Patents Assigned to Nikkiso Company Limited
  • Publication number: 20240157037
    Abstract: A blood purification apparatus configured such that the connection of a chamber member is prevented from being forgotten when blood purification treatment is performed after the switching to a single-needle state. A blood purification apparatus is arbitrarily switchable between a double-needle state and a single-needle state and includes a blood pump 4, a delivery-amount-detecting unit 11 configured to detect the amount of liquid delivery made with the operation of the blood pump 4, a pressure detector 6 configured to detect the pressure in a blood circuit, a chamber member 9 connected to an air-trap chamber 5 in the single-needle state and configured to receive and store the blood in the blood circuit in a blood-collection phase in which blood is collected from the patient and to discharge the stored blood into the blood circuit in a blood-return phase in which the blood is returned to the patient.
    Type: Application
    Filed: January 22, 2024
    Publication date: May 16, 2024
    Applicant: NIKKISO COMPANY LIMITED
    Inventors: Syu TASHIRO, Tomohiro SUZUKI
  • Patent number: 11969530
    Abstract: A system and a solution-preparation-determining apparatus which determines whether additional preparation of an undiluted dialysate solution is necessary.
    Type: Grant
    Filed: November 9, 2021
    Date of Patent: April 30, 2024
    Assignee: Nikkiso Company Limited
    Inventors: Shunsuke Taguchi, Ryouhei Matsumoto, Yutaka Ishikawa, Takeshi Ichikawa
  • Publication number: 20240131241
    Abstract: A blood purification apparatus includes a line section, a duplex pump, and a control unit. The line section includes a dialysate introduction line and a drain-liquid discharge line. The control unit is configured to execute a blood purification treatment process and a defatting washing process. The blood purification treatment process is executed when blood purification treatment is performed in which dialysate is delivered to a dialyzer. The dialysate is prepared by mixing an A-drug solution and a B-drug solution introduced into the line section and diluting the A-drug solution and the B-drug solution to predetermined concentrations. The defatting washing process is executed when defatting washing is performed in which oil and fat in the line section is removed by causing a sodium carbonate solution to flow through the line section. The sodium carbonate solution is obtained by heating the B-drug solution introduced into the line section.
    Type: Application
    Filed: December 26, 2023
    Publication date: April 25, 2024
    Applicant: NIKKISO COMPANY LIMITED
    Inventors: Satoru KAWARABAYASHI, Masahiro TOYODA, Kensaku TANAKA
  • Patent number: 11964089
    Abstract: A blood purification apparatus that includes a blood circuit including an arterial blood circuit and a venous blood circuit and having a flow route that allows a patient's blood to extracorporeally circulate from a distal end of the arterial blood circuit to a distal end of the venous blood circuit; a blood purifier connected to a proximal end of the arterial blood circuit and to a proximal end of the venous blood circuit and that purifies the blood flowing through the blood circuit; an air-trap chamber connected to the blood circuit and that traps bubbles contained in liquid flowing in the flow route of the blood circuit; and a blood pump provided to the arterial blood circuit and being capable of delivering the liquid within the blood circuit.
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: April 23, 2024
    Assignee: Nikkiso Company Limited
    Inventor: Shingo Ikuma
  • Publication number: 20240123129
    Abstract: A blood purification apparatus includes a line section, a duplex pump, and a control unit. The line section includes a dialysate introduction line and a drain-liquid discharge line. The control unit executes a blood purification treatment process and a defatting washing process. The blood purification treatment process is executed when blood purification treatment is performed in which dialysate is delivered to a dialyzer. The dialysate is prepared by diluting an A-drug solution and a B-drug solution. The defatting washing process is executed when defatting washing is performed where oil and fat in the line section is removed by causing a sodium carbonate solution obtained from the B-drug solution introduced into the line section to flow through the line section. The control unit uses a heating unit and a deaerator when executing a bicarbonate-solution-generating process where the sodium carbonate solution is generated by a predetermined amount while carbon dioxide is discharged.
