Patents Assigned to LightLab Imaging, Inc.
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Publication number: 20220039667Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.Type: ApplicationFiled: October 22, 2021Publication date: February 10, 2022Applicant: LightLab Imaging, Inc.Inventors: Joseph M. Schmitt, Joel M. Friedman, Christopher Petroff, Amr Elbasiony
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Publication number: 20220039668Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.Type: ApplicationFiled: October 22, 2021Publication date: February 10, 2022Applicant: LightLab Imaging, Inc.Inventors: Joseph M. Schmitt, Joel M. Friedman, Christopher Petroff, Amr Elbasiony
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Patent number: 11241154Abstract: In part, the invention relates to an image data collection system. The system can include an interferometer having a reference arm that includes a first optical fiber of length of L1 and a sample arm that includes a second optical fiber of length of L2 and a first rotary coupler configured to interface with an optical tomography imaging probe, wherein the rotary coupler is in optical communication with the sample arm. In one embodiment, L2 is greater than about 5 meters. The first optical fiber and the second optical fiber can both be disposed in a common protective sheath. In one embodiment, the system further includes an optical element configured to adjust the optical path length of the reference arm, wherein the optical element is in optical communication with the reference arm and wherein the optical element is transmissive or reflective.Type: GrantFiled: March 22, 2017Date of Patent: February 8, 2022Assignee: LightLab Imaging, Inc.Inventors: Desmond Adler, Joseph M. Schmitt, Mattias Dahlberg, Par Gustafsson, Ulrik Hubinette, Magnus Samuelsson, Johan Svanerudh
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Patent number: 11166668Abstract: In part, the disclosure relates to computer-based methods, devices, and systems suitable for pre-stent planning, stent planning and post-stent planning using one or more computing devices. In one embodiment, a method generates one or more stent profiles, such as a target stent profile, that are user configurable during a pre-stent planning stage by selecting one or more frames. The method performs a comparative analysis of the previously set target stent profile relative to a vessel lumen region post stent deployment. The method and related user interfaces can alert a user to move, remove, reposition, or inflate a stent. The location of jailed side branches can also be identified and displayed based upon the comparative analysis. Parameters that change based on the outcome of the stent deployment can be displayed in terms of the predicted parameter value and the value that is measured or determined after stent deployment.Type: GrantFiled: July 24, 2015Date of Patent: November 9, 2021Assignee: LightLab Imaging, Inc.Inventor: Ajay Gopinath
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Publication number: 20210251592Abstract: The disclosure relates generally to the field of vascular system and peripheral vascular system data collection, imaging, image processing and feature detection relating thereto. In part, the disclosure more specifically relates to methods for detecting position and size of contrast cloud in an x-ray image including with respect to a sequence of x-ray images during intravascular imaging. Methods of detecting and extracting metallic wires from x-ray images are also described herein such as guidewires used in coronary procedures. Further, methods for of registering vascular trees for one or more images, such as in sequences of x-ray images, are disclosed. In part, the disclosure relates to processing, tracking and registering angiography images and elements in such images. The registration can be performed relative to images from an intravascular imaging modality such as, for example, optical coherence tomography (OCT) or intravascular ultrasound (IVUS).Type: ApplicationFiled: April 8, 2021Publication date: August 19, 2021Applicant: LightLab Imaging, Inc.Inventors: Lorina Dascal, Itai Winkler
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Publication number: 20210217175Abstract: The disclosure relates, in part, to computer-based visualization of stent position within a blood vessel. A stent can be visualized using intravascular data and subsequently displayed as stent struts or portions of a stent as a part of a one or more graphic user interface(s) (GUI). In one embodiment, the method includes steps to distinguish stented region(s) from background noise using an amalgamation of angular stent strut information for a given neighborhood of frames. The GUI can include views of a blood vessel generated using distance measurements and demarcating the actual stented region(s), which provides visualization of the stented region. The disclosure also relates to display of intravascular diagnostic information such as indicators. An indicator can be generated and displayed with images generated using an intravascular data collection system. The indicators can include one or more viewable graphical elements suitable for indicating diagnostic information such as stent information.Type: ApplicationFiled: January 22, 2021Publication date: July 15, 2021Applicant: LightLab Imaging, Inc.Inventors: Sonal Ambwani, Christopher E. Griffin, James G. Peterson, Satish Kaveti, Joel M. Friedman
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Patent number: 11058308Abstract: An optical coherence tomography system and method with integrated pressure measurement. In one embodiment the system includes an interferometer including: a wavelength swept laser; a source arm in communication with the wavelength swept laser; a reference arm in communication with a reference reflector, a first photodetector having a signal output; a detector arm in communication with the first photodetector, a probe interlace; a sample arm in communication with a first optical connector of the probe interface; an acquisition and display system comprising: an A/D converter having a signal input in communication with the first photodetector signal output and a signal output; a processor system in communication with the A/D converter signal output; and a display in communication with the processor system; and a probe comprising a pressure sensor and configured for connection to the first optical connector of the probe interface, wherein the pressure transducer comprises an optical pressure transducer.Type: GrantFiled: November 30, 2018Date of Patent: July 13, 2021Assignee: LightLab Imaging, Inc.Inventors: Joseph M. Schmitt, Christopher Petroff
