Patents Assigned to The University of Edinburgh
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Patent number: 9989658Abstract: A positron emission tomography (PET) data processing method comprises obtaining PET data from a PET detector, wherein the PET detector comprises an array of detector elements, and wherein the PET data is representative of a PET measurement of at least part of a subject. The method comprises identifying in the PET data a plurality of paired events, wherein each paired event comprises a first photon event in a first region of the PET detector and a second photon event in a second region of the PET detector. The first photon event comprises an energy deposition in a first detector element of the array or in a first detection region of the first detector element due to a scattering of a first photon at a first azimuthal scattering angle and an associated energy deposition by the scattered first photon in a second detector element of the array or in a second detection region of the first detector element or of the second detector element.Type: GrantFiled: June 12, 2017Date of Patent: June 5, 2018Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Gary Douglas Smith, Daniel Watts
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Patent number: 9974846Abstract: The present invention relates to the field of the veterinary medicine of bovine animals. In particular the invention relates to a recombinant Trypanosoma theileri parasite, preferably comprising a heterologous nucleic acid sequence that is capable of encoding a protein for instance an antigen, a cytokine, a hormone, an antimicrobial protein, or an antibody. Also disclosed are uses of and methods for making and using the recombinant T. theileri parasite in medical or non-curative treatments; in particular as a sustained delivery vector for proteins to bovine animals, e.g. as a vaccine.Type: GrantFiled: July 29, 2011Date of Patent: May 22, 2018Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventor: Keith Roland Matthews
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Publication number: 20180127422Abstract: A first aspect of the-invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, (Formula (I)) wherein: R1 is (CH2)mNR11R12; R2 is selected from H, halo, OR13, NHR13, alkyl, alkenyl and alkynyl; R3 is selected from alkyl, alkenyl, alkynyl, aryl, halo, aryloxy, NHCO2R4, NHCONR5R6, NHCOR7, NH-alkyl, NH-alkenyl, NH(CH2);n-aryl, (CH2)p-heteroaryl, (CH2)qCO2R8, (CH2)rCOR9 and NHSO2R10, wherein each alkyl, alkenyl, aryl or heteroaryl moiety in the aforementioned list is optionally further substituted by one or more groups selected from alkyl, halo OH, NH2, alkoxy, aryloxy, alkylamino, arylamino, carboxyl and carboxamide; R4 to R10 and R13 are each independently selected from alkyl, alkenyl and aryl; R11 and R12 are each independently selected from alkyl and alkenyl; or R11 and R:12 are linked together with the nitrogen to which they are attached to form a heterocycloalkyl or heterocycloalkenyl group; n, m, p, q and r are each independently selected from 0, 1, 2, .3.Type: ApplicationFiled: April 15, 2016Publication date: May 10, 2018Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Asier UNCITI-BROCETA, Craig FRASER, Neil O.CARRAGHER
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Publication number: 20180112193Abstract: The present invention relates to compositions of matter and methods of using the same in enhancing regeneration or restoring function of an injured liver. The compositions of matter are useful in the treatment of hepatic disorders, for example, in the prevention and/or treatment of acute or chronic liver disease or as a supportive therapy to improve the outcomes following liver resection or liver transplantation.Type: ApplicationFiled: September 8, 2017Publication date: April 26, 2018Applicant: University Court Of The University Of EdinburghInventors: Stuart Forbes, David Hume, Ben Stutchfield, Deborah Gow, Graeme Bainbridge, Theodore Oliphant, Thomas L. Wilson
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Patent number: 9879054Abstract: The present invention provides novel sequences encoding Staphylococcus pseudintermedius proteins/nucleic acids potentially useful in the treatment and/or prevention of canine disorders. In particular, the various protein and/or nucleic acid sequences described herein may find application as vaccines for use in treating and/or preventing a variety of canine diseases and/or conditions caused or contributed to by Staphylococcus pseudintermedius.Type: GrantFiled: April 13, 2012Date of Patent: January 30, 2018Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Jeanette Bannoehr, Ross J. Fitzgerald, Nouri L. Ben Zakour