    Type: Application
    Filed: December 27, 2023
    Publication date: April 18, 2024
    Applicant: NIKKISO COMPANY LIMITED
    Inventors: Satoru KAWARABAYASHI, Masahiro TOYODA, Kensaku TANAKA
  • Patent number: 11951245
    Abstract: The present teachings provide a blood purification apparatus including a drain-liquid temporary chamber that stores drain liquid drained from a blood purifier that purifies blood of a patient, a first drain-liquid drain line through which the drain liquid flows into the drain-liquid temporary chamber, a second drain-liquid drain line through which the drain liquid stored in the drain-liquid temporary chamber is drained to an outside of the apparatus, a draining unit provided to the second drain-liquid drain line and that drains the drain liquid stored in the drain-liquid temporary chamber to the outside of the apparatus, a remaining-amount-detecting unit that detects an amount of drain liquid remaining in the drain-liquid temporary chamber, a judging unit that judges whether or not a reference remaining amount is reached by the drain liquid in the drain-liquid temporary chamber from a result of detection by the remaining-amount-detecting unit, and a control unit that controls the draining unit.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: April 9, 2024
    Assignee: Nikkiso Company Limited
    Inventors: Hideto Maki, Tomohiro Furuhashi, Kazuhide Ono
  • Patent number: 11944734
    Abstract: A blood purification apparatus that includes a blood circuit including an arterial blood circuit and a venous blood circuit and through which blood of a patient is allowed to extracorporeally circulate; a blood purification unit connected to and provided between the arterial blood circuit and the venous blood circuit and that purifies the blood flowing through the blood circuit; a blood pump provided to the arterial blood circuit and that delivers the blood of the patient from a distal end of the arterial blood circuit to a distal end of the venous blood circuit; a substitution line through which a substitution fluid is allowed to be introduced into the blood circuit; and an infusion portion attached to the substitution line and from which a predetermined liquid drug to be administered to the patient is allowed to be infused into the substitution line.
    Type: Grant
    Filed: September 30, 2021
    Date of Patent: April 2, 2024
    Assignee: Nikkiso Company Limited
    Inventor: Yuki Katayama
  • Patent number: 11948673
    Abstract: A blood purification system is provided that is capable of effectively utilizing accumulated histories stored during blood purification treatment and that helps take a quick and appropriate action in response to any event that occurs unsteadily or any transition of a parameter. The blood purification system includes an extracting unit that searches histories accumulated in a storage unit and extracts, as reference histories, a plurality of histories each including any of events having occurred during the current session of blood purification treatment or a plurality of histories each including a parameter approximate to that observed during the current session of blood purification treatment; a list-creating unit that creates a list of the plurality of reference histories extracted by the extracting unit; and a display control unit that controls the list created by the list-creating unit to be displayed on a display unit.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: April 2, 2024
    Assignee: Nikkiso Company Limited
    Inventors: Naoyuki Aota, Masahiro Toyoda, Yasunobu Hagiwara
  • Patent number: 11931499
    Abstract: A pressure detector including a case connectable to a flow route and attachable to a predetermined attaching surface; and a membrane member attached inside the case and with which a liquid-phase portion to be supplied with the liquid in the flow route and a gas-phase portion to be supplied with gas are separated from each other, the membrane member being displaceable in accordance with a pressure of the liquid supplied to the liquid-phase portion, the pressure detector detecting the pressure of the liquid in the flow route by detecting a pressure in the gas-phase portion. The pressure detector includes an inlet port including a connecting portion connectable to the flow route, and a flow-route portion through which the liquid flows into an inlet opening of the liquid-phase portion; and an outlet port including a connecting portion connectable to the flow route, and a flow-route portion through which the liquid having flowed into the liquid-phase portion is discharged from an outlet opening.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: March 19, 2024
    Assignee: Nikkiso Company Limited
    Inventors: Shingo Okamoto, Hiroyuki Kawajiri, Ryo Kato
  • Patent number: 11931498
    Abstract: A blood purification apparatus is provided in which waste liquid is prevented from flowing through an ultrafiltration pump during ultrafiltration so that the performance and accuracy of ultrafiltration can be maintained over a long period. The blood purification apparatus includes an ultrafiltration line one end of which is connected to a dialysate introduction line at a position on a downstream side with respect to a duplex pump. The ultrafiltration line is provided with the ultrafiltration pump. The ultrafiltration pump is capable of performing ultrafiltration by drawing dialysate in the dialysate introduction line through the ultrafiltration line such that the volume of the dialysate to be introduced into a dialyzer becomes smaller than the volume of waste liquid to be drained from the dialyzer.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: March 19, 2024
