Patents Assigned to Pola Chemical Industries Inc.
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Patent number: 6740315Abstract: Coated powder is obtained by applying a material having a refractive index of 1.9 to 3.1 to powder having a refractive index of 1.3 to 1.8 as a core and further applying a material having a refractive index of 1.3 to 1.8 to the coated core. When this powder is used for cosmetics or paints, natural coloring can be accomplished without deteriorating lightness because a screening effect is not high.Type: GrantFiled: March 17, 1999Date of Patent: May 25, 2004Assignee: Pola Chemical Industries, Inc.Inventors: Kazuhiro Nishikata, Hirochika Nishimura
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Patent number: 6721595Abstract: The present invention relates to percutaneous sorbefacients for electroporation consisting of monoterpene and being useful in elevating percutaneous absorbability of drugs, etc. By adding these percutaneous sorbefacients to compositions for electroporation, the percutaneous absorbability of drugs can be elevated.Type: GrantFiled: April 11, 2002Date of Patent: April 13, 2004Assignee: Pola Chemical Industries Inc.Inventors: Yoshihiro Tokudome, Koji Owaku, Kenichi Goto, Kenji Sugibayashi
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Patent number: 6703468Abstract: A composition comprising a polymer containing a compound represented by Formula (1) or a salt thereof as a constituent monomer, or a polymer containing a structure represented by Formula (9) as a partial structure is used for protecting or improving skin. In the formula, R1, R2 and R3 each independently represent hydrogen atom, an alkyl group, an alkoxyl group, or an alkylamino group; R4 represents an amino acid residue, a polyamine residue, or an aminoalcohol residue; and X represents oxygen atom or a group represented as NH. In the formula, R1, R2 and R3 each independently represent hydrogen atom, an alkyl group, an alkoxyl group, or an alkylamino group; R4 represents an amino acid residue, a polyamine residue, or an aminoalcohol residue; and X represents oxygen atom or a group represented as NH.Type: GrantFiled: August 20, 2001Date of Patent: March 9, 2004Assignee: Pola Chemical Industries Inc.Inventors: Michi Otiai, Takao Hattori, Yoshio Kitada, Hideo Kuroda, Midori Oyobikawa, Satoshi Ichinomiya
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Patent number: 6586633Abstract: The present invention relates to amine derivatives represented by formula (1) or salts thereof. R3 represents C1-C3 alkyl, hydroxylated C1-C5 alkyl, C1-C5 acyl; C2-C5 alkenyl, or a halogen atom; and k, l, and m are each an integer of 1 to 4.) Exhibiting excellent antifungal effect, these compounds are highly useful as antifungal agents, antifungal compositions, drugs, etc.Type: GrantFiled: April 5, 2001Date of Patent: July 1, 2003Assignee: Pola Chemical Industries, Inc.Inventors: Masayuki Yuasa, Yukio Kawazu, Toshimitsu Suzuki, Toshiro Majima, Takao Itoh, Takuji Nakashima, Akira Nozawa, Hiroyuki Takimoto, Kouji Yokoyama
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Patent number: 6495524Abstract: To provide an external agent for thee skin that not only exhibits excellent effects of prevention and amelioration of skin pigmentation but also has no fear of giving adverse influences to the skin and can be used safely, there is added to an external agent for the skin one or more compound(s) selected from compounds represented by formula (I) below: (wherein R1, R2, R3, R4, and R5, independently represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; and R represents a hydrogen atom, an acyl group, or a sugar residue).Type: GrantFiled: October 10, 2000Date of Patent: December 17, 2002Assignee: Pola Chemical Industries Inc.Inventors: Takao Hattori, Takayuki Katagiri, Yoshio Kitada, Takashi Yoshida, Hideyuki Ito
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Patent number: 6475748Abstract: Disclosed is a method for differentiating human peripheral blood granulocytes which comprises cultivating the granulocytes in the presence of an interferon and acting an immune complex on said granulocytes in the presence of a chemiluminescent substance, and measuring the chemiluminescent amounts induced. It contributes to the screening of patients suffering from serious infectious diseases or a range of inflammations, and is advantageous for monitoring the curative effects for those patients.Type: GrantFiled: May 16, 1994Date of Patent: November 5, 2002Assignee: Pola Chemical Industries, Inc.Inventors: Toshiro Majima, Ryoichi Nagatomi, Tasuke Konno, Toshikazu Awataguchi, Yoshimi Yano
