Patents Assigned to Pola Chemical Industries Inc.
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Publication number: 20100055220Abstract: A technology for delivering a ceramide across the horny layer of skin to sufficiently exert the effects of the ceramide is disclosed. Specifically, an external preparation for skin containing a ceramide delivers the ceramide across the horny layer to near the dermis when the skin preparation is applied on the skin surface. The described skin external preparation contains a ceramide, an organically modified clay mineral, a diester of N-acylglutamic acid, and a phytosterol as components in the form of water-in-oil emulsion.Type: ApplicationFiled: November 28, 2007Publication date: March 4, 2010Applicant: Pola Chemical Industries Inc.Inventors: Hidetaka Akatsuka, Ayako Seino, Tadahito Seto, Masashi Suzuki
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Publication number: 20100003210Abstract: To provide An external skin agent that prevents onset of atopic skin inflammations and is low irritant to skin, which is characterized by including: 1) clay modified by a compound having a quaternary amino group; and 2) a polymer or copolymer that has a side chain including a structure similar to a biological component.Type: ApplicationFiled: November 25, 2005Publication date: January 7, 2010Applicant: POLA CHEMICAL INDUSTRIES INC.Inventors: Yasuhiro Ohara, Masashi Suzuki, Norikazu Takano, Shunpei Mitsuyama
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Publication number: 20090162302Abstract: The present invention provides an organic inorganic composite powder which has a specific particle shape in accordance with to a washing solvent, which contains fine inorganic particles, and which easily disperses in water by: precipitating a metal salt dissolved in a reaction solvent from the reaction solvent through neutralization or reduction in the presence of a polymer or monomer dissolved in the reaction solvent; polymerizing the monomer after precipitation of the metal salt in the case where the monomer forms no composite with the metal salt during precipitation in the presence of the monomer; washing the obtained precipitate with a specific washing solvent; and drying the resultant.Type: ApplicationFiled: June 15, 2006Publication date: June 25, 2009Applicant: Pola Chemical Industries Inc.Inventors: Yutaka Takasuga, Eiji Takahashi
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Patent number: 7531576Abstract: Biphenyl derivatives represented by the following formula (1): wherein R1 represents a C5-7 alkyl group, R2 represents a substituted or unsubstituted aromatic hydrocarbon, or cycloalkyl group, R3 represents a tetrazolyl group, —NHCOCF3, —NHSO2CF3 or —SO2NHCONHR4 in which R4 represents a substituted or unsubstituted aromatic hydrocarbon group, and Z represents a single bond, a C1-4 alkylene group or —SO2NH—, and salts thereof; and ACAT inhibitors and medicines containing them as active ingredients. The compounds according to the present invention possess excellent ACAT inhibitory activities, and are useful as preventives and/or therapeutics for diseases cased by the enhancement of ACAT activity, for example, hypercholesterolemia, atherosclerosis and the like.Type: GrantFiled: December 5, 2001Date of Patent: May 12, 2009Assignee: Pola Chemical Industries, Inc.Inventors: Takayuki Namiki, Kenichi Kishii, Masaki Mitani, Masashi Tamai, Naoki Hiyama, Makoto Kimura, Satoshi Ichinomiya
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Publication number: 20090075946Abstract: In a triterpenic acid having hydroxyl groups, at least one of the hydroxyl groups is phosphorylated to produce a phosphorylated triterpenic acid and/or a salt thereof, thereby improving the solubility of the triterpenic acid in a preparation for external application for the skin and allowing the physiological activity of the triterpenic acid to be exerted satisfactorily. The phosphorylated triterpenic acid is preferably, for example, ursolic acid phosphate and/or a salt thereof. The preparation for external application for the skin is preferably a cosmetic, particularly preferably a quasi-drug.Type: ApplicationFiled: April 13, 2006Publication date: March 19, 2009Applicant: Pola Chemical Industries Inc.Inventors: Michio Ochiai, Kenichi Goto, Yoshihiro Tokudome, Shigenari Hirokawa
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Publication number: 20090054515Abstract: Disclosed are: a novel skin-whitening agent; and a skin-whitening cosmetic or quasi-drug which is highly effective for prevention/amelioration of melanopathy and is prepared using the skin-whitening agent. The cosmetic contains a compound represented by the general formula (I) and/or a salt thereof as an active ingredient. In the general formula (I), R1 and R2 independently represent a secondary or tertiary alkyl group having 3 to 7 carbon atoms; and R3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to carbon atoms.Type: ApplicationFiled: February 6, 2007Publication date: February 26, 2009Applicant: POLA CHEMICAL INDUSTRIES INC.Inventors: Takayuki Katagiri, Kouji Yokoyama, Makoto Kimura, Yuko Saitoh
