Abstract: The present invention relates to a method for rapidly detecting copies of at least one RNA molecule expressed in individual cells and uses thereof.

Abstract: Disclosed are co-continuous immiscible polymer blends of a polysulfone and a polyaryletherketone optionally reinforced with carbon fiber. A method of preparing such a co-continuous immiscible polymer blend of a polysulfone and a polyaryletherketone reinforced with a carbon fiber is also disclosed.

Abstract: The present invention relates in certain aspects to antibodies, binding polypeptides, and immunoconjugates specific for human EPH receptor A5 (EphA5).

Abstract: This disclosure provides an improved assay capable of identifying and distinguishing viral variants, such as SARS-CoV-2 variants and subvariants, including Alpha, Beta, Gamma, Delta, and Omicron, with high specificity and sensitivity. The disclosed assay can be used for real-time monitoring of viral variants (e.g., SARS-CoV-2 variants) spread without the need for whole-genome sequencing on all samples.

Abstract: Compositions and methods for rapid and efficient Toehold mediated strand displacement (TMSD) reactions are disclosed.

Abstract: This disclosure provides a nano-graphitic sponge (NGS) and methods for preparing the nano-graphitic sponge. The disclosed nano-graphitic sponge possesses many excellent properties, including large surface areas and pore volumes, low-mass densities, good electrical conductivities and mechanical properties. These excellent properties make the nano-graphitic sponge an ideal material for many applications, such as electrodes for batteries and supercapacitors, fuel cells and solar cells, catalysts and catalyst supports, and sensors.

Abstract: The present invention relates to anti-matriptase antibodies and immunoconjugates of anti-matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising an anti-matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase.

Abstract: Systems and methods of applying a prediction model to metal oxide sensors that change their electric resistances in response to surrounding gas concentrations for predicting equilibrium state resistance values of the sensors. The method includes heating a metal oxide sensor to for a predetermined period of time for the metal oxide sensor to interact with a surrounding gas; sampling transient resistance values of the metal oxide sensor to obtain sampled transient resistance values; determining an electrical resistance of the metal oxide sensor in a chemical equilibrium state of the interaction of the metal oxide sensor and the surrounding gas via applying a neural network; and determining a concentration level of the surrounding gas at the chemical equilibrium state by mapping the determined electrical resistance to a corresponding concentration level of the surrounding gas.

Abstract: Disclosed herein are methods of treating and identifying subjects with ER+ breast cancer that will or will not develop resistance of tamoxifen. In some examples such methods include measuring expression of adaptor-related protein complex 2, sigma-1 subunit (AP2S1) from the retrograde neurotrophin signaling pathway, cyclin-dependent kinase 2 (CDC2) from the loss of NLP from mitotic centrosomes pathway, general transcription factor IIIC subunit 3 (GTF3C3) from the RNA polymerase III transcription initiation from Type 2 promoter pathway, eukaryotic translation initiation factor 2-alpha kinase 3 (EIFA2AK3) from the EIF2 pathway, and leucyl-tRNA synthetase (LARS) from the valine, leucine and isoleucine biosynthesis pathway.

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms and apparatus providing a sensing platform wherein one or more headphone drivers are used as a versatile sensor to receive excitation signals therefrom indicative of direct or indirect pressures associated with the ear canal acoustically cooperating with the diaphragms operatively coupled to the drivers.

Abstract: Inhibitors of interferon regulatory factor 5 (IRF5) nuclear localization and methods of using the inhibitors to treat autoimmune diseases such as systemic lupus erythematosus (SLE) are described.

Abstract: The present disclosure relates to constructs useful in expressing biotinylated monomers and tetramers produced from these monomers. The present disclosure also relates to methods for production and use of these tetramers in identifying and isolating antigen specific B cells and cloning antibodies thereto.

Abstract: Augmented or synergized anti-inflammatory constructs are disclosed including anti-inflammatory terpenes and/or vanilloids covalently conjugated to one another so that the activity of the conjugate is greater than the sum of its parts. Also disclosed are methods of improving the potency of an anti-inflammatory terpene or vanilloid by linking it to another anti-inflammatory terpene or vanilloid via a carbamate linkage, where the potency of the conjugate is greater than the sum of its parts.

Abstract: The identification of hypermethylated gene loci associated with a high risk of progressing from Barrett's esophagus to esophageal adenocarcinoma is described. The genes with hypermethylated loci include one or more of KLHL14, USP44, TMEM178, TRIM71, CTNNA2, NCAM1, CPXM1, SNCB, BMP3, SHISA3, BDNF, COL2A1, CBS, CLEC4GP1, LRAT, TTYH1, TMEM90B, NTN1, VASH2 and LBXCOR1. The hypermethylated DNA loci can be used as biomarkers to guide diagnostic and treatment decisions for subjects with Barrett's esophagus.

Abstract: Systems and methods for edge assisted real-time object detection for mobile augmented reality are provided. The system employs a low latency offloading process, decouples the rendering pipeline from the offloading pipeline, and uses a fast object tracking method to maintain detection accuracy. The system can operate on a mobile device, such as an AR device, and dynamically offloads computationally-intensive object detection functions to an edge cloud device using an adaptive offloading process. The system also includes dynamic RoI encoding and motion vector-based object tracking processes that operate in a tracking and rendering pipeline executing on the AR device.

Abstract: The invention relates to a method of preparing titanium dioxide-coated nanostars. Titanium precursors are hydrolyzed into crystalline TiO2 polymorphs at low temperatures, allowing the delicate morphology of the nanostars to be preserved while maintaining their desirable photocatalytic properties.

Abstract: A railroad tie formed of a polymeric or polymeric composite material and configured for enhanced mechanical interaction with an underlying ballast. The tie includes at least a top longitudinal surface, a pair of side longitudinal surfaces, a bottom longitudinal surface, and two end faces. At least the bottom longitudinal surface includes a plurality of indentations formed along a length thereof. Additionally, the tie includes at least one serrated edge portion having a plurality of serrations, the at least one serrated edge portion formed along at least part of the longitudinal length of the tie at an edge between at least one of the side longitudinal surfaces and the bottom longitudinal surface to provide for enhanced mechanical interaction with the ballast.

Abstract: The present invention broadly provides different compositions, kits, vectors, and methods including monoclonal antibodies directed to epitopes found within lipoarabinomannan (LAM) and phosphatidyl-myo-inositol mannoside 6 (PIM6) for the diagnosis and treatment of Mycobacterium tuberculosis infections.

Abstract: A method for forming a carbon fiber-reinforced polymer matrix composite by distributing carbon fibers or nanotubes into a molten polymer phase comprising one or more molten polymers; and applying a succession of shear strain events to the molten polymer phase so that the molten polymer phase breaks the carbon fibers successively with each event, producing reactive edges on the broken carbon fibers that react with and cross-link the one or more polymers. The composite shows improvements in mechanical properties, such as stiffness, strength and impact energy absorption.

Abstract: A new and distinct peach variety of Prunus persica named ‘NJ362’ is provided. This variety is distinguished from other peach varieties by its unique combination of non-showy flowers, medium to large, round, freestone fruit, with a greyed-red to greyed-purple blush over a yellow-white ground, ripening in late-season, and possessing sweet, sub-acid flavor.