Patents Examined by Abigail Fisher
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Patent number: 9675636Abstract: A polymer composition for sequestering lipid-bile acid micelles in the gastrointestinal (GI) tract is provided. The polymer composition comprises a copolymer of a pH-sensitive monomer and one or more of positively-charged monomers. The polymer composition is able to bind micelles under various physiological conditions in the GI tract and possesses the ability to flocculate the bound micelle upon exposure to a particular pH. The flocculation of the polymer:micelle complex prevents absorption of the micelle thereby causing the polymer:micelle complex to be eliminated with the fecal matter. Thus, the polymer composition described herein may be effective in reducing cholesterol, bile acid, and/or triglyceride levels and promote weight loss.Type: GrantFiled: January 29, 2015Date of Patent: June 13, 2017Assignee: UNIVERSITY OF KANSASInventors: Cory Berkland, Jian Qian, Bradley Paul Sullivan
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Patent number: 9668988Abstract: Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with reduced side effects and/or longer time at maximum concentration.Type: GrantFiled: September 9, 2014Date of Patent: June 6, 2017Assignee: Pathologica LLCInventors: John McKearn, Jeremy Blitzer
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Patent number: 9668954Abstract: Formulations, kits, and methods for rebuilding the disulfide bonds in keratin found in hair, skin, or nails. Hair that is damaged due to a hair coloring treatment and/or other reducing treatment, such as during a permanent wave, can be treated with the formulations containing one or more active agents. The formulations may be applied subsequent to a hair coloring treatment or simultaneously with a hair coloring treatment. Use of the active agent formulations during a permanent wave treatment prevents the reversion of the hair to its previous state, for at least one week, preferably at least three months, more preferably at least one year, most preferably greater than one year, after one or more than one application of the formulation. Application of the active agent formulation to skin or nails can help repair damaged disulfide bonds due to natural wear and tear or natural aging.Type: GrantFiled: January 25, 2017Date of Patent: June 6, 2017Assignee: Liqwd, Inc.Inventors: Eric D. Pressly, Craig J. Hawker
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Patent number: 9669054Abstract: The present invention relates to a pH buffered bioactive glass, and its preparation process and use. The pH buffered bioactive glass comprises SiO2, CaO, Na2O, and P2O5, and further comprises solid acidic particles or a Tris buffer solution. The pH buffered bioactive glass can regulate the pH of formulations comprising bioactive glass, and has a good therapeutic effect with a low dosage.Type: GrantFiled: September 20, 2012Date of Patent: June 6, 2017Assignee: Changzhou Bio-Sheng Technology Co., LTDInventors: Jipin Zhong, Yongxiang Wang, Jiang Chang, Yuhong Xu
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Patent number: 9656874Abstract: A method for producing particles containing a metal oxide is provided, and the method includes: feeding a metal oxide sol having a pH of 7 or higher and containing metal oxide colloidal particles as dispersoids and water as a dispersion medium, into a liquid containing a solvent having a solubility in 20° C. water of 0.05 g/100 ml or more and having a relative permittivity of 30 or lower (protic solvent) or of 40 or lower (aprotic solvent) at 20° C., and thereby forming aggregates of the metal oxide colloidal particles in the liquid; and subjecting the aggregates to a treatment such as drying and heating, and thereby converting the aggregates into particles that are insoluble in water. By appropriately selecting the solvent, particles can be obtained in the form of flakes, fibers, spheres, and the like.Type: GrantFiled: January 11, 2012Date of Patent: May 23, 2017Assignee: NIPPON SHEET GLASS COMPANY, LIMITEDInventors: Kazuhiro Doshita, Toshitaka Furuichi
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Patent number: 9657183Abstract: A coated powder comprises (a) nanoparticles, and (b) a coating, on the surface of the nanoparticles. The coating comprises (1) silica moieties, (2) organo oxysilane moieties selected from the group consisting of mono-organo oxysilane moieties, bi-organo oxysilane moieties and tri-organo oxysilane moieties, and (3) poly(dialkyl)siloxane moieties.Type: GrantFiled: August 14, 2015Date of Patent: May 23, 2017Assignee: Nanophase Technologies CorporationInventors: Kushal D. Shah, Harry W. Sarkas, Patrick G. Murray