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Patent number: 6462003Abstract: A transparent solid soap or transparent soap material which comprises mainly of a salt of the fatty acid, is obtained by saponifying fatty acid or animal/vegetable oil with alkali, wherein 1) the alkali is sodium hydroxide and organic amine, and a molar ratio of sodium hydroxide to organic amine is from 1:0.8 to 1:2, and 2) a quantity of the alkali is 2 to 3 saponifying equivalents to the fatty acid or the animal/vegetable oil. The transparent solid soap and the transparent soap material according to the present invention can be easily produced without requiring a fine control of moisture content, and a maturing period till reduction in weight is settled, and, besides, good in stabilities of transparency and of weight with a passage of time.Type: GrantFiled: July 19, 2000Date of Patent: October 8, 2002Assignee: Pola Chemical Industries, Inc.Inventors: Isao Shimosato, Masanori Okada
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Patent number: 6340677Abstract: An object of the present invention is to provide a means of appropriately evaluating a skin conditioning-ameliorating agent for ameliorating bad skin conditions or preventing the skin conditions from getting worse and a composition for topical application to skin containing the above agent. The invention provides a method for evaluating a skin conditioning-ameliorating agent or a composition for topical application to skin containing the same using an animal having at least one skin portion with bad conditions, which comprises applying to the skin portion the skin conditioning-ameliorating agent or the composition for topical application to skin containing the agent and evaluating the agent or the composition using as an index changes of the degree of order of dermis collagen fiber bundle at the skin portion before and after application.Type: GrantFiled: September 13, 1999Date of Patent: January 22, 2002Assignee: Pola Chemical Industries, Inc.Inventors: Yasutomo Nishimori, Katsuo Matsumoto, Yukiko Kenjo
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Patent number: 6338854Abstract: Photoaging skin care preparations and methods of treating wrinkled skin are described. The photoaging skin care preparations contain at least one triterpenoid derivative which is a substituted form of ursolinic, oleanolic, or betulic acid. The photoaging skin care preparations inhibit photoaging and prevent and ameliorate wrinkled skin. The methods of treating wrinkled skin involve applying an effective amount of the skin care preparation to the wrinkled skin.Type: GrantFiled: October 24, 2000Date of Patent: January 15, 2002Assignee: Pola Chemical Industries, Inc.Inventors: Katsuo Matsumoto, Hiroki Tsuruoka, Norio Fujiwara, Yasutomo Nishimori, Yukiko Kenjo
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Patent number: 6329399Abstract: Novel amine derivatives having an excellent antimycotic effect represented by general formula (1) below and salts thereof are provided. [in the formula (1, R1 represents a C1-5 alkyl group which may be halogenated, R2 represents 4-(1,1-dimethylalkyl)benzyl group, 4-(1-methyl-phenylethyl)benzyl group, 1-or 2-naphthylmethyl group, or a hydrocarbon group having 3,3-dimethyl-1-butynyl group or a phenyl group at its terminal and 1 to 3 double bonds; R3 represents oxygen atom or a methylene group which may be substituted by a C1-4 alkyl group; and R4 represents 1-or 2 naphthyl group or a phenyl group which may be substituted.Type: GrantFiled: May 18, 2000Date of Patent: December 11, 2001Assignee: Pola Chemical Industries, Inc.Inventors: Takao Itoh, Takuji Nakashima, Akira Nozawa, Kouji Yokoyama, Hiroyuki Takimoto, Masayuki Yuasa, Yukio Kawazu, Toshimitsu Suzuki, Toshiro Majima
