Abstract: The present invention is in the area of coagulation analysis and relates to antibodies which bind specifically to an immune complex of prothrombin fragment F2/F1+2 and an F2/F1+2 neoepitope-specific antibody fragment, and to the preparation and the use thereof in methods for determining F2/F1+2.

Abstract: The invention relates to a retaining device (1) for a hollow needle (12) of a pipetting device in an automatic analysis apparatus. The retaining device (1) comprises a first retaining element (2), which can be secured releasably on a base plate that is movable in an automated manner, and a second retaining element (4), which is connected to the first retaining element (2), wherein at least one bearing bushing (14) is provided, which is fixed between the retaining elements (2, 4) and in which the hollow needle (12) is mounted.

Abstract: The invention is in the field of coagulation diagnostics and relates to in vitro methods for determining thrombocyte function using measuring cells, particularly measuring cells of the PFA system. The methods make it possible to obtain standardized measured results which are comparable, irrespective of the type of measuring cell used.

Abstract: The invention relates to a method of detecting nucleic acid molecules by immunoassay detection. Detection of a specific nucleic acid molecule of interest is achieved by using a nucleic acid probe in solution which hybridizes in solution to the nucleic acid molecule of interest. Immunoassay detection is achieved by using an antibody specific for the hybrid formed by hybridization of the nucleic acid probe to the nucleic acid molecule of interest.

Abstract: A homogeneous method for determining the enzymatic activity of an analyte in a sample permits simultaneous determination of the amount of enzyme in the same reaction mixture and determination of enzyme activators or inhibitors.

Abstract: An apparatus for separating rod-like or spherical agitating elements in an automatic analyzer allows quick and error-resistant separation and automated charging of cuvettes with the agitating elements. For this purpose, it comprises a lever provided with a bore, wherein the bore is configured such that it can accommodate one of the agitating elements. The bore, in a first position of the lever, is arranged beneath an entry opening and, in a second position of the lever, is arranged above an exit opening, wherein the lever, in the second position, closes the entry opening.

Abstract: The invention relates to a device and a method for the contactless capacitive filling level measurement of a filling medium in a container, the device having a plurality of measurement electrodes and at least one reference electrode.

Abstract: The present invention relates to a chromogenic method for simultaneously determining the activity of multiple coagulation proteases or for simultaneously determining the inhibition of multiple coagulation proteases in a single test reaction. For this purpose, use is made of two chromogenic substrates which have different absorption maxima and whose color signals can be separated spectrally.

Abstract: Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.

Abstract: The present invention is in the field of in-vitro diagnostics and relates to a method of determining the blood-clotting factor XIII (factor XIII, F XIII) with the aid of plasma-based reference material, and a test kit for carrying out the method.

Abstract: A device and a process for mixing a liquid sample in an automated analysis instrument comprises a support arm, a holder for a liquid container, a flexible intermediate element, arranged between the support arm and the holder for the liquid container, a shaking apparatus, and a coupling apparatus arranged on the holder for the liquid container, wherein the coupling apparatus can establish a detachable connection between the shaking apparatus and the holder for the liquid container.

Abstract: The invention lies in the area of platelet function diagnostics and relates to an in vitro method for the determination of platelet function under flow conditions. The method is particularly suitable for the determination of the effect of clopidogrel after oral intake and of other P2Y(12) antagonists with antithrombotic activity as well as the determination of P2Y(1) receptor antagonists with antithrombotic activity.

Abstract: A homogeneous method of determining inhibitors of proteolytically active coagulation factors (anticoagulants) in a sample, in particular direct thrombin and factor Xa inhibitors, and also a test kit to be used in such a method. Use is made of ligands which bind to the proteolytically active coagulation factor but are not cleaved by the latter and compete with the anticoagulant to be determined.

Abstract: A device for storing and/or dosing a solvent for dissolving a substance that is to be used in liquid form has a container, a mounting mechanism for mounting the container on a vessel, preferably a reagent vessel from the laboratory sector, and an opener for opening the container.

Abstract: The invention relates to a retaining device (1) for a hollow needle (12) of a pipetting device in an automatic analysis apparatus. The retaining device (1) comprises a first retaining element (2), which can be secured releasably on a base plate that is movable in an automated manner, and a second retaining element (4), which is connected to the first retaining element (2), wherein at least one bearing bushing (14) is provided, which is fixed between the retaining elements (2, 4) and in which the hollow needle (12) is mounted.

Abstract: A method for determining the activity of a proteolytic coagulation factor in a sample may include (a) providing and incubating a reaction mixture comprising (i) the sample, (ii) an agent for direct or indirect activation of the proteolytic coagulation factor in the sample, (iii) a cleavable substrate which has at least one cleavage site for the activated coagulation factor, (iv) a solid phase to which the cleavable substrate is bound or becomes bound during the incubation; (b) separating off the solid phase; and (c) determining the amount of solid-phase-bound, uncleaved substrate, wherein the determined amount of solid-phase-bound, uncleaved substrate indicates a quantitative measure of the activity of the proteolytic coagulation factor in the sample.

Abstract: The invention relates to a device (1) for closing an opening in a container lid, and to the use of said device (1) in a container lid that is provided for covering reagent vessel containers in automatic analysis apparatus. The closure device comprises a fastening element (2), a closure element (20), two levers (14), and a plurality of bearings (18, 16, 24).

Abstract: The invention relates to a method for the spectrophotometric determination of the concentration of multiple substances, preferably bilirubin, haemoglobin and lipids, in a sample of body fluid.

Abstract: The invention relates to a rotatable device (1) for transporting reaction vessels in an automatic analysis apparatus, said device (1) comprising a circular base plate (16), and a number of holders (2) which are connected to the base plate (16), are preferably made of a plastic and comprise the receiving positions (4, 6) for the reaction vessels.

Abstract: At least one embodiment of the invention relates to bone marrow precursor cells or bone marrow cells of a patient, the cells labeled with at least one contrast agent suitable for an imaging method, for use in an imaging method for diagnosing a metastasizing cancer, wherein the local accumulation of the labeled precursor cells or bone marrow cells indicates the presence of a metastasizing tumor growth. At least one embodiment also relates to a method for imaging a metastasizing tumor tissue in a patient, wherein a) bone marrow precursor cells or bone marrow cells are extracted from a patient, b) these precursor cells or bone marrow cells are labeled with at least one contrast agent suitable for an imaging method, c) the precursor cells or bone marrow cells thus labeled are retransplanted or reinjected into the patient, and d) the presence of metastasizing tumor cells is depicted with an imaging method.