Abstract: A system comprises a waveguide apparatus comprising a plurality of input waveguides, a multimode waveguide, and a guided-wave transition coupling the plurality of input waveguides to the multimode waveguide. The system further comprises at least one light source configured to excite in turn each of a plurality of the input waveguides, or each of a plurality of combinations of the input waveguides, thereby generating a plurality of different light patterns in turn at an output of the waveguide apparatus. The waveguide apparatus is configured to direct each of the plurality of different light patterns to a target region. The system further comprises at least one detector configured to detect light transmitted, reflected or emitted from the target region in response to each of the different light patterns, and to output signals representing the detected light.

Abstract: A synthetic multiphase product comprising BsIA is presented. Methods of producing a synthetic multiphase product comprising BsIA, and applications of BsIA in synthetic multiphase products are also presented.

Abstract: A probe for detecting bacteria and/or fungi in vitro and in vivo is provided, the probe having a core and a plurality of probe elements; each probe element within the plurality of probe elements extending from the core and having a fluorophore and a binding moiety, wherein the binding moiety is a bacteria binding moiety and selectively binds to bacteria and/or to fungi and not to animal cells. Methods of use of the probe and kits comprising the probe are also provided.

Abstract: An optical probe is presented comprising at least one fluorophore connected to at least one quencher by an enzyme cleavable peptide sequence; the or each fluorophore being substantially fluorescently quenched by the at least one quencher when connected to the enzyme cleavable peptide sequence; the or each fluorophore is separated from the at least one quencher when the enzyme cleavable peptide sequence of the at least one probe element is cleaved; and the enzyme cleavable peptide sequence is selectively cleavable by one or more matrix metalloproteinase (MMP). Methods of use of the optical probe are also presented.

Abstract: The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.

Abstract: A method and associated access point for processing data for transmission to communication devices, the method comprising determining or receiving channel state information, CSI, relating to a plurality of the communication devices; for each of one or more sub-carriers, determining which communication devices can communicate using the respective subcarrier according to, or based on, the channel state information or data derived therefrom; allocating communication devices to sub-carriers upon which each communication device can communicate; and providing data for at least one or more or each communication device on the sub-carriers to which the respective communication device has been allocated. Preferably, the method uses an adaptive bit loading algorithm to allocate communication devices to sub-carriers.

Abstract: A prosthesis (1) or an orthosis and method of operating the same. The prosthesis or orthosis comprising a moveable component (2), a motor (7) operable to move the component, wherein the motor has at least one operating parameter, the application of which to the motor results in the component having at least one operating condition; and an electronic device (28) operable to: determine at least one operating parameter of the motor and determine at least one instantaneous operating condition of the component from a predetermined operating profile of the motor and component and the determined at least one operating parameter of the motor, the predetermined operating profile of the motor and component being based on one or more operating parameter inputs to the motor and one or more resulting operating condition outputs of the component.

Abstract: A transmission system for transmitting data as part of a communications system, the data comprising a plurality of data symbols or elements, the transmission system being configured to divide the data into at least a first data portion and a second data portion, wherein the first data portion is communicated by transmitting signals in selected carrier channels, wherein the transmission system is configured to encode at least one data symbol or element by selecting a relative order of at least one first carrier channel having a first operational state and at least one second carrier channel having a second operational state.

Abstract: The present invention relates to recombinant factor H and variants and conjugates thereof and methods of their production, as well as uses and methods of treatment involving the materials.

Abstract: Immunogenic compositions containing Escherichia coli 0157:H7 flagella including fusion proteins and methods using the immunogenic compositions are disclosed. Inducing an immune response in an animal to Escherichia coli O157:H7 flagella will result in prevention of colonization by Escherichia coli O157:H7 in the animal or a reduction in the amount of Escherichia coli O157:H7 infecting the animal. The immune composition will prevent or reduce the attachment of Escherichia coli 0157:H7 to cells within the animal.

Abstract: A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, (Formula (I)) wherein: R1 is (CH2)mNR11R12; R2 is selected from H, halo, OR13, NHR13, alkyl, alkenyl and alkynyl; R3 is selected from alkyl, alkenyl, alkynyl, aryl, halo, aryloxy, NHCO2R4, NHCONR5R6, NHCOR7, NH-alkyl, NH-alkenyl, NH(CH2);n-aryl, (CH2)p-heteroaryl, (CH2)qCO2R8, (CH2)rCOR9 and NHSO2R10, wherein each alkyl, alkenyl, aryl or heteroaryl moiety in the aforementioned list is optionally further substituted by one or more groups selected from alkyl, halo OH, NH2, alkoxy, aryloxy, alkylamino, arylamino, carboxyl and carboxamide; R4 to R10 and R13 are each independently selected from alkyl, alkenyl and aryl; R11 and R12 are each independently selected from alkyl and alkenyl; or R11 and R:12 are linked together with the nitrogen to which they are attached to form a heterocycloalkyl or heterocycloalkenyl group; n, m, p, q and r are each independently selected from 0, 1, 2, 3, 4, 5

