Patents Assigned to The Governing Council of the University of Toronto
-
Publication number: 20220372068Abstract: A method and system for generating a protein sequence is implemented using a computer-implemented neural network. An empty or partially filed sequence of node elements, representing amino acid positions of the protein sequence, and an edge index, having edge elements defining physical interaction between amino acid positions, are received. The computer-implemented neural network operates to determine enhanced edge attribute values for edge elements of the edge index and enhanced amino acid values for node elements of the sequence. Amino acid values are generated for elements of the partially filed sequence having missing values.Type: ApplicationFiled: December 4, 2020Publication date: November 24, 2022Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Philip M. KIM, Alexey V. STROKACH, David B. ROMERO, Carlos CORBI VERGE, Alberto PEREZ RIBA
-
Patent number: 11501192Abstract: Techniques for use in connection with performing optimization using an objective function that maps elements in a first domain to values in a range. The techniques include using at least one computer hardware processor to perform: identifying a first point at which to evaluate the objective function at least in part by using an acquisition utility function and a probabilistic model of the objective function, wherein the probabilistic model depends on a non-linear one-to-one mapping of elements in the first domain to elements in a second domain; evaluating the objective function at the identified first point to obtain a corresponding first value of the objective function; and updating the probabilistic model of the objective function using the first value to obtain an updated probabilistic model of the objective function.Type: GrantFiled: September 4, 2018Date of Patent: November 15, 2022Assignees: President and Fellows of Harvard College, The Governing Council of the University of TorontoInventors: Ryan P. Adams, Roland Jasper Snoek, Kevin Swersky, Richard Zemel
-
Patent number: 11497809Abstract: Disclosed herein are multifunctional nanoparticle compositions. The compositions can be useful for the treatment of cancer by enhancing the anti-tumor effectiveness of radiation directed to a tissue, cell or a tumor and the methods of use thereof. The multifunctional nanoparticle composition comprises a metal oxide nanoparticle core; a functional coating on the surface of the metal oxide nanoparticle core; and a matrix carrier in which the coated nanoparticle is embedded.Type: GrantFiled: December 18, 2018Date of Patent: November 15, 2022Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Xiaoyu Wu, Claudia Regina Gordijo, Azhar Z. Abbasi, Preethy Prasad, Mohammad Ali Amini
-
Patent number: 11482948Abstract: A system for providing both driving and charging functionality by using a plurality of traction inverters and a plurality of energy storage devices coupled to one another across the electric motor; an AC/DC converter front-end circuit interfacing the first/second traction inverters and the power source; a controller circuit configured to control operating characteristics of the AC/DC converter front-end circuit, wherein the first/second traction inverters are provided gating signals to one or more switching gates of the first/second traction inverters to shape power characteristics of power delivered to the first/second energy storage devices, from the power source.Type: GrantFiled: June 13, 2018Date of Patent: October 25, 2022Assignees: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, ELEAPPOWER LTD.Inventors: Peter Lehn, Ruoyun Shi, Theodore Soong
-
Patent number: 11466240Abstract: The present disclosure provides a method of producing uniformly sized organoids/multicellular spheroids using a microfluidic device having an array of microwells. The method involves several successive steps. First, a microfluidic device containing parallel rows of microwells that are connected with a supplying channel is filled with a wetting agent. The wetting agent is a liquid that is immiscible in water. For example, the wetting agent may be an organic liquid such as oil. In the next step, the agent in the supplying channel and the microwells is replaced with a suspension of cells in an aqueous solution that contains a precursor for a hydrogel. Next, the aqueous phase in the supplying channel is replaced with the agent, which leads to the formation of an array of droplets of cell suspension in the hydrogel precursor solution, which were compartmentalized in the wells. The droplets are then transformed into cell-laden hydrogels.Type: GrantFiled: July 16, 2018Date of Patent: October 11, 2022Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Eugenia Kumacheva, Elisabeth Prince
-
Patent number: 11456856Abstract: Fully homomorphic encryption integrated circuit (IC) chips, systems and associated methods are disclosed. In one embodiment, a method of operation for a number theoretic transform (NTT) butterfly circuit is disclosed. The (NTT) butterfly circuit includes a high input word path cross-coupled with a low word path. The high input word path includes a first adder/subtractor, and a first multiplier. The low input word path includes a second adder/subtractor, and a second multiplier. The method includes selectively bypassing the second adder/subtractor and the second multiplier, and reconfiguring the low and high input word paths into different logic processing units in response to different mode control signals.Type: GrantFiled: July 6, 2020Date of Patent: September 27, 2022Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Alhassan Khedr, Glenn Gulak