    Assignee: Nikkiso Company Limited
    Inventors: Fumihiko Ishizaki, Sumiaki Matsuo
  • Patent number: 11931500
    Abstract: A pressure detector that includes a case connectable to a flow route for liquid, and a membrane member provided in the case and with which a liquid-phase portion to be supplied with the liquid in the flow route and a gas-phase portion to be supplied with gas are separated from each other, the membrane member being displaceable in accordance with a pressure of the liquid supplied to the liquid-phase portion, the pressure detector detecting the pressure of the liquid in the flow route by detecting a pressure in the gas-phase portion. The gas-phase portion has an opening through which the gas is allowed to be introduced or discharged in accordance with the displacement of the membrane member, and a secured portion secured for the introduction or discharge of the gas through the opening during the displacement of the membrane member toward a side of the gas-phase portion.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: March 19, 2024
    Assignee: Nikkiso Company Limited
    Inventors: Hiroyuki Kawajiri, Shingo Okamoto, Ryo Kato
  • Patent number: 11911544
    Abstract: A blood purification apparatus that includes a blood circuit including an arterial blood circuit and a venous blood circuit and that allows a patient's blood to extracorporeally circulate, with a blood purifier that is interposed between the arterial blood circuit and the venous blood circuit and purifies; a dialysate temporary chamber that temporarily stores dialysate received from a dialysate storage supported by a supporting unit; a substitution-fluid temporary chamber that temporarily stores substitution fluid received from a substitution-fluid storage supported by the supporting unit; a first dialysate introduction line through which the dialysate in the dialysate storage flows into the dialysate temporary chamber; and a substitution line through which the substitution fluid in the substitution-fluid storage flows into the substitution-fluid temporary chamber.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: February 27, 2024
    Assignee: Nikkiso Company Limited
    Inventors: Tomohiro Furuhashi, Yuki Eda, Masaaki Ohta, Kenji Furuhashi
  • Patent number: 11896751
    Abstract: An adjusting device for a pressure detector that is capable of arbitrarily adjusting the initial position of a membrane member is provided. An adjusting device for a pressure detector includes a control unit that sequentially executes a first step in which a predetermined adjusting pressure is generated in a first zone by activating a pump with the first zone being closed by the closing of an electromagnetic valve, and a second step in which a gas-phase portion, the first zone, and a second zone are combined into a closed space by disabling the closing of the electromagnetic valve; and an adjusting-pressure-acquiring unit that acquires the adjusting pressure to be generated in the first step, the adjusting pressure being acquired in accordance with a relationship between a pressure and a capacity of the first zone in the first step and a pressure and a capacity of the combination of the gas-phase portion, the first zone, and the second zone in the second step.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: February 13, 2024
    Assignee: Nikkiso Company Limited
    Inventors: Hideto Maki, Shinya Hasegawa, Yuki Eda
  • Patent number: 11872334
    Abstract: A pressure detector is provided that includes a case connectable to a flow route for liquid, and a membrane member attached inside the case and with which a liquid-phase portion to be supplied with the liquid in the flow route and a gas-phase portion to be supplied with gas are separated from each other, the membrane member being displaceable in accordance with a pressure of the liquid supplied to the liquid-phase portion, the pressure detector detecting the pressure of the liquid in the flow route by detecting a pressure in the gas-phase portion with a pressure detection sensor. The pressure detector includes a hydrophobic portion that allows gas to pass through but blocks liquid from passing through, the hydrophobic portion being provided between the gas-phase portion and the pressure detection sensor.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: January 16, 2024
    Assignee: Nikkiso Company Limited
    Inventors: Hiroyuki Kawajiri, Shingo Okamoto, Ryo Kato
  • Patent number: 11690942
    Abstract: A blood purification apparatus that is capable of, with no preparatory operations, performing substitution by supplying dialysate in a dialysate introduction line to a blood circuit during ultrafiltration treatment, or performing blood return by immediately supplying the dialysate in the dialysate introduction line to the blood circuit after the ultrafiltration treatment. A blood purification apparatus includes a dialyzer, a dialysate introduction line, a dialysate drain line L2 through which drain liquid from the dialyzer is drained, and an ultrafiltration pump capable of removing water from the blood in the blood circuit. The blood purification apparatus is capable of performing substitution or blood return by supplying the dialysate in the dialysate introduction line L1 to the blood circuit.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: July 4, 2023
