Patents Assigned to Nihon University
-
Patent number: 10696898Abstract: A reverse photochromic compound of the related art has difficulty in sensing light with a wavelength of 600 nm or greater in a visible light region which has been used for medical applications. Therefore, an object of the present invention is to provide a reverse photochromic compound and a polymer which have a high sensitivity to light having a wavelength of 600 nm or greater. The present invention relates to a compound and the like represented by the following general formula (1).Type: GrantFiled: January 31, 2018Date of Patent: June 30, 2020Assignees: FUJIFILM Wako Pure Chemical Corporation, NIHON UNIVERSITYInventors: Ryuzi Katoh, Masami Enoki, Kazuki Nemoto, Katsufumi Suzuki, Tetsuji Murase, Shigeaki Imazeki
-
Publication number: 20200149999Abstract: The present invention is to provide a tissue slice selection method and an embedded block-preparing cassette which are capable of suppressing occurrence of errors in inspection results. The present invention makes it possible to suppress the occurrence of errors in inspection results by including: an embedded block-preparing process of preparing an embedded block by embedding both a biological tissue fragment and a standard substance in the same embedding agent; an embedded tissue slice preparing step of slicing the embedded block to prepare a sheet-like embedded tissue slice having a tissue slice and standard substance slices appearing on a surface thereof; and a tissue slice selecting step of selecting the tissue slice to be inspected, based on a light signal from the standard substance slice.Type: ApplicationFiled: April 27, 2018Publication date: May 14, 2020Applicants: NIHON UNIVERSITY, NICHIREI BIOSCIENCES INC.Inventors: Shinobu MASUDA, Ryohei SUZUKI, Yuriko KITANO
-
Publication number: 20200121700Abstract: A pharmaceutical preparation efficaciously promotes tissue wound repair. The wound repair promoter according to the present invention includes at least one active ingredient selected from the group consisting of compounds represented by Formula (1), salts of the compounds, and hydrates of the compounds or the salts. In the formula, R1 and R2 are each, identically or differently, selected from hydrogen and a hydrocarbon group optionally having one or more substituents selected from the group consisting of halogens, —COOR3, —CONR32, —COR3, —CN, —NO2, —NHCOR3, —OR3, —SR3, —OCOR3, —SO3R3, and —SO2NR32, where R3 is, identically or differently in each occurrence, selected from hydrogen and an optionally substituted aliphatic hydrocarbon group; and n represents an integer of 1 or more.Type: ApplicationFiled: April 13, 2018Publication date: April 23, 2020Applicants: NAHLS CORPORATION CO., LTD., NIHON UNIVERSITY, RIKENInventors: Ryuzo YOSHIOKA, Yoko TANAKA, Manabu YAGUCHI, Takashi TANAKA
-
Publication number: 20200055993Abstract: The invention provides a novel polymer, a composition, and a molded article. The polymer contains a constitutional unit represented by the following formula (1): wherein X11 and X12 are the same as or different from each other, and are each a hydrogen atom, an alkyl group optionally containing a fluorine atom, or a phenyl group; Y11 is an oxygen atom or a sulfur atom; Rf11 is a hydrogen atom or an alkyl group optionally containing a fluorine atom; and a is an integer of 1 to 4.Type: ApplicationFiled: December 8, 2017Publication date: February 20, 2020Applicants: DAIKIN INDUSTRIES, LTD., NIHON UNIVERSITYInventors: Tsuyoshi NOGUCHI, Fumihiro KAMIYA, Tadashi KANBARA, Nobukatsu NEMOTO
-
Publication number: 20190381469Abstract: A temperature-responsive hydrogel exhibiting a high viscosity at a high temperature, a low viscosity at a low temperature and a high ratio of the viscosity at a high temperature to the viscosity at a low temperature produced by mixing of an aqueous solution containing a polyalkylene glycol having an average molecular weight of 20,000 to 10,000,000 with an aqueous dispersion containing a silicate salt so as to achieve a specific compositional range of the components in the hydrogel, at a mass concentration of A of 0.01 to 1.5% by mass, at a mass concentration of A of 0.1 to 0.4% by mass and at a mass concentration of B of 0.5 to 10% by mass, at a mass concentration of B of 1 to 5% by mass, with the mass ratio R of A to B (R=(mass of A)/(mass of B)) within the range of 0.01 to 0.5.Type: ApplicationFiled: March 2, 2018Publication date: December 19, 2019Applicants: Nissan Chemical Corporation, NIHON UNIVERSITYInventors: Yoshihiro KUDO, Kazutoshi HARAGUCHI
