Patents Assigned to The University of Edinburgh
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Publication number: 20220147768Abstract: An image data processing apparatus comprises processing circuitry configured to: receive first medical image data; obtain a first image feature data set from the first medical image data; obtain a second image feature data set from second medical image data and/or from stored image feature data; obtain style data; and generate synthesized image data based on the first image feature data set, the second image feature data set, and the style data.Type: ApplicationFiled: November 11, 2021Publication date: May 12, 2022Applicants: The University Court of the University of Edinburgh, CANON MEDICAL SYSTEMS CORPORATIONInventors: Spyridon THERMOS, Sotirios TSAFTARIS, Alison O'NEIL
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Patent number: 11296798Abstract: There is a photovoltaic (PV) panel 10 including an array of photovoltaic (PV) elements (12). Each PV element (12) is stand alone and can be electronically addressed individually. The PV panel (10) also includes a number of spectral filters (14), in this example, a red filter (14r), a green filter (14g) and a blue filter (14b) arranged over some of the PV elements (12) to filter out the red, green and blue spectral components from white (combined red, green and blue) light emitted from a red-green-blue (RGB) transmitter. Data can be transmitted by modulating the spectral components of the RGB transmitter such that the data in each of the spectral components can be recovered from the electrical signal generated by the PV elements (12).Type: GrantFiled: May 31, 2018Date of Patent: April 5, 2022Assignee: The University Court of the University of EdinburghInventors: Stefan I. Videv, Harald Haas, Sovan Das
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Patent number: 11285174Abstract: The present invention relates to alternatively activated macrophages (AAMs) for use in the treatment of liver injury and methods of treating and preventing liver injury using AAMs.Type: GrantFiled: September 18, 2017Date of Patent: March 29, 2022Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Stuart Forbes, Philip Starkey Lewis, Lesley Forrester
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Patent number: 11269641Abstract: A data processing apparatus is provided having branch prediction circuitry, the branch prediction circuitry having a Branch Target Buffer, BTB. A fetch target queue receives entries corresponding to a sequence of instruction addresses, at least one of the sequence having been predicted using the branch prediction circuitry. A fetch engine is provided to fetch instruction addresses taken from a top of the fetch target queue whilst a prefetch engine sends a prefetch probe to an instruction cache. The BTB is to detect a BTB miss when attempting to populate a storage slot of the fetch target queue and the BTB triggers issuance of a BTB miss probe to the memory to fetch at least one instruction from the memory to resolve the BTB miss using branch-prediction based prefetching.Type: GrantFiled: February 1, 2018Date of Patent: March 8, 2022Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Rakesh Kumar, Boris Grot, Vijay Nagarajan, Cheng Chieh Huang
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Publication number: 20220058484Abstract: A system and a method for training a neural network to deliver the viewpoint of objects, the method comprising minimizing distances between each training image of a first set of training images, the output of the neural network with the viewpoint of this training image, and each pair of a second set of training image pairs, the second image of each pair of the second set of training image pairs with the output of a decoder neural network when the first image of this pair is inputted to an encoder neural network, the second image of this pair is inputted to the neural network to obtain a viewpoint, the obtained encoded image is rotated according to the viewpoint, and the rotated encoded image is decoded.Type: ApplicationFiled: August 19, 2021Publication date: February 24, 2022Applicants: Toyota Jidosha Kabushiki Kaisha, The University Court of the University of EdinburghInventors: Sven Meier, Octave Mariotti, Hakan Bilen
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Publication number: 20210405069Abstract: A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, the reaction mixture is illuminated and at the same time incubated with intermittent agitation cycles, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample. Method of diagnosing alpha-synucleinopathies such as Parkinson's disease or Dementia with Lewy Bodies.Type: ApplicationFiled: August 23, 2021Publication date: December 30, 2021Applicant: The University Court of the University of EdinburghInventors: Alison Green, Graham Fairfoul
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Publication number: 20210279863Abstract: A medical image data processing apparatus comprises processing circuitry configured to: receive medical image data in respect of at least one subject; receive non-image data; generate a filter based on the non-image data; and apply the filter to the medical image data, wherein the filter is configured to limit a region of the medical image data.Type: ApplicationFiled: August 13, 2020Publication date: September 9, 2021Applicants: The University Court of the University of Edinburgh, CANON MEDICAL SYSTEMS CORPORATIONInventors: Grzegorz JACENKĂ“W, Sotirios TSAFTARIS, Brian MOHR, Alison O'NEIL, Aneta LISOWSKA
