Patents Assigned to University of Delaware
  • Patent number: 10059920
    Abstract: A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: August 28, 2018
    Assignee: University of Delaware
    Inventors: Eleftherios T. Papoutsakis, Sergios Nicolaou, Alan Fast, Vasiliki Falara, Robert Kyle Bennett, William Brian Whitaker, Nicholas Richard Sandoval, Jacqueline Gonzalez, Maciek Antoniewicz
  • Patent number: 10056638
    Abstract: A compound including a cation of the following structure is provided (1), wherein Q is selected from the group consisting of polymer residues and substituted or unsubstituted alkyl groups, and R is H or a polymer residue. A membrane including the above cation, and electrochemical devices employing this membrane, are also provided.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: August 21, 2018
    Assignee: UNIVERSITY OF DELAWARE
    Inventors: Yushan Yan, Bingzi Zhang, Shuang Gu
  • Patent number: 10018507
    Abstract: Electromagnetic detectors and methods for manufacturing electromagnetic detectors are described. The electromagnetic detectors include at least one electromagnetic sensor, where each electromagnetic sensor includes a conductive part having a perimeter, a first connection point on the perimeter of the conductive part, a second connection point on the perimeter of the conductive part, a connection point axis extending between the first and the second connection points, a secondary axis perpendicular to the connection point axis extending through a midpoint between the first and second connection points, the secondary axis dividing the conductive part into two portions that are asymmetrical to one another. The electromagnetic detector also includes a voltage detector coupled to the first and the second connection points to detect voltages produced by the conductive part when exposed to electromagnetic waves.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: July 10, 2018
    Assignee: UNIVERSITY OF DELAWARE
    Inventor: Siu-Tat Chui
  • Publication number: 20180179545
    Abstract: The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to produce a recombinant protein, and making a composition comprising the recombinant protein and a polysorbate. The production of endogenous lipoprotein lipase by the host cell is reduced. The endogenous lipoprotein lipase is present in the composition in a small amount, and is capable of degrading the polysorbate. The invention also relates to the relevant host cells and compositions, and preparation thereof.
    Type: Application
    Filed: February 15, 2018
    Publication date: June 28, 2018
    Applicant: University of Delaware
    Inventors: Kelvin LEE, Abraham Lenhoff, Kristin Valente, Nick Levy, Yatin Gokarn
  • Patent number: 9994961
    Abstract: A metallic alloy includes Cu and one or more metals M selected from the group consisting of Ti, V, Cr, Mn, Fe, Co, Ni and Zn, wherein the alloy has a surface in the form of a vermiculated arrangement of irregular, nanoporous lands separated by troughs or channels. It can be made by contacting a precursor alloy including Cu, M and Al with a caustic liquid under conditions sufficient to remove the Al. Or, a metallic alloy includes Cu and one or more metals M selected from the group consisting of Ti, V, Cr, Mn, Fe, Co, Ni and Zn, wherein the one or more metals M in total constitute in a range of 3 at. % to 7 at. %, relative to the total of Cu and M. Both types of alloy can be used as an electrocatalyst in a water electrolyzer or a hydrogen fuel cell.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: June 12, 2018
    Assignees: UNIVERSITY OF DELAWARE, THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Feng Jiao, Qi Lu, Gregory S. Hutchings, Jingguang Chen
  • Publication number: 20180124952
    Abstract: An embodiment includes a modular dewar comprising a vacuum chamber, and a dewar circuit board. The dewar circuit board includes an inner portion including an electronic device positioned inside the vacuum chamber, an outer portion including electrical connectors positioned outside the vacuum chamber, and electrical traces connecting the electronic device inside the vacuum chamber to the electrical connectors outside the vacuum chamber.
