Patents Assigned to Kansas State University Research Foundation
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Publication number: 20130123245Abstract: Methods of improving performance, increasing weight gain, and decreasing incidence of disease in ruminant and pre-ruminant animals, such as cattle, after undergoing painful processing procedures, such as castration and dehorning, are provided. Veterinary formulations for use in methods of the invention are also provided. The formulations comprise a compound selected from the group consisting of meloxicam, gabapentin, the pharmaceutically acceptable salts thereof, and combinations thereof. Methods of treating pathological pain in cattle are also provided.Type: ApplicationFiled: July 14, 2011Publication date: May 16, 2013Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Johann F. Coetzee, Stanley P. Kukanich
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Publication number: 20130099195Abstract: The invention generally related to a method for preparing a layer of graphene directly on the surface of a semiconductor substrate. The method includes forming a carbon-containing layer on a front surface of a semiconductor substrate and depositing a metal film on the carbon layer. A thermal cycle degrades the carbon-containing layer, which forms graphene directly upon the semiconductor substrate upon cooling. In some embodiments, the carbon source is a carbon-containing gas, and the thermal cycle causes diffusion of carbon atoms into the metal film, which, upon cooling, segregate and precipitate into a layer of graphene directly on the semiconductor substrate.Type: ApplicationFiled: October 16, 2012Publication date: April 25, 2013Applicants: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION, MEMC ELECTRONIC MATERIALS, INC.Inventors: MEMC Electronic Materials, Inc., Kansas State University Research Foundation
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Publication number: 20130058856Abstract: A catalyst comprising a physical mixture of particles of a catalytic material and particles of char is provided. The catalyst can be used in various processes, including the reforming of tars present in syngas generated during biomass gasification. The catalyst is produced through a mechanical mixing of the catalytic material and char particles, which results in significant time and energy savings over methods of catalyst preparation that involve impregnation and calcining of a support material.Type: ApplicationFiled: May 20, 2011Publication date: March 7, 2013Applicant: Kansas State University Research FoundationInventors: Wenqiao Yuan, Duo Wang
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Patent number: 8377465Abstract: The present invention provides feed or food products for consumption by animals or humans which include respective quantities of flax oil and non-flax carbohydrate. The flax oil and carbohydrate are mixed together and simultaneously subjected to an elevated temperature of at least about 120° F. and subsequently cooled; the flax oil is used at a level so that the final product contains at least about 5% by weight flax oil. It has been found that the products of the invention, when fed at effective levels, induce increased in vivo synthesis of desirable eicosapentaenoic acid (EPA).Type: GrantFiled: February 11, 2005Date of Patent: February 19, 2013Assignee: Kansas State University Research FoundationInventor: James S. Drouillard
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Publication number: 20130018004Abstract: The present invention broadly provides novel peptides that can be used to form hydrogels. The peptides are short (preferably 30 amino acid residues or less) and include hydrophilic and hydrophobic segments joined by a turning segment. The hydrogels are formed by altering the pH of a solution of these peptides to an acidic level, or by introducing a source of ions into a solution of these peptides. The resulting hydrogels are shear thinning gels that have high storage moduli and high rates of recovery after destruction. They find use in medical applications, including tissue engineering.Type: ApplicationFiled: March 10, 2011Publication date: January 17, 2013Applicant: Kansas State University Research FoundationInventors: Xiuzhi Susan Sun, Hongzhou Huang
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Patent number: 8324588Abstract: A detection system and methods are described for determining whether a target contains a selected substance or device such as an explosive device, illegal drugs, dangerous chemicals, or the like. According to some embodiments, a detection system is comprising a radiation source and one or more detectors. The detection system in this directs radiation from a distance and towards a target suspected to contain a dangerous device or substance. A response is detected from the target. The response is compared to one or more templates that represent known explosives, drugs, dangerous chemicals, or the like. A score may be generated that corresponds to a similarity between the targeted and known substances. When the score indicates that the target substance is likely to be dangerous or contraband, then an alarm or other indication may be generated in some embodiments.Type: GrantFiled: September 11, 2008Date of Patent: December 4, 2012Assignee: Kansas State University Research FoundationInventor: William L. Dunn