-
Publication number: 20180320123Abstract: A culture container includes: a culture container body; a partition plate disposed in the vicinity of a bottom of the culture container body to face the bottom so that a culture region is formed as a culture region between the partition plate and the bottom; and a sample inlet/outlet provided in the culture container body, the culture region and the sample inlet/outlet communicating with each other via an opening formed adjacent to one end of the partition plate. With the culture container and a culture method using this container, a large amount of adipocytes can be cultured at one time with easy handling. Dedifferentiation of a large amount of adipocytes and removal of cells having failed to dedifferentiate can be efficiently accomplished.Type: ApplicationFiled: November 1, 2016Publication date: November 8, 2018Applicant: NIHON UNIVERSITYInventors: Taro MATSUMOTO, Tomohiko KAZAMA, Kazuhiro HAGIKURA
-
Patent number: 10076291Abstract: The present invention has an object of providing an X-ray CT imaging device which can direct X-ray to an area of interest appropriately even when, for example, the height of the area of interest with respect to the X-ray detector, which is revolving, varies with respect to the revolution direction, and thus can reduce the amount of unnecessary exposure to the X-ray and can perform X-ray imaging of the area of interest with certainty. In an X-ray CT imaging device for performing X-ray CT imaging of a CT imaging area of a subject, during the X-ray CT imaging when a revolving arm is revolving, the expansion in a length direction of an X-ray cone beam, which is to be restricted by length direction blocking plates, is adapted to the shape of the CT imaging area in accordance with the revolution position of the revolving arm.Type: GrantFiled: November 30, 2012Date of Patent: September 18, 2018Assignees: Nihon University, J. Morita Manufacturing CorporationInventors: Yoshinori Arai, Makoto Honjo, Masakazu Suzuki, Susumu Kirimura, Hideki Yoshikawa
-
Patent number: 9995664Abstract: Seat members 31 are held in a state of being movable with respect to first slide members 21 or second slide members 22 correspondingly. By rotating screws 39 in directions to increase the distances d between surfaces A of the first slide members 21 or the second slide members 22 and surfaces B of the seat members 31, chucks 25 are moved in directions to increase the distance between the chucks to apply pretension to a test piece correspondingly. When backlash in a force transmission system from a support part to the respective chucks 25 is eliminated, a biaxial tensile test is started.Type: GrantFiled: May 14, 2014Date of Patent: June 12, 2018Assignees: Shimadzu Corporation, Nihon UniversityInventors: Noriaki Komine, Susumu Takahashi
-
Patent number: 9877678Abstract: A respiration signal of a seated person is detected with high accuracy by using a vehicle seat that includes a seat cushion; and a sensor detecting a pressure signal from a load applied from a seated person. The sensor is provided to be along an edge of a contact portion between the seat cushion and buttocks of the seated person. The sensor transmits the detected pressure signal to an arithmetic operation device of the seated person. In a respiration measuring device, the arithmetic operation device computes the detected pressure signal detected by the sensor to obtain a respiration signal of the seated person.Type: GrantFiled: April 18, 2013Date of Patent: January 30, 2018Assignees: TS Tech Co., Ltd., Josho Gakuen Educational Foundation, Nihon UniversityInventors: Shinji Sugiyama, Toyokazu Nakano, Mieko Ohsuga, Ichiro Kageyama, Yukiyo Kuriyagawa, Shu Iida
-
Patent number: 9738884Abstract: The present invention provides a therapeutic agent for epithelial and endothelial injury, and in particular, for epithelial and endothelial microinjury, and the like. The therapeutic agent according to the present invention comprises, for example, a peptide of the following (a), (b), etc., a derivative thereof, or their salt: (a) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 10, 4, 12 and 6; or (b) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 16, 18, 20 and 22.Type: GrantFiled: April 30, 2013Date of Patent: August 22, 2017Assignee: NIHON UNIVERSITYInventors: Chiaki Hidai, Hisataka Kitano, Atsushi Mamiya
