Abstract: An on-body antenna is provided that overcomes mismatch loss problems associated with current on-body antennas and is capable of operating over a wide range of frequencies with low transmission loss. At least a first antenna element of the on-body antenna is configured to receive an oscillating electric current and to radiate an oscillating electromagnetic field over a predetermined range of frequencies. The first antenna element is made of non-electrically-conductive material having a first relative permittivity. At least a second material having a second relative permittivity can be disposed on or in the first antenna element. Disposing the second material provides the first antenna element with an effective permittivity that can be closely matched to a frequency-dependent permittivity of biological tissue of a subject. The first non-electrically-conductive material and the second material can be preselected to have relative permittivities that allow anisotropy to be achieved.
Abstract: A fiber-to-fiber system for multi-layer ferroelectric on insulator waveguide devices is described. The system comprises a fiber-to-chip coupler that couples light from a standard optical fiber to multi-layer ferroelectric on insulator waveguides. The multi-layer ferroelectric on insulator waveguides are integrated with electrodes to implement an optical device, an electro-optical device, or a non-linear optical device, such as an electro-optical modulator, with microwave and optical waveguide crossings compatible with packaging. A second fiber-to-chip coupler outputs the light from the multi-layer ferroelectric on insulator device to a standard optical fiber.
Type:
Grant
Filed:
March 18, 2021
Date of Patent:
May 30, 2023
Assignee:
Ohio State Innovation Foundation
Inventors:
Ronald Reano, Jonathan Nagy, Karan Prabhakar, Ryan Patton
Abstract: In one aspect, the disclosure relates to relates to compositions, devices, and processes for drug delivery to an eye. The disclosed drug delivery compositions comprise a particle having a core component comprising a first polymer and a therapeutic agent, and a shell layer surrounding the core component comprising a second polymer. In a further aspect, the present disclosure relates to methods of treating an ophthalmological disease or disorder. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Type:
Grant
Filed:
April 11, 2019
Date of Patent:
May 30, 2023
Assignee:
Ohio State Innovation Foundation
Inventors:
Pengfei Jiang, Katelyn Elizabeth Reilly, Matthew Ohr
Abstract: A turboelectric distributed propulsion based on brushless doubly-fed machines (BDFMs) is provided, which minimizes power conversion, enhances mechanical reliability, and strengthens fault-tolerance capability of a DC-based propulsion system. A turboelectric distributed propulsion (TeDP) architecture using BDFMs for aviation applications, and a designed BDFM, inverter, and controller are provided. Simulations and systems are also provided.
Abstract: The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when administered in conjunction with rampamycin. SapC-DOPS/rapamycin combination therapy allows physicians to give lower doses of each drug and achieve better therapeutic efficacy. The compositions also allow for less toxicity and fewer off-target effects. Related methods and materials are also provided herein.
Type:
Grant
Filed:
June 28, 2019
Date of Patent:
May 30, 2023
Assignees:
University of Cincinnati, Ohio State Innovation Foundation
Abstract: A bending apparatus for a sample is disclosed. The bending apparatus includes a translation mechanism that translates a vertical displacement/force into a horizontal displacement/force for bending. Components of the bending apparatus are fabricated from a strong, radiolucent material. In these ways, the bending apparatus is compatible with micro-CT imaging, and as such, may be used to bend a sample during imaging. In a particular application, the bending apparatus may be used to measure biomechanical properties of a bone, such as bone strength, bone material properties, fracture toughness, and fracture propagation.
Type:
Grant
Filed:
September 9, 2021
Date of Patent:
May 23, 2023
Assignee:
Ohio State Innovation Foundation
Inventors:
Kyle Anthony Bodnyk, Richard T. Hart, Alan S. Litsky
Abstract: Disclosed herein is a process for preparing a stable suspension of a globular protein material in a dairy product. Also disclosed are products produced by this method.
Type:
Grant
Filed:
August 14, 2020
Date of Patent:
May 23, 2023
Assignee:
Ohio State Innovation Foundation
Inventors:
Rafael Jimenez-Flores, Joana Ortega-Anaya, Alba Mayta Apaza, Stiphany Tieu
Abstract: An example tunnel junction ultraviolet (UV) light emitting diode (LED) is described herein. The UV LED can include a mesa structure having at least one of: an n-doped bottom contact region, a p-doped region, and a tunnel junction arranged in contact with the p-doped region. Additionally, a geometry of the mesa structure can be configured to increase respective efficiencies of extracting transverse-electric (TE) polarized light and transverse-magnetic (TM) polarized light from the tunnel junction UV LED. The mesa structure can be configured such that an emitted photon travels less than 10 ?m before reaching the inclined sidewall.
Type:
Grant
Filed:
November 2, 2021
Date of Patent:
May 23, 2023
Assignee:
Ohio State Innovation Foundation
Inventors:
Siddharth Rajan, Yuewei Zhang, Zane Jamal-Eddine, Fatih Akyol
Abstract: A prosthetic heart valve includes a first upper frame portion and a stent frame connected to the first upper frame portion via at least two stent frame extensions. The stent frame includes a base and at least two stent posts extending upwardly from the base towards the first upper frame portion. The first upper frame portion, the base, and the at least two stent posts each has an inner surface and an outer surface. The prosthetic heart valve also includes at least one sheet of leaflet material configured to encircle the stent frame and weave through the stent frame between the first upper frame portion and the base.
