Abstract: Operations may include identifying variables corresponding to an optimization problem, each variable having an initial value. The operations may include calculating an objective function value based on the initial value of each variable and a plurality of function value changes. Each function value change may be calculated based on a different variable value change, each variable value change corresponding to a respective change made to a different one of the variables. The operations may include selecting a subset of the variables based on the respective function value changes and corresponding variable value changes made to the respective initial values of the variables of the subset and generating a surrogate quadratic unconstrained binary optimization (QUBO) model using the subset. The operations may include determining a solution to the optimization problem including a set of solution values using the surrogate QUBO model, each of the solution values corresponding to a different variable.

Abstract: There is provided herein a method for identifying and/or recovering at least one genetically encoded affinity reagent specific for a target molecule by screening using molecular display in conjunction with the sequencing of positive and negative selection pools from the screen.

Abstract: A semiconductor nanocrystal particle including a transition metal chalcogenide represented by Chemical Formula 1, the semiconductor nanocrystal particle having a size of less than or equal to about 100 nanometers, and a method of producing the same: M1M2Cha3??Chemical Formula 1 wherein M1 is Ca, Sr, Ba, or a combination thereof, M2 is Ti, Zr, Hf, or a combination thereof, and Cha is S, Se, Te, or a combination thereof.

Abstract: In some embodiments, techniques capable of obtaining high-quality fetal ECG (fECG) information using as few as two composite (maternal and fetal) maternal abdominal ECG (aECG) signals to derive the fetal ECG information are provided. In some embodiments, maternal ECG information and fetal ECG information are both obtained from the aECG signals, and are either presented or stored. The techniques may use novel proposed diffusion-based channel selection criteria. To validate the proposed techniques, analysis results of two publicly available databases are described, and compared with other available techniques in the literature.

Abstract: Provided herein are antiviral compounds having the structure of Formula (I) and compositions thereof for use in the treatment of viral infection. In particular, the compounds of Formula (I) are capable of interfering with the export of viral mRNA processing as reflected in the altered accumulation of viral RNA isoforms as well as transport from the nucleus to the cytoplasm. Such compounds show a reduction of HIV, adenovirus and coronavirus infection of cells. The invention provides compounds that may be suitable for the treatment of HIV/AIDS.

Abstract: A powertrain for electric and plug-in hybrid vehicle applications with integrated three-phase AC charging featuring buck-boost operation and optional vehicle-to-grid (V2G) capability, along with corresponding methods and machine instruction sets for switch control. The powertrain can include of a three-phase current source converter (CSC) front-end with an associated input filter, a polarity inversion module, and in an embodiment, a dual-inverter motor drive. The dual-inverter drive is the source of both the back emf and requisite DC inductance for the CSC. A compact design is thus provided as no additional magnetics are required and the on-board cooling system required for traction mode can be re-deployed for charging and V2G mode. The powertrain is mode shifted between charging and V2G mode through an optional polarity inversion module.

Abstract: A method comprising receiving data representing light intensity values corresponding to a flicker pattern of a reference light source powered by an alternating current (AC); operating a controllable illumination source, based, at least in part, on said data; capturing, using an imaging device, a sequence of images of a scene illuminated, at least in part, by said controllable illumination source; estimating an intensity value for at least one pixel in said array, correspondingly in each of said images in said sequence of images; and determining a temporal point in said flicker pattern of said reference light source, based, at least in part, on said estimating.

Abstract: According to an aspect of an embodiment, operations may include obtaining a first matrix associated with an optimization problem associated with a system and obtaining a second matrix associated with the optimization problem. The operations may include obtaining a local field matrix that indicates interactions between the variables of the system as influenced by their respective weights. The operations may include updating the local field matrix. Updating the local field matrix may include performing arithmetic operations with respect to a first portion of the first matrix and a second portion of the second matrix that correspond to a third portion of the local field matrix that corresponds to the one or more variables. The operations may include updating an energy value of the system based on the updated local field matrix and determining a solution to the optimization problem based on the energy value.

Abstract: It is provided a federated learning system for aggregating gradient information representing a result of training an AI model in an edge device, the federated learning system comprising the edge device and a server apparatus, the training module in the edge device being configured to generate an edge switch share in which the encrypted aggregated gradient is encrypted, and to transmit the generated edge switch share to the server apparatus, the encryption/decryption module in the server apparatus being configured to generate an encrypted aggregated gradient for decryption by adding edge switch shares received from the plurality of the edge device, generate an aggregated gradient by decrypting the generated encrypted aggregated gradient for decryption, and to transmit the generated aggregated gradient to the edge device, the training module in the edge device being configured to train the AI model by using the aggregated gradient received from the server apparatus.

Abstract: A method of communicating time correlated vector data within a network includes reading, by a transmitting node, a first vector data including a plurality of elements, selecting, by the transmitting node, a subset of elements of the plurality of elements based on a criteria and sending, by the transmitting node, the subset of elements to a receiving node. The receiving node receives the subset of elements and estimates a plurality of elements not included in the subset of elements based on a previously received subset of element based on a second vector data. The first vector data and the second vector data are part of a time series of vectors.

