at least one of a sensitive frequency and a sensitive attack angle of the voice-enabled device is identified.Type: ApplicationFiled: June 16, 2021Publication date: January 13, 2022Applicant: The Curators of the University of MissouriInventors: Chulsoon Hwang, Zhifei Xu, Jun Fan
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Patent number: 11213512Abstract: Compositions comprising bis(tryptophan) derivatives are provided that act as antimicrobials. Also provided are methods for reversing antibiotic resistance in a bacterium, or recovering or enhancing antimicrobial activity of an antibiotic against a variety of microbes, by co-administration with a bis(tryptophan) derivative.Type: GrantFiled: June 20, 2017Date of Patent: January 4, 2022Assignee: The Curators of the University of MissouriInventors: George W Gokel, Joseph W Meisel, Mohit B Patel
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Patent number: 11214729Abstract: The present invention generally relates to the composition of particle gels for CO2-EOR and CO2 storage. More particularly, CO2 resistant particle gels are provided that can re-crosslink at subterranean conditions. These particle gels can be deployed to improve the conformance of CO2 flooding, CO2 huff-puff, or Water-Alternative-Gas (WAG). The applications may also involve CO2 storage, such as the blocking of CO2 leakage and similar CO2 processing.Type: GrantFiled: August 27, 2019Date of Patent: January 4, 2022Assignee: The Curators of the University of MissouriInventors: Yifu Long, Baojun Bai, Thomas P. Schuman
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Patent number: 11209176Abstract: A high efficiency, low noise thermoelectric dehumidifier that includes a heat pipe array, a condensing heat sink, an air intake duct, and a thermoelectric cooler. A first air flow is directed over the condensing heat sink that is cooled by the thermoelectric cool such that the first air flow is dehumidified by the cooled condensing heat sink. Heat is removed from a hot side of the thermoelectric cooler via the heat pipe array. A second air flow is directed over the heat pipe array such that the heat extracted from the hot side of the thermoelectric cooler is extracted and circulated back into the ambient environment.Type: GrantFiled: April 30, 2018Date of Patent: December 28, 2021Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Hongbin Ma, Willard Hanson, Zaichun Feng
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Patent number: 11202840Abstract: Synthetic nucleic acids encoding mini and microdystrophin genes comprising the membrane binding motifs or domains of the R10-R11-R12 region are provided. Also provided are vectors, host cells, and related methods of using the same to treat a subject suffering from Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) or X-linked dilated cardiomyopathy (XLDC), or for ameliorating one or more adverse effects of DMD, BMD, or XLDC. Also provided are a fusion protein comprising a nNOS binding domain of dystrophin R16-R17 that is operably linked to a syntrophin PDZ domain and synthetic nucleic acids comprising the same that can be used to treat subjects with diseases characterized by loss of sarcolemmal neuronal nitric oxide synthase (nNOS) activity.Type: GrantFiled: June 21, 2017Date of Patent: December 21, 2021Assignee: The Curators of the University of MissouriInventors: Dongsheng Duan, Yi Lai, Junling Zhao, Yongping Yue
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Publication number: 20210384504Abstract: The present invention relates to various lithium ion battery cathodes as well as lithium ion batteries incorporating one or more of these cathodes. The present invention further relates to processes of preparing the lithium ion battery cathode.Type: ApplicationFiled: June 3, 2021Publication date: December 9, 2021Applicant: The Curators of the University of MissouriInventors: Xinhua Liang, Yan Gao
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Patent number: 11192094Abstract: Porous zeolite monolith compositions for the catalytic cracking of alkanes. The compositions may be prepared layer by layer using a 3D printer such that the compositions comprise a plurality of micropores and a plurality of mesopores and may be characterized by macro-meso-microporosity.Type: GrantFiled: September 27, 2019Date of Patent: December 7, 2021Assignee: The Curators of the University of MissouriInventors: Ali A. Rownaghi, Xin Li, Fateme Rezaei