Abstract: Methods and systems are provided for optimizing the use of network bandwidth by a mobile device. In one embodiment, a system is provided that includes a mobile application client. The mobile application client may log information regarding content requests to a content log and may log network connection statuses for the mobile device. The system may analyze content consumption of a user of the mobile device based on the content log and may create a user profile. The system may also compile a prefetching schedule based on the user profile and the prefetching schedule may be provided to the mobile device. The mobile device may prefetch content at least partially in accordance with the prefetching schedule.
Type:
Grant
Filed:
November 10, 2021
Date of Patent:
May 9, 2023
Assignee:
OHIO STATE INNOVATION FOUNDATION
Inventors:
Ahmed Abou-Elkheir, Hesham El Gamal, Nayer Wanas, Kareem Youssef, Hakem Zaid, John Tadrous
Abstract: Disclosed herein are methods and apparatus for making a determination about an eye in ambient lighting conditions comprising detecting ambient light reflected out of an eye of a subject from a retina of the eye of the subject and making a determination about the eye of the subject based upon the reflected ambient light.
Abstract: The present disclosure provides methods for freeform extrusion-based additive manufacturing via a robotic arm. In specific aspects, methods are particularly provided for minimally invasive, intracorporeal three-dimensional printing of biocompatible materials. An end effector of a robotic arm includes a sharp member and a reservoir filled with a printing material. The provided method may include piercing a substrate with the sharp member. A bulb or microbolus of material may be extruded beneath the substrate surface to act as an anchor. The end effector may be manipulated to extrude biomaterial along a printing path. Periodically along the printing path, the sharp member is used to pierce the substrate surface create additional respective anchors. In some instances, the method may terminate after extruding material to form a single layer construct. In other instances, the method includes forming one or more layers on top of the initial base layer anchored to the substrate.
Type:
Grant
Filed:
April 3, 2020
Date of Patent:
May 9, 2023
Assignee:
OHIO STATE INNOVATION FOUNDATION
Inventors:
David J. Hoelzle, Desmond M. D'Souza, Andrej Simeunovic, Ali Asghari Adib
Abstract: An example method of producing an electric machine is described herein. The method can include providing the electric machine. The electric machine can include a rotor and a stator, where the stator includes a magnetic core and a stator winding. Additionally, the magnetic core can include a plurality of teeth defining a plurality of slots between adjacent teeth. The stator winding can also include a first portion arranged inside a slot and a second portion arranged outside the slot. The method can further include optimizing, using a computing device, a geometry of the first portion of the stator winding, where the first portion of the stator winding in the provided electric machine has the optimized geometry.
Abstract: A device used in conjunction with fixation hardware to provide a two-stage process to address the competing needs of immobilization and re-establishment of normal stress-strain trajectories in grafted bone. A method of determining a patient-specific stress/strain pattern that utilizes a model based on 3D CT data of the relevant structures and cross-sectional data of the three major chewing muscles. The forces on each of the chewing muscles are determined based on the model using predetermined bite forces such that a stiffness of cortical bone in the patient's mandible is determined. Based on the stiffness data, suitable implantation hardware can be designed for the patient by adjusting external topological and internal porous geometries that reduce the stiffness of biocompatible metals to thereby restore normal bite forces of the patient.
Type:
Grant
Filed:
March 11, 2015
Date of Patent:
April 18, 2023
Assignees:
OHIO STATE INNOVATION FOUNDATION, THE UNIVERSITY OF TOLEDO
Inventors:
Howard David Dean, Mohammad H. Elahinia, Christoph Haberland, Michael J. Miller, Alok Sutradhar, Narges Shayesteh Moghaddam, Jason M. Walker, Roman Skoracki
Abstract: Disclosed herein methods of forming an Al—Ga containing film comprising: a) exposing a substrate comprising a ?-Ga2O3, wherein the substrate has a (100) or (?201) orientation, to a vapor phase comprising an aluminum precursor and a gallium precursor; and b) forming a ?-(AlxGa1-x)2O3 thin film by a chemical vapor deposition at predetermined conditions and wherein x is 0.01?x?0.7. Also disclosed herein are devices comprising the inventive films.
Type:
Grant
Filed:
April 15, 2021
Date of Patent:
April 11, 2023
Assignee:
Ohio State Innovation Foundation
Inventors:
Hongping Zhao, A F M Anhar Uddin Bhuiyan, Zixuan Feng
Abstract: The present disclosure relates to benzene-1,3,5-tricarboxamide derived ester lipid compounds, compositions, lipid-like nanoparticles, and methods for delivery of therapeutic, diagnostic, or prophylactic agents.
Abstract: Disclosed herein are methods and apparatus for making a determination about an eye in ambient lighting conditions comprising detecting ambient light reflected out of an eye of a subject from a retina of the eye of the subject and making a determination about the eye of the subject based upon the reflected ambient light, wherein the ambient light is adjusted for color temperature when making the determination about the eye.
Abstract: Disclosed herein are systems, methods and computer-program products to create synthetic immunohistochemistry (IHC) stained digital slides generated using artificial neural networks (ANNs). In some implementations, the created digital slides can be used as a ground truth to evaluate a method of analyzing IHC stained tissues.
Abstract: Described herein are Notch-modulating peptides (including monomers and multimers) capable of increasing or decreasing an immune response in a subject, compositions comprising the peptides, and methods of use thereof.
Type:
Grant
Filed:
March 26, 2018
Date of Patent:
March 28, 2023
Assignee:
Ohio State Innovation Foundation
Inventors:
Thomas J. Magliery, Mikhail M. Dikov, David Carbone, Nicholas Long, Brandon Sullivan, Elena Tchekneva