Patents Assigned to Kansas State University Research Foundation
  • Method for encapsulation of orally ingested materials to alter the site of digestion, site of action, or stability
    Patent number: 8828421
    Abstract: Comestible materials encapsulated by a film-forming composition including a plant protein source and methods of forming the same are provided. The film-forming composition affects the site of digestion of the comestible material within the digestive tract of an animal or a human thereby allowing the material to be most effectively utilized by the body. Also, the film-forming compositions may be used to enhance the stability of the encapsulated material and prevent undesired interaction with other components of a mixture.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: September 9, 2014
    Assignee: Kansas State University Research Foundation
    Inventors: James S. Drouillard, Thomas J. Herald, Matthew Greenquist
  • Off-axis silicon carbide substrates
    Patent number: 8823014
    Abstract: A method of epitaxial growth of a material on a crystalline substrate includes selecting a substrate having a crystal plane that includes a plurality of terraces with step risers that join adjacent terraces. Each terrace of the plurality or terraces presents a lattice constant that substantially matches a lattice constant of the material, and each step riser presents a step height and offset that is consistent with portions of the material nucleating on adjacent terraces being in substantial crystalline match at the step riser. The method also includes preparing a substrate by exposing the crystal plane; and epitaxially growing the material on the substrate such that the portions of the material nucleating on adjacent terraces merge into a single crystal lattice without defects at the step risers.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: September 2, 2014
    Assignees: Kansas State University Research Foundation, State University of New York Stony Brook, The University of Bristol
    Inventors: James Edgar, Michael Dudley, Martin Kuball, Yi Zhang, Guan Wang, Hui Chen, Yu Zhang
  • Compounds affecting gap junction activity
    Patent number: 8809368
    Abstract: This invention relates to novel quinoline compounds which affect gap junction activity. Also provided are methods of using such compounds and compositions containing the compounds to treat gap junction disorders.
    Type: Grant
    Filed: October 28, 2008
    Date of Patent: August 19, 2014
    Assignee: Kansas State University Research Foundation
    Inventors: Duy H. Hua, Dolores J. Takemoto, Thu Nguyen
  • Rift Valley Fever Virus Glycoproteins, GN and GC, and their Use
    Publication number: 20140212447
    Abstract: The present invention describes subunit vaccines containing Gn and Gc glycoproteins of the Rift Valley Fever Virus, including nucleic acids encoding such glycoproteins, host cells, vectors, and immunoreagents generated with the glycoproteins, methods of vaccination, methods of diagnosis, and kits.
    Type: Application
    Filed: January 28, 2014
    Publication date: July 31, 2014
    Applicants: The United States Government as represented by the Secretary of Agriculture, KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Juergen A. Richt, Bonto Faburay, William Wilson
  • Methods for alleviating chronic pain and improving performance of cattle undergoing dehorning or castration
    Patent number: 8791105
    Abstract: Methods of improving performance, increasing weight gain, and decreasing incidence of disease in ruminant and pre-ruminant animals, such as cattle, after undergoing painful processing procedures, such as castration and dehorning, are provided. Veterinary formulations for use in methods of the invention are also provided. The formulations comprise a compound selected from the group consisting of meloxicam, gabapentin, the pharmaceutically acceptable salts thereof, and combinations thereof. Methods of treating pathological pain in cattle are also provided.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: July 29, 2014
    Assignee: Kansas State University Research Foundation
    Inventors: Johann F. Coetzee, Stanley P. Kukanich
  • ELECTROCHEMICALLY-GROWN NANOWIRES AND USES THEREOF
    Publication number: 20140173786
    Abstract: Nanowire apparatus and methods of using the same are disclosed. The apparatus include nanowires that are attached to and extend from varying substrates and can be used in the manipulation of cells and/or sensing of cellular and subcellular characteristics. The methods include using the apparatus to sense forces exerted by a single cell or using the apparatus to manipulate one or more cells.
    Type: Application
    Filed: February 21, 2014
    Publication date: June 19, 2014
    Applicant: Kansas State University Research Foundation
    Inventors: Bret Flanders, Govind Paneru
  • SESQUITERPENES FOR ANTIFUNGAL APPLICATIONS
    Publication number: 20140135404
    Abstract: Bicyclic sesquiterpene compounds exhibiting antifungal characteristics are formulated into antifungal compositions for use in the treatment of fungal infections in humans, animals, and plants. Particularly, sesquiterpene alcohols derived from drimane have been discovered to possess broad-spectrum antifungal characteristics. Exemplary antifungal sesquiterpene compounds include albicanol and drimenol, which have been shown effective against a number of pathogenic fungi.