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Publication number: 20080304736Abstract: A method of estimating a visual evaluation value of beauty of a skin, and a device and a program for calculating a visual evaluation value of beauty of a skin are provided. Anybody can easily estimate a visual evaluation value of beauty of a skin objectively and quantitatively. A visual evaluation value of beauty of the skin is estimated by using a correlation between a visual evaluation value of beauty of the skin and a fractal dimension of a distribution of a color system signal of an image of the skin or a 3-dimensional skin surface relief value of a skin surface.Type: ApplicationFiled: September 26, 2007Publication date: December 11, 2008Applicants: Masahiro Nakagawa, Pola Chemical Industries Inc.Inventors: Masahiro Nakagawa, Koji Mizukoshi, Midori Oyobikawa, Katsuo Matsomoto
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Patent number: 7425427Abstract: A method for preparing corneocytes specimen, which comprises stripping off corneocytes from the surface of a skin using an adhesive material, staining the corneocytes in a solution of stain in solvent containing a water-miscible organic solvent, and mounting the stained corneocytes into an oil and fat constituent and/or composition that is liquid at 1 atm, 25° C.Type: GrantFiled: May 18, 2004Date of Patent: September 16, 2008Assignee: Pola Chemical Industries Inc.Inventors: Yoshikazu Hirai, Kenya Hirayama, Nobuo Kashibuchi, Sonoko Kawasaki, Hiroaki Imai, Yoko Zemba, Takanori Takahashi, Seiichi Takaya, Chikako Kamata, Toshikazu Yagi, Jiro Yabusaki
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Patent number: 7421105Abstract: A method for preparing corneocites specimen, which comprises stripping off corneocites from the surface of a skin using an adhesive material, staining the corneocites in a solution of stain in solvent containing a water-miscible organic solvent, and mounting the stained corneocites into an oil and fat constituent and/or composition that is liquid at 1 atm, 25° C.Type: GrantFiled: May 18, 2004Date of Patent: September 2, 2008Assignee: Pola Chemical Industries Inc.Inventors: Yoshikazu Hirai, Kenya Hirayama, Nobuo Kashibuchi, Sonoko Kawasaki, Hiroaki Imai, Yoko Zemba, Takanori Takahashi, Seiichi Takaya, Chikako Kamata, Toshikazu Yagi, Jiro Yabusaki
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Patent number: 7197359Abstract: The present invention relates to compositions for electroporation which are useful in elevating percutaneous absorbability of drugs, etc. By controlling electrolyte concentration of compositions for electroporation so as to make an osmotic pressure of the compositions not more than a physical osmotic pressure, the percutaneous absorbability of drugs can be elevated.Type: GrantFiled: April 6, 2000Date of Patent: March 27, 2007Assignee: Pola Chemical Industries Inc.Inventors: Yoshihiro Tokudome, Koji Owaku, Kenichi Goto, Kenji Sugibayashi
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Publication number: 20060229912Abstract: A beauty information providing system, includes: a first computer used in counseling of a customer who visits a merchandise store; a second computer used in counseling of a customer who visits an aesthetic treatment salon; a server connected to the first and second computers via communication networks; evaluation result creating unit which creates results of evaluating a customer's skin based on at least results of analysis on images of corneocytes collected from the customer's skin, results of analysis on enlarged images of the customer's skin, and the customer's answers to a skin evaluation questionnaire; and screen data creating unit which creates screen data for showing the evaluation results, screen data for showing skin care advice suited to the evaluation results, and screen data for showing an aesthetic treatment recipe suited to the evaluation results.Type: ApplicationFiled: April 5, 2006Publication date: October 12, 2006Applicant: Pola Chemical Industries Inc.Inventors: Shuji Negishi, Takanori Takahashi, Yoshikazu Hirai, Fukuyoshi Mori
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Patent number: 7089053Abstract: The present invention relates to compositions for electroporation which are useful in elevating a percutaneous absorbability of drugs, etc. By adding polyhydric alcohols to compositions for electroporation, the percutaneous absorbability of drugs is elevated.Type: GrantFiled: April 6, 2000Date of Patent: August 8, 2006Assignee: Pola Chemical Industries IncInventors: Yoshihiro Tokudome, Koji Owaku, Kenichi Goto, Kenji Sugibayashi
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Patent number: 7052866Abstract: A correct viable cell number of a microorganism in a biological tissue is measured by cultivating a fragment of the biological tissue such as skin infected with the microorganism and administered with an antimicrobial agent, in a medium containing a phospholipid, a nonionic surfactant, or both of the phospholipid and the nonionic surfactant.Type: GrantFiled: June 15, 2005Date of Patent: May 30, 2006Assignee: Pola Chemical Industries Inc.Inventors: Takuji Nakashima, Akira Nozawa, Takao Ito