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Patent number: 9878025Abstract: The present invention provides an antigenically restricted subset of the highly variant PfEMP1 rosetting antigen which possess epitopes which may be exploited to raise immune responses effective against many diverse strains and isolates of the malaria parasite, Plasmodium falciparum. In this regard, the invention provides one or more P. falciparum Erythrocyte Membrane Protein-1 (PfEMP1) antigen(s) or a fragment or fragments thereof, for use in raising immune responses in humans.Type: GrantFiled: November 22, 2012Date of Patent: January 30, 2018Assignee: The University Court of the University of EdinburghInventors: Jane Alexandra Rowe, Ashfaq Ghumra
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Patent number: 9862801Abstract: A method for the manufacture of a polymer is provided, the method comprising: Providing a first monomer, the first monomer comprising a bicyclic diamine moiety, a first nucleophilic group provided on a carbon atom of an aromatic moiety, and a second nucleophilic group provided on a carbon atom of an aromatic moiety; Providing a bridging compound comprising at least two sites vulnerable to nucleophilic attack; and Contacting the first monomer with the bridging compound. Polymers made by said method and uses of such polymers are also disclosed.Type: GrantFiled: November 5, 2015Date of Patent: January 9, 2018Assignee: The University Court of the University of EdinburghInventors: Neil Bruce McKeown, Mariolino Carta
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Patent number: 9854790Abstract: The present invention relates to methods and compositions useful for the prevention and/or treatment of PRRS in animals, typically domestic pigs. The invention relates to proteins which comprise fragments of CD163, nucleic acid constructs encoding such proteins, and methods of modifying expression or activity of CD 163 in vivo.Type: GrantFiled: July 24, 2014Date of Patent: January 2, 2018Assignee: The University Court of the University of EdinburghInventors: Tahar Ait-Ali, Simon Lillico, Alan Archibald, Christopher Bruce Alexander Whitelaw
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Patent number: 9834549Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3,3-disubstituted-(8-aza-bicyclo[3.2.1]oct-8-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone, 3,3-disubstituted-(6-aza-bicyclo[3.1.1]hept-6-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone, and 4,4-disubstituted piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds of the following formula that, inter alia, inhibit 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1).Type: GrantFiled: May 13, 2016Date of Patent: December 5, 2017Assignee: THE UNIVERSITY OF EDINBURGHInventors: Scott Peter Webster, Jonathan Robert Seckl, Brian Robert Walker, Peter Ward, Thomas David Pallin, Hazel Joan Dyke, Trevor Robert Perrior
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Patent number: 9725697Abstract: The present invention provides an isolated population of chondrocyte precursor cells wherein 1% or less of the cells express Oct4, Nanog and/or TRA-1-60, 7% or less of the cells express no collagen II, collagen X, CD105 or Stro-1 and 85% or more of the cells express CBFA1, methods for preparing such cells and uses of chondrocyte cells derived from said precursor cells.Type: GrantFiled: May 11, 2015Date of Patent: August 8, 2017Assignee: The University Court of The University of EdinburghInventors: Brendon Stewart Noble, David Matthew Pier
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Patent number: 9724019Abstract: A method, apparatus, computer program, system and device for measuring oscillatory motion comprising: receiving a plurality of signals related to a plurality of measurements of a direction of a vector parameter (at-1, at); determining a predominant measured direction of the vector parameter (?t) based on the plurality of measurements of the direction of the vector parameter; determining an angle of rotation (?t) between: a measured direction of the vector parameter (at) of one of the plurality of measurements of the direction of the vector parameter, and the predominant measured direction of the vector parameter (?t).Type: GrantFiled: May 16, 2011Date of Patent: August 8, 2017Assignee: The University Court of the University of EdinburghInventors: Damal Arvind, Andrew Bates
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Publication number: 20170196995Abstract: The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.Type: ApplicationFiled: January 23, 2017Publication date: July 13, 2017Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Tashfeen WALTON, Mark BRADLEY, Kev DHALIWAL, Nikolaos AVLONITIS, Chris HASLETT, Neil MCDONALD, Manuelle DEBUNNE
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Patent number: 9695420Abstract: The present invention provides a method of identifying host cell molecules which may be modulated to inhibit viral replication and method of testing antiviral compounds. In addition, the invention provides compositions, methods and medicaments for treating viral infections and/or diseases or conditions caused or contributed to by viruses.Type: GrantFiled: August 25, 2014Date of Patent: July 4, 2017Assignee: The University Court of the University of EdinburghInventor: Amy Buck