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Patent number: 11186376Abstract: An aerial payload delivery system uses a cruciform parachute canopy that is connected to base by plurality of suspension lines including an adjustable control line. A control system includes an actuator to selectively adjust the length of the control line. By adjusting the length of the control line, the parachute can be selectively set to glide or descend substantially vertically subject to wind. In an embodiment, the suspension lines also include a short line and a plurality of long lines. The parachute is set to glide by adjusting the control line to be about the same length as the short line and set to vertically descend by adjusting the length of the control line to differ from the short line.Type: GrantFiled: March 5, 2019Date of Patent: November 30, 2021Assignees: The Government of the United States, as represented by the Secretary of the Army, The Curators of the University of Missouri, The United Sates of America, as represented by the Secretary of the NavyInventors: Travis D. Fields, Oleg A. Yakimenko, Richard Benney
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Patent number: 11167048Abstract: Disclosed are compositions and methods relating to prostate cancer. In particular, disclosed are bivalent targeting ligands that specifically bind prostate specific membrane antigen and gastrin-releasing peptide receptor. Bivalent binding agents disclosed herein can be used to image a tissue in a subject in need thereof and to diagnose prostate cancer in a subject in need thereof. Bivalent binding agents disclosed herein can be used to treat prostate cancer in a subject in need thereof.Type: GrantFiled: December 13, 2019Date of Patent: November 9, 2021Assignee: The Curators of the University of MissouriInventors: Charles Jeffrey Smith, Rajendra Prasad Bandari
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Patent number: 11168331Abstract: Provided are plants that express, or overexpress, a pPLAIII? protein. Constitutive or seed-specific expression of pPLAIII? protein in Arabidopsis increases seed oil content, the amount of C20 and C22 fatty acids, and the amount of C56, C58, and C60 triacylglycerols, effectively resulting in significantly higher oil yield per plant. Use of pPLAIII? is therefore an effective biotechnological tool to significantly increase plant yield, including oil, and the amount of high value long chain fatty acids in agricultural and horticultural crops, especially oilseed crops.Type: GrantFiled: March 22, 2019Date of Patent: November 9, 2021Assignees: Donald Danforth Plant Science Center, The Curators of the University of MissouriInventors: Xuemin Wang, Maoyin Li
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Patent number: 11162016Abstract: This invention is broadly concerned with compositions and processes for oilfield applications. More specifically, this invention relates to novel polymer constructed packages that, when pumped into a petroleum well, provide tunable characteristics of transformation and delayed self-assembly with each other under reservoir conditions to yield strong, elastic, bulk gel materials. The compositions comprise a polymer, assembling agents, and optional additives used for the re-assembly stage are uniformly-distributed within the initial gel particles. The polymer particle packages absorb water and swell upon exposure to water, thus exposing the “assembling agents” that enable re-assembly. Both swelling and re-assembly are proportionally controlled via compositions to be tunable to allow functional dispersion and subsequent self-assembly under various reservoir conditions.Type: GrantFiled: June 1, 2017Date of Patent: November 2, 2021Assignee: The Curators of the University of MissouriInventors: Jingyang Pu, Baojun Bai, Thomas Schuman
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Patent number: 11160906Abstract: The present invention provides a series of injectable bionanocomposites that may be delivered via injection to various tissue repair sites including myocardial infarction, intervertebral disc reconstruction, reconstruction of skeletal muscle, and musculoskeletal applications, urinary incontinence, adipose tissue engineering, and orthopedic applications such as osteoporosis, and meniscus and articular cartilage repair.Type: GrantFiled: February 21, 2017Date of Patent: November 2, 2021Assignee: The Curators of the University of MissouriInventors: Sheila Ann Grant, David Grant, Daniel Grant
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Patent number: 11160260Abstract: Methods for protecting porcine fetuses from infection with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The methods comprise breeding a female porcine animal with a male porcine animal. The female porcine animal comprises modified chromosomal sequences in both alleles of its CD163 gene, wherein the modified chromosomal sequences reduce the susceptibility of the female porcine animal to infection by PRRSV, as compared to the susceptibility to infection by PRRSV of a female porcine animal that does not comprise any modified chromosomal sequences in the alleles of its CD163 gene. The male porcine animal comprises at least one wild-type CD163 allele.Type: GrantFiled: April 17, 2019Date of Patent: November 2, 2021Assignee: The Curators of the University of MissouriInventors: Randall S. Prather, Kevin D. Wells, Kristin M. Whitworth
