Abstract: Transcriptional regulatory regions and transcriptional regulatory factors for the human high affinity IgE receptor (Fc?RI) ?-chain gene are specified and are targets for the development of transcriptional regulatory agents for the Fc?RI ?-chain gene. The following are provided: DNA comprising the full length or a portion of the base sequence shown in SEQ ID NO:1, that regulates transcription of the human high affinity IgE receptor (Fc?RI) ?-chain gene; and DNA comprising the full length or a portion of the base sequence shown in SEQ ID NO:2, that regulates transcription of the human high affinity IgE receptor (Fc?RI) ?-chain gene. The present invention is promising for the development of novel agents for the prophylaxis/treatment of allergic diseases, autoimmune diseases, thrombosis, glomerulonephritis, and lupus nephritis.

Abstract: [Object] It is to raise operational frequency and S/N ratio of the pulsed homodyne detector to measure the quadrature amplitude of the signal pulse light. [Solution] The local pulse light in telecom band is yielded at repetition rate of 80 MHz. Two output lights are generated by interference of the local pulse light and the signal pulse light. The first photodiode and the second photodiode are connected differentially. The first photodiode converts one side output light to an electric signal. The second photodiode converts the other side output light to another electric signal. The M-derived low-pass filter eliminates the third harmonics of the local pulse light. Moreover, the higher frequency components than triple frequency of the repetition rate are eliminated. In this way, even when it is operated at high repetition rate of 80 MHz at maximum, the quadrature amplitude of the signal pulse light can be measured with high quantum efficiency of about 90% and with S/N ratio of more than 10 dB.

Abstract: A method of detecting Streptococcus pneumoniae, which is characterized in that it comprises amplifying a lytA gene derived from S. pneumoniae using a LAMP primer set comprising at least one primer having a nucleotide sequence that is identical to or complementary to a partial sequence in the region ranging from bp 40 to 450 of the nucleotide sequence region of the above-described lytA gene, and then detecting the obtained amplified product.

Abstract: The present invention is directed to a dendritic polyamidoamine phthalocyanine derivative which is useful as, for example, a fluorescent material or a photodynamic therapeutic drug for cancer. The derivative is represented by the following formula (1): (wherein each member of one to eight of R1 to R8 is a polyamidoamine dendron represented by the following formula (a): (wherein p is a number from 1 to 4; R9 represents —NH(CH2)tNH2 or OR10 (wherein R10 represents an alkyl group); and each of l, m, q, and t is a number from 1 to 8), and each member of the remainder represents a hydrogen atom; M represents a metal atom having a valency of two or more; and a ring marked with (N) is a benzene ring, a pyridine ring, or a pyrazine ring).

Abstract: A metamorphopsia simulator is capable of numerically simulating deformation of the retina of a metamorphopsia patient and irregularity in an arrangement of visual cells caused thereby. The metamorphopsia simulator of the present invention uses a method of digitizing a deformation amount of the retina according to an expression based on a probability density function, to find a movement amount of visual cells, and according to the movement amount of visual cells, find distortion of an image observed by the metamorphopsia patient.

Abstract: A method for testing dysgeusia, which is characterized in that it comprises amplifying at least a portion of a gene encoding a taste receptor belonging to the THTR family and a gene encoding a taste receptor belonging to the T2R family collected from a sample derived from the oral cavity; a primer used for the above amplification; and a kit used for the above test.

Abstract: The present invention provides: a method for testing zinc deficiency dysgeusia, which is characterized in that it comprises correlating the expression levels of a gene encoding a gustatory receptor belonging to the THTR family and a gene encoding a gustatory receptor belonging to the T2R family obtained from a sample derived from the oral cavity of a subject, with a serum zinc level obtained from the sample of the subject; and a kit used for the aforementioned test.

Abstract: A material hardness distribution display system (10) includes a probe unit (20) in which a plurality of probe elements (22) are two-dimensionally arranged. Each of the probe elements (22) has an oscillator (26) for introducing oscillation into a biological tissue and an oscillation detection sensor (28) which detects a reflected wave. The probe elements (22) are successively selected by a switch circuit (50) and connected to a hardness calculation unit (70) and a measurement depth calculation unit (82). The hardness calculation unit (70) executes a frequency component analysis for an incident wave signal to the oscillator (26) and a reflected wave signal from the oscillation detection sensor (28) to calculate the hardness of the biological tissue on the basis of the analysis results.

Abstract: Disclosed is a structural material using novel, high-purity aluminum, which is produced by using fine aluminum powder as the material, as well as a method for manufacturing such structural material. A processed aluminum material having the properties of an aluminum structural material constituted by aluminum, aluminum carbide and unavoidable impurities except aluminum and aluminum carbide is characterized in that a material obtained by uniformly dispersing stearic acid in fine aluminum powder is filled in an L-shaped bent die, and pressures are applied to the material from one direction and the other direction of the die wherein the pressure applied to the material from the one direction of the die is greater than the pressure applied to the material from the other direction of the die, to cause the material to pass through a hole of the L-shaped bent die so that the material is given and accumulates giant strain, and this process is performed continuously.

Abstract: It is directed to provide a novel apoptosis inhibitor. Specifically directed is an apoptosis inhibitor containing a biphenylcarboxamide compound represented by the following formula (1) as an active ingredient, wherein R1 represents a hydrogen atom or a lower alkoxy group; R2 represents a hydrogen atom or a lower alkanoyl group; and n represents a number of 2 to 5.

