Abstract: Systems (500, 1000) and methods (1700) for fabricating a soft tissue implant (100, 400). The methods generally involve: receiving implant data representative of the target implant; determining a planned weaving path for forming the soft tissue implant; and communicating the planned weaving path to an output device.

Abstract: This disclosure provides a novel gene editing method and system, termed dasCRISPR. dasCRISPR refines current approaches in gene editing by allowing an intended modification to be made in one genomic target while preventing modification to a second genomic target through protective sequestration. This balancing of repair and protection contributes to cellular survival by retention of one functional copy of a gene.

Abstract: Disclosed herein are compounds of formula (I), or a salt thereof and compositions comprising compounds of formula I that exhibit antibacterial activities, when tested alone and/or in combination with a bacterial efflux pump inhibitor. Also disclosed are methods of treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I alone or in combination with the administration of a bacterial efflux pump inhibitor.

Abstract: Systems and methods allow for incident data collection and management system based on unmanned aerial vehicles (UAVs), that is, drones to help accelerate the data collection and analytics, information dissemination, and decision support at incident sites. The system architecture may include onsite, server, and offline components including flight planning subsystem, flight execution and mission control subsystem, information dissemination subsystem to travelers and traveler information services, the interface with traffic management center, and the data analytic, visualization, and training subsystems. Other embodiments include the video-based 3D incident site reconstruction methods, site positioning and scaling methods with pre-collected static background infrastructure data, data management and user charging methods, and training methods with the generated 3D model.

Abstract: This invention relates to nucleic acids, reagents and methods for detecting Rifampicin-resistant Mycobacterium tuberculosis in a sample from a subject. In one aspect, the invention provides methods of detecting Rifampicin resistant M. tuberculosis in a sample comprising (a) amplifying a nucleic acid containing the rifampicin resistance determining region (RRDR) of the rpoB gene in a sample to provide an amplified nucleic acid; (b) probing the amplified nucleic acid with at least three molecular beacon probes for an RRDR mutant target; (c) conducting melting temperature (Tm) analysis to determine a Tm value for each probe; and (d) comparing the Tm value for each probe with a Tm value for a wild-type RRDR region, wherein a Tm value for at least one of the molecular beacon probes that is greater than the Tm value for the wild-type RRDR indicates the presence of rifampicin resistant M. tuberculosis in the sample.

Abstract: The present invention relates to organoids derived from a single cell, such as a kidney cancer cell, and methods and compositions relating to the production and use thereof, including cell culture medium for producing organoids and methods of personalized treatment for kidney cancer. The invention further provides a humanized mouse including a kidney organoid derived from a patient's kidney cell.

Abstract: Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.

Abstract: Disclosed is a method of treating a tumor in a patient, comprising (a) administering riluzole in an amount effective to sensitize the tumor cells to ionizing radiation, and (b) irradiating the tumor cells with ionizing radiation in a dose effective to reduce tumor cell growth. The method can further comprise administering an effective amount of one or more additional therapeutic agents.

Abstract: This disclosure provides a medical and healthcare service platform that is supported by a digital data currency system and provides medical and healthcare data processing, analyzing, and predicting based on a digital human system by integrating participating parties comprising individual persons, researchers, healthcare providers, and regulatory and public sectors.

Abstract: Disclosed are co-continuous immiscible polymer blends of a polysulfone and a polyaryletherketone optionally reinforced with carbon fiber. A method of preparing such a co-continuous immiscible polymer blend of a polysulfone and a polyaryletherketone reinforced with a carbon fiber is also disclosed.

Abstract: Endophytic bacteria, compositions comprising the same, and methods of use thereof are disclosed which increase the root and shoot growth of cotton host plants, suppress growth of soil borne fungal pathogens of host plants, and increase resistance of the plant to salt stress and other abiotic stressors.

Abstract: A method of light messaging, in which a hidden message is transmitted via coded image emitted from a display device and retrieved using a camera, comprises training a camera-display transfer model that receives images with hidden messages from an embedding model and generates modified coded images based on training data that accounts for properties of displays and cameras, the modified coded images delivered to a recovery model that decodes the hidden messages and outputs hidden message determinations, training both the embedding and recovery models using the CDTF model and training data to minimize differences between the input hidden messages and the hidden message determinations. After training the CDTF model and other models, embedding a hidden message in a carrier image using the embedding model, displaying the coded image using the display device, receiving the coded image at the camera, and retrieving the hidden message using the recovery model.

Abstract: The invention relates to a method of preparing titanium dioxide-coated nanostars. Titanium precursors are hydrolyzed into crystalline TiO2 polymorphs at low temperatures, allowing the delicate morphology of the nanostars to be preserved while maintaining their desirable photocatalytic properties.

Abstract: Provided herein are methods of identifying treatment-response signatures, such as in a subject with prostate cancer (such as a human or veterinary subject). In particular examples, the methods can determine with high accuracy whether a subject is likely to respond to a treatment. The methods can be computer-implemented methods.

Abstract: An antifungal peptide targeting P4-ATPase function is synthesized based on Cdc50 loop region to identify peptides sensitize caspofungin by blocking flippase function. It was found that myristylated peptides based on “AS15 sequence” was effective at high concentrations. A modified peptide, “AW9-Ma” showed minimum inhibitory concentration (MIC) of 64 ?g/mL against H99 wild type and fractional inhibitory concentration (FIC) index value of 0.5 when used with caspofungin. With the AW9-Ma peptide, C. neoformans wild type was highly sensitive to caspofungin with a MIC of 4 ?g/mL, the same as cdc50? mutant. Further assays with flow cytometry showed inhibition of lipid flippase enzyme activity and significant accumulation of phosphatidylserine on the cell surface. It was confirmed that the peptide co-localized with mCherry-tagged P4-ATPase protein Apt1 in C. neoformans.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: A system includes a device that is disposed within an environment and is adapted to communicate over a radio frequency communication link. The system also includes a wireless access point disposed within the environment, including a wireless transceiver in communication with the device over a radio frequency communication link using a plurality of channels, and recording a channel state information data set for the radio frequency communication link. The system also includes a monitoring device including a memory storing a plurality of activity profiles, each of which includes an activity and a channel state information profile corresponding to the activity, and a processor receiving, from the wireless access point, the channel state information data set and determining, based on a comparison of the channel state information data set to the channel state information profile of each of the plurality of activity profiles, the activity of the person in the environment.

Abstract: Compositions and methods for hydrogen production are disclosed.

Abstract: Described herein is a neuroaspiration catheter for removing a blood clot in a blood vessel. The neuroaspiration catheter includes a first tube, a second tube and a wire for guiding the navigation of the catheter. The wire can be navigated to the site of the blood clot, aid the navigation of the catheter, and left in the blood vessel during and after the aspiration. If the aspiration fails, the catheter can be quickly navigated back to the site of the blood clot using the wire as a guide. Also described herein is a method of removing a blood clot using the neuroaspiration catheter.

Abstract: A method of treating reduced pulmonary function by administering an effective dose of a Farnesoid X Receptor (FXR) agonist, particularly obeticholic acid, is disclosed. Also disclosed is an in vivo animal model of lung injury and altered functioning, useful for identifying compounds active in restoring pulmonary function.