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Publication number: 20120272868Abstract: Graphene particulates, especially graphene nanoribbons (GNRs) and graphene quantum dots Ds and and a high-throughput process for the production of such particulates is provided. The graphene particulates are produced by a nanotomy process in which graphene blocks are cut from a source of graphite and then exfoliated into a plurality of graphene particulates. Graphene particulates having narrow widths, on the order of 100 nm or less, can be produced having band gap properties suitable for use in a variety of electrical applications.Type: ApplicationFiled: November 22, 2010Publication date: November 1, 2012Applicants: THE UNIVERSITY OF KANSAS, KANSAS STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Vikas Berry, Nihar Mohanty, David S. Moore
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Publication number: 20120273702Abstract: Disclosed are electroactive polymer actuators and their use on microfluidic devices. Such actuators can comprise an electrode, an electroactive polymer, and a fluid-conducting channel. The electroactive polymer can be at least partially disposed between the electrode and the fluid-conducting channel. Furthermore, methods for creating a hydrodynamic force in a microfluidic device are disclosed by creating a potential difference across an electroactive polymer disposed on the microfluidic device.Type: ApplicationFiled: April 19, 2010Publication date: November 1, 2012Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Christopher T. Culbertson, Alexander K. Price
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Publication number: 20120246765Abstract: The present invention relates to compositions and methods for controlling nematode infestation of plants or animals. In particular, the present invention provides vectors comprising sequences designed to control nematodes by RNA interference (RNAi) and transgenic plants transformed with such vectors.Type: ApplicationFiled: November 11, 2010Publication date: September 27, 2012Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Harold N. Trick, Jiarui Li, Timothy C. Todd
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Patent number: 8268302Abstract: Stem cells from human sources can have a variety of useful applications in disease treatment and biotechnology. More particularly the umbilical cord matrix cell cultures of the invention have a variety of totipotent, pluripotent, or multipotent cells for a variety of end uses from a non-controversial, universally available, species-specific source. The technology can have application to any amniotic animal, including agricultural and laboratory animals and humans. The invention relates to isolating the stem cells, culturing the stem cells, maintaining the stem cells, transforming the stem cells into useful cell types using genetic or other transformation technologies, stem cell and tissue banking and using untransformed or transformed cells in disease treatment.Type: GrantFiled: May 4, 2010Date of Patent: September 18, 2012Assignee: Kansas State University Research FoundationInventors: Mark L. Weiss, Daryl L. Troyer, Duane Davis, Kathy E. Mitchell
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Patent number: 8228961Abstract: A feedback control module for stabilizing a carrier-envelope phase of an output of a laser oscillator system comprises a first photodetector, a second photodetector, a phase stabilizer, an optical modulator, and a thermal control element. The first photodetector may generate a first feedback signal corresponding to a first portion of a laser beam from an oscillator. The second photodetector may generate a second feedback signal corresponding to a second portion of the laser beam filtered by a low-pass filter. The phase stabilizer may divide the frequency of the first feedback signal by a factor and generate an error signal corresponding to the difference between the frequency-divided first feedback signal and the second feedback signal. The optical modulator may modulate the laser beam within the oscillator corresponding to the error signal. The thermal control unit may change the temperature of the oscillator corresponding to a signal operable to control the optical modulator.Type: GrantFiled: May 27, 2010Date of Patent: July 24, 2012Assignee: Kansas State University Research FoundationInventors: Zenghu Chang, Chenxia Yun, Shouyuan Chen, He Wang, Michael Chini
