Abstract: In one example aspect, a system is disclosed that includes an image capture device; a capillaroscope attachable to the image capture device, the capillaroscope including: a light source configured to provide offset light at an angle and location offset from a center horizontal axis and produce oblique remitted light off a patient site; a reverse lens through which the oblique remitted light passes therethrough; and one or more telescopic lenses through which the remitted light passes therethrough to a lens of the image capture device after passing through the reverse lens.

Abstract: The presently disclosed subject matter provides compositions and methods for administering a nanoparticle or microparticle and a therapeutic agent to the suprachoroidal space in the eye.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: A device may obtain field images of a tissue sample, apply, to the field images, spatial distortion and illumination-based corrections (including corrections for photobleaching of reagents) to derive processed field images, identify, in each processed field image, a primary area including data useful for cell or subcellular component characterization, identify, in the processed field images, areas that overlap with one another, and derive information regarding a spatial mapping of cell(s) and/or sub-cellular components of the tissue sample. Deriving the information may include performing segmentation based on the data included in the primary area of each processed field image, and obtaining flux measurements based on other data included in the overlapping areas.

Abstract: The present invention provides a method of inducing cell death by hyperactivation of motility networks.

Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: A cooling device according to the present invention includes a housing configured to accommodate fungi. Warm air enters the housing through an inlet located in the housing. The air flows through the housing, which holds fungi. The air exits the housing and can be driven by an exhaust fan. In some embodiments, a HEPA filter is included to purify the air and prevent dispersal of fungal spores.

Abstract: Disclosed herein are compositions and methods for treating uterine fibroids in vivo, and methods of reducing symptoms associated with uterine fibroids, including pain, bleeding and infertility. The disclosed compositions comprise collagenase in an amount effective to cause shrinkage and/or reduce stiffness of uterine fibroids.

Abstract: The present invention provides a targeted nanoplex platform for in vivo imaging and theranostic imaging of cancer to simultaneously provide non-invasive assessment of tumor burden and cancer-selective treatments.

Abstract: The present disclosure is directed to a composition or combination comprising at least one membrane-active peptide, such as melittin, and at least one therapeutic and/or diagnostic agent. Methods of using the membrane-active peptides of the disclosure to open a blood-brain barrier and to deliver a therapeutic and/or a diagnostic agent to a central nervous system (CNS) of a subject in need thereof are also provided.

Abstract: A system includes: a phantom object; one or more sensors within the phantom object; and a processor, a computer readable memory, a non-transitory computer readable storage medium associated with a computing device in communication with the phantom object, and program instructions executable by the computing device to cause the computing device to perform operations including: detecting a medical instrument within the phantom object based on sensor data captured by the one or more sensors; measuring a distance between the medical instrument and a target point based on the sensor data; and storing or outputting information identifying the distance between the medical instrument and the target point.

Abstract: A computer-implemented method includes: receipt and accession of magnetic field data from a constellation of satellites providing global coverage over the Earth in a time span less than one day; inter-calibrating the magnetic field data from all satellites to a common standard; quantifying the global magnetic disturbance and selecting quiescent intervals at least as short as one day for evaluation of Earth's internally-generated field; calculating global maps of the mean vector magnetic field for each quiet interval from the average of all satellite measurements in angular bins; converting the time sequence of global maps of the mean fields to time series of angular harmonic coefficients via direct convolution; applying spectral and regression analysis to the harmonic coefficient time series to identify and remove artifacts in the signals; reconstructing a continuous time and spatial representation of the magnetic field continuous in time and angular position globally.

Abstract: Additive manufacturing processes, systems and three-dimensional articles include the formation of voxels and/or portions of three-dimensional articles with different properties relative to other voxels and/or portions. The processes generally include changing one or more laser beam parameters including power level, exposure time, hatch spacing, point distance, velocity, and energy density during the formation of selected voxels and/or portions of the three-dimensional articles. Also disclosed are processes that include an additive manufacturing process that provides localized secondary heat treatment of certain voxels and/or regions at a temperature below the melting point of the three-dimensional article but high enough to effect a localized property change.

Abstract: An embodiment in accordance with the present invention provides a miniature microscope capable of performing in vivo, real-time imaging of multiple organ sites in awake and behaving animals (e.g. rodents). A microscope according to the present invention includes multiple optical contrast mechanisms (i.e. contrast arising from neural, hemodynamic and other physiological components). Exemplary contrast mechanisms include, but are not limited to fluorescence, hemoglobin level, deoxyhemoglobin level, and blood flow. The microscope is fully adaptable to in vitro and ex vivo imaging, can be customized to concurrently image at variable magnifications, conduct optogenetic/electrical/chemical stimulations, drug delivery, microdialysis, accompanied by electrical signal recording, wireless image transmission and charging.

Abstract: Disclosed are device implementations for a hybrid energy harvesting device and methods for harvesting mechanical energy from the ambient. The various device implementations utilize a combination of electrostatic energy conversion and piezoelectric energy conversion elements. The method simultaneously converts mechanical energy into electrical charge by electrostatic and piezoelectric energy harvesting. The devices include a piezoelectric harvester including a pair of electrodes and piezoelectric nanocomposite polymer, an electrostatic harvester including an electret film and a pair of electrostatic electrodes.

Abstract: Methods of the present disclosure provide for detection of mutations and splice variants of the androgen receptor using a non-invasive approach, RNAseq, for examining circulating tumor cells.

Abstract: A machine-implemented method, computing device, and at least one non-transitory computer-readable medium are provided. A dynamical network model is parameterized by state transition matrices based on monitored interictal brain data. A node influence-to network score for each respective node is calculated indicating how influential the respective node is. An influenced-by score is calculated for the each respective node indicating an amount by which the respective node is influenced by the nodes. A score is calculated for the each respective node based on a sink index, a source influence index, and a sink connectivity index. Nodes that are in the epileptogenic zone are determined based on the calculated score for each of the nodes. An indication of the nodes in the epileptogenic zone is provided.

Abstract: The present disclosure provides a system with an innovative electrode designed as an RF/microwave antenna as well as methods to monitor/assess biological tissue and perform surgical procedures.

Abstract: A calibration platform may display, via an optical see-through head-mounted display (OST-HMD), a virtual image having at least one feature. The calibration platform may determine, based on information relating to a gaze of a user wearing the OST-HMD, that the user performed a voluntary eye blink to indicate that the at least one feature of the virtual image appears to the user to be aligned with at least one point on the three-dimensional real-world object. The calibration platform may record an alignment measurement based on a position of the at least one point on the three-dimensional real-world object in a real-world coordinate system based on a time when the user performed the voluntary eye blink. Accordingly, the alignment measurement may be used to generate a function providing a mapping between three-dimensional points in the real-world coordinate system and corresponding points in a display space of the OST-HMD.

Abstract: The invention provides methods of delaying or preventing NF1-related malignancies or tumors using mebendazole. The administration of mebendazole results in decreased Ras activation in NF1-related tumor cells. Invention methods include the use of a cyclooxygenase-2 inhibitor such as celecoxib in combination with mebendazole. The methods include methods of treatment and methods of prevention or delaying of neurofibromatosis type 1-related malignancies or tumors.