Patents Assigned to Nihon University
-
Patent number: 11733131Abstract: The present invention is to provide a tissue slice selection method and an embedded block-preparing cassette which are capable of suppressing occurrence of errors in inspection results. The present invention makes it possible to suppress the occurrence of errors in inspection results by including: an embedded block-preparing process of preparing an embedded block by embedding both a biological tissue fragment and a standard substance in the same embedding agent; an embedded tissue slice preparing step of slicing the embedded block to prepare a sheet-like embedded tissue slice having a tissue slice and standard substance slices appearing on a surface thereof; and a tissue slice selecting step of selecting the tissue slice to be inspected, based on a light signal from the standard substance slice.Type: GrantFiled: April 27, 2018Date of Patent: August 22, 2023Assignees: NIHON UNIVERSITY, NICHIREI BIOSCIENCES INC.Inventors: Shinobu Masuda, Ryohei Suzuki, Yuriko Kitano
-
Publication number: 20220378752Abstract: The present invention has an object of providing a composition that is effective for the treatment of a prototheca disease. According to the present invention, a composition containing ravuconazole as an active ingredient, which is administered to an animal suffering from a prototheca disease caused by Prototheca wickerhamii or Prototheca zopfii, is provided.Type: ApplicationFiled: July 9, 2020Publication date: December 1, 2022Applicants: SEREN PHARMACEUTICALS INC., NIHON UNIVERSITYInventors: Rui KANO, Osamu OGAWA
-
Publication number: 20220361832Abstract: A panoramic X-ray imaging apparatus includes: an X-ray generating unit; an X-ray detecting unit; a support that supports the X-ray generating unit and the X-ray detecting unit; a drive mechanism that turns at least the X-ray generating unit and the X-ray detecting unit by driving the support; a displacement mechanism that adds movement including a displacement component in a direction different from the turning to the X-ray detecting unit; a subject holding unit that holds an imaging subject; a turning controller that controls the turning by a drive mechanism and the displacement mechanism. The turning controller controls the drive mechanism and the displacement mechanism so as to add the movement avoiding the contact with the shoulder of the imaging subject during the turning of the X-ray generating unit and the X-ray detecting unit by the drive mechanism during the panoramic X-ray imaging.Type: ApplicationFiled: May 4, 2022Publication date: November 17, 2022Applicants: NIHON UNIVERSITY, J. MORITA MANUFACTURING CORPORATIONInventors: Yoshinori ARAI, Hideki YOSHIKAWA
-
Patent number: 11488305Abstract: A learning model provided in a segmentation device is a learning model which is generated using training data such that segmentation data of a biologically important region is output when data of a constituent maxillofacial region is input.Type: GrantFiled: October 6, 2020Date of Patent: November 1, 2022Assignees: NIHON UNIVERSITY, J. MORITA MFG. CORP.Inventors: Yoshinori Arai, Yuu Nishimura, Hideki Yoshikawa, Tomoyuki Sadakane
-
Patent number: 11472109Abstract: A three-dimensional printing apparatus (1) allowing a linear filament (F) in which a fiber bundle (C) is impregnated with resin (P) to be continuously ejected includes twisting means (6) for allowing a total amount of twisting of the filament (F) or an amount of twisting of the fiber bundle (C) to be changed.Type: GrantFiled: February 13, 2018Date of Patent: October 18, 2022Assignees: NIHON UNIVERSITY, TOKYO UNIVERSITY OF SCIENCE FOUNDATIONInventors: Masahito Ueda, Ryosuke Matsuzaki, Yoshiyasu Hirano
-
Publication number: 20220235331Abstract: A method of producing induced pluripotent stem cells including a step for introducing an initialization factor into somatic cells of a mammal, and culturing in a neural stem cell culture medium to obtain induced neural stem cell-like cells, and a step for cultivating said induced neural stem cell-like cells in a growth medium to obtain induced pluripotent stem cells, wherein the initialization factor contains an OCT family, a SOX family, a KLF family, a MYC family, a LIN28 family and a P53 function inhibitor.Type: ApplicationFiled: April 17, 2020Publication date: July 28, 2022Applicants: Keio University, Nihon UniversityInventors: Hideyuki Okano, Seiji Shiozawa, Sho Yoshimatsu, Kazuya Edamura, Aozora Iguchi
-
Publication number: 20220213525Abstract: A nucleic acid detection kit including: (i) a first single-stranded circular DNA; (ii) a first oligonucleotide primer; (iii) a second single-stranded circular DNA; and (iv) a second oligonucleotide primer; wherein the first oligonucleotide primer is hound to a carrier through the 5?-end thereof, and the second oligonucleotide primer is bound, through the 5?-end thereof, to the carrier to which the first oligonucleotide primer is hound.Type: ApplicationFiled: April 16, 2020Publication date: July 7, 2022Applicant: Nihon UniversityInventors: Masayasu KUWAHARA, Hiroto FUJITA
-
