Patents Assigned to Research Development Foundation
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Publication number: 20240083920Abstract: Embodiments of the invention relate to a corrole according to formula [I]; wherein R1, R2, and R3 are each independently H, —COOH, CF3, or a halide selected from the group consisting of F—, Cl—, Br— and I, with the proviso that R1, R2, and R3 can not all be CF3, and when the compound is of Formula II, wherein M is a metallic ion or an elemental ion selected from the group consisting of an elemental ion of group 13-16 in row 3 or above and boron, preferably selected from the group consisting of: Fe, Mn, Ga, P, Mo, Re, Co and Cu, or a salt thereof. Methods for treatment, catalysis, and detection using the compounds are also described.Type: ApplicationFiled: January 11, 2022Publication date: March 14, 2024Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTDInventors: Zeev GROSS, Atif MAHAMMED
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Patent number: 11927117Abstract: A method for converting heat to mechanical work including providing incoming heat transfer fluid (HTF) at a first temperature to a mixing chamber, providing incoming compressed gas at a second temperature to the mixing chamber, enabling the gas and the HTF to mix, producing a gas-and-HTF mix, enabling the HTF in the gas-and-HTF mix to heat the gas and isothermal expansion of the gas in the gas-and-HTF mix, limiting volume of the gas-and-HTF mix, thereby increasing pressure of the gas and causing acceleration of a flow of the gas-and-HTF mix, causing the gas-and-HTF mix to eject through a nozzle, thereby converting the heat of the HTF to kinetic energy, and using the kinetic energy to produce mechanical work. Related apparatus and methods are also described.Type: GrantFiled: August 30, 2021Date of Patent: March 12, 2024Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Carmel Rotschild, Joseph Cassell
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Publication number: 20240079622Abstract: Polymeric ion conductors composed of a polymeric or co-polymeric backbone which comprises a plurality of backbone units, a metal ligand attached to at least a portion of the backbone units, and a metal ion attached to the metal ligand are provided. The metal ligand can be an N-heterocyclic carbene ligand and the metal can feature low oxophilicity. lonomeric materials, including, for example, ion exchange membranes such as anion exchange membranes, made of the polymeric ion conductor, and electrochemical systems and articles-of-manufacturing containing the polymeric ion conductor or the ion exchange membrane are also provided.Type: ApplicationFiled: December 31, 2021Publication date: March 7, 2024Applicant: Technion Research & Development Foundation LimitedInventors: Charles Eliezer DIESENDRUCK, Dario R. DEKEL
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Publication number: 20240065829Abstract: An aspect of some embodiments of the invention relates to methods of manufacturing a 3D printed implant, comprising printing a mold of a scaffold, generating said scaffold from said mold, seeding cells on said scaffold, where said generating said scaffold comprises generating parts of said scaffold with different levels of stiffness.Type: ApplicationFiled: January 4, 2022Publication date: February 29, 2024Applicants: Technion Research & Development Foundation Limited, Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventors: Shulamit LEVENBERG, Shira LANDAU, Shay DUVDEVANI
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Patent number: 11916148Abstract: A self-healing field-effect transistor (FET) device is disclosed in this application, the self-healing FET has a self-healing substrate, a self-healing dielectric layer, a gate electrode, at least one source electrode, at least one drain electrode, and at least one channel. The self-healing substrate and the self-healing dielectric layer have a disulfide-containing poly(urea-urethane) (PUU) polymer. The self-healing dielectric layer has a thickness of less than about 10 ?m. The electrodes have electrically conductive elongated nanostructures. The at least one channel has semi-conducting elongated nanostructures.Type: GrantFiled: December 17, 2022Date of Patent: February 27, 2024Assignee: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.Inventors: Hossam Haick, Muhammad Khatib
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Patent number: 11911373Abstract: Provided are methods for diagnosing or selecting a mammal in need of a stimulant ADHD drug, conducting a non-specific electro-dermal responses (EDAs) analysis and/or an auditory sustained attention (ASAT) analysis on the mammal and administering or adjusting the dose of a stimulant ADHD drug to be administered to the mammal.Type: GrantFiled: August 15, 2019Date of Patent: February 27, 2024Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Avraham Avital, Zev Brand