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Patent number: 6329382Abstract: The invention relates to a therapeutic and preventive medicament for respiratory diseases, comprising, as an active ingredient, a compound represented by the general formula (1): wherein R1 represents a linear, branched or cyclic alkyl group having 1 to 10 carbon atoms; and R2 represents a hydrogen or halogen atom, a substituted alkyl group, an amino group which may be substituted, a carboxyl group, an alkoxycarbonyl group, a carbamoyl group, or an alkylcarbamoyl group, or a salt thereof. This compound has excellent tracheobronchodilative effect and inhibitory effect on airway constriction.Type: GrantFiled: August 13, 1999Date of Patent: December 11, 2001Assignee: Pola Chemical Industries, Inc.Inventors: Takayuki Namiki, Masayuki Yuasa, Takako Takakuwa, Satoshi Ichinomiya, Masashi Tamai, Naoki Hiyama, Yukio Kawazu, Tomoaki Yahiro, Mayumi Sugio
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Patent number: 6207711Abstract: In order to obtain photoaging inhibitor comprising a triterpenoid compound having high safety and excellent photoaging inhibiting effect, a photoaging inhibitor comprises one or more compounds selected from triterpenoid derivatives and salts thereof, wherein the triterpenoid derivatives are derived by substituting a functional group for a hydrogen atom in a carboxyl group at the 28-position and/or a hydrogen atom in a hydroxyl group bonded to a carbon atom at the 3-position of ursolic, oleanolic or betulic acid, wherein at least one of the functional groups is a functional group having an aromatic ring.Type: GrantFiled: December 22, 1998Date of Patent: March 27, 2001Assignee: Pola Chemical Industries Inc.Inventors: Katsuo Matsumoto, Hiroki Tsuruoka, Norio Fujiwara, Yasutomo Nishimori, Yukiko Kenjo
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Patent number: 6156714Abstract: A transparent solid soap or transparent soap material which comprises mainly of a salt of the fatty acid, is obtained by saponifying fatty acid or animal/vegetable oil with alkali, wherein1) the alkali is sodium hydroxide and organic amine, and a molar ratio of sodium hydroxide to organic amine is from 1:0.8 to 1:2, and2) a quantity of the alkali is 2 to 3 saponifying equivalents to the fatty acid or the animal/vegetable oil.The transparent solid soap and the transparent soap material according to the present invention can be easily produced without requiring a fine control of moisture content, and a maturing period till reduction in weight is settled, and, besides, good in stabilities of transparency and of weight with a passage of time.Type: GrantFiled: May 3, 1999Date of Patent: December 5, 2000Assignee: Pola Chemical Industries, Inc.Inventors: Isao Shimosato, Masanori Okada
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Patent number: 6136863Abstract: This invention relates to compounds represented by the following formula (1): ##STR1## wherein R.sup.1 represents a substituted or unsubstituted phenyl group, R.sup.2 represents a substituted or unsubstituted phenylene group, R.sup.3 represents a substituted or unsubstituted phenyl group or an aliphatic hydrocarbon group containing at least four .pi. electrons, R.sup.4 represents an alkyl group having 1 to 4 carbon atoms, and m and n individually represent integers of from 1 to 4, or salts thereof, and also to compositions containing the same. These compounds have antifungal activities and are useful as drugs.Type: GrantFiled: August 7, 1998Date of Patent: October 24, 2000Assignee: Pola Chemical Industries, Inc.Inventors: Yukio Kawazu, Masayuki Yuasa, Toshimitsu Suzuki, Takuji Nakashima, Takao Itoh, Toshiro Majima
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Patent number: 6100280Abstract: A narcotic antagonist comprising, as its active component, a compound represented by the following formula (1) or a physiologically acceptable salt thereof: wherein each of R.sup.1 and R.sup.2, which may be identical to or different from each other, represents a hydrogen atom or a halogen atom; R.sup.3 represents a hydrogen atom, an alkyl group, or an acyl group; R.sup.4 represents a hydrogen atom, an alkyl group, an acyl group, an alkylsulfonyl group, or a carboxyl group which may be esterified; Ar represents a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, an alkyl group, an alkoxyl group, a nitro group, an amino group, an alkylamino group, and a hydroxyl group or Ar represents a monocyclic aromatic heterocyclic ring having a nitrogen atom; m represents a number of 1 to 5 inclusive; and n represents a number of 0 to 5 inclusive. Also, a medicament for the prevention and treatment of narcotic dependence is provided.Type: GrantFiled: May 28, 1998Date of Patent: August 8, 2000Assignee: Pola Chemical Industries, Inc.Inventors: Masato Inazu, Mariko Harada, Tomoko Masuda
