Patents Assigned to Labrador Diagnostics LLC
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Patent number: 11305275Abstract: Bodily fluid sample collection systems, devices, and method are provided. The sample is collected at a first location and subjected to a first sample processing step. The sample may be shipped to a second location and subjected to a second sample processing step that does not introduce contaminants into a plasma portion of the sample formed from the first processing step. The sample may also be mixed with other material(s) in the collection device.Type: GrantFiled: July 17, 2019Date of Patent: April 19, 2022Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Clarissa Lui, Michael Chen, Daniel Young
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Patent number: 11309856Abstract: In one embodiment, a femtowatt sensitivity optical detector is provided using one or more photodiodes, intended as a replacement for the photomultiplier based photon counting unit.Type: GrantFiled: September 3, 2020Date of Patent: April 19, 2022Assignee: Labrador Diagnostics LLCInventors: Karan Mohan, Marcelo Martinez
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Patent number: 11304638Abstract: Methods and devices are provided for sample collection. In one example, a device is provided comprising at least one capillary tube or collection channel directed to a sample vessel, wherein in a one-step removal step of detaching the sample vessel from the collection channel, a vacuum force is created within the sample vessel, due in part of the pulling of the sealed vessel away from the device, wherein this vacuum force draw out residual sample that may still be resident in the collection channel.Type: GrantFiled: May 8, 2020Date of Patent: April 19, 2022Assignee: Labrador Diagnostics LLCInventor: Zachary Morrison
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Patent number: 11300564Abstract: Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples.Type: GrantFiled: September 28, 2016Date of Patent: April 12, 2022Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Chinmay Pangarkar, Timothy Smith, Karan Mohan, Daniel Young, James Wasson, Samartha Anekal
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Patent number: 11291989Abstract: Methods and devices are provided for sample collection. In one example, a device is provided comprising at least one capillary tube or collection channel directed to a sample vessel, wherein in a one-step removal step of detaching the sample vessel from the collection channel, a vacuum force is created within the sample vessel, due in part of the pulling of the sealed vessel away from the device, wherein this vacuum force draw out residual sample that may still be resident in the collection channel.Type: GrantFiled: May 5, 2017Date of Patent: April 5, 2022Assignee: Labrador Diagnostics LLCInventor: Zachary Morrison
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Patent number: 11287421Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.Type: GrantFiled: April 12, 2018Date of Patent: March 29, 2022Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Shaunak Roy, Ian Gibbons, Shize Daniel Qi, Edmond Ku, Chris Todd, Melissa Takahashi, Bruce Johnson, Jeff Fenton, Keith Moravick, Uwe Springborn, Anthony Delacruz
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Publication number: 20220093269Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.Type: ApplicationFiled: December 6, 2021Publication date: March 24, 2022Applicant: Labrador Diagnostics LLCInventors: Elizabeth A. HOLMES, Ian GIBBONS, Daniel YOUNG, Seth G. MICHELSON
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Patent number: 11280712Abstract: Devices, systems and methods for holding and transferring small volume fluid samples are disclosed. Holding vessels, including holding vessels having two or more internal compartments for holding small volume fluid samples, are disclosed. Transfer vessels for receiving small volume fluid samples from such holding vessels are disclosed. Transfer vessels for combining small volume fluid samples from such holding vessels are disclosed. Methods for providing small volume fluid samples for analysis with small loss of sample are disclosed. Methods for providing small volume fluid samples for analysis using automated sample analysis devices and systems, with small loss of sample, are disclosed.Type: GrantFiled: September 19, 2019Date of Patent: March 22, 2022Assignee: Labrador Diagnostics LLCInventors: Clarissa Lui, Priyanshu Gupta
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Patent number: 11275013Abstract: Methods and devices are provided for use with a biological sample, wherein in one example, the device comprising a sample holder and an excitation source for providing excitation energy into the light conduit towards the sample holder. In one embodiment, the device comprises an imaging cytometer. Optionally, the device comprises a flow cytometer. Optionally, a light conduit comprises an optical fiber. Optionally, the optical fiber has an outer cross-sectional shape different from an inner optical core cross-sectional shape.Type: GrantFiled: July 19, 2018Date of Patent: March 15, 2022Assignee: Labrador Diagnostics LLCInventor: Peiqian Zhao
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Patent number: 11275094Abstract: Systems and methods are provided for processing a biological sample. In one embodiment, the method comprises receiving a sample vessel containing the sample; retrieving information from an information storage unit associated with the sample; using said information for selecting at least one cartridge front at least two or more different cartridges, each configured for use with a sample processing device; loading at least one or more reagents onto the cartridge, wherein the one or more reagents to be added are selected based at least in part on the information or instructions derived from the information; and placing the sample vessel in the cartridge.Type: GrantFiled: August 29, 2019Date of Patent: March 15, 2022Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Adrit Lath