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Patent number: 9655843Abstract: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.Type: GrantFiled: July 18, 2016Date of Patent: May 23, 2017Assignee: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Patent number: 9649279Abstract: Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.Type: GrantFiled: December 16, 2014Date of Patent: May 16, 2017Assignees: Massachusetts Institute of Technology, Tokitae LLCInventors: Ana Jaklenec, Xian Xu, Lowell L. Wood, Jr., Philip A. Eckhoff, William Gates, Boris Nikolic, Robert S. Langer
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Patent number: 9648872Abstract: A water dispersible granular composition comprising: i. microcapsules comprising of: a. at least one agrochemical active ingredient encapsulated within a polymeric shell wall; and, wherein the agrochemical active ingredient has a water solubility of less than 100 mg/liter; and, b. polyvinyl alcohol with a molecular weight of from 15,000 to 21,000, a degree of hydrolysis of from 87% to 89% and a viscosity of from 3.5 cps to 4.5 cps; ii. a filler base comprising of: a. at least one water insoluble filler; and b. at least one water soluble suspension adjuvant; and, iii. at least one agrochemical excipient.Type: GrantFiled: February 19, 2015Date of Patent: May 16, 2017Inventor: Deepak Shah
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Patent number: 9649413Abstract: Embodiments herein include coatings with crystallized active agent(s) and related methods. In an embodiment, a method is included for coating a medical device including selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device. In an embodiment, an elution control coating disposed on a medical device is included, the elution control coating including an active agent that is at least about 80% crystallized within one week of being disposed on the medical device. In an embodiment, a method is included for enhancing the formation of active agent crystals within a coating layer including adjusting the concentration of an active agent in a coating solution to reach some percentage of the active agent saturation point.Type: GrantFiled: June 29, 2015Date of Patent: May 16, 2017Assignee: Surmodics, Inc.Inventors: Ralph A. Chappa, Kimberly K. M. Lindsoe
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Patent number: 9642811Abstract: An abuse deterrent immediate release biphasic matrix solid dosage form that releases the drug at a desired rate for quick onset of action when a single unit or prescribed units of the dosage form are orally administered but exhibits a reduced rate of release when more than the prescribed number of units, are administered.Type: GrantFiled: March 25, 2015Date of Patent: May 9, 2017Assignee: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.Inventors: Nitin Bhalachandra Dharmadhikari, Yashoraj Rupsinh Zala, Dilip Shanghvi
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Patent number: 9636319Abstract: Described herein are pharmaceutical compositions comprising fumarate esters, methods for making the same, and methods for treating subjects in need thereof. In particular, oral controlled release pharmaceutical compositions comprising fumarate esters suspended in liquid matrices are described. One embodiment described herein is a pharmaceutical composition comprising fumarate esters suspended in a lipid or lipophilic liquid with enhanced bioavailability.Type: GrantFiled: December 21, 2016Date of Patent: May 2, 2017Assignee: BANNER LIFE SCIENCES LLCInventors: Jason M. Vaughn, Justin R. Hughey, Tanesha Roberts, Tatyana Dyakonov, Sunil Agnihotri, Aqeel A. Fatmi
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Patent number: 9636318Abstract: Described herein are pharmaceutical compositions comprising fumarate esters, methods for making the same, and methods for treating subjects in need thereof. In particular, oral controlled release pharmaceutical compositions comprising fumarate esters suspended in liquid matrices are described. One embodiment described herein is a pharmaceutical composition comprising fumarate esters suspended in a lipid or lipophilic liquid with enhanced bioavailability.Type: GrantFiled: August 26, 2016Date of Patent: May 2, 2017Assignee: BANNER LIFE SCIENCES LLCInventors: Jason M. Vaughn, Justin R. Hughey, Tanesha Roberts, Tatyana Dyakonov, Sunil Agnihotri, Aqeel A. Fatmi
