Abstract: The present invention is directed to the synthesis of metallic nickel-molybdenum-tungsten films and coatings with direct current sputter deposition, which results in fully-dense crystallographically textured films that are filled with nano-scale faults and twins. The as-deposited films exhibit linear-elastic mechanical behavior and tensile strengths above 2.5 GPa, which is unprecedented for materials that are compatible with wafer-level device fabrication processes. The ultra-high strength is attributed to a combination of solid solution strengthening and the presence of the dense nano-scale faults and twins. These films also possess excellent thermal and mechanical stability, high density, low CTE, and electrical properties that are attractive for next generation metal MEMS applications. Deposited as coatings these films provide protection against friction and wear.

Abstract: The presently disclosed subject matter provides compositions and methods for the expression of CRISPR guide RNAs using the H1 promoter. In particular, compositions and methods are provided for the use of the H1 promoter to express CRISPR guide RNA (gRNA) with altered specificity of the 5? nucleotide, as well as use of the H1 promoter sequence as a bidirectional promoter to express Cas9 nuclease and the gRNA simultaneously. Compositions and methods are also provided for the expression and regulation of gRNA expression in vivo through the use of RNA ribozymes and regulatable aptazymes.

Abstract: Provided is a method, device, and computer-readable medium for controlling a robot graphic user interface (“RGUI”) on a mobile device. The method can include determining a distance, a position, or both of the mobile device with respect to a first robot; and causing, by a processor, a first RGUI to be displayed on a display of the mobile device based on the determining.

Abstract: Some embodiments provide a method for magnetic resonance imaging of polysaccharide molecules, that includes providing a magnetic field that is sufficiently homogeneous over an imaging volume, generating a spatial encoding in the magnetic field, and acquiring one or more water proton signal intensity measurements at each of multiple voxels within the imaging volume. The signal intensity measurements are acquired at one or more irradiation frequencies at lower parts-per-million (ppm) than a baseline frequency associated with free water protons.

Abstract: Disclosed herein are system, method, and computer program product embodiments for providing machine-to-machine (M2M) trust using a distributed ledger. This trust may apply to the Internet of Things (IoT) and/or smart cities contexts. To provide M2M trust, a first computing node may generate a trust score for a second computing node. The trust score may comprise four subcomponents: an identification score, an experience score, a recommendation score, and a context score. These subcomponents may be assigned different weights based on different applications. The multifaceted approach to identifying trust for a particular node provides a flexible framework to provide trust between computing nodes in a network. Additionally, the trusts scores may be published to an immutable distributed ledger and used by other computing nodes to determine updated trust scores as additional interactions between computing nodes occur.

Abstract: Provided herein are systems and methods for monitoring and treatment of an injury. The system includes a control device, an implantable device and/or a wearable device, the implantable device configured to be implanted into a body, the implantable device having a sensing device for sensing a condition of the injury and a treatment device configured to apply a treatment to the injury based on the sensed conditions of the injury. Signals of the sensed condition are sent to the control device, and the control device controls the treatment device of the implantable device to apply treatment for the injury. When a wearable device is included, the wearable device may be configured to sense another condition related to the injury and send signal indicative thereof to the control device.

Abstract: An acoustic transducer includes a first layer including an elastomer, An acoustic impedance of the first layer substantially matches an acoustic impedance of a medium that the transducer is configured to monitor. The transducer also includes a second layer including an electrode. The transducer also includes a third layer including a polymer. The second layer is positioned at least partially between the first layer and the third layer.

Abstract: The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.

Abstract: Recent large-scale analyses have demonstrated that the genomic landscape of human cancer is complex and variable among individuals of the same tumor type. Such underlying genetic differences may in part be responsible for the varying therapeutic responses observed in cancer patients. To examine the effect of somatic genetic changes in colorectal cancer on sensitivity to a common targeted therapy, we performed complete exome sequence and copy number analyses of 129 tumors that were KRAS wild-type and analyzed their response to anti-EGFR antibody blockade in patient-derived tumorgraft models. In addition to previously identified genes, we detected mutations in ERBB2, EGFR, FGFR1, PDGFRA, and MAP2K1 as potential mechanisms of primary resistance to this therapy. Alterations in the ectodomain of EGFR were identified in patients with acquired resistance to EGFR blockade.