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Patent number: 11147451Abstract: Methods and systems for an integrated sensor network are described. In one embodiment, sensor data may be accessed from a plurality of motion sensors and a bed sensor deployed in a living unit for a first time period. An activity pattern for the first time period may be identified based on at least a portion of sensor data associated with the first time period. The activity pattern may represent a physical and cognitive health condition of a person residing in the living unit. Additional sensor data may be accessed from the motion sensors and the bed sensor deployed for a second time period. A determination of whether a deviation of the activity pattern of the first time period has occurred for the second time period may be performed. An alert may be generated based on a determination that the derivation has occurred. In some embodiments, user feedback is captured on the significance of the alerts, and the alert method is customized based on this feedback. Additional methods and systems are disclosed.Type: GrantFiled: January 18, 2019Date of Patent: October 19, 2021Assignee: The Curators of the University of MissouriInventors: Marjorie Skubic, Marilyn J. Rantz, Mihail Popescu, Shuang Wang, Isaac J. Sledge, Rainer Dane A. Guevara, Elena Florea, James M. Keller
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Patent number: 11150083Abstract: System and method for determining real-time sag and shape information of an electrical power line based on strain distribution along a length of an optical fiber associated with the power line. An embedded fiber coupled to an overhead transmission line measures strain using the backscatter of an optical signal, the optical signal is then interrogated using an interferometer.Type: GrantFiled: December 17, 2018Date of Patent: October 19, 2021Assignee: The Curators of the University of MissouriInventors: Jie Huang, Rui Bo
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Patent number: 11142675Abstract: A heat exchanging thermal liquid container system that comprises a main body at least partially defining a liquid reservoir structured and operable to retain a liquid, and a phase change material (PCM) liner comprising a PCM liner PCM having a selected melting temperature, and/or at least one PCM pod. Each of the at least one PCM pod(s) comprising a respective PCM pod PCM having a respective selected melting temperature. Wherein the PCM liner and/or the at least one PCM pod are disposable within the liquid reservoir such that when a liquid is disposed within the liquid reservoir the liquid will contact at least one of the PCM liner and the at least one PCM pod such that thermal energy can be exchanged between the liquid and the respective at least one of the PCM liner PCM and the at least one PCM pod PCM.Type: GrantFiled: November 6, 2017Date of Patent: October 12, 2021Assignee: The Curators of the University of MissouriInventors: Hongbin Ma, Michael Merwin, Hao Bai, Xiaoqin Liu, Robert Riegler, Chris Vincent
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Publication number: 20210310928Abstract: An open-ended hollow coaxial cable resonator probe configured to receive an aerosol sample for analysis. A metal post shorts the resonator's inner and outer conductors. A metal plate is spaced apart from an open end of the resonator by a dielectric layer that contains the received aerosol sample. Interrogator circuitry coupled to the resonator transmits an electromagnetic wave within the resonator and generates an electric field at the open end of the resonator. The interrogator circuitry is responsive to the generated electric field for determining a resonance frequency and an impedance of the resonator when the aerosol sample is present in the dielectric layer and is configured to identify virus particles in the aerosol sample as a function of the determined resonance frequency and impedance. A portable aerosol analyzer comprises the open-ended hollow coaxial cable resonator and a mouthpiece through which a subject expels a breath sample into the open end of the resonator.Type: ApplicationFiled: March 23, 2021Publication date: October 7, 2021Applicant: The Curators of the University of MissouriInventors: Jie Huang, Chen Zhu, Rex E. Gerald, II
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Patent number: 11136580Abstract: The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide targeting the Element 1 site on the SMN2 pre-mRNA and a Morpholino backbone is disclosed. In another aspect of the invention, a method of treating SMA patients by modulating the splicing of SMN2 pre-mRNA to increase the amount of full-length SMN is disclosed. Certain embodiments of the inventive method comprise administering an E1-targeting antisense oligonucleotide, such as Morpholino based antisense oligonucleotide, to a SMA subject.Type: GrantFiled: November 11, 2019Date of Patent: October 5, 2021Assignee: The Curators of the University of MissouriInventors: Christian Lorson, Erkan Osman