-
Patent number: 9702850Abstract: To provide an electrophoresis method and an electrophoresis device which can reduce difficulty in operation while implementing sufficient staining. An electrophoresis device includes a temperature gradient tank, a dispenser, a holder storage cabinet, a photographing unit, a PCR device, a chip rack, a chip disposal box, a DC power unit, a control unit, an arm, and a liquid feeder. A holder and a cassette removably attached to the holder are put on the temperature gradient tank. The control unit controls a carrying device, the arm, the liquid feeder, the temperature gradient tank, an excitation light source and a camera in the photographing unit, and the DC power unit. The control unit prestores a program for executing the control operation in its internal memory.Type: GrantFiled: April 30, 2013Date of Patent: July 11, 2017Assignees: SYSTEM INSTRUMENTS CO., LTD., NIHON UNIVERSITYInventors: Yoshinori Hatakeyama, Yoshihisa Ujima, Nobuaki Shimura
-
Patent number: 9706633Abstract: Provided is a magnetized coaxial plasma generation device having increased magnetization efficiency and capable of improving power conservation and reducing the thermal load on a coil. The magnetized coaxial plasma generation device generating spheromak plasma comprises: an external electrode (1); an internal electrode (2); a plasma generation gas supply section (3); a power supply circuit (4); a bias coil (5); a pulse power supply (6) for the bias coil; a magnetic flux conservation section (7); and a control section (8). The bias coil (5) is disposed inside the internal electrode and generates a bias magnetic field between the external and internal electrodes. The pulse power supply (6) for the bias coil pulse-drives the bias coil. The magnetic flux conservation section (7) is disposed outside the external electrode.Type: GrantFiled: June 30, 2014Date of Patent: July 11, 2017Assignee: NIHON UNIVERSITYInventors: Tomohiko Asai, Jun'ichi Sekiguchi, Tadafumi Matsumoto
-
Patent number: 9555466Abstract: A joining method includes punching respective laminated plate materials by a rivet shaft portion of a SPR, forming a crimp portion at the front end of the rivet shaft portion, and fastening and joining the laminated plate materials between the rivet head portion and the crimp portion. Washers are laid on and brought into contact with respective opposite surfaces relative to joining surfaces of the laminated plate materials, the washers each having an inner hole through which the rivet shaft portion is allowed to pass, the washers are used as jigs at the time of the punching, the punching by means of the rivet shaft portion is performed along the inner holes of the washers, and the joining is performed so that the washers left between the rivet head and the crimp portion and the opposite surfaces.Type: GrantFiled: March 1, 2012Date of Patent: January 31, 2017Assignee: NIHON UNIVERSITYInventors: Masahito Ueda, Hiroyuki Hasegawa, Kinya Watanabe, Naoya Fujii
-
Publication number: 20160374188Abstract: Provided is a magnetized coaxial plasma generation device having increased magnetization efficiency and capable of improving power conservation and reducing the thermal load on a coil. The magnetized coaxial plasma generation device generating spheromak plasma comprises: an external electrode (1); an internal electrode (2); a plasma generation gas supply section (3); a power supply circuit (4); a bias coil (5); a pulse power supply (6) for the bias coil; a magnetic flux conservation section (7); and a control section (8). The bias coil (5) is disposed inside the internal electrode and generates a bias magnetic field between the external and internal electrodes. The pulse power supply (6) for the bias coil pulse-drives the bias coil. The magnetic flux conservation section (7) is disposed outside the external electrode.Type: ApplicationFiled: June 30, 2014Publication date: December 22, 2016Applicant: NIHON UNIVERSITYInventors: Tomohiko Asai, Jun'ichi Sekiguchi, Tadafumi Matsumoto
-