Abstract: Disclosed herein is a battery anode compound including a metal oxide and a metal. Also disclosed herein is a method of providing a battery anode compound comprising synthesizing AlNb11O29 and combining AlNb11O29 and a metal. A Li-ion battery anode compound is also disclosed that includes a slurry comprising up to 70% AlNb11O29, up to 70% Li4Ti5O12, and up to 70% of a metal, wherein the metal is any one of Sb or Sn.

Abstract: The present disclosure relates to measuring gene expression of cells of a blood sample obtained from a mammalian subject suspected of having a tick-borne disease. In particular, the present disclosure provides tools for determining whether a human subject has acute Lyme disease by transcriptome profiling a peripheral blood mononuclear cell sample from the subject.

Abstract: The present invention describes methods of identifying drugs for the treatment or prevention of diabetes by measuring the activity of the human zinc transporter ZnT8 and pharmaceutical compositions.

Abstract: The present disclosure relates generally to fluorescent imaging devices, systems, and methods for an endoscopic procedure, and in particular, indocyanine green (ICG) fluorescence. In some embodiments, a device for fluorescent imaging during an endoscopic procedure may include an attachment connectable to a distal end of an endoscope. The attachment may include a first filter alignable with a light source of the endoscope, and a second filter alignable with an imaging device of the endoscope. The first filter may be positionable such that in a first position the first filter is aligned with the light source, and in a second position the first filter is out of alignment with the light source. The second filter may be positionable such that in a first position the second filter is aligned with the imaging device, and in a second position the second filter is out of alignment with the imaging device.

Abstract: An x-ray irradiation system includes a first x-ray tube constructed and arranged to be able to irradiate an object with at least a portion of a first x-ray beam emitted from the first x-ray tube, and a second x-ray tube constructed and arranged to be able to irradiate the object with at least a portion of a second x-ray beam emitted from said second x-ray tube simultaneously with said first x-ray beam. The first and second x-ray tubes are arranged such that the first and second x-ray beams are incident on, and intersect within, the object at respective first and second oblique angles to define a target volume such that a dose rate is substantially uniform as prescribed within said target volume.

Abstract: Fully automated computer-implemented deep learning techniques of contrast-enhanced cardiac MRI segmentation are provided. The techniques may include providing cardiac MRI data to a first computer-implemented deep learning network trained in order to identify a left ventricle region of interest to generate left ventricle region-of-interest-identified cardiac MRI data. The techniques may also include providing the left ventricle region-of-interest-identified cardiac MRI data to a second computer-implemented deep learning network trained in order to identify myocardium to generate myocardium-identified cardiac MRI data. The techniques may further include providing the myocardium-identified cardiac MRI data to at least one third computer-implemented deep learning network trained to conform data to geometrical anatomical constraints in order to generate anatomical-conforming myocardium-identified cardiac MRI data.

Abstract: An embodiment according to the present invention includes a method for a machine-learning based approach to the formation of ultrasound and photoacoustic images. The machine-learning approach is used to reduce or remove artifacts to create a new type of high-contrast, high-resolution, artifact-free image. The method of the present invention uses convolutional neural networks (CNNs) to determine target locations to replace the geometry-based beamforming that is currently used. The approach is extendable to any application where beamforming is required, such as radar or seismography.

Abstract: Described are methods of treating or preventing a disease in a subject treatable by modulating cell mechanics. The method includes administering to a subject having or at risk for such a disease a pharmaceutical composition.

Abstract: A sensor includes a first sensing element electronically sensitive to an analyte and to an interfering stimulus. The first sensing element provides a first electrical signal in response to a presence of the analyte and/or the interfering stimulus. The sensor also includes a second sensing element electronically sensitive to the analyte and to the interfering stimulus. The second sensing element provides a second electrical signal in response to the presence of the analyte and/or the interfering stimulus. A conductive link electrically connects the first sensing mechanism and the second sensing mechanism. An electrical property is measured within the sensor that is indicative of a concentration of the analyte based on the first electrical signal and the second electrical signal.

Abstract: Lacrimal canalicular delivery systems (LCDS) and their methods of use for the delivery of implants at a specific location into the canaliculus of a subject generally include a lumen, a guide wire, and an implant. The guide wire and implant are within the lumen. When pressure is applied to the guide wire, the guide wire pushes the implant out of the lumen into a specific location into the canaliculus of a subject.

Abstract: Disclosed are UAP inhibitors to inhibit glucose flux in the hexosamine biosynthetic pathway and methods of treating a disease using the inhibitors.