Abstract: Apparatus is described for administering a substance to a subject. A vial contains the substance and a stopper is disposed within the vial and is slidably coupled to the vial. A first threaded element is (a) rotatable with respect to the vial and (b) substantially immobile proximally with respect to the vial during rotation of the first threaded element. A second threaded element is threadedly coupled to the first threaded element. At least a distal end of the second threaded element is substantially non-rotatable with respect to the vial, and the distal end of the second threaded element defines a coupling portion that couples the second threaded element to the stopper. The first threaded element, by rotating, linearly advances the stopper and at least the distal end of the second threaded element toward a distal end of the vial. Other embodiments are also described.

Abstract: A liquid transfer device includes a monolithic trifurcated connector body defining a barrel at a first end thereof, a single IV spike at a second end thereof and a vial adapter lumen at a third end thereof. An IV port is connected to the barrel. The single IV spike has a first IV spike lumen fluidly connected at a proximal end thereof with only the vial adapter lumen via the trifurcated connector body and a second IV spike lumen fluidly connected at a proximal end thereof with only the IV port via the trifurcated connector body, thereby separating fluid communication between the vial adapter and the single IV spike from fluid communication between the IV port and the single IV spike.

Abstract: An injector includes a housing and an activation button assembly movably mounted thereto and translatable from an unactuated position to an actuated position. A cartridge door is configured to receive therein a cartridge containing a substance to be dispensed, and is movably mounted to the injector housing between open and closed positions. A deflectable interference member is mounted within the injector housing and, in a resting position, blocks movement of the activation button assembly from the unactuated to the actuated position thereof. The activation button assembly is configured to activate the injector when in the actuated position, and is movable from the unactuated position to the actuated position solely upon deflection of the interference element out of the resting position thereof. The cartridge door, when in the closed position thereof and having the cartridge received therein, deflects the interference element out of the resting position thereof.

Abstract: A telescopic screw assembly for an injector includes an inner screw, an outer screw and a middle screw. The middle and outer screws are in a first threaded engagement, and the inner and middle screws are in a second threaded engagement. The inner screw is nested with the middle screw and the middle screw is nested with the outer screw in a contracted configuration of the screw assembly. Rotation of the outer screw in one direction advances the middle screw relative to the outer screw via the first threaded engagement and advances the inner screw relative to the middle screw via the second threaded engagement to telescopically extend the screw assembly into an expanded configuration. At least two of the inner, middle and outer screws are identified with a different visual indicator to enhance visual distinction between the screws, and readily visually indicate an extension progress of the screw assembly.

Abstract: An injector includes a housing, a needle hub movably mounted within the housing and an injection needle supported by the hub. The hub and the needle are axially translatable between retracted and injection positions. A needle shield, having an aperture, is movably connected to the housing between first and second positions. The needle extends through the needle shield aperture in the injection position of the needle and the first position of the needle shield, and the needle is blocked from extending through the needle shield aperture in the second position of the needle shield. When the needle shield is in the second position and the hub and the needle are in the injection position, the needle shield covers the tip of the needle and subsequent movement of the needle shield toward the first position axially translates the hub and the needle back toward the retracted position.

Abstract: An automatic injector for delivering a pharmaceutical substance from a reservoir of a cartridge, the cartridge interconnected to a needle at its distal end and mechanically coupled to a plunger driver at its proximal end, the injector comprising a connecting feature on the cartridge a contact surface for contacting an injection site a frame connected to the contact surface, the frame having an interference element with a distal stop, the interference element sized to slidably link to the connecting feature and allow the cartridge to slide up to the distal stop, a snap element allowing the interference element to receive the connection feature, but inhibiting disconnection of the cartridge; the frame further comprising a driver mount, for fixedly containing a plunger driver, the driver for driving a plunger to empty the reservoir of the cartridge through the needle to inject fluid from the reservoir into the injection subject.

Abstract: A system is disclosed for inserting a pharmaceutical cartridge into a delivery device. Optionally the cartridge is inserted in an arbitrary orientation. Optionally, the system reorients the cartridge to a locked orientation. For example, a driver applies a torque to the cartridge to cause the reorienting. For example, said torque rotates the cartridge around an axis thereof until the cartridge reaches the locked orientation. Optionally, when the cartridge reaches the locked orientation an interference element on the cartridge interlocks with a complementary interference element on the delivery device to lock the cartridge in the locked orientation. Optionally when the cartridge is locked in the second orientation, the torque causes discharge the pharmaceutical.

Abstract: Disclosed is a cover for an injector having a needle, a needle cap, and a needle cap remover, the cap remover being a coupler for a needle cap and a user handle, the user handle having a protruding element opposite the coupler, the protruding element having a short dimension and a long dimension, the cover comprising: at least one adhesive layer covering a surface of an outside of the injector; at least one liner layer, covering the adhesive layer, an extension extending beyond the surface; a first aperture through the adhesive layer and the liner layer aligned to an opening in the surface, the first aperture sized and shaped for passage of the coupler therethrough; and a second elongated aperture, through the extension, having a length being shorter than the short dimension and shorter than the long dimension of the protruding element.