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Publication number: 20120157824Abstract: The present invention provides multifunctional nanoplatforms for assessing the activity of a protease in vivo or in vitro, along with methods of imaging and detecting the presence of cancerous or precancerous tissues, and the therapeutic treatment thereof, including monitoring of treatment. The diagnostic nanoplatforms comprise nanoparticles and are linked to each other or other particles via an oligopeptide linkage that comprises a consensus sequence specific for the target protease. Cleavage of the sequence by the target protease can be detected using various sensors, and the diagnostic results can be correlated with cancer prognosis. Individual unlinked nanoplatforms are also adaptable for therapeutic hyperthermia treatment of the cancerous tissue.Type: ApplicationFiled: August 31, 2010Publication date: June 21, 2012Applicants: NANOSCALE CORPORATION, KANSAS STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Stefan H. Bossmann, Deryl Troyer, Matthew T. Basel, Thilani Nishanthika Samarakoon, Hongwang Wang, Viktor Chikan, Franklin Orban Kroh, Olga Barbara Koper, Brandon Ray Walker, Xiaoxuan Leaym
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Patent number: 8163870Abstract: The present invention provides a family of peptides based upon the M2GlyR sequence. These peptides are derivatives of the M2GlyR sequence and can be modified at their ends to include a plurality of polar amino acid residues to enhance their solubility. Particularly preferred derivatives include portions of the M2GlyR sequence which are palindromic to another portion of the peptide or to the M2GlyR sequence itself. Preferably these portions are at least 7 amino acid residues in length. Peptides embraced by the present invention are characterized by having greater effects on the transepithelial electrical resistance of cells at lower concentrations. Peptides of the present invention have been shown to increase Isc in MDCK epithelial cell monolayers with half maximal effects observed at or below 30 ?M, a nearly 10-fold improvement over any peptide previously characterized in the M2GlyR family.Type: GrantFiled: June 14, 2004Date of Patent: April 24, 2012Assignee: Kansas State University Research FoundationInventors: John M. Tomich, Iwamoto Takeo, James R. Broughman, Bruce D. Schultz
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Publication number: 20120057611Abstract: A feedback control module for stabilizing a carrier-envelope phase of an output of a laser oscillator system comprises a first photodetector, a second photodetector, a phase stabilizer, an optical modulator, and a thermal control element. The first photodetector may generate a first feedback signal corresponding to a first portion of a laser beam from an oscillator. The second photodetector may generate a second feedback signal corresponding to a second portion of the laser beam filtered by a low-pass filter. The phase stabilizer may divide the frequency of the first feedback signal by a factor and generate an error signal corresponding to the difference between the frequency-divided first feedback signal and the second feedback signal. The optical modulator may modulate the laser beam within the oscillator corresponding to the error signal. The thermal control unit may change the temperature of the oscillator corresponding to a signal operable to control the optical modulator.Type: ApplicationFiled: May 27, 2010Publication date: March 8, 2012Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Zenghu Chang, Chenxia Yun, Shouyuan Chen, He Wang, Michael Chini
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Patent number: 8118545Abstract: A turbocharged engine includes an internal combustion engine and a variable geometry turbocharger. The turbocharger is adjustable to operate efficiently under various engine operating and environmental conditions. The turbocharger includes a turbine and compressor, with the compressor including a compressor housing, an impeller rotatably mounted in the housing, and an adjustable diffuser vane assembly. The diffuser vane assembly includes a plurality of pivotal diffuser vanes spaced about the impeller and a vane rotation drive that interconnects the vanes and permits simultaneous adjustment of the diffuser vanes to improve the efficiency and operating range of the turbocharger. The diffuser vane assembly also includes a vane locking drive operable to engage the pivotal vanes and prevent vane movement during turbocharger operation.Type: GrantFiled: October 1, 2008Date of Patent: February 21, 2012Assignee: Kansas State University Research FoundationInventors: Kirby Chapman, Ueli Honnegger