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Patent number: 11020078Abstract: The disclosure relates generally to the field of vascular system and peripheral vascular system data collection, imaging, image processing and feature detection relating thereto. In part, the disclosure more specifically relates to methods for detecting position and size of contrast cloud in an x-ray image including with respect to a sequence of x-ray images during intravascular imaging. Methods of detecting and extracting metallic wires from x-ray images are also described herein such as guidewires used in coronary procedures. Further, methods for of registering vascular trees for one or more images, such as in sequences of x-ray images, are disclosed. In part, the disclosure relates to processing, tracking and registering angiography images and elements in such images. The registration can be performed relative to images from an intravascular imaging modality such as, for example, optical coherence tomography (OCT) or intravascular ultrasound (IVUS).Type: GrantFiled: June 11, 2019Date of Patent: June 1, 2021Assignee: LightLab Imaging, Inc.Inventors: Lorina Dascal, Itai Winkler
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Publication number: 20210085275Abstract: Aspects of the disclosure relate to the combination and display of both live and non-live patient images. The features described include collecting angiographic image data, and correlating angiographic image frames to time-varying data relating to the patient's heart cycle. This time-varying data may then be compared with the patient's live heart cycle data so that the collected angiographic image frames can be interlaced within a display of live fluoroscopic images of the patient.Type: ApplicationFiled: September 18, 2020Publication date: March 25, 2021Applicant: LightLab Imaging, Inc.Inventor: Ajay Gopinath
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Publication number: 20210082121Abstract: In part, the disclosure relates to method for identifying regions of interest in a blood vessel. The method includes the steps of: providing OCT image data of the blood vessel; applying a plurality of different edge detection filters to the OCT image data to generate a filter response for each edge detection filter; identifying in each edge detection filter response any response maxima; combining the response maxima for each edge detection filter response while maintaining the spatial relationship of the response maxima, to thereby create edge filtered OCT data; and analyzing the edge filtered OCT data to identify a region of interest, the region of interest defined as a local cluster of response maxima. In one embodiment, one or more indicia are positioned in one or more panels to emphasize a reference vessel profile as part of a user interface.Type: ApplicationFiled: October 30, 2020Publication date: March 18, 2021Applicant: LightLab Imaging, Inc.Inventors: Ajay Gopinath, Desmond Adler
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Publication number: 20210042927Abstract: The present disclosure provides systems and methods to receiving OCT or IVUS image data frames to output one or more representations of a blood vessel segment. The image data frames may be stretched and/or aligned using various windows or bins or alignment features. Arterial features, such as the calcium burden, may be detected in each of the image data frames. The arterial features may be scored. The score may be a stent under-expansion risk. The representation may include an indication of the arterial features and their respective score. The indication may be a color coded indication.Type: ApplicationFiled: August 5, 2020Publication date: February 11, 2021Applicant: LightLab Imaging, Inc.Inventors: Gregory Patrick Amis, Ajay Gopinath, Mark Hoeveler
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Patent number: 10902599Abstract: The disclosure relates, in part, to computer-based visualization of stent position within a blood vessel. A stent can be visualized using intravascular data and subsequently displayed as stent struts or portions of a stent as a part of a one or more graphic user interface(s) (GUI). In one embodiment, the method includes steps to distinguish stented region(s) from background noise using an amalgamation of angular stent strut information for a given neighborhood of frames. The GUI can include views of a blood vessel generated using distance measurements and demarcating the actual stented region(s), which provides visualization of the stented region. The disclosure also relates to display of intravascular diagnostic information such as indicators. An indicator can be generated and displayed with images generated using an intravascular data collection system. The indicators can include one or more viewable graphical elements suitable for indicating diagnostic information such as stent information.Type: GrantFiled: October 22, 2018Date of Patent: January 26, 2021Assignee: LightLab Imaging, Inc.Inventors: Sonal Ambwani, Christopher E. Griffin, James G. Peterson, Satish Kaveti, Joel M. Friedman
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Publication number: 20210004955Abstract: The disclosure relates to stent detection and shadow detection in the context of intravascular data sets obtained using a probe such as, for example, and optical coherence tomography probe or an intravascular ultrasound probe.Type: ApplicationFiled: July 14, 2020Publication date: January 7, 2021Applicant: LightLab Imaging, Inc.Inventors: Sonal Ambwani, Christopher E. Griffin
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Patent number: 10878572Abstract: In part, the disclosure relates to method for identifying regions of interest in a blood vessel. The method includes the steps of: providing OCT image data of the blood vessel; applying a plurality of different edge detection filters to the OCT image data to generate a filter response for each edge detection filter; identifying in each edge detection filter response any response maxima; combining the response maxima for each edge detection filter response while maintaining the spatial relationship of the response maxima, to thereby create edge filtered OCT data; and analyzing the edge filtered OCT data to identify a region of interest, the region of interest defined as a local cluster of response maxima. In one embodiment, one or more indicia are positioned in one or more panels to emphasize a reference vessel profile as part of a user interface.Type: GrantFiled: April 9, 2018Date of Patent: December 29, 2020Assignee: LightLab Imaging, Inc.Inventors: Ajay Gopinath, Desmond Adler