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Publication number: 20210263049Abstract: A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to hind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to forum a reaction mixture, the reaction mixture is illuminated and at the same time incubated with intermittent agitation cycles, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample. Method of diagnosing alpha-synucleinopathies such as Parkinson's disease or Dementia with Lewy Bodies.Type: ApplicationFiled: May 17, 2021Publication date: August 26, 2021Applicant: The University Court of the University of EdinburghInventors: Alison Green, Graham Fairfoul
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Patent number: 11099197Abstract: A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, the reaction mixture is illuminated and at the same time incubated with intermittent agitation cycles, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample. Method of diagnosing alpha-synucleinopathies such as Parkinson's disease or Dementia with Lewy Bodies.Type: GrantFiled: July 6, 2017Date of Patent: August 24, 2021Assignee: The University Court Of The University of EdinburghInventors: Alison Green, Graham Fairfoul
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Publication number: 20210063722Abstract: A system comprises a medical device configured to be positioned at least partially within a scattering medium, the medical device comprising at least one optical fibre or other waveguide having a plurality of light-emitting regions arranged along at least part of the length of the at least one optical fibre or other waveguide; a pulsed light source configured to transmit pulsed light into a proximal end of the at least one optical fibre or other waveguide, such that the pulsed light is guided along the at least one optical fibre or other waveguide to the light-emitting regions and emitted by the light-emitting regions into the scattering medium; at least one detector configured to receive photons of the pulsed light that have passed through the scattering medium; and a processor configured to: select signals corresponding to at least some of the received photons; determine a respective location of each of the light-emitting regions based on the selected signals; and determine a path of at least part of the meType: ApplicationFiled: January 9, 2019Publication date: March 4, 2021Applicant: The University Court of the University of EdinburghInventors: Kevin Dhaliwal, Michael G. Tanner, Robert R. Thomson
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Patent number: 10858402Abstract: A synthetic multiphase product including an isolated biofilm surface layer protein A (BslA), wherein the BslA has the amino acid sequence set forth in SEQ ID NO: 28 or a variant thereof that is at least 80% identical to SEQ ID NO: 28.Type: GrantFiled: January 7, 2020Date of Patent: December 8, 2020Assignee: The University Court of the University of EdinburghInventors: Cait Macphee, Nicola Stanley-Wall, Keith Bromley, Ryan Morris, Laura Hobley
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Patent number: 10819427Abstract: A method and associated access point for processing data for transmission to communication devices, the method comprising determining or receiving channel state information, CSI, relating to a plurality of the communication devices; for each of one or more sub-carriers, determining which communication devices can communicate using the respective subcarrier according to, or based on, the channel state information or data derived therefrom; allocating communication devices to sub-carriers upon which each communication device can communicate; and providing data for at least one or more or each communication device on the sub-carriers to which the respective communication device has been allocated. Preferably, the method uses an adaptive bit loading algorithm to allocate communication devices to sub-carriers.Type: GrantFiled: October 6, 2017Date of Patent: October 27, 2020Assignee: The University Court of the University of EdinburghInventors: Zhe Chen, Harald Haas
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Patent number: 10774116Abstract: The present invention provides a recombinant protein capable of binding to complement factor H (CFH), and thereby inducing increased binding of C3d and C3b by bound CFH compared to unbound CFH. Methods and medical devices for using utilising the same are also described.Type: GrantFiled: July 6, 2018Date of Patent: September 15, 2020Assignee: The University Court of the University of EdinburghInventors: Paul Barlow, Andrew Herbert, Elisavet Makou
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Patent number: 10683486Abstract: Methods for producing hepatocytes from pluripotent human stem cells are disclosed herein. The stem cells are plated on a cell culture substrate comprising two laminins. The stem cells are then exposed to different cell culture mediums to induce differentiation. The resulting hepatocytes have higher metabolic capacity compared to hepatocytes cultured on different substrates.Type: GrantFiled: October 29, 2016Date of Patent: June 16, 2020Assignees: BIOLAMINA AB, THE UNIVERSITY OF EDINBURGHInventors: Louise Kristina Hagbard, Carl Gunnar Jesper Ericsson, Katherine Rachel Cameron, David Colin Hay, Stuart John Forbes, Hassan Rashidi
