Abstract: Disclosed are compounds that can penetrate the mitochondrial membrane and that are able to deliver cargo (e.g., therapeutic agents) specifically to the mitochondria.

Abstract: Apparatus and methods for a market-based control framework to coordinate a group of autonomous thermostatically controlled loads (TCL) to achieve system-level objectives with pricing incentives is disclosed. In one example of the disclosed technology, a method of providing power to a load via a power grid by submitting bids to a coordinator includes determining an energy response relating price data for one or more energy prices to quantity data for power to be consumed by the load, sending a bid for power for a finite time period based on the energy response to the coordinator, and receiving a clearing price based on: the bid, on bids received from a plurality of additional loads, and a feeder power constraint. In some examples, the energy response is based at least in part on an equivalent thermal parameter model and a control policy indicating one or more power states for the load.

Abstract: Frequency stabilization is provided in a microelectromechanical systems (MEMS) oscillator via tunable internal resonance (IR). A device comprises a MEMS resonator comprising a stepped-beam structure that is a thin-layer structure. The resonator may be configured to implement IR. The stepped-beam structure may be configured to provide flexibility to adjust modal frequencies into a n:m ratio, wherein n and m are integers. The thin-layer structure provides frequency tunability by controlling the mid-plane stretching effect with an applied DC bias. The thin-layer structure compensates for a frequency mismatch from a n:m ratio due to a fabrication error. The MEMS resonator may be an oscillator.

Abstract: Documents from a set of related documents in a domain are processed to identify keywords associated with each document. The documents are then further processed to identify the documents that are the most similar to each other. For each document, some or all of the keywords that are associated with the similar documents, but not the document itself, are selected as semantic tags for the document. These semantic tags determined for a document represent novel or hidden concepts and contexts that may relate to the document, but that do not actually appear in the document. The documents are used to train a model that generate semantic tags for a document or for keywords associated with the document. The generated model can then be used for a variety of purposes such the creation of an index for a set of documents or for query expansion.

Abstract: Described herein, in various embodiments, are peptides comprising: (i) a cyclic cell-penetrating peptide sequence (cCPP) and (ii) a CAL-PDZ binding sequence, which is conjugated, directly or indirectly, to an N-terminus of an amino acid in the cCPP, to a C-terminus of an amino acid on the cCPP, or on a side chain of an amino acid in the cCPP. In other embodiments, the peptides further comprise a physiologically cleavable group, wherein after entering the cell, the physiologically cleavable group is reduced, thereby providing a linear peptide. Without being bound by theory, the inventors discovered that the amino acid sequence in the cCPP, which facilities cytosolic delivery of the CAL-PDZ binding sequence also, surprisingly and unexpectedly, synergistically improves binding of CAL-PDZ binding sequence to the CAL-PDZ binding domain. Additionally, the cCPP sequence may also improve selectivity of the CAL-PDZ binding sequence for the CAL-PDZ domain relative to other PDZ binding domains.

Abstract: Various implementations include an assistive driving device including a base, a first post, a second post, a third post, and a selector. The first post is for receiving a portion of a palm of a hand of a user and has a proximal end and a distal end. The second post has a proximal end and a distal end. The third post has a proximal end and a distal end. The proximal ends of the first, second, and third posts are coupled to the base. The second post and the third post are positioned to receive a portion of an arm of the user. The selector is spaced apart from the first post and positioned such that the selector is actuatable with a dorsum of the hand of the user.

Abstract: Disclosed are systems, methods, and computer program products for tumor lesion identification, segmentation, tracking and analysis, wherein a 3D spatial distribution of the tumor lesions in a target organ forms a unique 3D point structure for a patient.

Abstract: Disclosed herein are methods and compositions related to antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).

Abstract: Systems and methods for magnetic resonance elastography (MRE) are disclosed. In one embodiment, MRE data corresponding to mechanical waves in tissue of interest of a subject is acquired. The MRE data is associated with stiffness of the tissue. The method also includes generating, based on the MRE data, a stiffness map representing stiffness of the tissue. Generating the stiffness map includes performing an unconstrained optimization cost function that is configured to reduce noise in the acquired MRE data and achieve inversion of the reduced-noise data.

Abstract: An endoscope has a control handle having angulation knobs, wherein the angulation knobs are oversized permitting the user to access the oversize angulation knobs without stressing the thumb. A control handle attachment secures to the control handle and urges the hand into a neutral anatomic position.

Abstract: A system includes a navigation antenna configured to receive first satellite signals transmitted from a first type of satellite in a first frequency band and second satellite signals transmitted from a second type of satellite in a second frequency band and generate RHCP signal responses based on the first and second satellite signals, a plurality of science antennas configured to receive the first satellite signals in the first frequency band and the second satellite signals in the second frequency band as reflected from a ground surface and generate LHCP signal responses and RHCP signal responses based on the first and second satellite signals, and a receiver module including a processing module and a plurality of receivers coupled between the navigation antenna and the plurality of science antennas and the processing module. The processing module is configured to generate telemetry data based on the received LHCP and RHCP signal responses.