Publication number: 20220142987Abstract: An object of the present invention is to provide an antifungal agent which is effective against cryptococcosis. The present invention provides an antifungal agent comprising ravuconazole as an active ingredient, wherein the agent is administered to an animal suffering from cryptococcosis. Further, the present invention provides an antifungal agent comprising ravuconazole as an active ingredient, wherein the agent is administered to an animal suffering from cryptococcus that is resistant to triazole-based antifungal agents selected from the group consisting of fluconazole, itraconazole and voriconazole.Type: ApplicationFiled: April 6, 2020Publication date: May 12, 2022Applicants: SEREN PHARMACEUTICALS INC., NIHON UNIVERSITYInventors: Rui Kano, Osamu Ogawa
-
Patent number: 11299699Abstract: A culture container includes: a culture container body; a partition plate disposed in the vicinity of a bottom of the culture container body to face the bottom so that a culture region is formed as a culture region between the partition plate and the bottom; and a sample inlet/outlet provided in the culture container body, the culture region and the sample inlet/outlet communicating with each other via an opening formed adjacent to one end of the partition plate. With the culture container and a culture method using this container, a large amount of adipocytes can be cultured at one time with easy handling. Dedifferentiation of a large amount of adipocytes and removal of cells having failed to dedifferentiate can be efficiently accomplished.Type: GrantFiled: November 1, 2016Date of Patent: April 12, 2022Assignee: NIHON UNIVERSITYInventors: Taro Matsumoto, Tomohiko Kazama, Kazuhiro Hagikura
-
Publication number: 20220013332Abstract: A magnetized plasmoid injection device including a cylindrical external electrode, a cylindrical internal electrode coaxially disposed inside the external electrode, a plasma generating gas supply unit that supplies plasma generating gas in a pulse shape between the external electrode and the internal electrode, a magnetic field generation unit that applies a magnetic field that generates magnetized plasmoid between the external electrode and the internal electrode, a power supply control unit that applies a discharge voltage between the external electrode and the internal electrode, and an impurity generation unit that contains an impurity in the magnetized plasmoid, the impurity generation unit having a cover electrode that opens to the external electrode, a thin-rod electrode that is located inside the cover electrode and is formed of an impurity, and an impurity generation power supply that applies a voltage to the cover electrode and the thin-rod electrode.Type: ApplicationFiled: October 30, 2019Publication date: January 13, 2022Applicant: Nihon UniversityInventors: Tomohiko Asai, Daichi Kobayashi, Taichi Seki
-
Publication number: 20210393660Abstract: There is provided with a method of treating cancer. A set of administration of a compound represented by General Formula (I) or a pharmaceutically acceptable salt thereof to a patient, at a dose such that 8 mg/kg or less of the compound represented by General Formula (I) is administered, and irradiation to the patient immediately following the administration is repeated. A total dosage of the irradiation to a cancer is 10 Gy or more.Type: ApplicationFiled: September 3, 2021Publication date: December 23, 2021Applicants: M.T.3, Inc., NIHON UNIVERSITY, SCHOOL CORPORATION, AZABU VETERINARY MEDICINE EDUCATIONAL INSTITUTIONInventors: Hiroeki SAHARA, Tomohiro NAKAYAMA, Takuya MARUO
-
Patent number: 11109752Abstract: A dental caries diagnosis device comprising a light source which is configured to emit examination light (R) and a light receiving unit (4f) which is configured to receive the examination light (R) with which a tooth has been irradiated includes: a head-side casing (4a1) which is inserted into a mouth in a contactless manner with respect to a tooth or a gum and which projects the examination light (R) toward a tooth; and a filter (4e) which is disposed in front of the light receiving unit (4f) and which is configured to remove a noise component from the received light, wherein the light receiving unit (4f) is configured to receive the examination light (R) which has been transmitted through the tooth.Type: GrantFiled: June 5, 2017Date of Patent: September 7, 2021Assignee: NIHON UNIVERSITYInventor: Takashi Kaneda
-
Patent number: 11104120Abstract: A three-dimensional printing system (1) includes: a head (2) to which a first continuous material (FL) including a resin and a second continuous material (FB) including fibers are fed; a platform (3) on which a printing material based on the first and second continuous materials from the head is stacked; a cutting device (10) which is capable of cutting at least fibers; and a controller (5) which controls an operation device including at least one of the head, the platform, and the cutting device.Type: GrantFiled: May 27, 2015Date of Patent: August 31, 2021Assignees: Nihon University, Tokyo University of Science FoundationInventors: Masahito Ueda, Yoshiyasu Hirano, Ryosuke Matsuzaki
-
Patent number: 11090318Abstract: A pharmaceutical preparation efficaciously promotes tissue wound repair. The wound repair promoter according to the present invention includes at least one active ingredient selected from the group consisting of compounds represented by Formula (1), salts of the compounds, and hydrates of the compounds or the salts. In the formula, R1 and R2 are each, identically or differently, selected from hydrogen and a hydrocarbon group optionally having one or more substituents selected from the group consisting of halogens, —COOR3, —CONR32, —COR3, —CN, —NO2, —NHCOR3, —OR3, —SR3, —OCOR3, —SO3R3, and —SO2NR32, where R3 is, identically or differently in each occurrence, selected from hydrogen and an optionally substituted aliphatic hydrocarbon group; and n represents an integer of 1 or more.Type: GrantFiled: April 13, 2018Date of Patent: August 17, 2021Assignees: NAHIS CORPORATION CO., LTD., NIHON UNIVERSITY, RIKENInventors: Ryuzo Yoshioka, Yoko Tanaka, Manabu Yaguchi, Takashi Tanaka