-
Publication number: 20220288246Abstract: A new class of mass-tag polymers is provided, which include enriched metal isotopes such as zirconium and hafnium mass tags. The chemistry of these new mass tags are different from that of lanthanide mass tags, and opens up new mass channels that can be used in mass cytometry. These polymers may be used for mass cytometry, therapeutic delivery of a radioactive isotope, or screening of a therapeutic isotope. Aspects include a kit, method of making, and method of using a polymer, isotopic composition, or both. A kit may include a polymer. The polymer may include pendant groups that chelate an enriched isotope, such as zirconium and/or hafnium. The kit may include an isotopic composition comprising an enriched zirconium or hafnium isotope. Polymers may be conjugated to a biologically active material. Aspects may also include making a kit. Aspects include use of a kit, such as for mass cytometry.Type: ApplicationFiled: August 7, 2020Publication date: September 15, 2022Applicants: Fluidigm Canada Inc., THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Peng Liu, Daniel Majonis, Vladimir Baranov, Mitchel A. Winnik, Hyungjun Cho
-
Patent number: 11435405Abstract: The present disclosure provides electrical architecture for electrochemical impedance spectroscopy (EIS). An EIS circuit comprises at least two current regulators and an electrical energy storage device, which are connected with one or more electrochemical cells in a configuration that decouples power flowing into the respective current regulators. The presence of the electrical energy storage device enables each regulator to operate simultaneously at lower power levels while inducing the desired EIS perturbation current. Operation at low power allows lower volume and cost for the same current compared to only dissipative or non-dissipative current regulators. Further, the electrical energy storage device allows the power flowing through the current regulators to be varied independently in order to achieve the desired EIS perturbation current while a minimum amount of heat is generated in the circuit, thus allowing the circuit to occupy minimal size and incur minimal cost.Type: GrantFiled: July 13, 2018Date of Patent: September 6, 2022Assignees: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, ELEAPPOWER LTD.Inventors: Zhe Gong, Olivier Trescases
-
Patent number: 11426356Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.Type: GrantFiled: February 27, 2019Date of Patent: August 30, 2022Assignees: Pendant Biosciences, Inc., The Governing Council of the University of TorontoInventors: Frantz Le Devedec, Christine Allen, David M. Stevens, Dean James Rager-Aguiar, Timothy Tordella Ruckh, Carl Eric Elmquist
-
Publication number: 20220264928Abstract: A fortified salt mixture includes sodium chloride salt grains and a multi-supplement food-additive admixed with the sodium chloride salt grains. The multi-supplement food additive includes particles, and each particle includes a core having a first supplement and a binder, a coating on the core, and a second supplement in the core and/or in the coating. A method for fortifying salt ncludes combining a first supplement, a second supplement, a binder and a coating to yield a multi-supplement food-additive; and admixing the multi-supplement food-additive with sodium chloride salt grains.Type: ApplicationFiled: July 20, 2020Publication date: August 25, 2022Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: LEVENTE LASZLO DIOSADY, OLUWASEGUN MODUPE, YAO LI
-
Patent number: 11425357Abstract: Energy-efficient epipolar imaging is applied to the ToF domain to significantly expand the versatility of ToF sensors. The described system exhibits 15+ m range outdoors in bright sunlight; robustness to global transport effects such as specular and diffuse inter-reflections; interference-free 3D imaging in the presence of many ToF sensors, even when they are all operating at the same optical wavelength and modulation frequency; and blur- and distortion-free 3D video in the presence of severe camera shake. The described embodiments are broadly applicable in consumer and robotics domains.Type: GrantFiled: January 19, 2018Date of Patent: August 23, 2022Assignees: CARNEGIE MELLON UNIVERSITY, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Srinivasa Narasimhan, Supreeth Achar, Kiriakos Kutulakos, Joseph Bartels, William Whittaker
-
Publication number: 20220257569Abstract: The present application pertains to methods of using indole-oxadiazole compounds of Formula I to modulate cannabinoid receptor activity: I In particular diseases, disorders or conditions that benefit from modulating cannabinoid receptor activity, such as non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), schizophrenia, bipolar disorder, psychosis, metabolic syndrome, type-2 diabetes, dyslipidaemia, obesity, eating disorders, cardiovascular diseases and disorders, and other conditions as described herein, may be treated. Also included in the present application are certain novel compounds of Formula Ia and pharmaceutical compositions comprising these compounds.Type: ApplicationFiled: September 12, 2019Publication date: August 18, 2022Applicants: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEENInventors: Iain Robert GREIG, Ruth ROSS, Amy RAMSEY, Catherine MIELNIK, Laurent Alain Claude TREMBLEAU, Mostafa Hamed ABDELRAHMAN
