Patents Assigned to University of Delaware
  • Patent number: 9597412
    Abstract: A method for enhancing chondrogenesis in a subject in need thereof comprises administering to the subject an effective amount of a pharmaceutical composition comprising a growth factor bound to hyaluronic acid (HA)-based hydrogel particles (HGPs). The hyaluronic acid (HA)-based hydrogel particles (HGPs) are conjugated with a heparan sulfate proteoglycan (HSPG). Related medicaments and methods for preparing the medicaments are provided.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: March 21, 2017
    Assignee: University of Delaware
    Inventors: Catherine E. Safran, Mary C. Farach-Carson, Xinqiao Jia, Padma P. Srinivasan, Amit Jha
  • Publication number: 20170068816
    Abstract: Malware detection methods systems, and apparatus are described.
    Type: Application
    Filed: September 6, 2016
    Publication date: March 9, 2017
    Applicant: UNIVERSITY OF DELAWARE
    Inventor: JOHN CAVAZOS
  • Publication number: 20170015775
    Abstract: Dimethoxyphenol-based monomers containing polymerizable functional groups such as [meth]acrylate groups are useful for the preparation of polymers, wherein one or more dimethoxyphenyl moieties are part of side chains pendant to the backbones of the polymers. The polymers thereby obtained may have different, improved properties, such as higher glass transition temperatures, thermal stability and solvent resistance, as compared to polymers based on other types of lignin-derived monomers.
    Type: Application
    Filed: July 12, 2016
    Publication date: January 19, 2017
    Applicant: University of Delaware
    Inventors: Angela H. HOLMBERG, Kaleigh H. RENO, Thomas H. EPPS, III
  • Patent number: 9512249
    Abstract: The present invention pertains to bio-based block polymers synthesized from functionalized lignin-based molecules (A-monomer) and functionalized fatty acids or fatty alcohols (B-monomer) derived from plant or animal oils, waxes or fats. The block polymers can be synthesized via numerous polymerization techniques, such as reversible addition-fragmentation chain transfer (RAFT). Most importantly, this class of bio-based block polymers shows promise as providing sustainable yet scalable and tunable thermoplastic elastomers and pressure-sensitive adhesives, among other applications.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: December 6, 2016
    Assignee: University of Delaware
    Inventors: Angela L. Holmberg, Joseph F. Stanzione, Richard Wool, Thomas H. Epps, III
  • Publication number: 20160333308
    Abstract: A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.
    Type: Application
    Filed: January 9, 2015
    Publication date: November 17, 2016
    Applicant: University of Delaware
    Inventors: Eleftherios T. Papoutsakis, Sergios Nicolaou, Alan Fast, Vasiliki Falara, Robert Kyle Bennett, William Brian Whitaker, Nicholas Richard Sandoval, Jacqueline Gonzalez, Maciek Antoniewicz
  • Publication number: 20160330432
    Abstract: Methods and systems for generating three-dimensional (3D) images, 3D light field (LF) cameras and 3D photographs are provided. Light representing a scene is directed through a lens module coupled to an imaging sensor. The lens module includes: a surface having a slit-shaped aperture and a cylindrical lens array positioned along an optical axis of the imaging sensor. A longitudinal direction of the slit-shaped aperture is arranged orthogonal to a cylindrical axis of the cylindrical lens array. The light directed through the lens module is captured by the imaging sensor to form a 3D LF image. A 3D photograph includes a 3D LF printed image of the scene and a cylindrical lens array disposed on the printed image, such that the combination of 3D LF printed image and the cylindrical lens array forms a 3D stereoscopic image.
    Type: Application
    Filed: December 23, 2014
    Publication date: November 10, 2016
    Applicant: University of Delaware
    Inventors: Jingyi Yu, Xinqing Guo, Zhan Yu
  • Publication number: 20160312226
    Abstract: The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to produce a recombinant protein, and making a composition comprising the recombinant protein and a polysorbate. The production of endogenous lipoprotein lipase by the host cell is reduced. The endogenous lipoprotein lipase is present in the composition in a small amount, and is capable of degrading the polysorbate. The invention also relates to the relevant host cells and compositions, and preparation thereof.
    Type: Application
    Filed: December 18, 2014
    Publication date: October 27, 2016
    Applicant: University of Delaware
    Inventors: Kelvin LEE, Abraham LENHOFF, Kristen VALENTE, Nick LEVY, Yatin GOKARN
  • Publication number: 20160272995
    Abstract: Plants are provided that express a modified plasmodesmata localized protein 5 (PDLP5). The modified PDLP5 protein may modify plasmodesmal connectivity. The plant may have at least one improved agronomic characteristic; for example, it may exhibit increase tolerance to stress, such as heat, cold or drought. The plant may exhibit at least one trait selected from the group consisting of: increased drought tolerance, increased yield, increased biomass, increased cold tolerance, early flowering and altered root architecture. Also included are related polypeptides, polynucleotides, recombinant DNA constructs, plant seeds and other plant parts that contain a modified PDLP5 protein, as well as methods of making and using the plants, seeds, polypeptides, polynucleotides, and recombinant DNA constructs.