Abstract: The present invention relates to a genetically edited animal, especially to a genetically edited pig in which expression or activity of the RELA protein has been modified. Such pigs have at least partial protection against the African Swine Fever Virus. The invention also provides, a cell nucleus, germ cell, stem cell, gamete, blastocyst, embryo, foetus and/or donor cell of a non-human animal comprising a genetic modification which alters the expression or function of RELA protein, methods for editing the genome of animals and methods for screening the efficacy of a pharmaceutical agent in such an animal.

Abstract: A transmission apparatus that produces, generates and/or transmits a unipolar signal representative of an original bipolar signal having one or more data frames, wherein each of the one or more frames of the original bipolar signal are converted into and/or transmitted as a plurality of unipolar portions, frames or frame portions of one or more information streams; and the transmission apparatus is configured to concurrently transmit the one or more information streams and at least one other information stream. Preferably, the different information streams are transmitted simultaneously on the same channel/link. Advantageously, one or more of the information streams are optionally arranged such that the interference due to the at least one other information stream on the at least one information stream does not adversely affect the information carried in the at least one information stream. The present invention also includes a corresponding receiver, system device and methods.

Abstract: The present invention relates to methods and compositions for enhancing expression from RNA expression vectores. The invention is based upon the observation that reducing the frequency of the dinucleotide CpG and UpA has a significant effect on expression from such vectores. Aspects of the invention include, amongst others, synthetic RNA vectores, virions, cells, methods of producing vaccines and methods of treatment or immunisation.

Abstract: A polyphosphonate, a lens including the polyphosphonate, a camera module including the polyphosphonate lens, and a method of producing the lens are provided. The polyphosphonate includes a constitutional repeating unit comprising a phosphate ester group and an aromatic ring, and the phosphate ester group is directly bonded to the aromatic ring in the constitutional repeating unit.

Abstract: A receiver system (100) having at least one receiver (101) for receiving optical communications signals (103b) that encode or transmit information; wherein the receiver system (100) is adapted to produce one or more electrical signals (104) from the received optical signal (103b) and/or from ambient light (103a) such that the receiver system (100) is usable as a source of electrical power and the encoded or transmitted information from the received optical communication signal (103b) is recovered or recoverable from the electrical signal(s) (104). Embodiments of the invention also relate to a communications system (400) that further comprises one or more transmitters (406) and a device having the receiver systems (401), along with associated methods of using and producing. Particular embodiments relate to identification tags (1000) and user devices (300) having a display (301) that at least partially overlaps the receiver(s) (302).

Abstract: A communications system having at least one transmitter and at least one receiver, wherein the transmitters and/or receivers have an angular dependence, such that at least one response of the receivers to a received signal and/or at least one property of the signals transmitted by the transmitters is angularly dependent; the receiver and transmitter and/or the signals transmitted by the transmitters of two or more transmitter-receiver pairs have a distinct associated angular arrangement or relationship, wherein the at least one angularly dependent response of the receivers to the signal and/or the at least one angularly dependent property of the signal is dependent on the angular arrangement or relationship; and the system is configured to use the angularly dependent property and/or response to identify or discriminate the transmitter from which the signal was transmitted and/or at least one communication channel associated therewith.

Abstract: A method and apparatus for communicating information by: dividing the information into at least a first information portion and a second information portion; modulating a plurality of domain resources to encode the first information using an index or grammar; and encoding the second information by modulation of domain resources. Optionally, the plurality of domain resources may be modulated to encode the first information by allocating at least two different modulation types to a plurality of sub-carriers. The modulation type is allocated to domain resources according to the index or grammar, which applies meaning to which modulation type is allocated to which domain resource. The modulation may include encoding part of the first information portion using one or more domain resources of a first domain and another part of the first information portion using one or more domain resources of a second domain.

Abstract: The present invention provides novel sequences encoding Staphylococcus pseudintermedius proteins/nucleic acids potentially useful in the treatment and/or prevention of canine disorders. In particular, the various protein and/or nucleic acid sequences described herein may find application as vaccines for use in treating and/or preventing a variety of canine diseases and/or conditions caused or contributed to by Staphylococcus pseudintermedius.

Abstract: The present invention provides a recombinant protein capable of binding to complement factor H (CFH), and thereby inducing increased binding of C3d and C3b by bound CFH compared to unbound CFH. Methods and medical devices for using utilizing the same are also described.