Abstract: Aspects of the disclosure provide a method including determining a measurement configuration for one or more piezoelectric devices in an electronic apparatus. The electronic apparatus includes an electronic device mounted on a substrate block using a bonding layer. The one or more piezoelectric devices including a first subset and a second subset are attached to one of the electronic device and the bonding layer. The method includes performing, based on the measurement configuration, a defect measurement on the electronic apparatus by causing the first subset to transmit and the second subset to receive one or more acoustic signals. The method includes determining whether at least one mechanical defect is located in at least one of (i) the bonding layer, (ii) the electronic device, (iii) the substrate block, (iv) interfaces of the electronic device, the bonding layer, and the substrate block based on the received one or more acoustic signals.

Abstract: Disclosed herein are compounds comprising dicarba-closo-dodecaborane. The compounds can be, for example, estrogen receptor beta (ER?) agonists. In some examples, the compounds can be selective ER? agonists. Also provided herein are methods of treating, preventing, or ameliorating cancer in a subject, suppressing tumor growth in a subject, treating an inflammatory disease in a subject, treating a neurodegenerative disease in a subject, treating a psychotropic disorder in a subject, or a combination thereof, by administering to a subject a therapeutically effective amount of one or more of the compounds or compositions described herein, or a pharmaceutically acceptable salt thereof.

Abstract: Membranes, methods of making the membranes, and methods of using the membranes are described herein. The membranes can comprise a support layer, and a selective polymer layer disposed on the support layer. The selective polymer layer can comprise a selective polymer matrix and carbon nanotubes dispersed within the selective polymer matrix. The carbon nanotubes can comprise multi-walled carbon nanotubes wrapped in a hydrophilic polymer, such as polyvinylpyrrolidone or a copolymer thereof, such as poly(1-vinylpyrrolidone-co-vinyl acetate). The membranes can exhibit selective permeability to gases. As such, the membranes can be for the selective removal of carbon dioxide and/or hydrogen sulfide from hydrogen and/or nitrogen.

Abstract: Systems and methods include providing a gaseous alkane input stream and metal sulfide (MSx) particles that can react with an alkane in the gaseous alkane input stream to generate an alkene, a reduced metal sulfide (MSx?1) particle, and at least one of: hydrogen sulfide (H2S) and at least one sulfur containing compound selected from: S2, CS, and CS2. A product stream can be collected that includes the alkene and at least one of: hydrogen sulfide (H2S) and the at least one sulfur containing compound. A reduced metal sulfide (MSx?1) particle reacts with sulfur in a sulfur stream and can generate the metal sulfide (MSx) particle and hydrogen (H2).

Abstract: A system and method for joining dissimilar metals. In one embodiment, a method comprises providing a first metal plate, a second metal plate, and an intermediate body that is positioned between the first metal plate and the second metal plate. The first metal plate is then driven into the intermediate body, which causes at least a portion of the intermediate body to collide with the second metal plate. As a result, the material of the intermediate body joins the first metal plate to the second plate. In another embodiment, a method for joining dissimilar metals comprises providing a first metal that is not amenable to welding, a second metal that is joinable to the first metal, and an intermediate body that is not joinable to at least the first metal. The intermediate body may have at least one hole such that the first metal and the second metal are positioned over and on opposite sides of the hole(s). At least a portion of the second metal may then be driven into the hole(s) to be joined to first metal.

Abstract: A low inductance power module with low power loop inductance and high-power density is provided. The power module may include a vertical power loop structure, a cooling layer, and a thermal dissipation structure. The vertical power loop structure may utilize a substrate bottom conduction layer for electrical conduction. The thermal dissipation structure may be disposed between the substrate bottom conduction layer and the cooling layer. The vertical power loop structure may include integrated decoupling capacitors. Alternatively, the structure may include no integrated decoupling capacitors. The vertical power loop structure may include one or more half-bridge structures connected in parallel, each with its own integrated decoupling capacitors. The vertical power loop structure reduces power loop inductance in the power module, and the thermal dissipation structure provides electrical insulation, mechanical support, and thermal conduction.

Abstract: A method includes receiving a first polynomial and a second polynomial, both of order n?1 and forming d polynomial segments from both the first polynomial and the second polynomial such that each polynomial segment is of order (n/d)?1. The polynomial segments of the first polynomial and the d polynomial segments of the second polynomial are used to form segment products. Each segment product is divided into a first polynomial substructure of order n/d and a second polynomial substructure of order (n/d)?1. A first polynomial substructure containing the first n/d coefficients of a product of the first polynomial and the second polynomial is summed with a second polynomial substructure to form a sum substructure. The sum substructure is used multiple times to determine coefficients of a polynomial representing the modulo xn+1 of the product of the first polynomial and the second polynomial.

Abstract: The present invention relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as SMA and ALS as well as Pompe disease and lysosomal storage disorders. It is disclosed that administration of a non-ionic, low-osmolar contrast agent, together with a rAAV9 vector for the expression of Survival Motor Neuron protein, improves the survival of SMN mutant mice as compared to the administration of the expression vector alone.

Abstract: The present invention relates to a nasal plug for diverting airflow from a natural flow path in a person's nostril. In some circumstances, the airflow is channeled and directed to a specific location in a person's nasal or sinus cavity. The person may adjust and self-select a preferred airflow path by adjusting the nasal plug's location in the nostril, e.g., rotating the plugs. A kit may include two plugs, which may be used singly or in combination with each other and are independently adjustable/rotatable. A method for reducing nasal discomfort or improving nasal functions by diverting channeled airflow in a nostril is also disclosed.