Abstract: Disclosed herein are a method for inducing apoptosis of cancer cells, which comprises administering an effective amount of a 2-nitroimidazole derivative represented by the general formula (1): ##STR1## wherein R represents an alkyl, alkenyl or alkynyl group substituted by 1 to 3 hydroxyl groups, and a method for treating a cancer, which comprises using the method for inducing apoptosis in combination with another means for killing cancer cells.

Abstract: A make-up cosmetic product, which enhances the appearance of complexion, is evaluated by irradiating lights having a wavelength range of visible light onto a surface on which the make-up cosmetic product is applied, from at least two directions with different incident angles, measuring a plurality of spectra of reflected lights obtained from the irradiated lights, respectively, and comparing the spectrum patterns with each other. This clarifies the optical theory by which the skin looks beautiful and provides a method for evaluating a make-up cosmetic product making the skin look beautiful.

Abstract: A mammal is immunized by using an antigen of a peptide having an amino acid sequence existing in a region having low homology to amino acid sequences of tyrosinase-related proteins but included in an amino acid sequence of human tyrosinase, and then the spleen cells of the mammal is fused with cultured cells to prepare a hybridoma producing monoclonal antibody which binds to human tyrosinase and mouse tyrosinase but does not bind to the tyrosinase-related proteins.

Abstract: A method for inhibiting dopamine re-uptake and treating Parkinson's disease is disclosed comprising administering a compound represented by formula (1) or a physiologically acceptable salt thereof as the active ingredient: ##STR1## wherein R.sup.1 and R.sup.2 represent each hydrogen or halogen, R.sup.3 represents hydrogen, alkyl or acyl, R.sup.4 represents hydrogen, alkyl, acyl, alkylsulfonyl or optionally esterified carboxyl, Ar represents optionally substituted phenyl or nitrogenous monocyclic heteroaromatic group, m represents a number of 1 to 5, and n represents a number of 0 to 5.

Abstract: High purity 2-nitroimidazole derivatives having excellent radiosensitivity and high safety and useful as a drug to be used along with radiotherapy of various cancers can be prepared at a high yield from inexpensive diester of tartaric acid according to the following reaction formua, ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each individually represents an aliphatic group or an aromatic group, and X represents a halogen atom.

Abstract: The cosmetic composition of this invention which is a 2-methacryloyloxyethylphosphorylcholine polymer (Poly MPC) in a preferable amount of 0.001% to 10% by weight based on the total weight of the cosmetic composition. The cosmetic composition can repair damage to the skin and hair, such as dryness, loss of luster, etc. and enhance the moisture preservation capability thereof. It also has a good feel when applied.

Abstract: A diphenylpiperazine derivative represented by general formula (1), salt thereof, and drug for the circulatory organs containing the same as the active ingredient: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents hydrogen, halogen, alkyl, alkoxy, nitro, amino, hydroxy, optionally esterified carboxyl or trifluoromethyl; R.sup.3 represents hydrogen, alkyl, aralkyl, acyl, nitro or optionally esterified carboxymethyl; Ar represents phenyl or naphthyl which may have one to three substituents such as halogen, alkyl, alkoxy, aryloxy, aralkyloxy, nitro, amino, cyano, acyl, hydroxy, optionally esterified carboxyl, substituted sulfonyl, aryl or trifluoromethyl; Z represents sulfur or -NR.sup.4 - wherein R.sup.4 represents hydrogen, alkyl, aralkyl, acyl, aryl, substituted sulfonyl or optionally esterified carboxyl; m represents a number of 1 to 5; and n represents a number of 0 to 5.

Abstract: Disclosed herein is an antiprotozoal composition containing a 2-nitroimidazole derivative as its active component. This drug is especially useful against Trypanosoma cruzi. Process for the preparation is also disclosed.

Abstract: The present invention relates to a 2-nitroimidazole derivative represented by the following general formula (I): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different from each other and mean individually a hydrogen atom or an acyl group, and a radiosensitizer containing the same. The compound (I) according to this invention has an excellent radiosensitizing effect and high safety, so that a radiosensitizer containing the same is remarkably useful in the radiotherapy of cancers.