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Publication number: 20200397405Abstract: In one aspect, the invention relates to one or more rotatable elements and one or more stationary element such that the elements are arranged along a common axis of rotation co-linear with or substantially parallel to an optical path. The optical path is a portion of a sample arm of an interferometer. Further, the rotatable and stationary elements are configured to couple electrical signals and optical signals between a data collection probe and an interface unit or other component of an imaging system. In one embodiment, the data collection probe is a combination ultrasound and OCT probe. In one aspect, the invention relates to a rotary joint in which the optical fiber and a fiber optic rotary joint lie in the center of one or more conductive elements of an electrical rotary joint which are annularly disposed around one or both of the optical fiber and optical rotary joint.Type: ApplicationFiled: September 2, 2020Publication date: December 24, 2020Applicant: LightLab Imaging, Inc.Inventors: Christopher Hutchins, Michael Atlas, Alexander Ship
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Publication number: 20200352446Abstract: In part, the invention relates to methods, apparatus, and systems suitable for determining a fractional flow reserve (FFR) and variations of modifications thereof One embodiment relates to a method and apparatus for obtaining a corrected FFR in a vessel having a stenosis. In one aspect, the invention relates to an apparatus for measuring corrected FFR of a vessel having a stenosis. In one embodiment, the apparatus includes a probe comprising an optical coherence tomography assembly and a pressure assembly; and a processor in communication with the optical coherence tomography assembly and the pressure assembly. In one embodiment, the pressure assembly measures values of pressure in predetermined locations the vessel and communicates them to the processor. In one embodiment, a dual guidewire is used to reduce the interference in the pressure measurement.Type: ApplicationFiled: July 23, 2020Publication date: November 12, 2020Applicant: LightLab Imaging, Inc.Inventors: Christopher Petroff, Joseph M. Schmitt
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Publication number: 20200355557Abstract: In part, the invention relates to systems and methods of calibrating a plurality of frames generated with respect to a blood vessel as a result of a pullback of an intravascular imaging probe being pullback through the vessel. A calibration feature disposed in the frames that changes between a subset of the frames can be used to perform calibration. Calibration can be performed post-pullback. Various filters and image processing techniques can be used to identify one or more feature in the frames including, without limitation, a calibration feature, a guidewire, a side branch, a stent strut, a lumen of the blood vessel, and other features. The feature can be displayed using a graphic user interface.Type: ApplicationFiled: January 15, 2020Publication date: November 12, 2020Applicant: LightLab Imaging, Inc.Inventors: Joel M. Friedman, Amr Elbasiony
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Publication number: 20200330070Abstract: In part, the disclosure relates to computer-based methods, devices, and systems suitable for detecting a delivery catheter using intravascular data. In one embodiment, the delivery catheter is used to position the intravascular data collection probe. The probe can collect data suitable for generating one or more representations of a blood vessel with respect to which the delivery catheter can be detected.Type: ApplicationFiled: May 8, 2020Publication date: October 22, 2020Applicant: LightLab Imaging, Inc.Inventors: James G. Peterson, Christopher E. Griffin, Sonal Ambwani
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Patent number: 10792012Abstract: In one aspect, the invention relates to one or more rotatable elements and one or more stationary element such that the elements are arranged along a common axis of rotation co-linear with or substantially parallel to an optical path. The optical path is a portion of a sample arm of an interferometer. Further, the rotatable and stationary elements are configured to couple electrical signals and optical signals between a data collection probe and an interface unit or other component of an imaging system. In one embodiment, the data collection probe is a combination ultrasound and OCT probe. In one aspect, the invention relates to a rotary joint in which the optical fiber and a fiber optic rotary joint lie in the center of one or more conductive elements of an electrical rotary joint which are annularly disposed around one or both of the optical fiber and optical rotary joint.Type: GrantFiled: February 4, 2013Date of Patent: October 6, 2020Assignee: LightLab Imaging, Inc.Inventors: Christopher Hutchins, Michael Atlas, Alexander Ship
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Publication number: 20200294659Abstract: In part, the disclosure relates to method of displaying a representation of an artery. The method may include storing an intravascular image dataset in a memory device of a diagnostic imaging system, the intravascular image dataset generated in response to intravascular imaging of a segment of an artery; automatically detecting lumen boundary of the segment on a per frame basis; automatically detecting EEL and displaying a stent sizing workflow. In part, the disclosure also relates to automatically detecting one or more regions of calcium relative to lumen boundary of the segment; calculating an angular or circumferential measurement of detected calcium for one or more frames; calculating a calcium thickness of detected calcium for one or more frames; and displaying the calcium thickness and the angular or circumferential measurement of detected calcium for a first frame of the one or more frames.Type: ApplicationFiled: March 17, 2020Publication date: September 17, 2020Applicant: LightLab Imaging, Inc.Inventors: Ajay Gopinath, Mark Hoeveler