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Patent number: 10655101Abstract: Methods of preparing ovarian tissue for primordial follicle growth are presented comprising the steps: providing an ovarian tissue sample comprising cortical tissue and stromal tissue; removing damaged tissue from the ovarian tissue sample where present; removing excess stromal tissue from the ovarian tissue sample where present; and then mechanically stretching the ovarian tissue sample along at least one dimension of the ovarian tissue sample, such that the size of the ovarian tissue sample along the at least one dimension is increased by at least 10%. Methods of growing viable oocyte in vitro, and methods of preparing individual ovarian follicles for growth are also presented.Type: GrantFiled: September 24, 2015Date of Patent: May 19, 2020Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Evelyn Elizabeth Telfer, Marie McLaughlin
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Patent number: 10647965Abstract: The present invention relates to a hetero-transglycosylase protein having cellulose:xyloglucan endotransglucosylase (CXE) activity in addition to mixed-linkage beta-glucan:xyloglucan endotransglucosylase (MXE) activity. The protein may comprise the amino acid sequence of any one of SEQ ID NOs: 2, 6 and 8 or a functional fragment thereof; or an amino acid sequence having at least 60% sequence identity to any one of SEQ ID NO: 2, 6 and 8, or to SEQ ID NO: 2 from amino acid 22 to 280, to SEQ ID NO: 6 from amino acid 26 to 283, or to SEQ ID NO: 8 from amino acid 29 to 287. The invention furthermore relates to an isolated nucleic acid encoding the protein described herein, a chimeric gene comprising, inter alia, the nucleic acid described herein, a vector comprising said chimeric gene, a host cell comprising said vector or said chimeric gene and an according transgenic plant. Further disclosed herein in are a method of producing a transgenic plant and a method of improving properties of cellulosic material.Type: GrantFiled: August 31, 2018Date of Patent: May 12, 2020Assignees: BASF SE, THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Frank Meulewaeter, Ilse Van Den Brande, Stephen C. Fry, Kyle E. Mohler, Lenka Frankova, Tom J. Simmons, Claire Holland, Andrew Hudson
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Patent number: 10648979Abstract: A probe is provided comprising a label and a binding moiety, wherein the binding moiety is adapted to bind to gram-negative bacteria, and to substantially not bind to animal cells or gram-positive bacteria. A method of detecting the presence of bacteria in a target area is also provided, which allows the detection of bacteria generally, and the determination of whether that bacteria is gram negative or gram positive.Type: GrantFiled: November 13, 2015Date of Patent: May 12, 2020Assignee: The University Court of the University of EdinburghInventors: Mark Bradley, Annamaria Helena Lilienkampf, Nikolaos Avlonitis, Marc Vendrell Escobar, Neil Alexander McDonald, Christopher Haslett, Kanwaldeep Dhaliwal, Timothy Simon Walsh
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Publication number: 20200116838Abstract: A sensor apparatus for photon sensing comprises a plurality of pixel devices, each pixel device comprising: a plurality of photon detectors arranged to produce photon detection signals in response to photon detection events; a processing resource configured to process photon detection signals to produce photon detection event signals, wherein each photon detection event signal comprises time data representative of a photon detection time at which a respective photon detection event occurred; a pixel memory; a further processing resource configured to process the photon detection event signals to obtain detection data representative of photon detection events over a detection period; a communication resource for transmitting the detection data from the pixel device, wherein the processing of the photon detection event signals is such that storing and/or transmission of the detection data uses less storage capacity and/or communication capacity than would be used by storage and/or transmission of the photon detType: ApplicationFiled: December 28, 2017Publication date: April 16, 2020Applicant: The University Court of the University of EdinburghInventors: Ahmet Erdogan, Robert Henderson, Richard Walker
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Patent number: 10611756Abstract: The present invention relates to methods and/or uses for treating pancreatitis, kidney diseases and other various disorders as described herein, for conditions or disorders mediated by KMO inhibitors, which comprises administering 6-chlorobenzoxazine compounds of Formula (I): or pharmaceutically acceptable salts and/or corresponding pharmaceutical compositions thereof.Type: GrantFiled: February 8, 2019Date of Patent: April 7, 2020Assignee: The University Court of The University of EdinburghInventors: Anne Marie Jeanne Bouillot, Alexis Denis, John Liddle, Olivier Mirguet, Ann Louise Walker
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Patent number: 10588919Abstract: The invention provides a method of treating a vascular condition within a subject comprising administering a therapeutic agent to said subject that is capable of modulating the expression levels of a long non-coding RNA (IncRNA) selected from the group consisting of lncRNA2, lncRNA4, lncRNA5, lncRNA6, ncRNA7 and ncRNA8 as defined in FIG. 39.Type: GrantFiled: March 16, 2016Date of Patent: March 17, 2020Assignee: The University Court of the University of EdinburghInventors: Andy Baker, Margaret Dickson Ballantyne