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Patent number: 11913043Abstract: The invention is directed to cell-targeted cytotoxic agents, including sortase serine protease constructs. Methods for targeted cell killing for treatment of proliferative diseases, for example, cancer, are provided. Exemplary embodiments comprise an R-spondin ligand for targeting the cytotoxic agents to effect the cell killing.Type: GrantFiled: November 4, 2021Date of Patent: February 27, 2024Assignee: Research Development FoundationInventors: Xinjian Lin, Xiying Shang, Stephen B. Howell
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Patent number: 11911745Abstract: Provided herein is a porous ?-cyclodextrin-containing monolith having a microstructure templated by the external phase of a HIPE, as well as processes of manufacturing the same and uses thereof.Type: GrantFiled: August 2, 2021Date of Patent: February 27, 2024Assignee: Technion Research & Development Foundation LimitedInventors: Rajashekharayya A. Sanguramath, Inna Berezovska, Michael S. Silverstein
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Patent number: 11906498Abstract: Compositions comprising electrospun fibers and colorimetric detection encapsulated thereto are provided. Further, methods of use of said composition, including, but not limited to in-situ detection of molecules of interest, such as explosive compounds, are provided.Type: GrantFiled: October 19, 2020Date of Patent: February 20, 2024Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Eyal Zussman, Yuval Eshed, Reshef Gal-Oz
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Publication number: 20240054699Abstract: A method for reconstructing spatial information, the method includes: (i) Obtaining an under-sampled frequency domain representation (FDR) of the spatial information. The under-sampled FDR was obtained by sampling an FDR of the spatial information with a sampling mask. (ii) Feeding the under-sampled FDR and the sampling mask to a machine learning process. (iii) Reconstructing the spatial information by the machine learning process. The machine learning process was trained using a training data set that includes training under-sampled FRDs of training spatial information, and one or more training sampling masks that were used to sample FDRs of training spatial information.Type: ApplicationFiled: August 14, 2023Publication date: February 15, 2024Applicant: Technion Research & Development Foundation LimitedInventors: Mordechay Pinchas Freiman, Nitzan Avidan
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Publication number: 20240041543Abstract: An assembly for driving movement of an elongate surgical tool, comprising: a plurality of adjacent pairs of driving wheels, each pair of driving wheels having a space therebetween such that spaces of the plurality of pairs of driving wheels are axially aligned to form a channel for the elongate surgical tool to extend through; wherein at least one pair of driving wheels out of the plurality of pairs is arranged to lie on a plane different than a plane on which at least one other pair of driving wheels lies.Type: ApplicationFiled: October 19, 2023Publication date: February 8, 2024Applicants: Microbot Medical Ltd., Technion Research & Development Foundation LimitedInventors: Simon SHARON, Idan BOADER, Evgeny KOFMAN, Zev SOHN, Moshe SHOHAM, Eran COHEN, Eyal MORAG
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Publication number: 20240039246Abstract: A surface-emitting light source system for generating coherent light having two spin modes comprises a two-dimensional material exhibiting a direct band gap. The two-dimensional material is coupled to a planar heterostructure cavity having an inversion asymmetric core region at least partially surrounded by an inversion symmetric cladding region.Type: ApplicationFiled: July 27, 2023Publication date: February 1, 2024Applicant: Technion Research & Development Foundation LimitedInventors: Erez HASMAN, Kexiu RONG
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Patent number: 11883447Abstract: Disclosed are methods and probiotic compositions for the treatment of a metabolic disease or disorder such as, e.g., obesity, type 2 diabetes, or fatty liver. In some embodiments, heat-inactivated Parabacteroides goldsteinii is enterically administered to a subject, such as a human patient, to treat the metabolic disease or disorder or to promote the development of warm microbiota to treat the metabolic disease or disorder. In some aspects, spermine or spermidine may be administered to a subject or used in vitro to promote the growth of microbiota that can be used for the treatment of a metabolic disease or disorder.Type: GrantFiled: September 18, 2020Date of Patent: January 30, 2024Assignee: Research Development FoundationInventors: Mirko Trajkovski, Claire Chevalier, Melis Çolako{hacek over (g)}lu
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Patent number: 11883813Abstract: Compositions comprising a tetraaryl ammonium salt, a tetraaryl ammonium salt covalently bound to a polymer and methods for manufacturing the same are disclosed. The disclosed compositions are useful e.g., for an anion exchange membrane, or an anion conducting polymer, and may further be used in electrochemical devices such as alkaline fuel cells, and alkaline redox-flow batteries.Type: GrantFiled: August 29, 2019Date of Patent: January 30, 2024Assignee: Technion Research & Development Foundation LimitedInventors: Charles Eliezer Diesendruck, Dario Dekel
