Patents Assigned to Marquette University
  • Quenched Fluorophores Conjugated to Peptides Via Linkers Containing Dithio Groups
    Publication number: 20130122600
    Abstract: Disclosed are dithio compounds that include a quenched fluorophore and a non-fluorophore peptide linked via a dithio bond to the fluorophore. The dithio compounds may be used in methods for detecting thiol-containing compounds or dithio-containing compounds. The dithio compounds also may be used as cellular probes where the peptide portion of the compounds targets the compounds to a specific cellular location.
    Type: Application
    Filed: October 31, 2012
    Publication date: May 16, 2013
    Applicant: MARQUETTE UNIVERSITY
    Inventor: MARQUETTE UNIVERSITY
  • Cysteine prodrugs to treat schizophrenia and drug addiction
    Patent number: 8435997
    Abstract: The present invention provides cysteine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.
    Type: Grant
    Filed: October 4, 2010
    Date of Patent: May 7, 2013
    Assignees: Marquette University, UWM Research Foundation, Inc.
    Inventors: James M. Cook, Edward Merle Johnson, II, David A. Baker, Wenyuan Yin
  • CYSTEINE AND CYSTINE PRODRUGS TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS
    Publication number: 20120220596
    Abstract: The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.
    Type: Application
    Filed: May 7, 2012
    Publication date: August 30, 2012
    Applicants: UWM RESEARCH FOUNDATION, INC., MARQUETTE UNIVERSITY
    Inventors: James M. Cook, David A. Baker, Wenyuan Yin, Edward Merle Johnson, II
  • Passive Ankle Prosthesis with Energy Return Simulating That of a Natural Ankle
    Publication number: 20120203359
    Abstract: Disclosed are passive lower limb prosthetic devices comprising at least a two degree of freedom mechanism and a network of compression springs.
    Type: Application
    Filed: February 3, 2012
    Publication date: August 9, 2012
    Applicant: Marquette University
    Inventors: Joseph M. Schimmels, Shuguang Huang
  • Cysteine and cystine prodrugs to treat schizophrenia and reduce drug cravings
    Patent number: 8173809
    Abstract: The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction. Exemplary prodrugs include the cysteine compound having the formula as well as cystine dimers thereof.
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: May 8, 2012
    Assignees: Marquette University, UWM Research Foundation, Inc.
    Inventors: James M. Cook, David A. Baker, Wenyuan Yin, Edward Merle Johnson, II
  • Bioaugmentation of Anaerobic Digester Systems
    Publication number: 20110244541
    Abstract: Disclosed herein are methods for improving performance of an anaerobic digester system. The methods typically include adding a culture comprising hydrogenotrophic methanogens to the system, otherwise referred to as bioaugmentation.
    Type: Application
    Filed: April 4, 2011
    Publication date: October 6, 2011
    Applicant: MARQUETTE UNIVERSITY
    Inventor: Daniel Zitomer
  • Preservation of Methanogenic, Hydrogen-Utilizing Microbial Cultures
    Publication number: 20110244540
    Abstract: Disclosed are drying methods for preserving cultures of methanogens and dried cultures obtained by the disclosed drying methods. The dried cultures of methanogens may be reconstituted and utilized to bioaugment anaerobic digester systems.
    Type: Application
    Filed: April 4, 2011
    Publication date: October 6, 2011
    Applicant: MARQUETTE UNIVERSITY
    Inventor: Daniel Zitomer
  • Low-Field Magnetic Domain Wall Injection Pad and High-Density Storage Wire
    Publication number: 20110111259
    Abstract: Disclosed herein are magnetic storage devices and uses therefor. The devices comprise an injection pad and a nanowire extending from an outer edge of the injection pad. The injection pad and the nanowire of the disclosed magnetic storage devices have a geometry that is designed to optimize high density memory storage via low magnetic field domain wall shifting. The devices may be utilized, for example, for generating and storing magnetic domain walls for application in memory devices, sensor devices, and logic devices.
    Type: Application
    Filed: November 12, 2010
    Publication date: May 12, 2011
    Applicant: MARQUETTE UNIVERSITY
    Inventor: Andrew Kunz
  • CYSTEINE PRODRUGS TO TREAT SCHIZOPHRENIA AND DRUG ADDICTION
    Publication number: 20110021533
    Abstract: The present invention provides cysteine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.
    Type: Application
    Filed: October 4, 2010
    Publication date: January 27, 2011
    Applicants: Marquette University, University of Wisconsin- Milwaukee
    Inventors: James M. Cook, David A. Baker, Edward Merle Johnson, III, Wenyuan Yin
  • Quenched Fluorophores Conjugated to Peptides Via Linkers Containing Dithio Groups
    Publication number: 20100317119
    Abstract: Disclosed are dithio compounds that include a quenched fluorophore and a non-fluorophore peptide linked via a dithio bond to the fluorophore. The dithio compounds may be used in methods for detecting thiol-containing compounds or dithio-containing compounds. The dithio compounds also may be used as cellular probes where the peptide portion of the compounds targets the compounds to a specific cellular location.