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Patent number: 9549997Abstract: The present invention relates to methods of visualizing cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalized by the cells and thus permits subsequent visualization by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualizing cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualizing cells by virtue of internalization and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.Type: GrantFiled: April 5, 2012Date of Patent: January 24, 2017Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Tashfeen Walton, Mark Bradley, Kev Dhaliwal, Nikolaos Avlonitis, Chris Haslett, Neil McDonald, Manuelle Debunne
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Publication number: 20160289391Abstract: A polyphosphonate, a lens including the polyphosphonate, a camera module including the polyphosphonate lens, and a method of producing the lens are provided. The polyphosphonate includes a constitutional repeating unit comprising a phosphate ester group and an aromatic ring, and the phosphate ester group is directly bonded to the aromatic ring in the constitutional repeating unit.Type: ApplicationFiled: March 18, 2016Publication date: October 6, 2016Applicants: Samsung Electro-Mechanics Co., Ltd., The University Court of The University of EdinburghInventors: Hoe-Chul JUNG, Michael Patrick Shaver, Emily Kate Macdonald
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Patent number: 9403893Abstract: The present invention provides avian CSF1 genes encoding proteins which bind avian colony stimulating factor 1 receptor (CSF1R) and which exhibit immunomodulatory properties.Type: GrantFiled: June 22, 2010Date of Patent: August 2, 2016Assignee: The University Court of the University of EdinburghInventors: David Arthur Hume, Dave Burt, David Sester, Valerie Garceau, Jacqueline Smith, Bob Paton
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Patent number: 9374246Abstract: A radio frequency digital receiver system and method is described in which the radio frequency digital receiver system uses a discrete Fourier transform where detection decisions are made based on a spectral estimate. The spectral estimate is formed from an output of the, in which the spectral estimate is improved by enabling spatially variant apodization (SVA) such that the detection ability of the RF digital receiver is improved. In a further embodiment, the SVA is optimized for use with Digital Signal Processing.Type: GrantFiled: March 9, 2012Date of Patent: June 21, 2016Assignees: SELEX ES LTD, THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Graham Henry MacKerron, Bernerd Mulgrew
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Patent number: 9365564Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3,3-disubstituted-(8-aza-bicyclo[3.2.1]oct-8-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone, 3,3-disubstituted-(6-aza-bicyclo[3.1.1]hept-6-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone, and 4,4-disubstituted piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds of the following formula that, inter alia, inhibit 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1).Type: GrantFiled: March 10, 2011Date of Patent: June 14, 2016Assignee: The University Of EdinburghInventors: Scott Peter Webster, Jonathan Robert Seckl, Brian Robert Walker, Peter Ward, Thomas David Pallin, Hazel Joan Dyke, Trevor Robert Perrior
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Patent number: 9307940Abstract: A testing apparatus for testing a user's sustained attention comprises at least one stimulus-provider and a controller for controlling the stimulus-provider to provide at least one target stimulus, wherein the controller is configured to perform at least one operating procedure and the or each operating procedure comprises controlling the stimulus-provider to provide a sequence of target stimuli to the user.Type: GrantFiled: October 7, 2010Date of Patent: April 12, 2016Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Alasdair MacLullich, Laura Brown, Jonathan Adler
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Patent number: 9309495Abstract: A homogenous, symmetrically dividing population of adherent neural stem cells is obtained from ES cells or foetal or adult brain isolates, using an activator of a signalling pathway downstream of a receptor of the EGF receptor family, optionally in combination with an activator of a signalling pathway downstream of an FGF receptor. The neural stem cell population is highly pure and retains the ability to differentiate into neurons after in excess of 100 passages.Type: GrantFiled: July 21, 2014Date of Patent: April 12, 2016Assignee: The University Court of The University of EdinburghInventors: Luciano Conti, Steven Michael Pollard, Austin Gerard Smith