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Publication number: 20240023813Abstract: Apparatus, systems and methods for ultrasound and photoacoustic guidance of coronary procedures are disclosed herein. Certain embodiments include a first catheter comprising an ultrasound transceiver, and a second catheter comprising a proximal end and a distal end, with a photoacoustic excitation light transmitter positioned at the distal end of the second catheter. The photoacoustic excitation light transmitter can be configured to emit excitation light in a conical pattern and at a specific pulse duration. The second catheter can be configured to detect photoacoustic signals resulting from the absorption of excitation light emitted by the photoacoustic excitation light transmitter.Type: ApplicationFiled: September 14, 2021Publication date: January 25, 2024Applicant: RESEARCH DEVELOPMENT FOUNDATIONInventors: Thomas E. MILNER, Marc D. FELDMAN, Nitesh KATTA
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Patent number: 11879632Abstract: A system for generating light, comprises a spectral light source, characterized by a spectral line shape described by a visibility function; and a multimode waveguide, characterized by an optical path difference distribution described by a standard deviation. The standard deviation typically matches, within a predetermined tolerance, a location of a zero point of the visibility function at which a contrast of the visibility function is less than 0.1.Type: GrantFiled: April 16, 2021Date of Patent: January 23, 2024Assignee: Technion Research & Development Foundation LimitedInventors: Carmel Rotschild, Daria Negri, Michal Shimanovich, Matej Kurtulik
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Publication number: 20240018195Abstract: Provided herein are chimeric polypeptides that may be used, e.g., for the diagnosis of or vaccination against Ehrlichia chaffeensis and/or Ehrlichia canis.Type: ApplicationFiled: September 5, 2023Publication date: January 18, 2024Applicant: Research Development FoundationInventors: Jere W. McBRIDE, David H. WALKER
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Publication number: 20240018592Abstract: A method of analyzing the therapeutic efficacy of a therapeutic agent for treating an immune-related disorder is disclosed. The method comprises contacting blood cells of the subject with the agent, measuring the expression of at least 20 genes in the blood cells of the subject; obtaining an immune age value based on the expression of the at least 20 genes, and comparing the immune age value with an immune age value of the subject calculated on the basis of expression of the at least 20 genes in blood cells of the subject, in the absence of the agent.Type: ApplicationFiled: October 26, 2021Publication date: January 18, 2024Applicants: Technion Research & Development Foundation Limited, Rambam Med-Tech Ltd.Inventors: Shai S. SHEN-ORR, Yehuda CHOWERS, Ayelet ALPERT, Shiran GERASSY-VAINBERG, Erik FELDMAN
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Patent number: 11875199Abstract: A system comprising: at least one hardware processor; and a non-transitory computer-readable storage medium having stored thereon program instructions, the program instructions executable by the at least one hardware processor to: receive a data stream representing events; receive a plurality of complex event patterns (CEPs) comprising (a) a set of conditions reflecting relations among said events, and (b) a set of attributes associated with each of said events; and calculate an optimal multi-pattern evaluation plan corresponding to said CEPs by: (i) generating an initial evaluation plan, (ii) applying a search method to calculate modified versions of said initial evaluation plan, (iii) assigning a score to each of said modified versions based on a cost function, and (iv) selecting one of said modified versions having a highest said score as said optimal multi-pattern evaluation plan.Type: GrantFiled: January 7, 2020Date of Patent: January 16, 2024Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Ilya Kolchinsky, Assaf Schuster
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Publication number: 20240010742Abstract: In some aspects, mutant or variant Fc domains are provided that can exhibit increased affinity or selectivity for Fc?RIIB. The variant Fc domain may be a mutant IgG1 Fc domain. In some embodiments, a mutant or variant Fc domain may be present in a therapeutic antibody such as, e.g., an agonistic antibody. Additional methods for using and identifying mutant Fc domains are also provided.Type: ApplicationFiled: June 9, 2023Publication date: January 11, 2024Applicant: Research Development FoundationInventors: George Georgiou, Jin Eyun Kim, Chang-Han Lee, George Delidakis