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Publication number: 20120037811Abstract: A detection system and methods are described for determining whether a target contains a selected substance or device such as an explosive device, illegal drugs, dangerous chemicals, or the like. According to some embodiments, a detection system is comprising a radiation source and one or more detectors. The detection system in this directs radiation from a distance and towards a target suspected to contain a dangerous device or substance. A response is detected from the target. The response is compared to one or more templates that represent known explosives, drugs, dangerous chemicals, or the like. A score may be generated that corresponds to a similarity between the targeted and known substances. When the score indicates that the target substance is likely to be dangerous or contraband, then an alarm or other indication may be generated in some embodiments.Type: ApplicationFiled: September 11, 2008Publication date: February 16, 2012Applicant: Kansas State University Research FoundationInventor: William L. Dunn
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Publication number: 20120021020Abstract: The present invention provides branched amphipathic peptides and vesicles formed thereof. The peptides comprise a polar/positively charged C-terminal segment, a branch point, and two hydrophobic N -terminal segments extending from the branch point. The vesicles are formed using a plurality of first and second peptides, wherein the first peptide has a different chain length from the second peptide. When a plurality of the first and second peptides are mixed together, they self-assemble to form small spheres defined by a membrane consisting of an interlocking peptide network bilayer and having a liquid-receiving interior space (i.e., hollow core). In the bi-layer, the respective hydrophobic segments of the peptides form beta-sheet structures having a hydrogen bond-stabilized, anti-parallel orientation in which the opposed sequences interlock to form a zipper-like structure in three dimensions. Thus, the peptide assembly (i.e.Type: ApplicationFiled: March 26, 2010Publication date: January 26, 2012Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATIONInventors: John M. Tomich, Takeo Iwamoto, Yasuaki Hiromasa, Sushanth Gudlur
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Patent number: 8073026Abstract: A chirped pulse amplification laser system. The system generally comprises a laser source, a pulse modification apparatus including first and second pulse modification elements separated by a separation distance, a positioning element, a measurement device, and a feedback controller. The laser source is operable to generate a laser pulse and the pulse modification apparatus operable to modify at least a portion of the laser pulse. The positioning element is operable to reposition at least a portion of the pulse modification apparatus to vary the separation distance. The measurement device is operable to measure the carrier envelope phase of the generated laser pulse and the feedback controller is operable to control the positioning element based on the measured carrier envelope phase to vary the separation distance of the pulse modification elements and control the carrier envelope phase of laser pulses generated by the laser source.Type: GrantFiled: June 21, 2007Date of Patent: December 6, 2011Assignee: Kansas State University Research FoundationInventors: Zenghu Chang, Chengquan Li, Eric Moon
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Publication number: 20110287165Abstract: A lipophilic starch is provided along with methods of making the same. The starch is prepared by modifying the starch with an organic acid anhydride reagent, such as octenyl succinic anhydride, drying the modified starch to a moisture content of less than 15% by weight, and then heat treating the dried starch at a temperature of at least 100° C. for at least one minute.Type: ApplicationFiled: February 3, 2010Publication date: November 24, 2011Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Yong-Chen Shi, Yanjie Bai
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Patent number: 8017019Abstract: Improved fluidized bed precipitators (20, 46, 62, 74, 108, 112, 134, 168) especially useful for the treatment of waste waters containing soluble phosphorus are provided, having upright, primary fluidized bed sections (22, 48, 64, 76, 110, 114, 136) and obliquely oriented solids settling sections (28, 54, 68, 120, 144) which enhance the settling of small particles (166) and return thereof to the fluidized bed sections (22, 48, 64, 76, 110, 114, 136). The precipitators (20, 46, 62, 74, 108, 112, 134, 168) may also be equipped with a solids detection/withdrawal assembly (178) made up of one or more pressure transducers (180, 182) operable to determine the pressures within the fluidized bed sections 22, 48, 64, 76, 110, 114, 136) as a measure of bed densities, along with a selectively operable valve (172) which may be opened to periodically remove solids without clogging.Type: GrantFiled: June 13, 2008Date of Patent: September 13, 2011Assignees: Kansas State University Research Foundation, Kansas Environmental Management Associates, LLCInventors: Gina Young Becker, Sigifredo Castro Diaz, Michael Hanson, Kylo Martin Heller, Dean Thompson