Abstract: Disclosed herein is a pharmaceutical delivery device comprising a cartridge containing a fluid, the cartridge including a light pipe section which acts as a light pipe having an input location; and a light diffusing section optically coupled to the light pipe; and a light source optically coupled to the cartridge at the input location to the light pipe, such that at least some light from the light source entering at the input location is diffused at the light diffusing section.

Abstract: An injector includes an injection needle and an activation button assembly operatively connected to the injection needle. The activation button assembly is translatable from an unactuated position to an actuated position, the actuated position being visually different than the unactuated position. A position of the activation button assembly between the unactuated position thereof and the actuated position thereof defines a threshold point, and movement of the activation button assembly beyond the threshold point secures the activation button assembly in the actuated position, and drives the injection needle from a retracted position thereof to an injection position thereof.

Abstract: An alignment assembly for a cartridge interface of a drug delivery device is disclosed. The assembly optionally includes a coupling for opening fluid communication between the cartridge and the delivery device. For example, the coupling optionally includes a cannula insertable through a septum of the cartridge. The assembly may include a guide for positioning the cartridge and/or an access channel thereof within a first precision of a loaded position. The assembly optionally includes a cartridge engagement fitting (for example a gripping expander sleeve collar) attached to the coupling. Optionally when the cartridge is engaged to the fitting, the coupling is retained in connection with the access channel to within a second precision. The second precision is optionally higher than the first precision. In some embodiments one or more compliant supports movably retain the fitting oriented to engage the cartridge when the access channel is in the loaded position.

Abstract: A method and assembly are disclosed for interfacing between a drug cartridge and a drug delivery device. Optionally, the drug delivery device includes a compartment that retains the cartridge during drug delivery and/or a stopper pushing assembly mounted to the device behind (proximal to) the compartment. In some embodiments, the cartridge may be inserted laterally into the compartment in front of the pushing assembly. For example, the delivery device may include a moving cartridge bay. The cartridge is optionally inserted into the bay and/or the bay and cartridge optionally move into the cartridge compartment. Alternatively or additionally, the cartridge compartment may have a proximal opening into which the cartridge is inserted and/or the pushing assembly may be moved into position after insertion of the cartridge. In some embodiments the cartridge may have a distal seal that is broken by a longitudinal movement.

Abstract: An electronic injector including a needle insertion assembly configured to move a needle in an insertion direction from a first needle position where the needle is above the surface of a patient's skin to a second needle position where the needle pierces the patient's skin. The injector further includes a member mechanically coupled to the needle and configured to move when the needle. The injector further includes an optical detector having a generally planar detection surface and configured to detect movement of the member based on a change in a transverse projection of the member onto the detection surface and output a signal based on the change in the transverse projection. Additional, a processor is configured to determine the position of the needle based on the output signal, and the transverse projection of the member changes when the needle moves.

Abstract: An autoinjector including a syringe, a driver for driving the plunger of the syringe and a stabilizing adaptor for holding the injector on the skin of a patient is provided. The stabilizing adaptor has an adhesive base with a long axis to short axis ratio of at least 1.5 to 1. The syringe is orientated with its axis at an angle of between 60 and 120 degrees to the base during operation of the autoinjector.

Abstract: An add-on for a self-injector including an adaptor and a bent fluid path is provided. The adaptor includes at least one coupling sized and shaped to couple the adaptor to a fluid reservoir. The bent fluid path is configured at a first end to penetrate tissue and coupled at a second end to the adaptor. The add-on coupled to the fluid reservoir forms an integral self-injector cartridge unit configured to be sterilized and filled with an injectable. The adaptor is configured to couple to a self-injector at least one of a plurality of reservoirs having different sizes and tip types.

Abstract: A wearable medical device may be unpacked, prepared, and/or used while being grasped with a single hand position. For example, the device may be removed from a package, primed, and/or adhered to the skin of a user while being grasped with the single hand position. Optionally, the device may be used with a single hand. Optionally, the device includes a delivery interface (for example, including a needle tip and/or a skin contact surface). Optionally, the device includes a protector that preserves sterility of the delivery interface. Optionally, the cover can be removed with a single hand. Optionally, removal of the cover is performed with the same hand position as placement of the device on a delivery site.

Abstract: A system is disclosed for inserting a pharmaceutical cartridge into a delivery device. Optionally the cartridge is inserted in an arbitrary orientation. Optionally, the system reorients the cartridge to a locked orientation. For example, a driver applies a torque to the cartridge to cause the reorienting. For example, said torque rotates the cartridge around an axis thereof until the cartridge reaches the locked orientation. Optionally, when the cartridge reaches the locked orientation an interference element on the cartridge interlocks with a complementary interference element on the delivery device to lock the cartridge in the locked orientation. Optionally when the cartridge is locked in the second orientation, the torque causes discharge the pharmaceutical.

Abstract: An injector including at least one fluid reservoir having a needle, a surface attached to skin and coupled to the fluid reservoir by at least a first joint and a second joint at least a portion of one of the joints being slidable or having interlocking arms. At least a portion of a path of translation of a slidable portion of the first joint and a portion of a path of translation of the second joint are angled in respect to each another.