    Type: Application
    Filed: September 12, 2014
    Publication date: September 22, 2016
    Applicant: UNIVERSITY OF DELAWARE
    Inventor: Jung-Youn Lee
  • Publication number: 20160263210
    Abstract: This disclosure describes a modified live infectious laryngotracheitis virus (ILTV) developed from a strain of ILTV grown at a reduced incubation temperature, vaccines that include the modified live ILTV, methods for producing the live modified ILTV, and methods that include administering the modified ILTV to a subject.
    Type: Application
    Filed: October 29, 2014
    Publication date: September 15, 2016
    Applicant: UNIVERSITY OF DELAWARE
    Inventors: Jack Gelb, JR., Brian S. Ladman, Miguel Ruano
  • Publication number: 20160251679
    Abstract: A method for controlling male fertility of a plant comprises regulating a biological activity of a phasiRNA in a male reproductive organ of the plant. The phasiRNA is selected from the group consisting of 21-nt phasiRNAs and 24-nt phasiRNAs. The male fertility of the plant is thereby increased or decreased. Preferably, the plant is a monocotyledon and becomes male sterile. The resulting male sterile plant and its uses are also provided.
    Type: Application
    Filed: October 10, 2014
    Publication date: September 1, 2016
    Applicant: University of Delaware
    Inventors: Blake MEYERS, Jixian ZHAI, Virginia WALBOT
  • Publication number: 20160253824
    Abstract: Multi-perspective cameras, systems and methods for reconstructing a scene are provided. Light representing a scene is directed through a lens module coupled to an imaging sensor. The lens module includes: first and second cylindrical lenses positioned along an optical axis of the imaging sensor, and first and second slit-shaped apertures disposed on the respective first and second cylindrical lenses. A cylindrical axis of the second cylindrical lens is arranged at an angle away from parallel with respect to a cylindrical axis of the first cylindrical lens. The light directed through the lens module is captured by the imaging sensor to form at least one multi-perspective image. The at least one multi-perspective image is processed to determine a reconstruction characteristic of the scene.
    Type: Application
    Filed: October 3, 2014
    Publication date: September 1, 2016
    Applicant: University of Delaware
    Inventors: Jingyi YU, Jinwei YE, Yu JI
  • Publication number: 20160231548
    Abstract: Compact microscope apparatus and methods of use are disclosed. One apparatus includes a stage, a light source, an objective, a dichroic element, and an imaging sensor. The stage is configured to hold a sample thereon. The light source is configured to emit light toward the stage. The objective is positioned to focus light from the stage. The dichroic element is configured to pass or reflect respective ones of the light emitted by the light source and the light from the stage. The imaging sensor is positioned to receive the light from the stage. The stage, the light source, the objective, the dichroic element, and the imaging sensor are arranged such that they may be received within an enclosure having dimensions no longer than about 300 mm. The apparatus may include a clinostat operable to continuously rotate the components of the apparatus about an axis.
    Type: Application
    Filed: February 3, 2016
    Publication date: August 11, 2016
    Applicant: University of Delaware
    Inventors: Chandran Sabanayagam, Aroshan Jayasinghe
  • Publication number: 20160203257
    Abstract: Methods and computer readable storage mediums for identifying structurally or functionally significant amino acid sequences encoded by a genome are disclosed. At least one structurally or functionally significant amino acid sequence encoded by a genome may be identified by compiling an observed frequency for each of a plurality of amino acid words encoded by the genome, calculating with a computer an expected frequency for each of the plurality of amino acid words encoded by the genome, and identifying at least one structurally or functionally significant amino acid sequence encoded by the genome based at least in part on the observed and expected frequencies for each of the plurality of amino acid words encoded by the genome.
    Type: Application
    Filed: March 21, 2016
    Publication date: July 14, 2016
    Applicants: Board of Regents of the Nevada System of Higher Education, on Behalf of the Desert Research Inst., University of Delaware
    Inventors: Adam G. Marsh, Joseph J. Grzymski
  • Publication number: 20160203261
    Abstract: Provided are methods, systems, and computer readable media for comparing word statistics between a significant amino acid sequence and a significant nucleotide sequence.