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Patent number: 11268130Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.Type: GrantFiled: August 2, 2019Date of Patent: March 8, 2022Assignee: Labrador Diagnostics LLCInventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
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Patent number: 11262308Abstract: Methods and devices for cytometric analysis are provided. A cytometry apparatus is provided which may be used with a stationary sample cuvette for analysis of a stationary sample or with a flow sample cuvette for analysis of a flowing sample. The methods and devices provided herein may be used to perform cytometric analysis of samples under a wide range of experimental and environmental conditions.Type: GrantFiled: October 23, 2020Date of Patent: March 1, 2022Assignee: Labrador Diagnostics LLCInventors: Chinmay Pangarkar, Karan Mohan
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Patent number: 11257215Abstract: Systems and methods are provided for collecting, preparing, and/or analyzing a biological sample. A sample collection site may be utilized with one or more sample processing device. The sample processing device may be configured to accept a sample from a subject. The sample processing device may perform one or more sample preparation step and/or chemical reaction involving the sample. Data related to the sample may be sent from the device to a laboratory. The laboratory may be a certified laboratory that may generate a report that is transmitted to a health care professional. The health care professional may rely on the report for diagnosing, treating, and/or preventing a disease in the subject.Type: GrantFiled: January 31, 2020Date of Patent: February 22, 2022Assignee: Labrador Diagnostics LLCInventor: Elizabeth A. Holmes
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Patent number: 11254960Abstract: Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases, ligases, and primers.Type: GrantFiled: September 8, 2015Date of Patent: February 22, 2022Assignee: Labrador Diagnostics LLCInventors: Kamila Belhocine, Pranav Patel, Josephine Lee, Aaron Richardson, Scott Tabakman
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Patent number: 11249799Abstract: Provided herein are medical testing devices, systems, and methods that integrate multiplex, multi-technology, multi-configuration, multisample, or multi-threading capabilities. These capabilities are achieved using one or more of a level operations and communications architecture, a protocol execution engine, and a machine vision and processing system, method, or device in order to make testing of biologic or other samples more efficient in terms of cost, time, energy, or by prioritizing at least one other objective.Type: GrantFiled: February 14, 2014Date of Patent: February 15, 2022Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Daniel Young
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Patent number: 11247208Abstract: Methods and devices are provided for sample collection and sample separation. In one embodiment, a device is provided for use with a formed component liquid sample, the device comprising at least one sample inlet for receiving said sample; at least a first outlet for outputting only a liquid portion of the formed component liquid sample; at least a second outlet for outputting the formed component liquid sample at least a first material mixed therein.Type: GrantFiled: September 9, 2016Date of Patent: February 15, 2022Assignee: Labrador Diagnostics LLCInventors: Deborah Sloan, Channing Robertson
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Patent number: 11215610Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications. In particular, the medical device reduces interference with an optical signal which is indicative of the presence of an analyte in a bodily sample.Type: GrantFiled: April 12, 2018Date of Patent: January 4, 2022Assignee: Labrador Diagnostics LLCInventors: Ian Gibbons, Michael O'Connell
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Patent number: 11204349Abstract: A composition is described comprising superparamagnetic particles. Optionally, the particles comprise microbeads. Optionally, the particles comprise nanobeads. Optionally, the particles are non-spherical particles. Optionally, the particles are non-spherical particles suitable for RNA or DNA extraction. A method is described for forming microparticles. Optionally, the method comprises using citrate precipitation. Optionally, a kit comprising one or more of the particles is described. Optionally, a kit for sample preparation for nucleic acid extraction is described comprising non-spherical microparticles or nanoparticles.Type: GrantFiled: October 26, 2018Date of Patent: December 21, 2021Assignee: Labrador Diagnostics LLCInventor: Alex Ho Fai Lee
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Patent number: 11199538Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.Type: GrantFiled: April 13, 2018Date of Patent: December 14, 2021Assignee: Labrador Diagnostics LLCInventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
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Patent number: 11199489Abstract: The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.Type: GrantFiled: August 20, 2015Date of Patent: December 14, 2021Assignee: Labrador Diagnostics LLCInventors: Ian Gibbons, Anthony Nugent, Anthony Delacruz, Daniel Young, Elizabeth A. Holmes, Andrew Drake, Timothy Michael Kemp, Sunny Balwani, Chinmay Pangarkar