Abstract: Disclosed are a make-up cosmetic product containing, as a film-forming agent, a copolymer with a mean molecular weight of from 10,000 to 1,000,000, as prepared by copolymerizing an acrylate and a polymerizing carboxylic acid at a determined ratio or by copolymerizing an acrylate, at least one selected from vinyl acetate, methyl methacrylate and acrylamide and a polymerizing carboxylic acid at a determined ratio; and a double-coat type make-up cosmetic product comprising, a combination of an under make-up base for a first layer containing as a main component an adhesive film-forming agent such as said copolymer and a finishing make-up material for a second layer containing as a main component an aluminum powder.

Abstract: A container is capable of containing a plurality of creamy substances and of simultaneously extruding the plurality of creamy substances through holes formed in an upper wall. The container includes a tubular case provided with a plurality of chambers for containing the plurality of creamy substances, a tubular member disposed in each chamber for axial movement, a hollow cylinder rotatably fitted over the tubular member and having longitudinal teeth on its outer surface, the hollow cylinder being interlocked with the tubular member by means of screw threads, an extrusion plunger, fitted in each chamber for axial movement and including a plate member fitted in the chamber in a liquid-tight manner and a tubular boss projecting downwardly from the plate member, the latter being fitted between the tubular member and the hollow cylinder, and an operating member capable of simultaneously rotating the two hollow cylinderes.

Abstract: A novel heterocyclic derivative of formula (I): ##STR1## wherein R.sub.1 represents ##STR2## and R.sub.2 represents hydrogen or acyl. When R.sub.2 is acyl, the derivative can be prepared, for example, by the following process: ##STR3## wherein R.sub.4 is acyl and R.sub.1 is ##STR4## The derivative is less toxic and has radiosensitizing activity and antiviral activity even at a low concentration.Radiosensitizing agents and antiviral agents containing the derivative as active component are also disclosed.

Abstract: Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives are disclosed. The compounds are represented by the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 individually represent a hydrogen atom, a linear or branched alkyl group which may have a substituent, a cycloalkyl or phenyl group which may have a substituent, or a heterocyclic group which may have a substituent, and R.sub.3 is a hydrogen atom or a cyano group. The compounds have excellent circulatory disease curing activities as well as bronchodilation activities.

Abstract: A compact case designed with a technique of enabling a cosmetic material to be discharged always smoothly while maintaining the desired performance of sealing the cosmetic material to prevent the same from hardening. A flat plate is disposed movably in a case body, and a sealed sack to be filled with the cosmetic material is disposed under this flat plate. A pump capable of being driven by the flat plate to discharge the cosmetic material is provided in the sealed sack. The pump has a discharge hole formed in the flat plate. A cover is stretched over the upper surface of the flat plate to cover the discharge hole. A slit is formed in the cover so as to communicate with the discharge hole.

Abstract: A novel heterocyclic derivative of formula (I): ##STR1## wherein R.sub.1 represents ##STR2## and R.sub.2 represents hydrogen or acyl. When R.sub.2 is acyl, the derivative can be prepared, for example, by the following process: ##STR3## wherein R.sub.4 is acyl and R.sub.1 is ##STR4## The derivative is less toxic and has radiosensitizing activity and antiviral activity even at a low concentration.Radiosensitizing agents and antiviral agents containing the derivative as active component are also disclosed.

Abstract: An ultrasonic sealing apparatus is disclosed wherein a pair of sheet-like members a bottom portion of a tubular member is fuse-bonded together by frictional heat generated by ultrasonic vibration. The apparatus includes horn (1) and anvil (2) means interposed with members to be fuse-bonded together. The horn and anvil provide contact surfaces (3) in contact with the members to be fused. Each of the contact surfaces is formed with a plurality of grooves (4) to provide a plurality of protrusions (5). Each of the protrusions has a flat upper surface and slanted side surfaces (6), so that the protrusion has a trapezodial cross-section. The horn means applies ultrasonic vibration to the fuse-bonding surfaces of the members to be fused in a direction oblique or parallel therewith in association with the anvil means.