    Type: Application
    Filed: October 27, 2017
    Publication date: May 3, 2018
    Applicant: UNIVERSITY OF DELAWARE
    Inventors: Fouad E. Kiamilev, Andrea Waite
  • Publication number: 20180112280
    Abstract: This invention relates to polynucleotide sequences encoding a gene that can confer resistance to the plant pathogen Colletotrichum, which causes anthracnose stalk rot, leaf blight and top dieback in corn and other cereals. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to the plant pathogen Colletotrichum, and processes of making said plants and seeds. The invention further presents sequences that can be used as molecular markers that in turn can be used to identify the region of interest in corn lines resulting from new crosses and to quickly and efficiently introgress the gene from corn lines carrying said gene into other corn lines that do not carry said gene, in order to make them resistant to Colletotrichum and resistant to stalk rot.
    Type: Application
    Filed: December 27, 2017
    Publication date: April 26, 2018
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY, UNIVERSITY OF DELAWARE
    Inventors: KAREN E. BROGLIE, KARLENE H. BUTLER, MARYMAR GONCALVES BUTRUILLE, ALEXANDRE DA SILVA CONCEICAO, TRAVIS JAMES FREY, JAMES A. HAWK, JENNIFER S. JAQUETH, ELIZABETH S. JONES, DILBAG S. MULTANI, PETRA J. WOLTERS
  • Patent number: 9954129
    Abstract: Described herein are materials and systems for efficient upconversion of photons. The materials may be disposed in a system comprising two semiconductor materials with an interface therebetween, the interface comprising a valence and/or conduction band offset between the semiconducting materials of about ?0.5 eV to about 0.5 eV, including 0, wherein one of the semiconductor materials is a material with discrete energy states and the other is a material with a graded composition and/or controlled band gap. The system can upconvert photons by: a) controlling energy levels of discrete energy states of a semiconducting material in a system to direct tunneling and exciton separation; b) controlling a compositional profile of another semiconducting material in the system to funnel charges away from an upconversion region and into a recombination zone; and c) utilizing the discrete energy states of the semiconducting material in the system to inhibit phonon relaxation.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: April 24, 2018
    Assignee: UNIVERSITY OF DELAWARE
    Inventors: Matthew Doty, Joshua Zide
  • Patent number: 9932591
    Abstract: The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to produce a recombinant protein, and making a composition comprising the recombinant protein and a polysorbate. The production of endogenous lipoprotein lipase by the host cell is reduced. The endogenous lipoprotein lipase is present in the composition in a small amount, and is capable of degrading the polysorbate. The invention also relates to the relevant host cells and compositions, and preparation thereof.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: April 3, 2018
    Assignee: University of Delaware
    Inventors: Kelvin Lee, Abraham Lenhoff, Kristin Valente, Nick Levy, Yatin Gokarn
  • Patent number: 9935332
    Abstract: Copolymers useful as components of polymer electrolytes are provided in which the copolymer comprises at least one block sequence represented by formula (I): A—(T)—B ??(I) wherein A is a vinyl aromatic block, T is a tapered copolymer region copolymerized from a vinyl aromatic monomer and an oligo(oxyalkylene) acrylate monomer and B is an oligo(oxyalkylene) acrylate block.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: April 3, 2018
    Assignee: UNIVERSITY OF DELAWARE
    Inventors: Thomas H. Epps, III, Wei-Fan Kuan
  • Publication number: 20180080822
    Abstract: Spectral imaging sensors and methods are disclosed. One spectral imaging sensor includes a light source, an array of coded apertures, one or more optical elements, and a photodetector. The light source is configured to emit a plurality of pulses of light toward an object to be imaged. The array of coded apertures is positioned to spatially modulate light received from the object to be imaged. The optical elements are configured to redirect light from the array of coded apertures. The photodetector is positioned to receive light from the one or more optical elements. The photodetector comprise a plurality of light sensing elements. The plurality of light sensing elements are operable to sense the light from the one or more optical elements in a plurality of time periods. The plurality of time periods have a same frequency as the plurality of pulses of light.