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Patent number: 6057330Abstract: The invention relates to compounds represented by the following general formula (1): ##STR1## wherein R.sup.1 represents an alkyl group, R.sup.2 represents an amino group, alkyl group or the like, and R.sup.3 represents a nitro group, amino group, heterocyclic group, alkylsulfonylamino group or the like, or salts thereof, medicines comprising such a compound, a preparation process of the compounds, and intermediates useful for preparation thereof. The compounds (1) are useful for the prevention and treatment of a respiratory disease.Type: GrantFiled: January 25, 1999Date of Patent: May 2, 2000Assignee: Pola Chemical Industries, Inc.Inventors: Takayuki Namiki, Masayuki Yuasa, Takako Takakuwa, Satoshi Ichinomiya, Yukio Kawazu, Kenichi Kishii, Norio Funayama, Mariko Harada, Kyoko Taneda, Naoki Hiyama, Tomoaki Yahiro, Mayumi Sugio, Masashi Tamai
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Patent number: 6015925Abstract: This invention relates to compounds represented by the following formula (1): ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aromatic hydrocarbon group having 6 to 18 carbon atoms, R.sup.2 represents a hydrogen atom or a substituted or unsubstituted aromatic hydrocarbon group having 6 to 18 carbon atoms, R.sup.3 represents an alkyl group having 1 to 4 carbon atoms, R.sup.4 represents a substituted or unsubstituted phenyl group or an aliphatic hydrocarbon group containing at least four .pi. electrons, and m and n individually represent integers of from 1 to 4, or salts thereof, and also to compositions containing the same. These compounds have antifungal activities and are useful as drugs and the like.Type: GrantFiled: September 22, 1998Date of Patent: January 18, 2000Assignee: Pola Chemical Industries, Inc.Inventors: Yukio Kawazu, Toshimitsu Suzuki, Masayuki Yuasa, Yuichi Yokomizo, Toshiro Majima, Takao Ito, Takuji Nakashima, Akira Nozawa
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Patent number: 5976515Abstract: A steroid derivative is used as a blood flow amount-improving agent, which is blended with a cosmetic preferably in a ratio of 0.000001 to 10% by weight with respect to a total amount of the cosmetic.Type: GrantFiled: October 21, 1996Date of Patent: November 2, 1999Assignees: Pola Chemical Industries, Inc., Kuniro TsujiInventors: Kuniro Tsuji, Junichi Shibata, Masanori Okada, Yasunori Inaoka
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Patent number: 5952308Abstract: A mineral absorption promoting agent containing oligouronic acid, e. g. oligogalacturonic acid or oligomannuronic acid ?degree of polymerization (n)=1 to 9! is described. Since this oligouronic acid ?polymerization degree (n)=1 to 9! forms a complex with mineral, it promotes absorption of minerals into living organisms by simply adding it to foods, drinks or pharmacentical compositions for oral use. Since the agent has no problem with safety, the agent is suitable for repeated eating, drinking or taking, and the agent is very effective.Type: GrantFiled: July 24, 1992Date of Patent: September 14, 1999Assignee: Pola Chemical Industries Inc.Inventors: Noboru Nakanishi, Yoshio Kitada
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Patent number: 5942515Abstract: The invention relates to compounds represented by the following general formula (1): ##STR1## wherein R.sup.1 represents an alkyl group, R.sup.2 represents an amino group, alkyl group or the like, and R.sup.3 represents a nitro group, amino group, heterocyclic group, alkylsulfonylamino group or the like, or salts thereof, medicines comprising such a compound, a preparation process of the compounds, and intermediates useful for preparation thereof. The compounds (1) are useful for the prevention and treatment of a respiratory disease.Type: GrantFiled: February 2, 1998Date of Patent: August 24, 1999Assignee: Pola Chemical Industries, Inc.Inventors: Takayuki Namiki, Masayuki Yuasa, Takako Takakuwa, Satoshi Ichinomiya, Yukio Kawazu, Kenichi Kishii, Norio Funayama, Mariko Harada, Kyoko Taneda, Naoki Hiyama, Tomoaki Yahiro, Mayumi Sugio, Masashi Tamai