Patents Assigned to Labrador Diagnostics LLC
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Patent number: 11195624Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.Type: GrantFiled: April 13, 2018Date of Patent: December 7, 2021Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Ian Gibbons, Daniel Young, Seth G. Michelson
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Patent number: 11187651Abstract: Methods and devices are provided to provide clean signals even in the presence of spectral interference. At least some of these methods can be applied for cases when interfering signals are to be accounted for. These cases include, but are not limited to, hemolysis detection, icterus detection, and assays. They can be implemented in with data collected with spectrophotometers, instruments that can collect absorbance values at the few wavelengths of interest, and, in the case of the method based on background subtraction, simple imaging setups with only two filters (such as but not limited to narrow-band and wide-band) per absorption peak of interest.Type: GrantFiled: July 31, 2019Date of Patent: November 30, 2021Assignee: Labrador Diagnostics LLCInventor: Toan Huynh
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Patent number: 11162936Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: May 15, 2017Date of Patent: November 2, 2021Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Daniel Young, Timothy Smith, Joy Roy, Alexander Loo
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Patent number: 11162947Abstract: The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection in a sample of bodily fluid.Type: GrantFiled: January 8, 2018Date of Patent: November 2, 2021Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Ian Gibbons
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Patent number: 11161116Abstract: Devices, methods and systems are provided for reducing the sample volume required for analysis. Inserts placed within a sample container, and substitute sample containers having smaller volume sample chambers are provided. Methods are provided for detection and quantification of target substances in reduced volume samples. Methods include placing a small-volume of sample in a small-volume insert. Methods include diluting a small-volume sample, and placing the diluted sample in a small-volume insert.Type: GrantFiled: August 1, 2019Date of Patent: November 2, 2021Assignee: Labrador Diagnostics LLCInventors: Xinwei Sam Gong, Daniel Young, William Westrick
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Patent number: 11162946Abstract: Methods, devices, and systems for analyzing biological samples are provided. A biological sample may be analyzed for the presence of an analyte by an initial assay, and the performance of, or method of performance of, a subsequent assay may be contingent upon the results of the initial assay. For example, the following may be contingent on the results of a prior assay: whether or not a subsequent assay is performed; which subsequent assay is performed; the method of performing a subsequent assay; the order of performance of a sequence of subsequent assays; the steps, or order of steps, performed in a subsequent assay; the timing of the performance of a subsequent assay; the choice of a reagent used in a subsequent assay; the detection method used in a subsequent assay; and other particulars of assays may be contingent on the results of a prior assay.Type: GrantFiled: September 15, 2015Date of Patent: November 2, 2021Assignee: Labrador Diagnostics LLCInventors: Daniel Young, Elizabeth A. Holmes
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Patent number: 11158429Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.Type: GrantFiled: April 13, 2018Date of Patent: October 26, 2021Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Ian Gibbons, Daniel Young, Seth G. Michelson
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Patent number: 11156618Abstract: Assays for rapid measurement of total vitamin D in blood are provided. Vitamin D is measured following the rapid and irreversible release of vitamin D due to denaturation and digestion of vitamin D binding proteins by aspartyl peptidases (e.g., pepsin) under acidic conditions. Such measurements may be made using a vitamin D binder (e.g., an antibody) to measure competition between free vitamin D and added, labeled vitamin D. Synergy between denaturation and degradation is believed to provide more rapid and more complete release of vitamin D than would occur with acid or enzyme alone.Type: GrantFiled: June 4, 2018Date of Patent: October 26, 2021Assignee: Labrador Diagnostics LLCInventor: Tina Noyes
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Patent number: 11143647Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.Type: GrantFiled: May 20, 2016Date of Patent: October 12, 2021Assignee: Labrador Diagnostics, LLCInventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
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Patent number: 11143655Abstract: Methods for obtaining a sample from a subject include providing a sample collection room within a retail store; and obtaining a sample from a subject at a retail location. Sample collection rooms may house a sample analysis device or system. Samples may be small, e.g., a finger-stick capillary blood sample.Type: GrantFiled: July 1, 2016Date of Patent: October 12, 2021Assignee: Labrador Diagnostics LLCInventors: Daniel Young, Chinmay Pangarkar
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Patent number: 11139084Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.Type: GrantFiled: August 24, 2016Date of Patent: October 5, 2021Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Ian Gibbons, Daniel Young, Seth G. Michelson
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Patent number: 11137391Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.Type: GrantFiled: April 13, 2018Date of Patent: October 5, 2021Assignee: Labrador Diagnostics LLCInventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
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Patent number: 11112418Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: July 31, 2017Date of Patent: September 7, 2021Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Daniel Young, Samartha Anekal, Chinmay Pangarkar
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Patent number: 11092593Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.Type: GrantFiled: September 8, 2015Date of Patent: August 17, 2021Assignee: Labrador Diagnostics LLCInventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
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Patent number: 11090655Abstract: In one embodiment described herein, a cartridge is provided comprising a cartridge frame; a plurality of diluents each in an expandable container; a plurality of reagents each in an expandable container; and a plurality of mixing vessels comprising empty expandable containers.Type: GrantFiled: January 2, 2020Date of Patent: August 17, 2021Assignee: Labrador Diagnostics LLCInventors: Gary Frenzel, Samartha Anekal, Daniel Young
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Publication number: 20210223163Abstract: The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.Type: ApplicationFiled: December 28, 2020Publication date: July 22, 2021Applicant: Labrador Diagnostics LLCInventors: Anthony J. NUGENT, Daniel L. YOUNG, Elizabeth A. HOLMES, Michael SIEGEL, Ryan WISTORT
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Patent number: 11061022Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.Type: GrantFiled: May 20, 2016Date of Patent: July 13, 2021Assignee: Labrador Diagnostics LLCInventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
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Patent number: 11054432Abstract: Systems and methods are provided for sample processing. The system, in one configuration, includes a sample processing apparatus for use with a biological sample and/or a reagent, a housing and a touchscreen display mounted to the housing. The system, in one configuration, contains a cartridge insertion location; at least one optical detector; a control unit having a processor that is programmed to execute computer-readable commands; and a sample handling system.Type: GrantFiled: March 16, 2017Date of Patent: July 6, 2021Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Joy Roy, Peter Kardassakis
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Patent number: 11046992Abstract: Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.Type: GrantFiled: February 1, 2019Date of Patent: June 29, 2021Assignee: Labrador Diagnostics LLCInventors: Alexander Loo, Elizabeth A. Holmes
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Patent number: 11009516Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: September 21, 2015Date of Patent: May 18, 2021Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Michael Chen, Pey-Jiun Ko