    Type: Application
    Filed: January 21, 2014
    Publication date: May 15, 2014
    Applicant: Kansas State University Research Foundation
    Inventors: Govindsamy Vediyappan, Duy H. Hua
  • Pseudomonas AVR and HOP proteins, their encoding nucleic acids, and use thereof
    Patent number: 8716460
    Abstract: One aspect of the present invention relates to isolated nucleic acid molecules encoding avirulence proteins or polypeptides of Pseudomonas syringae pv. syringae DC 3000, or nucleic acid molecules which are complementary thereto. Expression vectors, host cells, and transgenic plants which include the DNA molecules of the present invention are also disclosed. Another aspect relates to the isolated proteins or polypeptides and compositions containing the same. The various nucleic acid molecules and proteins of the present invention can be used to impart disease resistance to a plant, make a plant hypersusceptible to colonization by nonpathogenic bacteria, modify a metabolic pathway in a cell, cause eukaryotic cell death and treat a cancerous condition, as well as inhibit programmed cell death.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: May 6, 2014
    Assignees: Kansas State University Research Foundation, The Board of Regents of the University of Nebraska, Cornell Research Foundation, Inc., The United States of America as Represented by the Secretary of Agriculture
    Inventors: James R. Alfano, Alan Collmer, Samuel W. Cartinhour, David J. Schneider, Xiaoyan Tang
  • ACTIVE AIR CONTROL
    Publication number: 20140102397
    Abstract: An air-balanced engine assembly is configured to operate efficiently while producing a reduced level of harmful emissions. The engine assembly includes a two-stroke internal combustion engine with multiple power cylinders and intake and exhaust manifolds that fluidly communicate with the cylinders. The engine assembly also includes an air balancing assembly with valves that control intake air flow from the intake manifold to the cylinders. The valves cooperate to balance intake air flow among the cylinders and are configured to substantially equalize trapped equivalence ratios among the cylinders.
    Type: Application
    Filed: December 19, 2013
    Publication date: April 17, 2014
    Applicant: Kansas State University Research Foundation
    Inventors: Kirby S. Chapman, Diana K. Grauer
  • Vaccine Adjuvants from Self-Assembling Peptides
    Publication number: 20140086952
    Abstract: Pharmaceutical or veterinary compositions, vaccine systems, methods, and kits for treating or protecting a subject from a condition using peptide-based adjuvants are provided. The peptide adjuvants comprise a peptide having a hydrophobic region, a turning region, and a hydrophilic region. The turning region comprises amino acid residues GSII (SEQ ID NO: 10). The peptide adjuvants can be used to immunopotentiate active agents by improving the immune response to the active agent.
    Type: Application
    Filed: May 25, 2012
    Publication date: March 27, 2014
    Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Xiuzhi Susan Sun, Jishu Shi
  • MAYETIOLA DESTRUCTOR SUSCEPTIBILITY GENE ONE (MDS-1) AND ITS APPLICATION IN PEST MANAGEMENT
    Publication number: 20140026252
    Abstract: Plants having increased resistance to a pest relative to corresponding control plants are provided. The resistant plants have inhibited expression, activity, or function of a susceptibility gene, and thereby have decreased expression, activity, or function of the susceptibility gene in the presence of the pest as compared to a control plant in which the wild-type susceptibility gene is normally expressed in the presence of the pest. Methods of producing plants with increased resistance are also provided. The methods involve altering the expression, activity, or function of a susceptibility gene, such as Mds-1, in the plant. Isolated Mds-1 sequences are provided that can be manipulated to enhance pest resistance in modified plants. Modified plants, plant cells, tissues, seeds, and progeny are also provided having enhanced pest resistance.
    Type: Application
    Filed: January 9, 2012
    Publication date: January 23, 2014
    Applicants: UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE, KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Harold Trick, Xiuming Liu, Ming-Shun Chen
  • ENCAPSULATED ZINC COMPOUNDS AND METHODS FOR PREPARING AND USING SAME
    Publication number: 20140007796
    Abstract: Disclosed are encapsulated zinc compounds, together with methods for preparing and use the same. Also disclosed are methods for mixing the encapsulated zinc mixtures with a cement, and the resulting concrete compositions.
    Type: Application
    Filed: March 23, 2012
    Publication date: January 9, 2014
    Applicants: Kansas State University Research Foundation, Board of Regents of the University of Texas System
    Inventors: Maria C.G. Juenger, Sarah Clare Taylor Lange, Kyle Riding
  • Active air control
    Patent number: 8622045
    Abstract: An air-balanced engine assembly is configured to operate efficiently while producing a reduced level of harmful emissions. The engine assembly includes a two-stroke internal combustion engine with multiple power cylinders and intake and exhaust manifolds that fluidly communicate with the cylinders. The engine assembly also includes an air balancing assembly with valves that control intake air flow from the intake manifold to the cylinders. The valves cooperate to balance intake air flow among the cylinders and are configured to substantially equalize trapped equivalence ratios among the cylinders.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: January 7, 2014
    Assignee: Kansas State University Research Foundation
    Inventors: Kirby S. Chapman, Diana K. Grauer
  • PRESSURE SENSITIVE ADHESIVES, COATINGS, AND FILMS FROM PLANT OILS
    Publication number: 20130330549
    Abstract: Compositions useful for preparing pressure sensitive adhesives, coatings, and/or films are provided, along with methods of making and using the same. The compositions are made from renewable, plant-based materials. The compositions comprise plant oil triglycerides that are polymerized and crosslinked to yield polymer matrices. Plant-based carriers and/or tackifiers can be used in the invention, including epoxidized plant oil triglycerides, acrylated epoxidized plant oil triglycerides, and dihydroxylated plant oil triglycerides. Natural tackifiers such as rosin esters and terpenes can also be used in the compositions. Dihydroxylated plant oil triglyceride tackifiers for use in biobased and synthetic adhesives are also provided.