    Type: Application
    Filed: March 18, 2016
    Publication date: March 22, 2018
    Applicants: University of Delaware, University of Kentucky
    Inventors: Daniel L. Lau, Gonzalo R. Arce
  • Publication number: 20180073523
    Abstract: Variable flow rate fuel ejectors, and methods of use therefore, are disclosed. One variable flow rate ejector includes a primary nozzle, a needle, a motor, a first stop portion, and a first impact-absorbing portion. The primary nozzle is connected to a first inlet chamber to receive a first fluid and transmit a flow of the first fluid through the primary nozzle opening. The needle is disposed to create a gap between the tapered portion of the needle and the primary nozzle opening. The motor is coupled to axially move the needle to vary a size of the gap. The first stop portion delimits the axial movement of the needle in a direction of retraction of the needle from the primary nozzle opening. The first impact-absorbing element is positioned to contact the first stop portion or the needle, respectively, when the needle is fully retracted from the primary nozzle opening.
    Type: Application
    Filed: April 15, 2016
    Publication date: March 15, 2018
    Applicant: University of Delaware
    Inventors: Douglas A. Brunner, Manish Bajpai, John Adam C. Kinzey, Shane Marcks, Ajay Prasad, Suresh Advani
  • Publication number: 20180072761
    Abstract: A substituted trans-cycloheptene according to formula (I); wherein: a) Z and L are each selected from the group consisting of SiR1R2, CH2, CHOH, and CHR2; R1 is phenyl or CH3; R2 is phenyl, CH3, (CH2)nCN, or (CH2)nOH, wherein n is an integer from 1 to 5; Ra and Rb are each individually selected from the group consisting of H, OH, and CH3; and Z and L are not both SiR1R2; or b) Z is BocN, L is CH2, Ra is H, and Rb is H; or c) Z is C=0, L is CH2, Ra is H, and Rb is H.
    Type: Application
    Filed: April 7, 2016
    Publication date: March 15, 2018
    Applicant: University of Delaware
    Inventors: Joseph FOX, Han ZHANG, Yinzhi FANG
  • Patent number: 9917323
    Abstract: A redox flow battery is provided having a double-membrane (one cation exchange membrane and one anion exchange membrane), triple-electrolyte (one electrolyte in contact with the negative electrode, one electrolyte in contact with the positive electrode, and one electrolyte positioned between and in contact with the two membranes). The cation exchange membrane is used to separate the negative or positive electrolyte and the middle electrolyte, and the anion exchange membrane is used to separate the middle electrolyte and the positive or negative electrolyte. This design physically isolates, but ionically connects, the negative electrolyte and positive electrolyte. The physical isolation offers great freedom in choosing redox pairs in the negative electrolyte and positive electrolyte, making high voltage of redox flow batteries possible. The ionic conduction drastically reduces the overall ionic crossover between negative electrolyte and positive one, leading to high columbic efficiency.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: March 13, 2018
    Assignee: University of Delaware
    Inventors: Yushan Yan, Shuang Gu, Ke Gong
  • Patent number: 9897547
    Abstract: A nanocomposite structure includes: a) a charged fibrous substrate including fibers having disposed on their surfaces a multilayer structure including a layer of a first polyelectrolyte and disposed thereon a layer of a second polyelectrolyte of opposite charge from the first, the second polyelectrolyte forming the outermost layer of the charged fibrous substrate; and b) charged nanorods having a charge opposite that of the charged fibrous substrate, including gold nanorods each having disposed on its surface one or more layers, the outermost of which is a third polyelectrolyte having a charge opposite that of the second polyelectrolyte, wherein the first and third polyelectrolytes may be the same or different; wherein the charged nanorods are disposed unaligned with respect to each other on the charged fibrous substrate.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: February 20, 2018
    Assignee: UNIVERSITY OF DELAWARE
    Inventors: John F. Rabolt, Wenqiong Tang, D. Bruce Chase, Donald L. Sparks
  • Patent number: 9884896