    Assignee: Nikkiso Company Limited
    Inventors: Takeshi Ichikawa, Satoshi Takeuchi
  • Patent number: 11642446
    Abstract: A blood purification system is provided that is capable of effectively utilizing accumulated histories stored during blood purification treatment and that helps take a quick and appropriate action in response to a particular incident that occurs unsteadily. In a blood purification system, a history stored in a storage device includes particular incidents having occurred unsteadily in blood purification treatment. The blood purification system includes an extracting device capable of searching the histories accumulated in the storage device and extracting a desired one of the particular incidents, a calculating device capable of calculating a time when the particular incident extracted by the extracting device occurs a predetermined or more number of times as a frequent-occurrence time slot, and a display control device capable of displaying the frequent-occurrence time slot calculated by the calculating device on a display during a current session of blood purification treatment.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: May 9, 2023
    Assignee: Nikkiso Company Limited
    Inventors: Naoyuki Aota, Masahiro Toyoda, Yasunobu Hagiwara
  • Patent number: 11633585
    Abstract: A medical connector that allows ventilation of vapor used in vapor sterilization and has an internal flow route that is tightly closable without using any separate clamping device. A medical connector includes a body having an internal flow route connected to an other flow route, proximal portions included in the body and having respective one-side connection ports at which the internal flow route is connectable to the one flow route, a distal portion having an other-side connection port at which the internal flow route is connectable to the other flow route, one-side lid portion, and an other-side lid portion whose state is switchable between a closing state and a ventilating state in which the other-side lid portion covers the other-side connection port such that ventilation is allowed.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: April 25, 2023
    Assignee: Nikkiso Company Limited
    Inventors: Shigeru Sasahara, Kazuhide Ono, Ryo Kato, Hironobu Sugiyama
  • Patent number: 11566927
    Abstract: An optical measurement device is provided with: a light source that irradiates, with light, a measurement object which has a fluid flowing thereinside; a light receiving unit which, upon receipt of scattered light from the measurement object irradiated with light, outputs a light reception signal according to the intensity of the scattered light; a disturbance generation unit which generates a disturbance signal for causing oscillation of a drive current to be supplied to the light source; and an adjustment unit which adjust the drive current on the basis of the result of a comparison between the disturbance signal and a signal generated on the basis of the light reception signal.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: January 31, 2023
    Assignees: AIR WATER BIODESIGN INC., NIKKISO COMPANY LIMITED
    Inventors: Kiyoshi Tateishi, Mitsuru Sato, Tadashi Kondo, Wataru Onodera, Tomoya Murakami, Akari Agata, Genki Adachi
  • Patent number: 11554202
    Abstract: Microbubbles detached from a blood circuit and a blood purification unit are discharged with the use of a backflow generated at the instant that a roller of a blood pump releases a squeezable tube. In a normal rotation step, a region filled with a priming solution after a priming step is closed by a closing unit, and a rotor of a blood pump is rotated normally until a roller of the blood pump releases a squeezable tube to generate a backflow. After the backflow is generated at the release of the squeezable tube by the roller of the blood pump, bubbles are moved by reversely rotating the rotor while disabling the closing by the closing unit. Thus, the bubbles are discharged through a discharge unit.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: January 17, 2023
    Assignee: Nikkiso Company Limited
    Inventors: Shunichi Koda, Shunsuke Kawamura, Shingo Okamoto
  • Patent number: 11529078
    Abstract: This fluid evaluation device is provided with an irradiation unit for irradiating a fluid with light, a light reception unit for receiving scattered light from the fluid and outputting a light reception signal, and an estimation unit for estimating at least one from among flow rate and density by mapping input points, which are on a first plane defined by flow rate and frequency and are expressed by light amount information indicating the amount of scattered light included in the light reception signal and frequency information indicating a frequency for a beat signal resulting from the Doppler shifting of the light included in the light reception signal, onto a second plane defined by fluid flow rate and fluid density.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: December 20, 2022
    Assignees: AIR WATER BIODESIGN INC., NIKKISO COMPANY LIMITED
    Inventors: Kiyoshi Tateishi, Wataru Onodera, Atsuya Ito, Tomoya Murakami, Akari Agata, Genki Adachi