    Type: Application
    Filed: January 20, 2012
    Publication date: December 12, 2013
    Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Xiuzhi Susan Sun, Byungjun Kollbe Ahn, Donghai Wang
  • RENILLA/GAUSSIA TRANSFECTED CELLS AS A LIGHT SOURCE FOR IN-SITU PHOTODYNAMIC THERAPY OF CANCER
    Publication number: 20130243741
    Abstract: A method for photodynamic therapy treatment of cancerous cells and tissue is provided. The method comprises administering tumor-trophic cells expressing a luminescent protein to a subject. A photosensitizing agent is then separately administered to the subject, followed by an optional iron chelator. On the day of treatment, a luminogenic substrate corresponding to the luminescent protein is administered to the subject. The substrate reacts with the luminescent protein in the vicinity of the cancerous tissue to produce light which activates the photosensitizing agent resulting in the selective destruction of the cancerous tissue.
    Type: Application
    Filed: September 19, 2011
    Publication date: September 19, 2013
    Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Stefan H. Bossmann, Deryl L. Troyer, Matthew T. Basel, Tej B. Shrestha, Hongwang Wang
  • FERMENTATION PROCESS TO PRODUCE NATURAL CAROTENOIDS AND CAROTENOID-ENRICHED FEED PRODUCTS
    Publication number: 20130224333
    Abstract: Methods of fortifying animal feeds nutrients typically lacking therefrom through the action of microorganisms are provided. Fermentation of animal feed materials with selected microorganisms, such as certain varieties of red yeasts, are shown to fortify the feed materials with natural carotenoids. Further, in certain embodiments, these methods can result in an increase in levels of nutritionally beneficial fatty acids, and a decrease in dietary fiber and nitrogen levels.
    Type: Application
    Filed: October 26, 2011
    Publication date: August 29, 2013
    Applicant: Kansas State University Research Foundation
    Inventors: Ananda Nanjundaswamy, Praveen V. Vadlani
  • Char supported catalysts for syngas cleanup and conditioning
    Patent number: 8506846
    Abstract: A catalyst comprising a physical mixture of particles of a catalytic material and particles of char is provided. The catalyst can be used in various processes, including the reforming of tars present in syngas generated during biomass gasification. The catalyst is produced through a mechanical mixing of the catalytic material and char particles, which results in significant time and energy savings over methods of catalyst preparation that involve impregnation and calcining of a support material.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: August 13, 2013
    Assignee: Kansas State University Research Foundation
    Inventors: Wenqiao Yuan, Duo Wang
  • PROTEASE SELECTIVE SUPRAMOLECULAR ASSEMBLIES
    Publication number: 20130183702
    Abstract: Supramolecular assemblies for delivering active agents to cancerous or precancerous tissues in a subject are provided. These supramolecular assemblies are also useful in assays for detecting and imaging of cancerous and precancerous cells. The assemblies are protease-sensitive and comprise a peptide linkage containing a protease consensus sequence. The assemblies can be selectively targeted to cancerous tissue where the protease enzymes degrade the peptide linkage thereby releasing the active agents which were physically or mechanically contained in or retained by the supramolecular assembly.
    Type: Application
    Filed: March 13, 2013
    Publication date: July 18, 2013
    Applicant: Kansas State University Research Foundation
    Inventor: Kansas State University Research Foundation
  • B2-GLYCOPROTEIN I PEPTIDE INHIBITORS
    Publication number: 20130165391
    Abstract: Therapeutic peptides (and peptoids) for preventing or inhibiting tissue damage associated with ischemia and/or reperfusion are provided, along with peptides (and peptoids) for preventing or inhibiting cancerous tissue growth. The peptides are derived from ?2-glycoprotein I. Pharmaceutical and veterinary compositions comprising the peptides are also provided. Methods of using the peptides to prevent or inhibit tissue damage associated with ischemia and/or reperfusion and/or to prevent or inhibit tissue damage or the growth of cancerous tissue are also provided.
    Type: Application
    Filed: March 1, 2013
    Publication date: June 27, 2013
    Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
    Inventor: Kansas State University Research Foundation
  • DOUBLE-STRANDED RNA-BASED NANOPARTICLES FOR INSECT GENE SILENCING
    Publication number: 20130137747
    Abstract: Nanoparticles for insect RNAi via oral delivery are provided, along with methods of silencing a target gene in a target insect using RNAi are provided. The nanoparticles comprise a polymer matrix and insect dsRNA. The dsRNA comprises at least one sequence having a region of complementarity substantially complementary to at least a portion of an mRNA transcript of the target gene. Insect baits comprising the nanoparticles are also provided. Methods of screening target gene functions are also provided using the methods disclosed herein.
    Type: Application
    Filed: May 31, 2012
    Publication date: May 30, 2013
    Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Kun Yan Zhu, Xin Zhang, Jianzhen Zhang