Patents Assigned to Novo Nordisk Biotech, Inc.
  • Polypeptides having galactose oxidase activity and nucleic acids encoding same
    Patent number: 6277612
    Abstract: The present invention relates to isolated polypeptides having galactose oxidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: August 21, 2001
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Elizabeth Golightly, Randy M. Berka, Michael W. Rey
  • Polypeptides having phytase activity and nucleic acids encoding same
    Patent number: 6221644
    Abstract: The present invention relates to isolated polypeptides having phytase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to composite feeds and methods of reducing phytate levels.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: April 24, 2001
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey, Alan V. Klotz
  • Nucleic acids encoding polypeptides having laccase activity
    Patent number: 6207430
    Abstract: The present invention relates to polypeptides having laccase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: March 27, 2001
    Assignee: Novo Nordisk of Biotech, Inc.
    Inventors: Debbie Sue Yaver, Kimberley M. Brown, Sakari Kauppinen, Torben Halkier
  • Polypeptides having aminolevulinic acid activity and nucleic acids encoding same
    Patent number: 6207433
    Abstract: The present invention relates to isolated polypeptides having 5-aminolevulinic acid synthase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: January 4, 2000
    Date of Patent: March 27, 2001
    Assignee: Novo Nordisk Biotech, Inc.
    Inventor: Greg Gambetta
  • Polypeptides having uroporphyrinogen decarboxylase activity and nucleic acids encoding same
    Patent number: 6200795
    Abstract: The present invention relates to isolated polypeptides having uroporphyrinogen decarboxylase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: March 13, 2001
    Assignee: Novo Nordisk Biotech, Inc.
    Inventor: Susan L. Elrod
  • Carboxypeptidases and nucleic acids encoding the same
    Patent number: 6187578
    Abstract: The present invention relates to polypeptides having carboxypeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to methods of obtaining protein hydrolysates useful as flavor improving agents.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: February 13, 2001
    Assignees: Novo Nordisk Biotech, Inc., Novo Nordisk A/S
    Inventors: Alexander Blinkovsky, Randy Berka, Michael Rey, Elizabeth Golightly, Alan Klotz, Thomas Erik Mathisen, Claus Dambmann, Kimberly M. Brown
  • Morphological mutants of filamentous fungi
    Patent number: 6184026
    Abstract: The present invention relates to methods of obtaining a mutant cell from a filamentous fungal parent cell, comprising: (a) obtaining mutant cells of the parent cell; (b) identifying the mutant cell which exhibits a more restricted colonial phenotype and/or a more extensive hyphal branching than the parent cell; and (c) identifying the mutant cell which has an improved property for production of a heterologous polypeptide than the parent cell, when the mutant and parent cells are cultured under the same conditions.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: February 6, 2001
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Jeffrey R. Shuster, John C. Royer
  • Polypeptides having pectin acetylesterase activity and nucleic acids encoding same
    Patent number: 6184028
    Abstract: The present invention relates to isolated polypeptides having pectin acetylesterase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: August 26, 1999
    Date of Patent: February 6, 2001
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Michael D. Thomas, Kimberly M. Brown
  • Polypeptides having aminopeptidase activity and nucleic acids encoding same
    Patent number: 6184020
    Abstract: The present invention relates to isolated polypeptides having aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: February 6, 2001
    Assignees: Novo Nordisk Biotech, Inc., Novo Nordisk A/S, Japan Tobacco, Inc.
    Inventors: Alexander Blinkovsky, Tony S. Byun, Alan V. Klotz, Alan Sloma, Kimberly Brown, Maria Tang, Mikio Fujii, Chigusa Marumoto
  • Methods for producing heterologous polypeptides in trichothecene-deficient
    Patent number: 6180366
    Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the production of the polypeptide, wherein (i) the mutant cell comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence comprising a modification of at least one of the genes involved in the production of a trichothecene and (ii) the mutant produces less of the trichothecene than the parent filamentous fungal cell when cultured under the same conditions; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to mutants of filamentous fungal cells and methods for obtaining the mutant cells. The present invention also relates to isolated trichodiene synthases and isolated nucleic acid sequences encoding the trichodiene synthases.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: January 30, 2001
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: John C. Royer, Lynne M. Christianson, Gregory A. Gambetta, Howard Brody, Suzanne M. Otani, Wendy T. Yoder
  • Methods of producing polynucleotide variants
    Patent number: 6159688
    Abstract: A method for the construction of a library of recombined polynucleotides from a number of different starting single or double stranded parental DNA templates is disclosed, wherein the starting single or double stranded parental DNA templates represent discrete points in a population of genes encoding evolutionary or synthetic homologues of a peptide having homologies ranging over a broad spectrum from less than 15% to more than 80%, said population exhibiting at least one identification sequence, and whereby said genes are subjected to a gene shuffling procedure to generate shuffled mutants of said population of genes representing additional discrete points between those of said starting templates.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: December 12, 2000
    Assignees: Novo Nordisk A/S, Novo Nordisk BioTech, Inc.
