Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-diarrheal agents.
Abstract: New compositions containing as the principle active ingredient a 1,4-disubstituted-1,2-dihydro-1,3,5-triazin-2-one are used for remedial or prophylactic treatment of diarrhea and organic gastrointestinal disorders accompanied by diarrheal symptoms.
Type:
Grant
Filed:
November 13, 1978
Date of Patent:
May 20, 1980
Assignee:
William H. Rorer, Inc.
Inventors:
John Yelnosky, George H. Douglas, Ghulam N. Mir, Dahyabhai M. Patel, Chong M. Won, Ronald L. Alioto
Abstract: 1,4-disubstituted-1,2-dihydro-1,3,5-triazine-2-ones and their pharmaceutically acceptable salts are used in the prevention and treatment of gastrointestinal disorders associated with hyperactivity of the secretory glands in the gastrointestinal tract.
Type:
Grant
Filed:
November 13, 1978
Date of Patent:
May 20, 1980
Assignee:
William H. Rorer, Inc.
Inventors:
George H. Douglas, Ghulam N. Mir, Chong M. Won, William L. Studt
Abstract: 1,4-disubstituted-1,2-dihydro-1,3,5-triazin-2-ones and their pharmaceutically acceptable salts are used in the control of abdominal spasticity especially the treatment of spasmodic conditions of the gastrointestinal tract by administering an effective amount of the triazinone in suitable pharmaceutical dosage forms including oral or parenteral dosage forms compounded with pharmaceutically acceptable carrier materials to patients having spasmodic syndromes.
Type:
Grant
Filed:
November 13, 1978
Date of Patent:
May 20, 1980
Assignee:
William H. Rorer, Inc.
Inventors:
John Yelnosky, George H. Douglas, Ghulam N. Mir, Chong M. Won
Abstract: An improved method for testing the effect of chemical substances on contact with the skin by use of a protective shield to be worn by laboratory test animals in identification purposes and to prevent removal of a topically applied test substance.
Abstract: This invention describes a method of treating inflammation in warm-blooded animals by topically administering an effective amount of a benzylideneaniline derivative, and the compositions therefore.
Type:
Grant
Filed:
September 15, 1978
Date of Patent:
April 29, 1980
Assignee:
William H. Rorer, Inc.
Inventors:
George W. Nuss, Jr., Norman J. Santora, George H. Douglas
Abstract: 1,4-Disubstituted-1,2-dihydro-1,3,5-triazin-2-ones are used to block conduction of high frequency nerve impulses by selectively acting to substantially completely block high frequency impulses without significantly blocking conduction of a single impulse. The effect is reversible when the drug is withdrawn.
Type:
Grant
Filed:
November 13, 1978
Date of Patent:
April 15, 1980
Assignee:
William H. Rorer, Inc.
Inventors:
George A. Condouris, John Yelnosky, Richard L. Riley, Chong M. Won, George H. Douglas, William L. Studt
Abstract: New compositions containing as the principle active ingredient a 1,4-disubstituted-1,2-dihydro-1,3,5-triazin-2-one are used for remedial or prophylactic treatment of diarrhea and organic gastrointestinal disorders accompanied by diarrheal symptoms.
Type:
Grant
Filed:
November 13, 1978
Date of Patent:
April 15, 1980
Assignee:
William H. Rorer, Inc.
Inventors:
John Yelnosky, George H. Douglas, Ghulam N. Mir, Dahyabhai M. Patel, Chong M. Won, Ronald L. Alioto
Abstract: This invention describes a method of treating inflammation in warm blooded animals by topically administering an effective amount of benzylideneaniline or its derivatives.
Type:
Grant
Filed:
September 26, 1978
Date of Patent:
April 15, 1980
Assignee:
William H. Rorer, Inc.
Inventors:
George W. Nuss, Jr., Norman J. Santora, George H. Douglas
Abstract: Compositions for treating radiation induced erythemas and for protecting the human skin against the harmful effects of sunlight, containing as the active ingredient N-benzylideneaniline and its derivatives.
Type:
Grant
Filed:
September 15, 1978
Date of Patent:
February 5, 1980
Assignee:
William H. Rorer, Inc.
Inventors:
George W. Nuss, Jr., Norman J. Santora, George H. Douglas
Abstract: This invention describes novel chemical compounds which are 1-amidino-3-phenylureas. The method of preparing these compounds and their pharmaceutical uses is also disclosed.
Abstract: Compositions effective for topically treating skin conditions, especially psoriasis and eczema which contains as an essential ingredient coal tar in a gel base.
Abstract: This invention describes a method of treating inflammation in warm blooded animals by topically administering an effective amount of benzylideneaniline or its derivatives.
Type:
Grant
Filed:
October 6, 1977
Date of Patent:
November 27, 1979
Assignee:
William H. Rorer, Inc.
Inventors:
George W. Nuss, Jr., Norman J. Santora, George H. Douglas
Abstract: The method of treating patients by administering an effective amount of a mercapto, lower acyl thio or lower alkyl thio substituted ethynylbenzene compound, and the pharmaceutical preparation thereof.
Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
Type:
Grant
Filed:
August 18, 1978
Date of Patent:
September 25, 1979
Assignee:
William H. Rorer, Inc.
Inventors:
George H. Douglas, William L. Studt, Stuart A. Dodson