Abstract: The present invention provides a target gene-specific histone modification regulator, which comprises a conjugate between a histone modification regulator and a polyamide capable of recognizing a regulatory region in a target gene. This enables the provision of a target gene-specific histone modification regulator.

Abstract: There is disclosed a method of synthesizing a quinoxaline derivative in which toxicity, corrosiveness and permeation are low and which is excellent in safety and which attains a reduced reaction time, a greatly improved yield and excellent economical efficiency. The object is achieved by a method of synthesizing a quinoxaline derivative which comprises adsorbing a benzofuroxan derivative and a ?-diketone derivative on a solid support, and then heating the derivatives in a solid state by microwave irradiation to dehydrocyclize them.

Abstract: The present invention is to provide a communication network designing method based on an actual condition of social network structured on a communication network, a communication network designing program, and a recording medium on which the program is recorded. A communication network designing method executed by a communication network designing apparatus which is connected to a communication network in which a plurality of communication terminals are connected to each other and which designs the communication network is characterized in that a social network formed on the communication network is analyzed, and the communication network is designed on the basis of the analysis result.

Abstract: N (integer equal to or above 3) quaternary phase shift keying (QPSK) outputs having different amplitude levels, i.e., r2=r1×2?(i?1), i=2 . . . N with respect to a maximum amplitude level r1 are superposed after power amplification to form M(=22N)-valued/quadrature amplitude modulation (QAM), and N-1 outputs si except the quaternary phase shift keying QPSK-1 having the maximum amplitude r1 are subjected to power amplification in this formation, then the outputs are combined by a directional coupler to obtain a combined signal, and an output of the quaternary phase shift keying QPSK-1 and the combined signal are transmitted from two systems of antennas to be vectorially superposed and combined in a space.

Abstract: An implanter is provided, which enables rebuilding of an interdental papilla with a simple method. An implanter 1 is made up of a T-shaped steel member as a main body. The lateral side portions centering a web portion 2 in a flange portion 3 are inclined so as to be closer to the web portion 2 with respect to a plane perpendicular to the web portion 2, to provide an angular shape, with its peak residing in a portion joining with the web portion. A plurality of holes 4 large enough for gingival fibers to thrust in are opened in the flange portion 3. One or more embedding portions 5 are projected from a tip end portion (lower end portion) of the web portion 2. Each of the embedding portions 5 has a tip end portion with at least an acute shape, or a shape that enables embedding by being driven into alveolar bone 10.

Abstract: The present invention provides a method for evaluating cancer, which comprises the following steps of: (a) collecting total RNA from an analyte; (b) measuring the expression level of at least one gene selected from among the genes shown in Tables 1 to 8; and (c) evaluating cancer using the measurement result as an indicator.

Abstract: It is intended to provide means capable of specifically recognizing CRP in a test sample and assaying it with high sensitivity. The present invention provides an anti-CRP antibody which reacts with a C-reactive protein (hereinafter referred to as CRP) and recognizes an epitope located at residues 147 to 172 in a CRP amino acid sequence represented by SEQ ID NO: 1.

Abstract: The present invention provides a method of detecting Haemophilus influenzae, which enables accurate and rapid detection of H. influenzae, a primer set for detecting H. influenzae, and a kit for detecting H. influenzae. Nucleic acid amplification is carried out using the DNA of H. influenzae as a template, and also using the LAMP primers as shown in SEQ ID NOS: 1 to 5 given as examples of the present invention. Thus, the presence or absence of the amplified product is detected. When primers having sequences that are complementary to the sequences as shown in SEQ ID NOS: 1 to 5 are used, such primers are excellent in terms of detection sensitivity and promptness of detection, as well as specificity. In addition, as another example of the present invention, nucleic acid amplification is carried out using LAMP primers as shown in SEQ ID NOS: 43 to 47, and the presence or absence of the amplified product is detected. Thereby, H.

Abstract: A TGF-? gene expression inhibitor containing a pyrrole-immidazole polyamide comprising an N-methylpyrrole unit (hereinafter also referred to as Py), an N-methylimidazole unit (hereinafter also referred to as Im) and a ?-aminobutyric acid unit which can be folded into an U-shaped conformation at the above-described ?-aminobutyric acid unit site in a minor groove of a double-stranded region (hereinafter referred to as the target region) containing a part or the whole of the following base sequence (SEQ ID NO: 2) corresponding to ?450 to ?310 of human transforming growth factor ?1 (hereinafter also referred to as h TGF-?1) promoter and a strand complementary thereto and in which a Py/Im pair, an Im/Py pair and a PY/Py pair correspond respectively to a C-G base pair, a G-C base pair and an A-T base pair and a T-A base pair.

Abstract: A human spinal column measuring and displaying system includes a spinal column measuring apparatus capable of measuring bending or a circumflex (twist) angle of the spinal column of the human body as a detaching amount measuring data from a reference value, an input apparatus for inputting gender, height data of the measurement subject, an image processing apparatus for inputting the detaching amount measuring data from the spinal column measuring apparatus and data from the input apparatus and generating a three-dimensional spinal column image of the measurement subject based on the detaching amount measuring data and the gender, height data of the measurement subject, and a display apparatus for displaying an image data from the image processing apparatus.