Abstract: Processes, systems and microorganisms are described herein for producing glycolate from ethylene glycol. The processes generally comprise supplying a fermentation broth into a fermentation vessel, wherein the fermentation broth comprises ethylene glycol and a microorganism having a functional metabolic pathway for utilizing ethylene glycol as a carbon source. In a growth phase, an oxygen-containing gas is injected into the fermentation broth to provide oxygen bio-availability conditions to promote cell growth of the microorganism and limit accumulation of glycolate in the fermentation broth. In a production phase, an oxygen-containing gas is injected into the fermentation broth to provide oxygen bio-availability conditions to promote production of glycolate from ethylene glycol by the microorganism and accumulation of the glycolate in the fermentation broth, to produce a glycolate enriched broth.

Abstract: Methods are disclosed to restore the halide ions lost in the purification (ligand removal) of photoluminescent cesium lead halide or FA lead halide perovskite quantum dots. Quantum dots thus prepared can be used to deposit solid films with high packing density featuring dots with <0.4 nm gaps therebetween, low trap density 1/40 of previously reported, high mobility 100× previously reported, high photoluminescent quantum yield exceeding 90%, high external quantum yield exceeding 20%, and increased stability under electrical current. The quantum dots are used to formulate inks suitable for ink jet printing, drop casting, spin coating, and other solution-based methods for forming emissive layers used in light producing semiconductor devices.

Abstract: A method of automated measurement of motility and morphology parameters of the same single motile sperm. Automated motility and morphology measurements of the same single sperm are performed under different microscope magnifications. The same single motile sperm is automatically positioned and kept inside microscope field of view and in focus after magnification switch. A method of automated non-invasive measurement of sperm morphology parameters under high magnification of imaging. Sperm morphology parameters including subcellular structures are automatically measured without invasive sample staining. A method of automatically selecting sperms with normal motility and morphology and DNA integrity for infertility treatment.

Abstract: In one aspect, an electronic device for continuous and simultaneous powering and data transfer is provided, the electronic device comprising: an inductive power receiver operable to generate a power signal from a sensed magnetic field, the power signal; an LC tank and diode pair electrically coupled to the power receiver and operable to obtain the power signal, the LC tank and diode pair cooperating to generate a corresponding clipped signal thereof; and an antenna comprising a high-pass filter, the antenna electrically coupled to the diode pair and operable to emit a pulse-train by high-pass filtering the clipped signal.

Abstract: According to an aspect of an embodiment, operations may include performing, based on weights and local field values associated with an optimization problem, a stochastic process with respect to changing a respective state of one or more variables that each represent a characteristic related to the optimization problem. The stochastic process may include performing trials with respect to one or more of the variables, in which a respective trial determines whether to change a respective state of a respective variable. The operations additionally may include determining an acceptance rate of state changes of the variables during the stochastic process and adjusting a degree of parallelism with respect to performing the trials based on the determined acceptance rate.

Abstract: The present invention is related to the field of CRISPR-Cas9 gene editing platforms. In particular, the present invention has identified Type II-C Cas9 anti-CRISPR (Acr) inhibitors that control Cas9 gene editing activity. Co-administration of such Acr inhibitors may provide an advantageous adjunct in permitting safe and practical biological therapeutics through spatial or temporal control of Cas9 activity; controlling Cas9-based gene drives in wild populations to reduce the ecological consequences of such forced inheritance schemes; and contributing to general research into various biotechnological, agricultural, and medical applications of gene editing technologies.

Abstract: The present application relates to the treatment of nematode infections.

Abstract: Described herein is a genetic modifier of cystic fibrosis (CF), which may serve as a predictor of the efficacy of a CFTR-directed therapy. SNPs rs7512462 or rs2869027 in non-coding regions of SLC26A9 are shown to correlate with CF lung disease severity in patients having CFTR mutations that leave protein at the cell surface, e.g. gating mutations such as G551D. It is also shown that patient response to Ivacaftor correlates with SLC26A9 genotype. Given the biology of SLC26A9, risk alleles of SLC26A9 should correlate with reduced SLC26A9. SLC26A9 activity (marked by e.g. genotype or expression level) is therefore a predictor of treatment efficacy for any CFTR-directed therapeutic, such as Ivacaftor or Lumacaftor. Associated methods of selecting and treating patients are described, along with related kits, uses, and drug discovery platforms.

Abstract: There is provided a catalytic system including a fibrous hydrophobic substrate, a first layer having a first layer thickness including copper or copper alloy nanoparticles covering the polymeric substrate, and a second layer having a second layer thickness over the first layer and including amorphous nitrogen-doped carbon, wherein the catalytic system includes confined interlayer spaces defined by regions where the first layer and the second layer are spaced apart from each other. The catalytic system can be used for catalyzing the electrochemical reduction of carbon dioxide, carbon monoxide, or a combination thereof. Thus, there is also provided a method for the electrochemical reduction of carbon dioxide, carbon monoxide, or a combination thereof, using the catalytic system.

Abstract: A method and system for generating a protein sequence is implemented using a computer-implemented neural network. An empty or partially filed sequence of node elements, representing amino acid positions of the protein sequence, and an edge index, having edge elements defining physical interaction between amino acid positions, are received. The computer-implemented neural network operates to determine enhanced edge attribute values for edge elements of the edge index and enhanced amino acid values for node elements of the sequence. Amino acid values are generated for elements of the partially filed sequence having missing values.