Abstract: Small molecule radiohalogenated PSMA inhibitors and metal complexes thereof and their use in radioimaging and radiotherapy for treating PSMA-related diseases, including prostate cancer, are disclosed. The combination of small molecule radiohalogenated PSMA inhibitors with a competitive PSMA ligand for reducing off target accumulation of the radiohalogenated PSMA inhibitor also is disclosed.

Abstract: Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.

Abstract: The present invention features methods for characterizing mutational profiles in patients with bladder cancer.

Abstract: A gel polymer electrolyte (GPE) composition and a method of forming the same are provided. The GPE includes a polymer network and an electrolyte composition comprising a deep eutectic solvent (DES) having a eutectic point of less than or equal to 25° C. An electrochemical cell including a GPE and a method of forming the same are also provided.

Abstract: A system can include a plurality of satellites synchronized in a Waves constellation tailored to maximize coverage of a target ground location at one or more predetermined latitudes with a minimal number of satellites. The plurality of satellites can orbit the Earth in a plurality of orbital planes evenly spaced in right ascension of ascending node. The plurality of satellites can be evenly spaced in true anomaly within each orbital plane. The Waves constellation can phase the plurality of orbital planes, such that satellites in neighboring orbital planes simultaneously cross the Equator together with synchronized true anomaly positions, all in ascending or descending motion, thereby forming a wave of satellites in all orbital planes that rise and fall together.

Abstract: A communications system may include a transmitter, a receiver, and a link analyzer. The transmitter may be configured to encode a message with an error correction code, and also modulate and transmit the encoded message via a communications link. The receiver may be configured to receive the message via the communications link, demodulate the transmission to generate demodulated coded information, and decode the demodulated coded information using the error correction code to generate a decoded message. The link analyzer may be configured to re-encode the decoded message to generate re-encoded information, compare the re-encoded information to the demodulated coded information, and generate a link quality metric value based on the comparison of the re-encoded information with the demodulated coded information. The link quality metric value may be indicative of a link quality of the communications link.

Abstract: This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.

Abstract: A rapid material development process for a powder bed fusion additive manufacturing (PBF AM) process generally utilizes a computational fluid dynamics (CFD) simulation to facilitate selection of a simulated parameter set, which can then be used in a design of experiments (DOE) to generate an orthogonal parameter space to predict an ideal parameter set. The orthogonal parameter space defined by the DOE can then be used to generate a multitude of reduced volume build samples using PBF AM with varying laser or electron beam parameters and/or feedstock chemistries. The reduced volume build samples are mechanically characterized using high throughput techniques and analyzed to provide an optimal parameter set for a 3D article or a validation sample, which provides an increased understanding of the parameters and their independent and confounding effects on defects and microstructure.

Abstract: The present disclosure provides methods and compositions useful for diagnosing and treating activated alternative pathway of complement in a human subject with a SARS-CoV-2 infection. Also provided are methods of treating an infection by a betacoronavirus, e.g., SARS-CoV, MERS-CoV, or SARS-CoV-2, in a human subject. The methods of treatment include administering to the human subject a therapeutically effective amount of at least one complement factor D inhibitor. Also provided herein are compounds for treating an infection by a betacoronavirus and their use in the manufacture in a medicament for treating an infection by a betacoronavirus.

Abstract: Compositions for the treatment of colorectal cancer target bacterial biofilms in the gastrointestinal tract. Methods of treatment include one or more agents which target bacteria and the bacterial biofilms.

Abstract: Provided herein are methods of detecting a pathogen, such as a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), in aerosol samples. Related devices, kits, systems, and computer program products are also provided.

Abstract: Techniques for retinal layer segmentation are presented. The techniques include obtaining current optical coherence tomography (OCT) data for a retina; generating an estimated current en face image based on the current OCT data and an estimated current retinal layer segmentation; determining a registered previous retinal layer segmentation based on a previous retinal layer segmentation, a previous en face image, the estimated current en face image, and the estimated current retinal layer segmentation; updating the estimated current retinal layer segmentation using a deep neural network and based on the current OCT data and the registered previous retinal layer segmentation; repeating the generating, the determining, and the updating to obtain a current retinal layer segmentation as the estimated current retinal layer segmentation; and outputting a property of the retina determined at least in part from the current retinal layer segmentation.

Abstract: Provided herein are methods of detecting pathogen antibodies, such as a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), in samples. Related devices, kits, reaction mixtures, and systems are also provided.

Abstract: Provided herein are methods of generating medical images that include the use of a generative adversarial network (GAN) in certain embodiments. Related methods, systems, and computer program products are also provided.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: The present disclosure relates generally to the field of medical devices and establishing access to body passageways. In particular, the present disclosure relates to devices, systems and methods to facilitate entry of a guidewire or other endoscopic accessory tool into and/or through patient-specific anatomies. For example, the devices, systems and methods of the present disclosure may rotate a proximal end of a guidewire to transmit mechanical motion to the distal end of the guidewire to facilitate atraumatic access to tortuous or otherwise restricted anatomies.

Abstract: The present invention relates to a method of identifying epigenetic reprogramming. Identifying epigenetic reprogramming comprises detecting large organized heterochromatin lysine (K)-9 modified domains (LOCKs) and large DNA hypomethylated blocks in a sample containing DNA from a subject having cancer, for example, PDAC.

Abstract: Methods, system, and media for identifying one or more ablation locations in an atrial tissue region in an atrial fibrillation (AF) patient with atrial fibrosis are disclosed. Three-dimensional imaging data representing the atria of the patient may be received. A patient-specific model of the atria may be generated from the three-dimensional imaging data. Simulation of the AF on the patient-specific model may be conducted to identify AF-perpetrating regions. One or more ablation locations in the atria may be identified from the AF-perpetrating regions.

Abstract: An embodiment in accordance with the present invention provides a continuum dexterous manipulator (CDM) with a specially designed flexible tool, to be used as a handheld or robotic steerable device for treatment of hard-tissue-related diseases. The CDM of the present invention works well in treatment of soft and sticky material (similar to a lesion) as well as milling the hard tissues (e.g. sclerotic liner of osteolytic lesions) and bone tumors. The present invention is also directed to flexible drilling tools as well as characterization and evaluation of integrating these tools with the CDM in curved-drilling of hard bone towards treatment of hard tissue related diseases (e.g. osteonecrosis or pelvic fracture). The present invention can also include use of various types of drill geometries, aspiration and irrigation, and endoscope view in curved-drilling and trajectory planning.

Abstract: A system and method for metal artifact avoidance in 3D x-ray imaging is provided. The method includes determining a 3D location of metal in an object or volume of interest to be scanned; estimating a source-detector orbit that will reduce the severity of metal artifacts; moving an imaging system to locations consistent with the source-detector orbit that was estimated; and scanning the object according to the source-detector orbit.