-
Patent number: 10961353Abstract: The invention provides a novel polymer, a composition, and a molded article. The polymer contains a constitutional unit represented by the following formula (1): wherein X11 and X12 are the same as or different from each other, and are each a hydrogen atom, an alkyl group optionally containing a fluorine atom, or a phenyl group; Y11 is an oxygen atom or a sulfur atom; Rf11 is a hydrogen atom or an alkyl group optionally containing a fluorine atom; and a is an integer of 1 to 4.Type: GrantFiled: December 8, 2017Date of Patent: March 30, 2021Assignees: DAIKIN INDUSTRIES, LTD., NIHON UNIVERSITYInventors: Tsuyoshi Noguchi, Fumihiro Kamiya, Tadashi Kanbara, Nobukatsu Nemoto
-
Patent number: 10829903Abstract: A device for calculating construction assistance information includes: an acquisition unit that acquires, from a vibratory hammer construction machine, information that contains at least values indicating a eccentricity force of a vibratory hammer which the vibratory hammer construction machine imparts to a construction object, the number of impacts, and a depth of penetration of the construction object; and a calculation unit that calculates a accumulated impact force indicating a work load of construction on the basis of the information acquired by the acquisition unit.Type: GrantFiled: March 10, 2016Date of Patent: November 10, 2020Assignees: NIHON UNIVERSITY, Marufuji Sheet Piling Co., Ltd.Inventors: Shuichi Shimomura, Masaki Nakai, Yasuo Sato
-
Publication number: 20200347458Abstract: The object of the present invention is to provide a method for determining the sensitivity of a subject to an SGLT2 inhibitor, and a sensitivity marker for the SGLT2 inhibitor. The present invention provides a method for determining the sensitivity of a subject to an SGLT2 inhibitor, comprising measuring a biomarker in the biological sample of a subject, and determining the sensitivity of the subject to the SGLT2 inhibitor using the measured biomarker value as an indicator.Type: ApplicationFiled: February 24, 2020Publication date: November 5, 2020Applicants: NIHON UNIVERSITY, OSAKI CITY, NIPPON KAYAKU KABUSHIKI KAISHAInventors: Tadateru TAKAYAMA, Masahiro USUI, Keiko KUDO
-
Patent number: 10813605Abstract: A first position setting unit receives an operation to designate a position in a mesiodistal on a panoramic tomographic image displayed on a display, and sets a first position on a curved section based on the designation operation. The fluoroscopic imaging information providing unit provides information irradiating a subject with an X-ray beam along a direction having a component of a tangential direction at the first position of the curved section to execute fluoroscopic imaging acquiring a fluoroscopic image to a main body. A second position setting unit receives an operation to designate a position in a buccolingual direction on the fluoroscopic image displayed on the display, and sets a second position in the buccolingual direction based on the designation operation.Type: GrantFiled: August 20, 2018Date of Patent: October 27, 2020Assignees: J. MORITA MANUFACTURING CORPORATION, NIHON UNIVERSITYInventors: Yoshinori Arai, Hideki Yoshikawa
-
Patent number: 10779792Abstract: A medical X-ray CT imaging apparatus includes an X-ray generator that generates a cone beam, an X-ray detector, a support that supports the X-ray generator and the X-ray detector while the X-ray generator and the X-ray detector are opposed to each other, a turning drive unit that turns the X-ray generator and the X-ray detector, which are supported by the support, an imaging information receiving unit, and an X-ray output condition setting unit. The imaging information receiving unit receives an imaging area setting relating to at least one of a size of an imaging area, an imaging purpose, and an imaging region. The X-ray output condition setting unit automatically sets an output condition of the X-ray generator according to at least one of the size of the imaging area, the imaging purpose, and the imaging region, which are received by the imaging information receiving unit.Type: GrantFiled: October 26, 2018Date of Patent: September 22, 2020Assignees: J. MORITA MANUFACTURING CORPORATION, NIHON UNIVERSITYInventors: Yoshinori Arai, Yoshito Sugihara, Tomoyuki Sadakane
-
Patent number: 10696898Abstract: A reverse photochromic compound of the related art has difficulty in sensing light with a wavelength of 600 nm or greater in a visible light region which has been used for medical applications. Therefore, an object of the present invention is to provide a reverse photochromic compound and a polymer which have a high sensitivity to light having a wavelength of 600 nm or greater. The present invention relates to a compound and the like represented by the following general formula (1).Type: GrantFiled: January 31, 2018Date of Patent: June 30, 2020Assignees: FUJIFILM Wako Pure Chemical Corporation, NIHON UNIVERSITYInventors: Ryuzi Katoh, Masami Enoki, Kazuki Nemoto, Katsufumi Suzuki, Tetsuji Murase, Shigeaki Imazeki