    Type: Application
    Filed: March 21, 2016
    Publication date: July 14, 2016
    Applicants: Board of Regents of the Nevada System of Higher Education, on Behalf of the Desert Research Instit, University of Delaware
    Inventors: Joseph J. Grzymski, Adam G. Marsh
  • Publication number: 20160154004
    Abstract: A method of determining the activation energy Ea for degradation of a chemical species includes in sequence the steps of a) simultaneously incubating a plurality of samples of the chemical species in a single unitary device at a plurality of constant temperatures T, in each case for an incubation time t selected to result in loss of at most 20 mol % of the amount originally present; b) quenching each of the samples to stop degradation; c) determining the mole fraction m of the chemical species remaining in each of the quenched samples, relative to the amount present before incubating; d) determining for each sample a reaction rate coefficient kobs according to the equation k obs ? ( T ) = 1 - m ? ( T ) t ; and e) performing numerical regression of the kobs values obtained in step d) and the corresponding temperatures T in ° K to derive the activation energy Ea according to the following equation k obs = k 0 ? exp ? ( E a R ? ( 1 T - 1 T 0 ) ) , or to
    Type: Application
    Filed: November 16, 2015
    Publication date: June 2, 2016
    Applicants: UNIVERSITY OF DELAWARE, AMGEN
    Inventors: CHRISTOPHER J. ROBERTS, GREGORY V. BARNETT, VLADIMIR I. RAZINKOV, BRUCE A. KERWIN
  • Patent number: 9329021
    Abstract: A system for use in monitoring a structure is provided. The system includes a strip of piezoresistive material including nano-elements, electrodes coupled to the strip, and a resistance detector configured to measure a resistance of the strip.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: May 3, 2016
    Assignees: The Boeing Company, University of Delaware
    Inventors: Michael J. DeLuca, Christopher J. Felker, Dirk Heider, Gaurav Pandey, Ahmad Abu-Obaid, Erik T. Thostenson, John W. Gillespie, Jr.
  • Publication number: 20160069811
    Abstract: A nanocomposite structure includes: a) a charged fibrous substrate including fibers having disposed on their surfaces a multilayer structure including a layer of a first polyelectrolyte and disposed thereon a layer of a second polyelectrolyte of opposite charge from the first, the second polyelectrolyte forming the outermost layer of the charged fibrous substrate; and b) charged nanorods having a charge opposite that of the charged fibrous substrate, including gold nanorods each having disposed on its surface one or more layers, the outermost of which is a third polyelectrolyte having a charge opposite that of the second polyelectrolyte, wherein the first and third polyelectrolytes may be the same or different; wherein the charged nanorods are disposed unaligned with respect to each other on the charged fibrous substrate.
    Type: Application
    Filed: March 12, 2014
    Publication date: March 10, 2016
    Applicant: UNIVERSITY OF DELAWARE
    Inventors: JOHN F. RABOLT, WENQIONG TANG, D. BRUCE CHASE, DONALD L. SPARKS
  • Publication number: 20160058326
    Abstract: Gait and mobility assessment systems and methods are disclosed. A gait and mobility assessment system comprises a shoe, a plurality of force sensors mounted on the shoe, a plurality of motion sensors mounted on the shoe, and a microprocessor affixed to the shoe. The shoe is adapted to be secured to a foot of a user such that the user may freely ambulate in an unrestricted environment. The force sensors are configured to sense forces exerted by the foot of the user. The motion sensors are configured to sense a motion of the shoe. The microprocessor is coupled to receive data from the plurality of force sensors representing the sensed forces and from the plurality of motion sensors representing the sensed motion. The microprocessor is programmed to (i) store the received data in a memory affixed to the shoe, or (ii) wirelessly transmit the received data to a remote location.
    Type: Application
    Filed: April 14, 2014
    Publication date: March 3, 2016
    Applicant: UNIVERSITY OF DELAWARE
    Inventors: Kyle N. WINFREE, Ingrid A. PRETZER-ABOFF, Sunil K. AGRAWAL
  • Patent number: 9273405
    Abstract: The present invention generally relates to cathodes used to produce chlorine gas from gaseous hydrogen chloride. The cathode comprises a cathode electrolyte comprising Fe(II) compounds and Fe(III) compounds in contact with an electron conductor. A reactor comprises a reactor solution comprising an oxidant in fluid contact with the cathode electrolyte. The fluid contact of the reactor solution with the cathode electrolyte allows the cathode electrolyte rich in Fe(II) compounds to be transferred to the reactor and combined with the reactor solution and the reactor solution rich in Fe(III) compounds to be transferred from the reactor to the cathode electrolyte after the oxidant of the reactor solution reacts with the electrolyte rich in Fe(II) compounds to form the reactor solution rich in Fe(III) compounds.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: March 1, 2016
    Assignee: University of Delaware
    Inventors: Yushan Yan, Yun Zhao
  • Patent number: 9272914
    Abstract: A uniform Si—NH—Si terminated Si(111) surface is formed by contacting a chlorine-terminated silicon surface with ammonia and a solvent such as an ether.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: March 1, 2016
    Assignee: UNIVERSITY OF DELAWARE
    Inventors: Fangyuan Tian, Douglass F. Taber, Andrew V. Teplyakov