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Patent number: 9636362Abstract: Compositions and methods are provided for the manufacture and use of a pullulan-based collagen hydrogel film with controlled porosity. The hydrogel is fabricated with salt-induced phase inversion and cross-linking to form a reticular scaffold. This soft collagen scaffold displays excellent handling characteristics, durability, and a porous dermal-like ultrastructure that is maintained in vitro. Cells, including cells involved in tissue repair, are viably sustained within the scaffold. The hydrogel films are biodegradable, and find particular use in wound healing, where the hydrogel scaffold can be replaced by dermal cells over time.Type: GrantFiled: March 3, 2011Date of Patent: May 2, 2017Assignee: The Board of Trustees of The Leland Stanford Junior UniversityInventors: Geoffrey C. Gurtner, Kirit Bhatt, Jayakumar Rajadas
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Patent number: 9623010Abstract: This invention relates to a an orally disintegrating tablet obtainable by direct compression of a dry powdered mixture, said mixture comprising up to 15% by weight of calcium silicate, at least 50% of a diluent, a disintegrant agent and an active ingredient. It also relates to a process for preparing the tablets by homogeneous blending the specific excipients in powder form and subsequent direct compression of the mixture. Said tablets disintegrate quickly in the cavity of the mouth, in particular in less than 15 seconds.Type: GrantFiled: September 30, 2008Date of Patent: April 18, 2017Assignee: LABORATORIOS LESVI, S.L.Inventors: Carmen Úbeda Pérez, Ignacio Díez Martín, Pablo Pablo Alba
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Patent number: 9615576Abstract: This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.Type: GrantFiled: March 25, 2014Date of Patent: April 11, 2017Assignee: Dow AgroSciences LLCInventors: James E. Hunter, William C. Lo, Gerald B. Watson, Akshay Patny, Gary D. Gustafson, Dan Pernich, William K. Brewster, Debra L. Camper, Beth Lorsbach, Michael R. Loso, Thomas C. Sparks, Hemant Joshi, Adiraj Mandaleswaran, Ramadevi Sanam, Rambabu Gundla, Pravin S. Iyer
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Patent number: 9610232Abstract: The invention relates to the use of sphinganine for improving the visual appearance of skin and hair, for caring for, for protecting and/or for stimulating the growth of skin and hair.Type: GrantFiled: July 4, 2012Date of Patent: April 4, 2017Assignee: EVONIK DEGUSSA GMBHInventors: Mike Farwick, Tim Koehler, Matthias Mentel
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Patent number: 9604983Abstract: The present invention relates to herbicidal benzyloxy-substituted phenyl-diones and phenyl-dioxo-thiazinones of formula (I), as well as to herbicidal compositions comprising such compounds, and to the use of such compounds or compositions in controlling undesirable plant growth, in particular in controlling weeds, such as broad-leaved dicotyledonous weeds, in crops of useful plants. Formula (I), or a salt or N-oxide thereof, wherein A1 is N or CR1; A3 is C(O) or S(O)2; G is hydrogen or C(O)R6; R1, R3, X and Y are i.a. hydrogen, alkyl or haloalkyl; n is 0-5; each Z is i.a. alkyl, haloalkyl or alkoxy; and R6 is i.a. alkyl, alkenyl or alkynyl.Type: GrantFiled: October 24, 2014Date of Patent: March 28, 2017Assignee: Syngenta LimitedInventors: Stephen Edward Shanahan, Alan Joseph Hennessy, Timothy Jeremiah Cornelius O'Riordan, Paul Matthew Burton
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Patent number: 9597288Abstract: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.Type: GrantFiled: June 30, 2016Date of Patent: March 21, 2017Assignee: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Patent number: 9597267Abstract: Slurry powder cosmetic composition comprising particulates coated with a binder composition, a silicone gel composition, and the evaporation residue of an alcohol based composition and a method for making the composition.Type: GrantFiled: March 26, 2013Date of Patent: March 21, 2017Assignee: ELC Management LLCInventors: Talal Finjan, Syed Rizvi, John R. Castro