    Abstract: This invention relates to polynucleotide sequences encoding a gene that can confer resistance to the plant pathogen Colletotrichum, which causes anthracnose stalk rot, leaf blight and top dieback in corn and other cereals. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to the plant pathogen Colletotrichum, and processes of making said plants and seeds. The invention further presents sequences that can be used as molecular markers that in turn can be used to identify the region of interest in corn lines resulting from new crosses and to quickly and efficiently introgress the gene from corn lines carrying said gene into other corn lines that do not carry said gene, in order to make them resistant to Colletotrichum and resistant to stalk rot.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: February 6, 2018
    Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY, UNIVERSITY OF DELAWARE
    Inventors: Karen E. Broglie, Karlene H. Butler, Marymar G. Butruille, Alexandre Da Silva Conceicao, Travis James Frey, James A. Hawk, Jennifer S. Jaqueth, Elizabeth S. Jones, Dilbag S. Multani, Petra Johanna Cecilia Christina Wolters
  • Patent number: 9874563
    Abstract: The present invention relates to a novel method for detecting efficient cryptic HIV replication in a patient who receives a suppressive antiviral therapy followed by administration of the HIV integrase inhibitor in an effective amount for intensifying the suppressive antiviral therapy, and has undetectable plasma viremia prior to the administration of the HIV integrase inhibitor. The method comprises making a pre-intensification measurement and one or more post-intensification measurements of the concentration of an episomal artifact in samples from the patient, and computing a pre-intensification HIV infection success ratio (R). A pre-intensification HIV infection success ratio (R) sufficiently close to 1 indicates that the patient has the efficient cryptic HIV replication. The method may further comprise quantifying the efficient cryptic HIV replication.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: January 23, 2018
    Assignee: University of Delaware
    Inventor: Ryan Zurakowski
  • Publication number: 20180017439
    Abstract: Electromagnetic detectors and methods for manufacturing electromagnetic detectors are described. The electromagnetic detectors include at least one electromagnetic sensor, where each electromagnetic sensor includes a conductive part having a perimeter, a first connection point on the perimeter of the conductive part, a second connection point on the perimeter of the conductive part, a connection point axis extending between the first and the second connection points, a secondary axis perpendicular to the connection point axis extending through a midpoint between the first and second connection points, the secondary axis dividing the conductive part into two portions that are asymmetrical to one another. The electromagnetic detector also includes a voltage detector coupled to the first and the second connection points to detect voltages produced by the conductive part when exposed to electromagnetic waves.
    Type: Application
    Filed: June 8, 2017
    Publication date: January 18, 2018
    Applicant: UNIVERSITY OF DELAWARE
    Inventor: SIU-TAT CHUI
  • Publication number: 20180002226
    Abstract: In various aspects, the processes disclosed herein may include the steps of inducing an electric field about a non-conductive substrate, and depositing functionalized nanoparticles upon the non-conductive substrate by contacting a nanoparticle dispersion with the non-conductive substrate, the nanoparticle dispersion comprising functionalized nanoparticles having an electrical charge, the electric field drawing the functionalized nanoparticles to the non-conductive substrate. In various aspects, the related composition of matter disclosed herein comprise functionalized nanoparticles bonded to a surface of a non-conductive fiber, the surface of the non-conductive fiber comprising a sizing adhered to the surface of the non-conductive fiber. This Abstract is presented to meet requirements of 37 C.F.R. §1.72(b) only. This Abstract is not intended to identify key elements of the processes, and related apparatus and compositions of matter disclosed herein or to delineate the scope thereof.
    Type: Application
    Filed: August 9, 2017
    Publication date: January 4, 2018
    Applicant: University of Delaware
    Inventor: ERIK THOSTENSON
  • Patent number: D814161
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: April 3, 2018
    Assignees: DIAPEDIA, LLC, UNIVERSITY OF DELAWARE
    Inventors: Peter R. Cavanagh, Timothy B. Hurley, John J. Tierney, John W. Gillespie, Jr.