    Inventors: Torben Vedel Borchert, Titus Kretzschmar, Joel R. Cherry, Jesper Vind
  • Polypeptides having choline oxidase activity and nucleic acids encoding same
    Patent number: 6146864
    Abstract: The present invention relates to isolated polypeptides having choline oxidase activity and isolated nucleic acid sequences encoding the polypeptide from Fusarium venenatum. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: November 14, 2000
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Debbie Yaver, Randy M. Berka, Michael W. Rey
  • Polypeptides having phospholipase B activity and nucleic acids encoding same
    Patent number: 6146869
    Abstract: The present invention relates to isolated polypeptides having phospholipase B activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: November 14, 2000
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Paul Harris, Kimberly M. Brown
  • Enzymatic methods for dyeing with reduced vat and sulfur dyes
    Patent number: 6129769
    Abstract: The present invention relates to methods for dyeing a material, comprising (a) treating the material with a dyeing system which comprises one or more reduced vat dyes and/or one or more reduced sulfur dyes; and (b) oxidizing the one or more reduced vat dyes or one or more reduced sulfur dyes adsorbed onto the treated material with an oxidation system comprising (i) an oxygen source and one or more enzymes exhibiting oxidase activity or (ii) a hydrogen peroxide source and one or more enzymes exhibiting peroxidase activity, to convert the one or more reduced dyes to their original oxidized insoluble colored forms; wherein the material is a fabric, yarn, fiber, garment or film made of cotton, diacetate, flax, fur, hide, leather, linen, lyocel, polyacrylic, polyamide, polyester, ramie, rayon, silk, tencel, triacetate, viscose or wool.
    Type: Grant
    Filed: August 24, 1999
    Date of Patent: October 10, 2000
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Feng Xu, Sonja Salmon, Heinz-Josef Wilhelm Deussen, Henrik Lund
  • Method for increasing hemoprotein production in filamentous fungi
    Patent number: 6100057
    Abstract: The present invention relates to methods of producing hemoproteins comprising (a) introducing into a filamentous fungal cell, which is capable of producing the hemoprotein, (i) one or more first control sequences capable of directing the expression of a heme biosynthetic enzyme encoded by a first nucleic acid sequence endogenous to the filamentous fungal cell, wherein the one or more of the first control sequences are operably linked to the first nucleic acid sequence; and/or (ii) one or more copies of one or more second nucleic acid sequences encoding a heme biosynthetic enzyme; (b) cultivating the filamentous fungal cell in a nutrient medium suitable for production of the hemoprotein and the heme biosynthetic enzymes; and (c) recovering the hemoprotein from the nutrient medium of the filamentous fungal cell.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: August 8, 2000
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Susan L. Elrod, Joel R. Cherry, Aubrey Jones
  • Polypeptides having galactose oxidase activity and nucleic acids encoding same
    Patent number: 6090604
    Abstract: The present invention relates to isolated polypeptides having galactose oxidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: February 24, 1999
    Date of Patent: July 18, 2000
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Elizabeth Golightly, Randy M. Berka, Michael W. Rey
  • Morphological mutants of filamentous fungi
    Patent number: 6066493
    Abstract: The present invention relates to methods of obtaining a mutant cell from a filamentous fungal parent cell, comprising: (a) obtaining mutant cells of the parent cell; (b) identifying the mutant cell which exhibits a more restricted colonial phenotype and/or a more extensive hyphal branching than the parent cell; and (c) identifying the mutant cell which has an improved property for production of a heterologous polypeptide than the parent cell, when the mutant and parent cells are cultured under the same conditions.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: May 23, 2000
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Jeffrey R. Shuster, John C. Royer
  • Polypeptides having choline oxidase activity and nucleic acids encoding same
    Patent number: 6063607
    Abstract: The present invention relates to isolated polypeptides having choline oxidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: May 16, 2000
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Debbie S. Yaver, Randy M. Berka, Michael W. Rey
  • Non-toxic, non-toxigenic, non-pathogenic Fusarium expression system
    Patent number: 6060305
    Abstract: The present invention relates non-toxic, non-toxigenic, non-pathogenic recombinant Fusarium host cells of the section Discolor or a teleomorph or synonym thereof, comprising a nucleic acid sequence encoding a heterologous protein operably linked to a promoter.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: May 9, 2000
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: John C. Royer, Donna L. Moyer, Yoder T. Wendy, Jeffrey R. Shuster
  • Nucleic acids encoding polypeptides having cellobiose dehydrogenase activity
    Patent number: 6033891
    Abstract: The present invention relates to isolated nucleic acid sequences encoding polypeptides having cellobiose dehydrogenase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as recombinant methods for producing the polypeptides.
    Type: Grant
    Filed: March 9, 1999
    Date of Patent: March 7, 2000
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Elizabeth Golightly, Kimberly Brown