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Patent number: 6929927Abstract: A correct viable cell number of a microorganism in a biological tissue is measured by cultivating a fragment of the biological tissue such as skin infected with the microorganism and administered with an antimicrobial agent, in a medium containing a phospholipid, a nonionic surfactant, or both of the phospholipid and the nonionic surfactant.Type: GrantFiled: July 31, 2001Date of Patent: August 16, 2005Assignee: Pola Chemical Industries Inc.Inventors: Takuji Nakashima, Akira Nozawa, Takao Ito
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Patent number: 6881841Abstract: Dibenzosuberanyl piperazine derivatives represented by the following formula (I): wherein R represents an aliphatic hydrocarbon group, which may contain one or more heteroatom-containing substituent groups and may preferably contain 2 to 30 carbon atoms, and physiologically acceptable salts thereof; and medicinal compositions containing these dibenzosuberanyl piperazine derivatives and/or physiologically acceptable salts thereof. These compounds show effectiveness in allowing resistance-acquired causes of diseases to restore sensitivity to drug, that is, a resistance overcoming effect.Type: GrantFiled: November 20, 2001Date of Patent: April 19, 2005Assignees: Pola Chemical Industries, Inc.Inventors: Tsutomu Takeuchi, Hiroaki Takayanagi, Seiki Kobayashi, Yumiko Osa, Yumiko Suzuki, Yoko Sato, Masakazu Sakaguchi, Yoshiyuki Miyata
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Patent number: 6878548Abstract: The present invention is a composition for percutaneous administration suitable for electroporation. Percutaneous absorption of a drug and so forth in a composition for electroporation can be promoted by adding alkaline earth metal ions to the composition.Type: GrantFiled: February 19, 2002Date of Patent: April 12, 2005Assignee: Pola Chemical Industries Inc.Inventors: Yoshihiro Tokudome, Toshihiro Hinokitani, Kenichi Goto, Kenji Sugibayashi, Koji Owaku, Yasunori Inaoka
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Patent number: 6797711Abstract: Benzofuran derivatives represented by formula (I) or salts thereof: (wherein R1 represents a phenyl group or a hydrogen atom; k is 0 or 1; each of m, n, o, p, and q is an integer of 0 to 5; and each of R2 and R3 represents a hydrogen atom or a hydroxyl group, or R2 and R3 together represent an oxygen atom, with proviso that k, q, and m, or n, o, and p are not simultaneously 0). The compounds inhibit phosphorylation of STAT 6 and are useful in the treatment or prevention of allergic diseases.Type: GrantFiled: June 26, 2003Date of Patent: September 28, 2004Assignee: Pola Chemical Industries, Inc.Inventors: Nobuyuki Kawakatsu, Takayuki Namiki, Norihisa Yamazaki, Masayuki Yuasa, Toyohiko Miki, Noriko Suenobu, Tomomasa Shimanuki
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Patent number: 6786100Abstract: A device for measuring mechanical properties of an elastic body, comprising: at least two contacts adapted to contact a surface of an elastic body to be measured, at least one of said contacts being a movable contact; a drive section for moving said movable contact; a control section for controlling an action of said drive section; a detecting section for detecting a stress generated by the movement of said contact as an electric signal; and a processing section for processing the electric signal for the stress detected by said detecting section and an amount of movement of said movable contact, wherein the action of said contacts making contact with the surface of said elastic body includes a closing action of the two of the contacts and a stationarily holding action after the closing action.Type: GrantFiled: July 19, 2002Date of Patent: September 7, 2004Assignee: Pola Chemical Industries Inc.Inventors: Ai Oba, Yasutomo Nishimori
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Patent number: 6743925Abstract: A nitroimidazole derivative represented by the following formula (1): [wherein R1 represents a hydrogen atom or a C1-C4 alkanoyl group; and X represents a fluorine atom or an isotope thereof], and a diagnostic imaging agent containing the derivative as an active ingredient. The derivative enables imaging of the ischemic sites of a circulatory organ or imaging of cancer cells, and thus the derivative can provide information about the position and the amount of the ischemic sites or the cancer cells. Therefore, the derivative contributes to selection of appropriate treatment of ischemia or cancer.Type: GrantFiled: August 7, 2002Date of Patent: June 1, 2004Assignees: Pola Chemical Industries, Inc.Inventors: Yoshihiro Takai, Tatsuo Ido, Michihiko Tsujitani
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Patent number: D611354Type: GrantFiled: April 27, 2009Date of Patent: March 9, 2010Assignee: POLA Chemical Industries, Inc.Inventors: Takeshi Usui, Takashi Matsui, Yushi Watanabe, Kentaro Ito, Haruyo Eto