Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.

Abstract: The present invention relates to products and methods for modulating cardiac function.

Abstract: A method for locating a vessel, the method comprising illuminating at least a portion of the vessel with a background light having a substantially high susceptibility to absorption by particles in said portion of the vessel; detecting backscattered light from said illuminated portion of the vessel; reproducing an image from said backscattered light; and identifying dark regions within said reproduced image.

Abstract: The invention provides metal-peptoid complexes for use as electrocatalyst in water oxidation processes.

Abstract: An optical digital to analog converter (oDAC) that may include (a) multiple optical paths that are parallel to each other; (b) a combiner, (c) a splitter that is configured to receive an optical signal at a splitter input and split the optical signal between multiple splitter outputs to provide multiple path input signals to the multiple optical paths. The multiple optical paths are configured to optically process, in parallel, path input signals to provide path output signals. Each optical path is configured to apply an optical process that comprises applying optical modulation, by an optical gate of the optical path and under a control of an electrical modulator, to provide an optical signal having a value selected out of multiple constellation levels. The combiner is configured to add the multiple path output signals to provide an oDAC output signal having a value selected from values of a single quadrature constellation.

Abstract: The current disclosure provides for methods for differentiating stem and progenitor cells into neural cells through an approach that excludes the use of SMAD or Noggin inhibition. Aspects of the disclosure relate to a method for differentiating stem or progenitor cells into neural cells, the method comprising contacting the cells with a compound selected from DMH1, DMH2, K02288, A8301, or combinations thereof.

Abstract: An airfoil surface skin, comprising a network of a solid material, embedded in a base of deformable solid material. Fluid pressure applied to the interface between the network and the surrounding embedding material, opens an internal network of channels by viscous peeling of the surrounding solid from the network. The network is offset from the centerline the surround material, such that pressure driven viscous flow through the narrow channels generates two types of deformation of the skin—an in-plane elongation and a curvature of the skin plane itself. The shape of the internal solid core element and its material, and the material of the encompassing solid are chosen to achieve a desired integral structural rigidity. The injected fluid pressure determines the extent of extension and bending. Use of this skin enables shape amending airfoils having reduced drag compared with similar airfoils having conventional flap mechanisms.

Abstract: The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.

Abstract: The invention provides a method for treating cancer in which a level of reduced folate carrier (RFC) or folylpolyglutamate synthetase (FPGS) in cancer cells of the biopsy is determined. If the level of RFC or FPGS in the cancer cells is below a threshold value, the cancer is treated with an inhibitor of serine-hydroxymethyl-transferase (SHMT)1. If the level of RFC or FPGS in the cancer cells is above the threshold value, the cancer is treated with an inhibitor of SHMT2.

Abstract: The present invention discloses a scintillator structure and to a method for producing an output optical signal at a specific wavelength range. The scintillator structure comprises a multilayer nanostructure formed by at least one pair of alternating first and second layered material being arranged along one or more principal axes. The multi-layer nanostructure defines predetermined geometrical parameters and the structure is made of at least two different material compositions. At least one of the first layered material, the second layered material, or the combination of both, define scintillation properties. The invention also discloses a detector system for detecting an input radiation comprising a scintillator structure being as defined above and being configured and operable to collect most of the emitted optical signal.

Abstract: Provided herein is forward osmosis-based water purification process, that includes contacting a solution of a soluble draw agent with a dehydrated insoluble draw agent, separating the now hydrated insoluble draw agent from the now concentrated draw solution, and exerting a stimulus on the hydrated insoluble draw agent for extracting water therefrom, thereby regenerating a dehydrated insoluble draw agent, wherein the osmotic concentration (osmolality) of the insoluble draw agent is greater than the osmotic concentration of the diluted draw solution, and the insoluble draw agent is impermeable to the soluble draw agent.

Abstract: A method for localization of a drone within a building, the method may include (a) detecting, by an acoustic detection unit of the drone, sounds generated by a propulsion unit of the drone while the drone is located within the building; and (b) determining, by a processing unit of the drone, the location of the drone within the building, based on the sounds and on building acoustic information regarding sounds detected at different portions of the building.

Abstract: Modified quinolones (e.g., fluoroquinolones) featuring a quinolone (e.g., fluoroquinolone) skeleton having conjugated thereto, via selected linkers, a metal chelating moiety, and metal complexes thereof, are provided. Uses of the compounds and complexes in treating medical conditions associated with pathogenic microorganism are also provided.

Abstract: An adaptor for coupling a proximal portion of an elongate surgical tool to a motorized robotic surgical device, the adaptor comprising: a recess shaped and sized for receiving a proximal portion of an elongate surgical tool; one or more movers positioned to contact and move a control component of the proximal portion; and transmission coupling which couples the one or more movers to motorized transmission of the robotic surgical device.

Abstract: Systems for detecting fluorescence from a molecule comprising an ion-impermeable film comprising at least one ion-conducting nanopore; a first and second liquid reservoir separated by the film; a means to induce movement of the molecule from the first reservoir to the second reservoir via the nanopore; a light source capable of exciting the molecule to emit fluorescence, wherein the light source shines into the second reservoir; a metallic layer adhered to the film by an adhesion layer and comprising a nanowell structure located adjacent to the nanopore; and a detector configured to detect the fluorescence emitted by the molecule are provided. Methods of use of the systems are also provided.

Abstract: A system and method of detecting acoustic waves including directing a continuous-wave source laser beam to an optical resonator that is impinged by acoustic the waves. Optionally, the source laser beam can propagate through the optical resonator, thereby generating a propagated laser beam. Using an interferometer, the acoustic waves can be detected by monitoring transients in an optical phase of the propagated laser beam.

Abstract: A device that may include a transmitter that is configured to transmit, per each sensing iteration, a radiation pulse; an array of pixels, each pixel comprises multiple subpixels, each subpixel comprises single photon avalanche diodes (SPADs) that are coupled to each other in parallel, and one or more quenching circuits, wherein each subpixel is configured to output a subpixel output signal indicative of a reflected radiation pulse sensed by one or more SPADs of the subpixel; wherein the reflected radiation pulse is reflected from an area of an object that was illuminated by the radiation pulse; and a processing circuit that is configured to: read, for each pixel, multiple subpixel output signals from the multiple subpixels of the pixel; receive, per each sensing iteration, transmission timing information indicative of a timing of transmission of the radiation pulse; and determine, per each sensing iteration and per each subpixel, a timing of a first detection of the reflected pulse detected by any of the SPA

Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.

Abstract: A semiconductor laser element a first ring resonator. The first ring resonator includes a first semiconductor stack including a first n-side semiconductor layer, a first p-side semiconductor layer, and a first active layer located between the first n-side semiconductor layer and the first A-side semiconductor layer, wherein the first ring resonator comprises a diffraction grating. The semiconductor laser element further includes a second ring resonator optically coupled to the first ring resonator by evanescent field coupling. The second ring resonator includes a second semiconductor stack including a second n-side semiconductor layer, a second p-side semiconductor layer, and a second active layer located between the second n-side semiconductor layer and the second p-side semiconductor layer, wherein a peak wavelength of light emitted by the second ring resonator is the same as a peak wavelength of light emitted by the first ring resonator.

Abstract: Exemplary embodiments of the present disclosure include systems and methods for treatment of occlusions, including coronary artery chronic total occlusions.