Patent number: 9522978Abstract: To provide a safe and stable medicine useful for prevention and treatment of prostate cancer. A novel PI polyamide is acquired that recognizes and binds to a specific base sequence of an Oct1 gene binding sequence present in a transcriptional regulatory region (AR response region) of an ACSL3 gene and regulating the transcription activity of AR. This leads to the provision of an ACSL3 gene expression inhibitor and a preventive and/or therapeutic agent of prostate cancer containing the PI polyamide as an active ingredient.Type: GrantFiled: March 11, 2014Date of Patent: December 20, 2016Assignee: NIHON UNIVERSITYInventors: Daisuke Obinata, Satoru Takahashi, Kyoko Fujiwara, Satoshi Inoue, Kenichi Takayama
-
Patent number: 9474770Abstract: The present invention provides a sepsis therapeutic drug useful for prophylaxis and treatment of sepsis. A prophylactic agent and/or a therapeutic agent for sepsis containing 5-aminolevulinic acid (5-ALA) or a derivative thereof or a pharmacologically acceptable salt of 5-ALA or the derivative as an active ingredient is prepared. The prophylactic agent and/or the therapeutic agent preferably contains a metal-containing compound such as ferrous sodium citrate in addition to the ALAs. Preferred examples of the ALAs include ALA; various esters of ALA such as methyl, ethyl, propyl, butyl, and pentyl esters; and hydrochlorides, phosphates, sulfates of ALA and the esters.Type: GrantFiled: August 10, 2012Date of Patent: October 25, 2016Assignees: SBI Pharmaceuticals Co., Ltd., Nihon UniversityInventors: Kosaku Kinoshita, Katsuhisa Tanjoh, Akihiro Noda, Atsushi Sakurai, Tohru Tanaka, Kiwamu Takahashi, Motowo Nakajima, Fuminori Abe
-
Patent number: 9371523Abstract: The present invention provides a cell migration regulator capable of promoting or inhibiting cell migration, a method for regulating cell migration, and a pharmaceutical composition comprising such a regulator, etc. The cell migration regulator of the present invention comprises a peptide, a derivative thereof, or a salt of the peptide or the derivative, wherein the peptide comprises the full-length blood coagulation factor IX, a segment derived from the full-length blood coagulation factor IX by removal of the trypsin domain, the light chain of blood coagulation factor IX, or the EGF1 domain of blood coagulation factor IX, or the EGF3 domain of the endothelial cell locus-1 protein.Type: GrantFiled: December 12, 2011Date of Patent: June 21, 2016Assignee: NIHON UNIVERSITYInventors: Chiaki Hidai, Hisataka Kitano, Atsushi Mamiya
-
Publication number: 20160113970Abstract: It is a problem of the present invention to provide a convenient and safe periodontal tissue regeneration material and provide a method of regenerating a periodontal tissue. The present invention provides a periodontal tissue regeneration material comprising dedifferentiated fat cells (DFAT) as the convenient and safe periodontal tissue regeneration material. The present invention provides a method of regenerating a periodontal tissue with the periodontal tissue regeneration material.Type: ApplicationFiled: June 2, 2014Publication date: April 28, 2016Applicant: NIHON UNIVERSITYInventors: Masaki HONDA, Daisuke AKITA, Koichiro KANO, Taro MATSUMOTO, Tadashi KANEKO, Katsuyuki YAMANAKA, Yuuhiro SAKAI
-
Patent number: 9278992Abstract: The present invention provides a VDR ligand which does not induce hypercalcemia that is an adverse reaction of a vitamin D3 preparation; and a composition which comprises lithocholic acid propionate, a salt thereof, a solvate thereof, or a prodrug thereof.Type: GrantFiled: January 7, 2008Date of Patent: March 8, 2016Assignee: Nihon UniversityInventors: Makoto Makishima, Michiyasu Ishizawa, Manabu Matsunawa, Sachiko Yamada
-
Publication number: 20160032057Abstract: To provide a safe and stable medicine useful for prevention and treatment of prostate cancer. A novel PI polyamide is acquired that recognizes and binds to a specific base sequence of an Oct1 gene binding sequence present in a transcriptional regulatory region (AR response region) of an ACSL3 gene and regulating the transcription activity of AR. This leads to the provision of an ACSL3 gene expression inhibitor and a preventive and/or therapeutic agent of prostate cancer containing the PI polyamide as an active ingredient.Type: ApplicationFiled: March 11, 2014Publication date: February 4, 2016Applicant: NIHON UNIVERSITYInventors: Daisuke OBINATA, Satoru TAKAHASHI, Kyoko FUJIWARA, Satoshi INOUE, Kenichi TAKAYAMA