Abstract: A method for increasing cardiotonic contractility in humans or other animals using a class of benzodiazinonepryidazinone and hydroxy-pyrazolyl compounds and pharmaceutical compositions including the same.
Type:
Grant
Filed:
November 22, 1985
Date of Patent:
February 16, 1988
Assignee:
William H. Rorer, Inc.
Inventors:
Donald E. Kuhla, Henry F. Campbell, William L. Studt, William C. Faith, Bruce F. Molino
Abstract: Process and composition for the topical treatment of acne which comprises as ingredients a peroxide of an organic acid and an erythromycin compound selected from the group consisting of erythromycin and its stearate and glucoheptonate derivatives and in which said peroxide is from one-half to thirty times, the weight of said erythromycin compound, and a suitable pharmaceutically acceptable carrier.
Abstract: A class of bicyclic benzo-oxy heterocyclic ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
Type:
Grant
Filed:
July 2, 1986
Date of Patent:
May 26, 1987
Assignee:
William H. Rorer, Inc.
Inventors:
Donald E. Kuhla, Henry F. Campbell, William L. Studt, Kent W. Neuenschwander
Abstract: A method for increasing cardiotonic contractility in humans or other animals using a class of hydroxy and aminothiazolyl-benzodiazinone compounds and pharmaceutical compositions including the same.
Type:
Grant
Filed:
November 22, 1985
Date of Patent:
May 19, 1987
Assignee:
William H. Rorer, Inc.
Inventors:
Donald E. Kubla, Henry F. Campbell, William L. Studt, Bruce F. Molino, Thomas J. Tucker
Abstract: A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
Type:
Grant
Filed:
May 23, 1986
Date of Patent:
March 3, 1987
Assignee:
William H. Rorer, Inc.
Inventors:
Donald E. Kuhla, Henry F. Campbell, William L. Studt
Abstract: A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
Type:
Grant
Filed:
November 1, 1985
Date of Patent:
January 27, 1987
Assignee:
William H. Rorer, Inc.
Inventors:
Donald E. Kuhla, Henry F. Campbell, William L. Studt
Abstract: A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
Type:
Grant
Filed:
April 27, 1984
Date of Patent:
January 20, 1987
Assignee:
William H. Rorer, Inc.
Inventors:
Donald E. Kuhla, Henry F. Campbell, William L. Studt
Abstract: A sliding and pivoting joint, and a retractable medicament spray dispenser having such a joint. A sleeve is telescopically mounted on the dispenser housing by engaging a pair of pin-like projections on a pair of ears on the sleeve into slots which are in opposite side walls of the housing. An elongated stud protrudes perpendicularly from the inward end of each pin. When the sleeve has been telescopically extended relative to the housing, abutments in the housing interact with the protruding studs to prevent the sleeve from being pivoted to any positions beyond those which correspond to the storage and the operating configurations of the dispenser.
Type:
Grant
Filed:
January 19, 1984
Date of Patent:
January 20, 1987
Assignee:
William H. Rorer, Inc.
Inventors:
Clarence A. Wachinski, Thomas J. Bigger
Abstract: A class of bicyclic nitrogen heterocyclic ether and thioether compounds exhibiting pharmacological activity including cytoprotective, H.sub.2 -antagonist, anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions are disclosed.
Type:
Grant
Filed:
March 20, 1984
Date of Patent:
December 30, 1986
Assignee:
William H. Rorer, Inc.
Inventors:
Henry F. Campbell, Donald E. Kuhla, William L. Studt, Stuart A. Dodson
Abstract: A class of bicyclic benzo-oxy heterocyclic ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastro-intestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
Type:
Grant
Filed:
October 23, 1984
Date of Patent:
September 16, 1986
Assignee:
William H. Rorer, Inc.
Inventors:
Donald E. Kuhla, Henry F. Campbell, William L. Studt, Kent W. Neuenschwander
Abstract: This invention relates to an improvement comprising coating agitated particles of substantially anhydrous antacid with a solvent-free mixture of electronegatively charged material in a non-toxic inert substantially water insoluble oil.
Type:
Grant
Filed:
November 30, 1984
Date of Patent:
August 12, 1986
Assignee:
William H. Rorer, Inc.
Inventors:
John D. Buehler, Hans J. Medal, Gregory A. Rhoa
Abstract: A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including gastrointestinal anti-ulcerogenic and cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
Type:
Grant
Filed:
October 23, 1984
Date of Patent:
June 17, 1986
Assignee:
William H. Rorer, Inc.
Inventors:
Donald E. Kuhla, Henry F. Campbell, William L. Studt, Stuart A. Dodson
Abstract: Cardiotonic 5-heteroaryl-substituted-2-pyridone compounds, pharamaceutical compositions, and a method for the treatment of congestive heart failure.
Abstract: A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
Type:
Grant
Filed:
October 24, 1984
Date of Patent:
May 13, 1986
Assignee:
William H. Rorer, Inc.
Inventors:
William L. Studt, Donald E. Kuhla, Henry F. Campbell
Abstract: This invention relates to a novel class of heterocyclic amidinourea and heterocyclic amidinothiourea compounds wherein the heterocyclic substitution is at the 1-N urea nitrogen atom. These compounds exhibit pharmaceutical activity and may be incorporated into pharmaceutical preparations for producing anti-ulcerogenic, antisecretory, antispasmodic, antimotility, cardiovascular, antidiarrheal or antiparasitic action.
Type:
Grant
Filed:
February 24, 1984
Date of Patent:
January 21, 1986
Assignee:
William H. Rorer, Inc.
Inventors:
William L. Studt, Harry K. Zimmerman, George H. Douglas
Abstract: A method of inducing blood pressure reduction in humans and mammals by administering 2,6-disubstituted phenyl N-alkyl amidinoureas in which the phenyl ring is additionally substituted by a hydroxy, alkoxy, aralkoxy, alkenyloxy, alkynyloxy, acyloxy or halo acyloxy group and a novel class of amidinourea compounds having pharmaceutical uses, including blood pressure lowering activity.
Type:
Grant
Filed:
February 2, 1984
Date of Patent:
January 14, 1986
Assignee:
William H. Rorer, Inc.
Inventors:
William L. Studt, Richard L. Riley, George H. Douglas