    Type: Application
    Filed: June 15, 2010
    Publication date: December 16, 2010
    Applicant: MARQUETTE UNIVERSITY
    Inventor: Daniel S. Sem
  • Modulation of KCNQ Potassium Channel Activity for Treatment of Psychiatric Disorders and the Symptoms Thereof
    Publication number: 20100310681
    Abstract: Disclosed herein are compositions and methods for treating a psychiatric disorder or symptoms thereof in a patient. The compositions comprise a compound that modulates KCNQ (Kv7) potassium channel activity and the methods include administering an effective amount of the compound that modulates KCNQ (Kv7) potassium channel activity.
    Type: Application
    Filed: June 3, 2010
    Publication date: December 9, 2010
    Applicant: MARQUETTE UNIVERSITY
    Inventor: Mohammadhossein Behnam Ghasemzadeh
  • Chemical Fragment Screening and Assembly Utilizing Common Chemistry for NMR Probe Introduction and Fragment Linkage
    Publication number: 20100305326
    Abstract: Disclosed herein are methods related to drug development. The methods typically include steps whereby two chemical fragments are identified as binding to a target protein and subsequently the two chemical fragments are joined to create a new chemical entity that binds to the target protein.
    Type: Application
    Filed: June 2, 2010
    Publication date: December 2, 2010
    Applicant: Marquette University
    Inventor: Daniel S. Sem
  • Chemical Proteomic Assay for Optimizing Drug Binding to Target Proteins
    Publication number: 20100304998
    Abstract: Disclosed herein are methods related to drug development. The methods typically include steps whereby an existing drug is modified to obtain a derivative form or whereby an analog of an existing drug is identified in order to obtain a new therapeutic agent that preferably has a higher efficacy and fewer side effects than the existing drug.
    Type: Application
    Filed: June 2, 2010
    Publication date: December 2, 2010
    Applicant: MARQUETTE UNIVERSITY
    Inventor: Daniel S. Sem
  • Cysteine prodrugs to treat schizophrenia and drug addiction
    Patent number: 7829709
    Abstract: The present invention provides cysteine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: November 9, 2010
    Assignees: Marquette University, University of Wisconsin - Milwaukee
    Inventors: James M. Cook, David A. Baker, Edward Merle Johnson, II, Wenyuan Yin
  • Dithio compounds
    Patent number: 7820833
    Abstract: Disclosed herein are dithio compounds that include at least one fluorophore. The compounds additionally may include a different fluorophore or a non-fluorophore. The dithio compounds may be used as reagents for detecting thiol-containing compounds.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: October 26, 2010
    Assignee: Marquette University
    Inventors: Daniel S. Sem, Phani Kumar Pullela
  • Methods for detecting thiol-containing nucleotide diphosphates with thiol-reactive fluorescent reagents
    Patent number: 7807399
    Abstract: Disclosed are methods for detecting thiol-containing nucleotide diphosphates. The methods utilize thiol-reactive fluorescent reagents.
    Type: Grant
    Filed: July 13, 2009
    Date of Patent: October 5, 2010
    Assignee: Marquette University
    Inventor: Daniel S. Sem
  • Modified dental prosthesis
    Patent number: 7781531
    Abstract: Phosphate-containing co-polymers useful for making denture bases, denture liners and tissue conditioners with phosphate anion-charged surfaces are disclosed. The phosphate anions enable the denture bases, denture liners and tissue conditioners to adsorb cationic antimicrobial molecules. Dentures, denture bases materials, denture liners and tissue conditioners made of the above co-polymers are also disclosed. Further disclosed are methods for synthesizing the co-polymer(s) and for making the denture bases, denture liners and tissue conditioners.
    Type: Grant
    Filed: September 26, 2007
    Date of Patent: August 24, 2010
    Assignee: Marquette University
    Inventors: Antony R. Periathamby, Andrew R. Dentino
  • CYSTEINE AND CYSTINE BIOISOSTERES TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS
    Publication number: 20100048587
    Abstract: The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.
    Type: Application
    Filed: April 16, 2009
    Publication date: February 25, 2010
    Applicants: Marquette University, University of Wisconsin - Milwaukee
    Inventors: James M. Cook, David A. Baker, Wenyuan Yin, Edward Merle Johnson, II
  • Methods for Detecting Thiol-Containing Nucleotide Diphosphates with Thiol-Reactive Fluorescent Reagents
    Publication number: 20090325179
    Abstract: Disclosed are methods for detecting thiol-containing nucleotide diphosphates. The methods utilize thiol-reactive fluorescent reagents.
    Type: Application
    Filed: July 13, 2009
    Publication date: December 31, 2009
    Applicant: Marquette University
    Inventor: Daniel S. Sem
  • Method for detecting kinase activity with thiol reactive fluorescent reagents
    Patent number: 7585643
    Abstract: Disclosed are assays useful for detecting kinase activity. The assays utilize thiol-reactive fluorescent reagents and include reacting a reaction mixture that contains an ATP analog such as ATP?S to form an ADP analog such as ADP?S if kinase activity is present in the reaction mixture. The ADP analog reacts with the thiol-reactive fluorescent reagent and the reagent exhibits a change in fluorescence, thereby indicating that kinase activity is present in the reaction mixture.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: September 8, 2009
    Assignee: Marquette University
    Inventor: Daniel S. Sem