-
Patent number: 11397774Abstract: There is provided a system, method, and computer program for digital enhancement of hippocampal replay. In an embodiment, the method includes: creating one or more digital memories, each digital memory created by: receiving a tag associated with the digital memory from a user; receiving a captured digital memory from the user; and associating one or more additional attributes with the digital memory; creating a replay session, the replay session comprising one or more digital memories, by: associating a target digital memory with the replay session; and associating one or more other digital memories with the replay session if such one or more other digital memories meet a measure of commonality with the target digital memory, the measure of commonality at least based on the additional attributes; and displaying the replay session to the user within a predetermined period.Type: GrantFiled: November 8, 2019Date of Patent: July 26, 2022Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Christopher Honey, Morgan Barense, Christopher Martin, Andrew Xia, Bryan Hong, Rachel Newsome
-
Publication number: 20220229068Abstract: A system and method for detecting interactions between a first protein or fragment thereof (bait protein) and a second protein or fragment thereof (prey protein) comprising: (a) a bait construct comprising the bait protein, a first epitope tag and an intein N-terminal fragment (IN); and (b) a prey construct comprising the prey protein, a second epitope tag, and an intein C-terminal fragment (IC).Type: ApplicationFiled: June 30, 2020Publication date: July 21, 2022Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Zhong YAO, Igor STAGLJAR
-
Patent number: 11390959Abstract: The invention relates to a catalyst system for catalyzing conversion of carbon dioxide into multi-carbon compounds comprising a boron-doped copper catalytic material and associated methods.Type: GrantFiled: April 23, 2019Date of Patent: July 19, 2022Assignees: TOTAL SE, The Governing Council of the University of TorontoInventors: Edward Sargent, Phil De Luna, Fanglin Che, Yansong Zhou
-
Patent number: 11366110Abstract: Described herein are systems and methods for detecting a target analyte in a sample with electrodes, comprising a linker and an antibody attached to the linker, and measuring an electrocatalytic signal changes generated by binding of an analyte in the sample to the antibody. Also disclosed herein are kits for electrochemical detection of protein analytes.Type: GrantFiled: March 15, 2019Date of Patent: June 21, 2022Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Jagotamoy Das, Shana O. Kelley
-
Patent number: 11364234Abstract: The present application relates to the treatment of nematode infections.Type: GrantFiled: September 10, 2019Date of Patent: June 21, 2022Assignees: The Governing Council of the University of Toronto, Ontario Institute for Cancer Research (OICR)Inventors: Peter Roy, Sean Harrington, Jacob Pyche, Daniel Kulke, Genna M. Luciani, Andrew Burns, Mark Lautens, Rachel Ross, David Uehling
-
Patent number: 11341665Abstract: There is provided a system and method for optimizing depth imaging. The method including: illuminating one or more scenes with illumination patterns; capturing one or more images of each of the scenes; reconstructing the scenes; estimating the reconstruction error and a gradient of the reconstruction error; iteratively performing until the reconstruction error reaches a predetermined error condition: determining a current set of control vectors and current set of reconstruction parameters; illuminating the one or more scenes with the illumination patterns governed by the current set of control vectors; capturing one or more images of each of the scenes while the scene is being illuminated with at least one of the illumination patterns; reconstructing the scenes from the one or more captured images using the current reconstruction parameters; and estimating an updated reconstruction error and gradient; and outputting at least one of control vectors and reconstruction parameters.Type: GrantFiled: May 3, 2019Date of Patent: May 24, 2022Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Kiriakos Neoklis Kutulakos, Seyed Parsa Mirdehghan, Wenzheng Chen
-
Patent number: 11321111Abstract: The present disclosure provides systems, methods, and computer-readable media for managing graphics processing unit (GPU) allocation for a virtual machine (VM). A first GPU driver, associated with a first GPU, is offloaded from an operating system (OS) of the VM. Then, the first GPU is deallocated from the VM. A second GPU is allocated to the VM, and a second GPU driver, associated with the second GPU, is loaded in the OS of the VM. To restore a GPU context from the first GPU within the second GPU, a GPU command log from the first GPU is replayed to the second GPU.Type: GrantFiled: September 5, 2016Date of Patent: May 3, 2022Assignees: Huawei Technologies Co., Ltd., The Governing Council of the University of TorontoInventors: Eyal de Lara, Daniel Kats, Graham Allsop, Weidong Han, Feng Xie
-
Patent number: 11312722Abstract: Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related diseases.Type: GrantFiled: May 6, 2020Date of Patent: April 26, 2022Assignees: TRUSTEES OF BOSTON UNIVERSITY, The Governing Council of the University of TorontoInventors: Lauren Elaine Brown, David S Huang, Leah E. Cowen, Luke Whitesell, Paul Marcyk